成果論文リスト

• 2024年度
• 2023年度
• 2022年度
• 2021年度
• 2020年度
• 2019年度
• 2018年度
• 2017年度
• 2016年度

2024年度

1. Yasuko Okano, Kengo Usui, Takeshi Hanami, Masataka Taguri, Toshinari Yamashita, and Yohei Miyagi
   Association between polymorphisms of NRF2 and breast cancer risk in Japanese population.
   Japanese Journal of Clinical Pharmacology and Therapeutics 55(2):67-73, 2024. DOI:10.3999/jscpt.55.2_67

2023年度

1. Nakano W, Ozaki E, Kato M, Tsukamoto T, Ono S, Tomida S, Kuriyama N, Koyama T.
   Association between bone health and dynapenic obesity in postmenopausal women.
   Geriatr Gerontol Int. 24(4):378-384, 2024. DOI:10.1111/ggi.14849
2. Hiramatsu R, Ozaki E, Kuriyama N, Tomida S, Koyama T.
   One Cup of Coffee a Day Modulates the Relationship between Metabolic Syndrome and Eating Fast: A Cross-Sectional Study.
   Healthcare 12:603, 2024. DOI:10.3390/healthcare12060603
3. Takihira S, Yamada D, Osone T, Takao T, Sakaguchi M,.., Toshiyuki Kunisada, Toshifumi Ozaki, Takeshi Takarada
   PRRX1-TOP2A interaction is a malignancy-promoting factor in human malignant peripheral nerve sheath tumours.
   British Journal of Cancer 130(9):1493-1504, 2024. DOI:10.1038/s41416-024-02632-8
4. Ayako Oda, Yosuke Suzuki, Haruki Sato, Teruhide Koyama, Masahiro Nakatochi, Yukihide Momozawa, et al.
   Evaluation of the usefulness of plasma 4β-hydroxycholesterol concentration normalized by 4α-hydroxycholesterol for accurate CYP3A phenotyping.
   Clin Transl Sci 17(3):e13768, 2024. DOI:10.1111/cts.13768
5. Ukawa S, Kato Y, Lee Y, Ohara K, Mori K
   FACTORS THAT INFLUENCE THE SENSE OF ATTACHMENT TO THE COMMUNITY IN THE JAPANESE SUBURBAN POPULATION.
   Proceedings of the International Conference on Public Health 8(2):37-46, 2024. DOI:10.17501/24246735.2023.8205
6. Hao W, Shan YF, Kimura T, Ukawa S, Ohira H, Okabayashi S, Wakai K, Ando M, Tamakoshi A.
   Dual decline in subjective gait speed and domain-specific cognition is associated with higher risk of incident dementia in older Japanese adults: A 15-year age-specific cohort study.
   Arch Gerontol Geriatr. 117:105254, 2024. DOI:10.1016/j.archger.2023.105254
7. Kurano M, Saito Y, Yatomi Y.
   Comprehensive Analysis of Metabolites in Postmortem Brains of Patients with Alzheimer's Disease.
   J Alzheimers Dis. 97(3):1139-1159, 2024. DOI:10.3233/JAD-230942
8. Y. N. Koyanagi, M. Nakatochi, S. Namba, I. Oze, H. Charvat, A. Narita, T. Kawaguchi, H. Ikezaki, A. Hishida, M. Hara, T. Takezaki, T. Koyama, Y. Nakamura,
   Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people.
   Sci Adv 10(4):eade2780, 2024. DOI:10.1126/sciadv.ade2780
9. Miyake A, Harada S, Takebayashi T, Iida M, et al
   Reliability of Time-Series Plasma Metabolome Data over 6 Years in a Large-Scale Cohort Study.
   Metabolites 14:77, 2024. DOI:10.3390/metabo14010077
10. M. Iwase, Y. Taniyama, Y. N. Koyanagi, Y. Kasugai, I. Oze, N. Masuda, H. Ito and K. Matsuo.
    A Century of Change: Unraveling the Impact of Socioeconomic/Historical Milestones on Age at Menarche and Other Female Reproductive Factors in Japan.
    J Epidemiol , 2024. DOI:10.2188/jea.JE20230155
11. Harada S, Iida M, Miyagawa N, Hirata A, Kuwabara K, Matsumoto M, Okamura , Soga T, Takebayashi T, et al.
    Study Profile of the Tsuruoka Metabolomics Cohort Study (TMCS).
    J Epidemiol , 2024. DOI:10.2188/jea.JE20230192
12. Oshima T, Hashimoto I, Hiroshima Y, Kimura Y, Tanabe M, Onuma S, Morita J, Nagasawa S, Kanematsu K, Aoyama T, Yamada T, Ogata T, Rino Y, Saito A, Miyagi Y.
    Clinical Significance of Pregnancy Zone Protein Expression in Patients With Locally Advanced Gastric Cancer After Curative Resection.
    Anticancer Res. 44:369-374, 2024. DOI:10.21873/anticanres.16820
13. Oshima T, Hashimoto I, Hiroshima Y, Kimura Y, Tanabe M, Onuma S, Nagasawa S, Kanematsu K, Aoyama T, Yamada T, Ogata T, Rino Y, Saito A, Miyagi Y.
    Asialoglycoprotein Receptor 2 Expression in Patients With Locally Advanced Gastric Cancer After Curative Resection.
    Anticancer Res. 44:397-402, 2024. DOI:10.21873/anticanres.16824
14. Oshima T, Hashimoto I, Hiroshima Y, Kimura Y, Tanabe M, Onuma S, Nagasawa S, Kanematsu K, Aoyama T, Yamada T, Ogata T, Rino Y, Saito A, Miyagi Y.
    Clinical Significance of Chitinase-3-like Protein 1 Gene Expression in Patients With Locally Advanced Gastric Cancer.
    Anticancer Res. 44:307-312, 2023. DOI:10.21873/anticanres.16813
15. Taniguchi R, Ukawa S, Zhao W, Okabayashi S, Kimura T, Shan Y, Ando M, Wakai K, Tsushita K, Kawamura T, Tamakoshi A.
    Associations of depressive symptoms and instrumental activities of daily living decline by employment or participation in social activities among younger-older Japanese in the New Integrated Suburban Seniority Investigation (NISSIN) Project.
    Archives of Gerontology and Geriatrics Plus 1(2):100013, 2023. DOI:10.1016/j.aggp.2024.100013
16. Takahashi T, Tomonobu N, Kinoshita R,.., Toyooka S, Zamami Y, Sakaguchi M
    Lysyl oxidase-like 4 promotes the invasiveness of triple-negative breast cancer cells by orchestrating the invasive machinery formed by annexin A2 and S100A11 on the cell surface.
    Frontiers in Oncology 14:371342, 2024. DOI:10.3389/fonc.2024.1371342
17. Hayashi Y, Ozono T, Beck G, Yonenobu Y, Yamashita R, Ikenaka K, Okuno T, Murayama S, Mochizuki H.
    Successful treatment of seronegative immune-mediated necrotizing myopathy developing during pregnancy: A case report and literature review.
    Neurology and Clinical Neuroscience 12(2):113-117, 2024. DOI:10.1111/ncn3.12781
18. Kato M, Ozaki E, Omichi C, Kurita Y, Nakano S, Takagi D, Kuriyama N, Koyama T.
    Association between poor sleep quality and locomotive syndrome in middle-aged and older women: A community-based, cross-sectional study.
    Mod Rheumatol. 14:188-198, 2024. DOI:10.1093/mr/road025
19. Shiraishi K, Takahashi A, Momozawa Y, Daigo Y, Takano A, Miyagi Y, Ito H, Wakai K, Shimizu A, Yamamoto M, Iwasaki M, Matsuda K, Inazawa J, Kohno T, et. al.
    Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses.
    Cancer Communication 44(2):287-293, 2024. DOI:10.1002/cac2.12498
20. Iwasaka C, Yamada Y, Nishida Y, Hara M, Yasukata J, Miyoshi N, Shimanoe C, Nanri H, Furukawa T, Koga K, Horita M, Higaki Y, Tanaka K.
    Association Between the Appendicular Extracellular-to-Intracellular Water Ratio and All-Cause Mortality: A 10-Year Longitudinal Study.
    J Gerontol A Biol Sci Med Sci. 79(2):glad211, 2024. DOI:10.1093/gerona/glad211
21. Tomida S, Koyama T, Wakai K, Matsuo K., et al.
    Seven-plus hours of daily sedentary time and the subsequent risk of breast cancer: Japan Multi-Institutional Collaborative Cohort Study.
    Cancer Sci. 115(2):611-622, 2024. DOI:10.1111/cas.16020
22. Shan Y, Zhao W, Hao W, Kimura T, Ukawa S, Ohira H, Kawamura T, Wakai K, Ando M, Tamakoshi A, Wang C.
    Five-year changes of social activity and incident long-term care needs among depressed older adults: A 15-year follow up.
    Arch Gerontol Geriatr 116:105163, 2024. DOI:10.1016/j.archger.2023.105163
23. Asami Yamada, Jun-ichirou Yasunaga, Toshiki Watanabe, Kisato Nosaka, Masao Matsuoka, et al.
    Anti-HTLV-1 immunity combined with proviral load as predictive biomarkers for adult T-cell leukemia-lymphoma.
    Cancer Science 115(1):310-320, 2024. DOI:10.1111/cas.15997
24. Takatsu F, Suzawa K, Tomida S, Thu YM, Sakaguchi M,.., Shien K, Yamamoto H, Nakayama A, Okazaki M, Sugimoto S, Toyooka S
    Periostin secreted by cancer-associated fibroblasts promotes cancer progression and drug resistance in non-small cell lung cancer.
    Journal of molecular medicine (Berlin, Germany) 101:1603-1614, 2023. DOI:10.1007/s00109-023-02384-7
25. Mikiko Tokiya, Takaomi Kobayashi, Mizuho A. Kido , Akiko Matsumoto
    ALDH2 polymorphism rs671 and alcohol consumption: possible explanatory factors for race/ethnic differences in bone density.
    Osteoporosis International 34:2133-2135, 2023. DOI:10.1007/s00198-023-06909-1
26. Adachi Y, Nojima M, Mori M, Yamano HO, Sasaki Y, Nakase H, Lin Y, Wakai K, Tamakoshi A; for JACC study
    Association of serum superoxide dismutase activity and the incidence of colorectal cancer in a nested case-control study.
    Cancer Epidemiol 87:102455, 2023. DOI:10.1016/j.canep.2023.102455
27. Tarutani A, Kametani F, Tahira M, Saito Y, Yoshida M, Robinson AC, Mann DMA, Murayama S, Tomita T and Hasegawa M,
    Distinct tau folds initiate templated seeding and alter the post-translational modification profile.
    Brain 146(12):4988-4999, 2023. DOI:10.1093/brain/awad272
28. Ishikawa S, Konta T, Susa S, Ishizawa K, Makino N, Ueno Y, Okuyama N, Iino M.
    Associations between subjective well-being, number of teeth, and self-rated mastication in Japanese adults: A cross-sectional study.
    Medicine (Baltimore) 102:e36354, 2023. DOI:10.1097/MD.0000000000036354
29. Daisuke Takagi, Michitaka Kato, Etsuko Ozaki, Yasunari Kurita, Wataru Nakano, Daisuke Matsui, Teruhide Koyama.
    The combination of locomotive syndrome and poor sleep quality is a risk factor of falls among community-dwelling middle-aged and older women: A cross-sectional study.
    Geriatrics & Gerontology International 23:912-918, 2023. DOI:10.1111/ggi.14710
30. Teramoto M, Yamagishi K, Shirai K, Muraki I, Ukawa S, Tamakoshi A, Iso H
    Television viewing time and all-cause and cardiovascular disease mortality among Japanese adults with and without a history of stroke or myocardial infarction.
    Journal of Atherosclerosis and Thrombosis 30:1817-1827, 2023. DOI:10.5551/jat.63959
31. Sayaka Saito, Kei Mukohara , Kazuhiro Shimomura, Kenta Murotani
    Public perceptions of physician-pharmaceutical industry relationships and trust in physicians.
    Plos ONE 18:e0294854, 2023. DOI:10.1371/journal.pone.0294854
32. Li M, Nishimura T, Takeuchi Y, Hongu T, Wang Y, Shiokawa D, Wang K, .., Nakato R, Suzuki S, Tojo A, Voon VC, Ogawa S, Okamoto K, Foukakis T, Gotoh N
    FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters.
    J Clin Invest 133:e166666, 2023. DOI:10.1172/JCI166666
33. D. Nishimoto, R. Ibusuki, I. Shimoshikiryo, K. Shibuya, S. Tanoue, C. Koriyama, T. Takezaki, I. Oze, H. Ito, A. Hishida, T. Tamura, Y. Kato, Y. Tamada,
    Association between awareness of limiting food intake and all-cause mortality: A cohort study in Japan.
    J Epidemiol , 2023. DOI:10.2188/jea.JE20220354
34. Harada S, Ohmono H, Matsumoto M, Sata M, Iida M, Soga T, Takebayashi T, et al.
    Metabolomics profiles alterations in cigarette smokers and heated tobacco product users.
    Journal of Epidemiology , 2023. DOI:10.2188/jea.JE20230170
35. Mezawa Y, Wang T, Daigo Y, Takano A, Miyagi Y, Yokose T, Yamashita T, Yang L, Maruyama R, Seimiya H, Orimo A
    Glutamine deficiency drives TGF-β signaling activation that gives rise to myofibroblastic carcinoma-associated fibroblasts.
    Cancer Science 114(11):4376-4387, 2023. DOI:10.1111/cas.15955
36. M. Sawabe, D. Kawakita, I. Oze, S. Iwasaki, Y. Hasegawa, S. Murakami, H. Ito, N. Hanai and K. Matsuo.
    The Heterogeneous Impact of Prediagnostic Folate Intake for Fluorouracil-Containing Induction Chemotherapy for Head and Neck Cancer.
    Cancers 15(21):5150, 2023. DOI:10.3390/cancers15215150
37. Kato M, Ozaki E, Matsui D, Nakano W, Nakano S, Ono S, Kito K, Koyama T.
    Locomotive syndrome and depressive symptoms: A cross-sectional study in middle-aged women.
    Mod Rheumatol 34(4):858–863, 2023. DOI:10.1093/mr/road096
38. Y. Kojima, E. Mishiro-Sato, T. Fujishita, K. Satoh, R. Kajino-Sakamoto, I. Oze, Y. Narita, K. Matsuo, K. Muro, M. M. Taketo, T. Soga, M. Aoki.
    Decreased liver B vitamin-related enzymes as a metabolic hallmark of cancer cachexia.
    Nat Commun 14:6246, 2023. DOI:10.1038/s41467-023-41952-w
39. Hosaka T, Tsuji H, Terada M, Tomidokoro Y, Ishii A, Nakamagoe K, Ishii K, Terashi H, Aizawa H, Tamaoka A, Kwak S
    Glutamine/arginine site-unedited GluA2 mRNA in cerebrospinal fluid as a biomarker for amyotrophic lateral sclerosis.
    J Neurol Neurosurg Psychiat 94:876-878, 2023. DOI:10.1136/jnnp-2023-331164
40. Teranishi Y, Miyawaki S, Nakatochi M, Okano A, Ikemura M, Komura D, Katoh H, Mitsui J, Morishita S, Ushiku T, Ishikawa S, Nakatomi H, Saito N.
    Meningiomas in patients with neurofibromatosis type 2 predominantly comprise ‘immunogenic subtype’ tumours characterised by macrophage infiltration.
    Acta Neuropathologica Communications 11(1):156, 2023. DOI:10.1186/s40478-023-01645-3
41. Vail M.E, Farnsworth R.H, Hii L, Allen S, Arora S, Anderson R.L, Dickins R.A, Orimo A, Wu S.Z, Swarbrick A, Scott A.M, Janes P.W.
    Inhibition of EphA3 expression in tumour stromal cells suppresses tumour growth and progression.
    Cancers 15(18):4646, 2023. DOI:10.3390/cancers15184646
42. Sato S, Nakagawa M, Terashima T, Morinaga, S, Miyagi Y, Yoshiada E, Yoshimura T, Seiki M, Kaneko S, Ueno M, Yamashita T, Koshikawa N.
    EphA2 proteolytic fragment as a sensitive diagnostic biomarker for very early-stage pancreatic ductal carcinoma.
    Cancer Res Communi. 3(9):1862-1874, 2023. DOI:10.1158/2767-9764.CRC-23-0087
43. Takuya Hiratsuka, Shinji Ito, Rika Sakai, Tomoyuki Yokose, Tatsuya Endo, Yataro Daigo, Yohei Miyagi, Tatsuaki Tsuruyama
    Proteome analysis of CD5-positive diffuse large B cell lymphoma FFPE tissue reveals downregulation of DDX3X, DNAJB1, and B cell receptor signaling pathway proteins including BTK and Immunoglobulins.
    Clinical proteomics 20:36, 2023. DOI:10.1186/s12014-023-09422-z
44. Watanabe H, Murakami R, Tsumagari K, Morimoto S, Hashimoto T, Imaizumi K, Sonn I, Yamada K, Saito Y, Murayama S, Iwatsubo T, Okano H
    Astrocytic APOE4 genotype-mediated negative impacts on synaptic architecture in human pluripotent stem cell model.
    Stem Cell Reports 18:1854-1869, 2023. DOI:10.1016/j.stemcr.2023.08.002
45. Scammell BH, Tchio C, Song Y, Nishiyama T, Louie TL, Dashti HS, Nakatochi M, Zee PC, Daghlas I, Momozawa Y, Cai J, Ollila HM, Redline S, Wakai K, Sofer T, Suzuki S, Lane JM, Saxena R.
    Multi-ancestry genome-wide analysis identifies shared genetic effects and common genetic variants for self-reported sleep duration.
    Hum Mol Genet. 32(18):2797-2807, 2023. DOI:10.1093/hmg/ddad101
46. Fujita K, Homma H, Jin M, Yoshioka Y, Jin X, Saito Y, Tanaka H, Okazawa H.
    Mutant a-synuclein propagates via the lymphatic system of the brain in the monomeric state.
    Cell Reports 42(8):112962, 2023. DOI:10.1016/j.celrep.2023.112962
47. Koyama Y, Okazaki H, Koyama T, Katakura A, Yasukawa T*, Orimo A. et al.
    Increased RUNX3 expression mediates tumor-promoting ability of human breast cancer-associated fibroblasts.
    Cancer Med. 12(17):18062-18077, 2023. DOI:10.1002/cam4.6421
48. Kawachi H, Teramoto M, Muraki I, Shirai K, Yamagishi K, Tamakoshi A, Iso H
    Childhood secondhand smoke exposure and respiratory disease mortality among never-smokers: the Japan collaborative cohort study for evaluation of cancer risk.
    Journal of Public Health 45:604-611, 2023. DOI:10.1093/pubmed/fdad056
49. Nakae A, Ozaki E, Kuriyama N, Tomida S, Koyama T.
    Copeptin is associated with microalbuminuria and renal function in the general Japanese population.
    Endocr J. 70:797-804, 2023. DOI:10.1507/endocrj.EJ23-0005
50. Suzuki MM, Iijima K, （以下17名）Yutaka Kondo
    TUG1-mediated R-loop resolution at microsatellite loci as a prerequisite for cancer cell proliferation.
    Nature Communications 14(1):4521, 2023. DOI:10.1038/s41467-023-40243-8
51. Kurasawa S, Imaizumi T, Maruyama S, Tanaka K, Kubo Y, …, Kuriki K, et al.
    Association of kidney function with cancer incidence and its influence on cancer risk of smoking: The Japan Multi-Institutional Collaborative Cohort Study.
    Int J Cancer. 153(4):732-741, 2023. DOI:10.1002/ijc.34554
52. Mori K, Shigenobu K, Beck G, Uozumi R, Satake Y, Suzuki M, Kondo S, Gotoh S, Yonenobu Y, Kawai M, Suzuki Y, Saito Y, Morii E, Hasegawa M, Mochizuki H,
    A heterozygous splicing variant IVS9-7A > T in intron 9 of the MAPT gene in a patient with right-temporal variant frontotemporal dementia with atypical 4 repeat tauopathy.
    Acta Neuropathol Commun. 11:130, 2023. DOI:10.1186/s40478-023-01629-3
53. Nanri H, Hara M, Nishida Y, Shimanoe C, Iwasaka C, Higaki Y, Tanaka K.
    Association between green tea and coffee consumption and body iron storage in Japanese men and women: a cross-sectional study from the J-MICC Study Saga.
    Front Nutr. 10:1249702, 2023. DOI:10.3389/fnut.2023.1249702
54. Tarutani A, Lövestam S, Zhang X, Kotecha A, Robinson AC, Mann DMA, Saito Y, Murayama S, Tomita T, Goedert M, Scheres SHW, Hasegawa M.
    Cryo-EM structures of tau filaments from SH-SY5Y cells seeded with brain extracts from cases of Alzheimer’s disease and corticobasal degeneration.
    FEBS Open Bio 13:1394-1404, 2023. DOI:10.1002/2211-5463.13657
55. Ikezaki H, Furusyo N, Ai M, Okazaki M, Kohzuma T, Hayashi J, Shimono N, Schaefer EJ
    Relationship between the cholesterol and triglyceride content of lipoprotein subclasses and carotid intima-media thickness: a cross-sectional population-based study.
    Clinica Chimica Acta 548:117521, 2023. DOI:10.1016/j.cca.2023.117521
56. Murata H, Yasui Y, Oiso K, Ochi T, Tomonobu N, Yamamoto KI, Kinoshita R, Sakaguchi M
    STAT1/3 signaling suppresses axon degeneration and neuronal cell death through regulation of NAD+-biosynthetic and consuming enzymes.
    Cellular signalling 108:110717, 2023. DOI:10.1016/j.cellsig.2023.110717
57. Tamura T, Wakai K, Kato Y, Tamada Y, Kubo Y, Okada R, Nagayoshi M, …, Kuriki K, et al.
    Dietary Carbohydrate and Fat Intakes and Risk of Mortality in the Japanese Population: the Japan Multi-Institutional Collaborative Cohort Study.
    J Nutr. 153(8):2352-2368, 2023. DOI:10.1016/j.tjnut.2023.05.027
58. Arseni D, Chen R, Murzin AG, Peak-Chew SY, Garringer HJ, Newell KL, Kametani F, Robinson AC, Vidal R, Ghetti B, Hasegawa M & Ryskeldi-Falcon B.
    TDP-43 forms amyloid filaments with a distinct fold in type A FTLD-TDP.
    Nature. 620:898-903, 2023. DOI:10.1038/s41586-023-06405-w
59. Satsuki Owatari, Yasuko Sagara, Hitomi Nakamura, Kenji Ishitsuka, et al.
    A decrease in newly diagnosed patients with adult T-cell leukemia/lymphoma in Kagoshima, a highly endemic area of HTLV-1 in southwestern Japan.
    Leukemia & Lymphoma 64:865-873, 2023. DOI:10.1080/10428194.2023.2173524
60. Yusuke Okuyama, Daisuke Matsui, Etsuko Ozaki, Yoshiyuki Watanabe
    Association of low occlusal force as an oral hypofunction with the prevalence of irritable bowel syndrome in Japanese adults.
    Journal of Gastroenterology and Hepatology 38(8):1269-1276, 2023. DOI:10.1111/jgh.16175
61. Tsukamoto M, Hishida A, Tamura T, Nagayoshi M, Okada R, Kubo Y, Kato Y, …, Kuriki K, et al.
    GWAS of folate metabolism with gene-environment interaction analysis revealed the possible role of lifestyles in the control of blood folate metabolites in Japanese - the J-MICC Study.
    J Epidemiol. 34(5):228-237, 2023. DOI:10.2188/jea.JE20220341
62. Kitajima H, Maruyama R, Niinuma T, Yamamoto E, Takasawa A, Takasawa K, Ishiguro K, Tsuyada A, Suzuki R, Sudo G, Kubo T, Mitsuhashi K, Idogawa M, Tange S, ..Kai M, Yanagihara K, Tokino T, Osanai M, Nakase H, Suzuki H.
    TM4SF1-AS1 inhibits apoptosis by promoting stress granule formation in cancer cells.
    Cell Death & Disease 14:424, 2023. DOI:10.1038/s41419-023-05953-3
63. 田中 ひかり, 岡澤 均
    DNA損傷と神経疾患.
    BIO Clinica 38(9), 2023.
64. 岡澤 均
    DNA 損傷と修復の疾患病態における役割.
    BIO Clinica 38(9), 2023.
65. Maehara T, Nishimura R, Yoshitake A, Tsukamoto M, Kadomatsu Y, Kubo Y, Okada R, Nagayoshi M, Tamura T, Hishida A, Takeuchi K, Wakai K, Naito M.
    Association of daily physical activity and leisure-time exercise with dysphagia risk in community-dwelling older adults: a cross-sectional study.
    Sci Rep. 13(1):10893, 2023. DOI:10.1038/s41598-023-37605-z
66. Shinohara N, Zhao W, Shan Y, Ukawa S, Ohira H, Kawamura T, Okabayashi S, Wakai K, Ando M, Tsushita K, Tamakoshi A.
    Temporal change in the association between life satisfaction and functional decline with gender differences: an age-specific prospective cohort study.
    Environ Health Prev Med 28:42, 2023. DOI:10.1265/ehpm.23-00019
67. 田中 ひかり, 岡澤 均
    神経変性疾患における自然免疫応答.
    臨床免疫・アレルギー科 80(1):56-62, 2023.
68. Y. Sugimoto, Y. N. Koyanagi, Y. Kawakatsu, I. Oze, Y. Taniyama, Y. Kasugai, T. Tanaka, T. Abe, M. Tajika, Y. Shimizu, H. Ito, K. Wakai and K. Matsuo. 
    Mediation analysis unveils a carcinogenic effect of ADH1B rs1229984 through mechanisms other than change in drinking intensity: oesophageal cancer case-control study.
    Jpn J Clin Oncol 53:581-588, 2023. DOI:10.1093/jjco/hyad028
69. Shigekazu Ukawa, Yusuke Kato, Yonggeun Lee, Kazuoki Ohara, Kazuhiko Mori
    Factors Influencing the Preference for Homes as the Location for Long-term Care in the Japanese Population.
    Open Public Health Journal 16(1):1-7, 2023. DOI:10.2174/18749445-v16-e230419-2022-178
70. Tage H, Yamaguchi K, Nakagawa S, Kasuga S, Takane K, Furukawa Y, Ikenoue T
    Visinin-like 1, a novel target gene of the Wnt/β-catenin signaling pathway, is involved in apoptosis resistance in colorectal cancer.
    Cancer Medicine 12(12):13426-13437, 2023. DOI:10.1002/cam4.5970
71. Sayaka Saito, Kei Mukohara, Kazuhiro Shimomura, Kenta Murotani
    Changes in Japanese physicians’ relationships with the pharmaceutical industry between 2008 and 2021: A national survey.
    PLoS ONE 18:e0286339, 2023. DOI:10.1371/journal.pone.0286339
72. Sumimoto H, Takano A, Igarashi T, Hanaoka J, Teramoto K, Daigo Y.
    Oncogenic epidermal growth factor receptor signal-induced histone deacetylation suppresses chemokine gene expression in human lung adenocarcinoma.
    Scientific Report 13(1):5087, 2023. DOI:10.1038/s41598-023-32177-4
73. Shi J, Shiraishi K, Choi J, Matsuo K, Chen TY, Dai J, Hung RJ, Chen K, Shu XO, Kim YT, Landi MT et al.
    Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population.
    Nature Communications 14(1):3043, 2023. DOI:10.1038/s41467-023-38196-z
74. Hayashida H, Matsumoto A, Nanri H, Nishida Y, Takagi Y, Hara M.
    ALDH2 rs671 variant allele is associated with higher energy intake in middle-aged and elderly Japanese who routinely consume alcohol.
    Environ Health Prev Med. 28:29, 2023. DOI:10.1265/ehpm.22-00276
75. Gatsiou A, Tual-Chalot S, Bonini F, Cesarini V, Kwak S, Stellos K. et al.
    The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation.
    Immunity 56:979-997, 2023. DOI:10.1016/j.immuni.2023.03.021
76. Beck G, Yonenobu Y, Kawai M, Ikenaka K, Sera F, Ozono T, Shimada Y, Yamashita R, Sakata Y, Morii E, Yoshinaga T, Ando Y, Murayama S, Mochizuki H.
    RNA interference in late-stage hereditary transthyretin amyloidosis: a clinicopathological study.
    Journal of Neurology 270(9):4544-4548, 2023. DOI:10.1007/s00415-023-11754-7
77. Qi C, Hasegawa M, Takao M, Sakai M, Sasaki M, Mizutani M, Akagi A, Iwasaki Y, Miyahara H, Yoshida M, Scheres SHW, Goedert M.
    Identical tau filaments in subacute sclerosing panencephalitis and chronic traumatic encephalopathy.
    Acta Neuropathol Commun. 11:74, 2023. DOI:10.1186/s40478-023-01565-2
78. Nakamura S, Watanabe R, Saito Y, Watanabe K, Chung UI, Narimatsu H
    The ME-BYO index: A development and validation project of a novel comprehensive health index.
    Front Public Health. 11:1142281, 2023. DOI:10.3389/fpubh.2023.1142281
79. Jun Sone, Shinji Ueno, Akio Akagi et al.
    NOTCH2NLC GGC repeat expansion causes retinal pathology with intranuclear inclusions throughout the retina and causes visual impairment.
    Acta Neuropathologica Communications 11:71, 2023. DOI:10.1186/s40478-023-01564-3
80. Iwasaka C, Yamada Y, Nishida Y, Hara M, Yasukata J, Miyoshi N, Shimanoe C, Nanri H, Furukawa T, Koga K, Horita M, Higaki Y, Tanaka K.
    Association of appendicular extracellular-to-intracellular water ratio with age, muscle strength, and physical activity in 8,018 community-dwelling middle-aged and older adults.
    Arch Gerontol Geriatr. 108:104931, 2023. DOI:10.1016/j.archger.2023.104931
81. Iwasaka C, Yamada Y, Nishida Y, Hara M, Yasukata J, Miyoshi N, Shimanoe C, Nanri H, Furukawa T, Koga K, Horita M, Higaki Y, Tanaka K.
    Dose-response relationship between daily step count and prevalence of sarcopenia: A cross-sectional study.
    Exp Gerontol. 175:112135, 2023. DOI:10.1016/j.exger.2023.112135
82. Kato H, Naito M, Saito T, Hideyama T, Terashi H, Kwak S, Aizawa H
    Effect of Serum Perampanel Concentration on Sporadic Amyotrophic Lateral Sclerosis Progression.
    J Clin Neurol 19:280-287, 2023. DOI:10.3988/jcn.2022.0213
83. A. Hanyuda, M. Nakatochi, I. Oze, T. Koyama, S. Katsuura-Kamano, H. Ikezaki, K. Tanaka, A. Shimizu, K. Matsuo, K. Wakai, M. Sasaki, M. Yamamoto and M. Iwasaki.
    Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation.
    Sci Rep 13:7052, 2023. DOI:10.1038/s41598-023-33966-7
84. Ito A, Matsui Y, Takeshita M, Katashima M, Goto C, Kuriki K.
    Gut microbiota-mediated associations of green tea and catechin intakes with glucose metabolism in individuals without type 2 diabetes mellitus: a four-season observational study with mediation analysis.
    Arch Microbiol. 205(5):191, 2023. DOI:10.1007/s00203-023-03522-y
85. Yang Y, Yamagishi K, Kihara T, Cui R, Eshak ES, Muraki I, Shirai K, Tamakoshi A, Iso H
    Smoking Cessation and Mortality from Aortic Dissection and Aneurysm: Findings from the Japan Collaborative Cohort (JACC) Study.
    Journal of Atherosclerosis and Thrombosis 30:348-363, 2023. DOI:10.5551/jat.63258
86. Muraki I, Iso H, Imano H, Cui R, Ikehara S, Yamagishi K, Tamakoshi A
    Alcohol Consumption and Long-Term Mortality in Men with or without a History of Myocardial Infarction.
    Journal of Atherosclerosis and Thrombosis 30:415-428, 2023. DOI:10.5551/jat.63517
87. Choong CJ, Aguirre C, Kakuda K, Beck G, Nakanishi H, Kimura Y, .., Badawy SMM, Murayama S, Nagano S, Goto Y, Miyanoiri Y, Nagai Y, Mochizuki H, Ikenaka K.
    Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson's disease-related fibril polymorphism.
    Acta Neuropathologica 145:573-595, 2023. DOI:10.1007/s00401-023-02555-3
88. 佐々木良元、森本 悟、小久保康昌
    紀伊ALS.
    Clinical Neuroscience 41:126-128, 2023.
89. 小久保康昌
    紀伊ALS.
    Clinical Neuroscience 41:322-324, 2023.
90. Satake M, Sagara Y, Hamaguchi I.
    Lower prevalence of anti-HTLV-1 as expected by previous models among first-time blood donors in Japan.
    Journal of Medical Virology 95:e28606, 2023. DOI:10.1002/jmv.28606
91. Kimura H, Yamagishi K, Muraki I, Tamakoshi A, Iso H
    Prospective cohort study on potato intake and mortality from cardiovascular diseases: the Japan Collaborative Cohort Study (JACC study).
    European Journal of Nutrition 62:1859-1866, 2023. DOI:10.1007/s00394-023-03111-1
92. Ota K, Yamagishi K, Kishida R, Kihara T, Cui R, Tamakoshi A, Iso H
    Relationships between Age at Menarche and Risk of Cardiovascular Disease Mortality among Japanese Women: The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC) Study.
    Journal of Atherosclerosis and Thrombosis 30:247-254, 2023. DOI:10.5551/jat.63321
93. Nishizuka SS, Nakatochi M, Koizumi Y, Hishida A, Okada R, Kawai S, Sutoh Y, Koeda K, Shimizu A, Naito M, Wakai K.
    Anti-Helicobacter pylori antibody status is associated with cancer mortality: A longitudinal analysis from the Japanese DAIKO prospective cohort study.
    PLOS Glob Public Health. 3(2):e0001125, 2023. DOI:10.1371/journal.pgph.0001125
94. Adachi Y, Nojima M, Mori M, Kubo T, Akutsu N, Sasaki Y, Nakase H, Lin Y, Kurozawa Y, Wakai K, Tamakoshi A.
    Serum soluble Fas levels and incidence of liver cancer in nested case-control study.
    Cancer Epidemiol Biomarkers Prev. 32:260-265, 2023. DOI:10.1158/1055-9965.EPI-22-0902
95. Teramoto M, Yamagishi K, Cui R, Shirai K, Tamakoshi A, Iso H
    Body Mass Index and Mortality from Nonrheumatic Aortic Valve Disease among Japanese Men and Women.
    Journal of Atherosclerosis and Thrombosis 30:150-159, 2023. DOI:10.5551/jat.63452
96. Sakashita T, Nakamura Y, Sutoh Y, Shimizu A, Hachiya T, Otsuka-Yamasaki Y, Takashima N, …, Kuriki K, et al.
    Comparison of the loci associated with HbA1c and blood glucose levels identified by a genome-wide association study in the Japanese population.
    Diabetol Int. 14(2):188-198, 2023. DOI:10.1007/s13340-023-00618-0
97. Naito M, Hideyama T, Teramoto S, Saito T, Kato H, Kwak S, Aizawa H
    Pathological features of glial cells and motor neurons in the anterior horn of the spinal cord in sporadic ALS using ADAR2 conditional knockout mice.
    J Neurol Sci 444:120520, 2023. DOI:10.1016/j.jns.2022.120520
98. Yasumasa Kokubo
    Amyotrophic Lateral Sclerosis / Parkinsonism-Dementia Complex (ALS/PDC) in the Kii peninsula of Japan. – A s a tauopathy -.
    Guam Medical Journal 3:60-63, 2023.

2022年度

1. Yamaguchi K, Horie C, Takane K, Ikenoue T, Nakagawa S, Isobe Y, Ushiku T, Tanaka M, Fujishiro J, Hoshino N, Nishizuka S, Aikou S, Shida D, Furukawa Y, et al.
   Identification of odontogenic ameloblast associated as a novel target gene of the Wnt/β-catenin signaling pathway.
   Cancer Sci. 2023;114(3):948-960. DOI:10.1111/cas.15657
2. Yamaguchi K, Yamaguchi R, Sheridan P, Takane K, Ikenoue T, Nagatoishi S, Kozuka-Hata H, Oyama M, Shida D, Tsumoto K, Miyano S, Imoto S, Furukawa Y, et al.
   Bromodomain protein BRD8 regulates cell cycle progression in colorectal cancer cells through a TIP60-independent regulation of the pre-RC complex.
   iScience 2023;26(4):106563. DOI:10.1016/j.isci.2023.106563
3. Nagayoshi M, Hishida A, Shimizu T, Kato Y, Kubo Y, Okada R, Tamura T, Otonari J, ..., Kuriki K, et al.
   BMI and cardiometabolic traits in Japanese: a Mendelian randomization study.
   Journal of Epidemiology 2023. DOI:10.2188/jea.JE20220154
4. Watanabe T, Arisawa K, Nguyen TV, Ishizu M, Katsuura-Kamano S, Hishida A, Tamura T, ..., Kuriki K, et al.
   Coffee and metabolic phenotypes: A cross-sectional analysis of the Japan multi-institutional collaborative cohort (J-MICC) study.
   Nutr Metab Cardiovasc Dis. 2023;33(3):620-630. DOI:10.1016/j.numecd.2022.12.019
5. Kitaoka K, Miura K, Takashima N, Kadota A, Harada A, Nakamura Y, Kita Y, ..., Kuriki K, et al.
   Association between Dietary Patterns and Serum Low Density Lipoprotein Cholesterol in Japanese Women and Men: The Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.
   J Atheroscler Thromb. 2023. DOI:10.5551/jat.63675
6. Nakamura S, Fang X, Saito Y, Narimatsu H, Ota A, Ikezaki H, Shimanoe C, ..., Kuriki K, et al.
   Effects of gene-lifestyle interactions on obesity based on a multi-locus risk score: A cross-sectional analysis.
   PLoS One 2023;18(2):e0279169. DOI:10.1371/journal.pone.0279169
7. Katagiri R, Goto A, Nakano S, Nakatochi M, Koyanagi YN, Iwagami M, Hanyuda A, ..., Kuriki K, et al.
   Association of 25-hydroxyvitamin D with risk of overall and colorectal cancer among Japanese using a Mendelian randomization approach.
   Sci Rep 2023;13:2384. DOI:10.1038/s41598-023-29596-8
8. Y. Usui, Y. Taniyama, M. Endo, Y. N. Koyanagi, Y. Kasugai, I. Oze, H. Ito, I. Imoto, T. Tanaka, M. Tajika, Y. Niwa, Y. Iwasaki, T. Aoi, N. Hakozaki, S. Takata, K. Suzuki, C. Terao, M. Hatakeyama, M. Hirata, K. Sugano, T. Yoshida, Y. Kamatani, H. Nakagawa, K. Matsuda, Y. Murakami, A. B. Spurdle, K. Matsuo and Y. Momozawa.
   Helicobacter pylori, Homologous-Recombination Genes, and Gastric Cancer
   N Engl J Med 2023;388:1181-1190. DOI:10.1056/NEJMoa2211807
9. Gao T, Yang X, Fujisawa M, Sakaguchi M, Yoshimura T, Matsukawa A.
   SPRED2: A Novel Regulator of Epithelial-Mesenchymal Transition and Stemness in Hepatocellular Carcinoma Cells
   Int. J. Mol. Sci. 2023;24(5):4996. DOI:10.3390/ijms24054996
10. Kasano-Camones CI, Takizawa M, Ohshima N, Sakaguchi M, Gonzalez FJ, Inoue Y.
    PPARα activation partially drives NAFLD development in liver-specific Hnf4a-null mice.
    The Journal of Biochemistry 2023;173(5):393–411. DOI:10.1093/jb/mvad005
11. Hirabayashi D, Yamamoto KI, Maruyama, A Toyooka S, Inoue Y, Sakaguchi M.
    LOXL1 and LOXL4 are novel target genes of the Zn2+-bound form of ZEB1 and play a crucial role in the acceleration of invasive events in triple-negative breast cancer cells.
    Frontiers in Oncology 2023;13:1142886. DOI:10.3389/fonc.2023.1142886
12. Gohara Y, Tomonobu N, Kinoshita R, Watanabe M, Kumon H, Sakaguchi M.
    Novel extracellular role of REIC/Dkk-3 protein in PD-L1 regulation in cancer cells.
    J Mol Med 2023;101:431–447. DOI:10.1007/s00109-023-02292-w
13. Goto R, Kurihara M, Kameyama M, Komatsu H, Higashino M, Hatano K, Ihara R, Higashihara M, Nishina Y, Matsubara T, Kanemaru K, Saito Y, Murayama S, Iwata A.
    Correlations between cerebrospinal fluid homovanillic acid and dopamine transporter SPECT in degenerative parkinsonian syndromes.
    J Neural Transm 2023;130:513-520. DOI:10.1007/s00702-023-02611-y
14. Nelson PT, Lee EB, Cykowski MD, .... , Saito Y, ..... , Neumann M.
    LATE-NC staging in routine neuropathologic diagnosis: an update.
    Acta Neuropathol. 2023;145:159-173. DOI:10.1007/s00401-022-02524-2
15. Adachi Y, Nojima M, Mori M, Kubo T, Akutsu N, Sasaki Y, Nakase H, Lin Y, Kurozawa Y, Wakai K, Tamakoshi A.
    Serum soluble Fas levels and incidence of liver cancer in nested case-control study.
    Cancer Epidemiol Biomarkers Prev. 2023;32(2):260-265. DOI:10.1158/1055-9965.EPI-22-0902
16. Yonenobu Y, Beck G, Kido K, Maeda N, Yamashita R, Inoue K, Saito Y, Hasegawa M, Ito H, Hasegawa K, Morii E, Iwaki T, Murayama S, Mochizuki H.
    Neuropathology of spinocerebellar ataxia type 8: Common features and unique tauopathy.
    Neuropathology 2023. DOI:10.1111/neup.12894
17. Kurihara M, Komatsu H, Sengoku R, Shibukawa M, Morimoto S, Matsubara T, Arakawa A, Orita M, ..., Saito Y, Murayama S, Kanemaru K, Iwata A.
    CSF P-Tau181 and Other Biomarkers in Patients With Neuronal Intranuclear Inclusion Disease.
    Now published in Neurology. DOI:10.1212/WNL.0000000000201647
18. Kentaro Minegishi, Yoh Dobashi, Teruhide Koyama, Yuko Ishibashi, Miki Furuya, Hiroyoshi Tsubochi, Yasukazu Ohmoto, Sachiyo Nomura.
    Diagnostic utility of trefoil factor families for the early detection of lung cancer and their correlation with tissue expression.
    Oncology Letters 2023;25(4):139. DOI:10.3892/ol.2023.13725
19. Takuma Shibuki, Miho Iida, Sei Harada, Toru Takebayashi, et al.
    The association between sleep parameters and sarcopenia in Japanese community-dwelling older adults.
    Archives of Gerontology and Geriatrics 2023;109:104948. DOI:10.1016/j.archger.2023.104948
20. Beck G, Yamashita R, Kido K, Ikenaka K, Chiba T, Yonenobu Y, Saito Y, Morii E, Hasegawa M, Murayama S, Mochizuki H.
    An autopsy case of progressive supranuclear palsy treated with monoclonal antibody against tau.
    Neuropathology 2023. DOI:10.1111/neup.12890
21. Teramoto M, Yamagishi K, Muraki I, Tamakoshi A, Iso H.
    Coffee and Green Tea Consumption and Cardiovascular Disease Mortality Among People With and Without Hypertension.
    Journal of the American Heart Journal 2023;12(2):e026477. DOI:10.1161/JAHA.122.026477
22. Yasuto Takeuchi, Noriko Gotoh.
    Inflammatory cytokines-enriched microenvironment plays key roles for the development of breast cancers.
    Cancer Sci. 2023;114(5):1792-1799. DOI:10.1111/cas.15734
23. Hanyuda A, Goto A, Wakai K,Momozawa Y, Tanno K, Shimizu A, Hozawa A, Kinoshita K, Matsuo K, Yamamoto M, Sasaki M, Tsugane S, Iwasaki M et al.
    Association between glycemic traits and primary open-angle glaucoma: A Mendelian randomization study in the Japanese population.
    Am J Ophthalmol 2023;245:193-201. DOI:10.1016/j.ajo.2022.09.004
24. Yao J, Takenaga K, Koshikawa N, Kida Y, Lin J, Watanabe T, Maru Y, Hippo Y, Yamamoto S, Zhu Y, Nagase H.
    Anticancer effect of a pyrrole-imidazole polyamide-triphenylphosphonium conjugate selectively targeting a common mitochondrial DNA cancer risk variant in cervical cancer cells.
    Int J Cancer 2023;152(5):962-976. DOI:10.1002/ijc.34319
25. Kurihara M, Mano T, Eto F, Yao I, Ishiura H, Ikemura M, Matsubara T, Morishima M, Saito Y, Murayama S, Toda T, Setou M, Iwata A.
    Proteomic profile of nuclei containing p62-positive inclusions in a patient with neuronal intranuclear inclusion disease.
    Neurobiology of Disease 2023;177:105989. DOI:10.1016/j.nbd.2023.105989
26. Ikeda K, Kaneko R, Tsukamoto E, Funahashi N, Koshikawa N.
    Proteolytic cleavage of membrane proteins by membrane type-1 MMP regulates cancer malignant progression.
    Cancer Sci. 2023;114(2):348-356. DOI:10.1111/cas.15638
27. Megumi Hara, Yuichiro Nishida, Keitaro Tanaka, Chisato Shimanoe, Kayoko Koga, Takuma Furukawa, Yasuki Higaki, Koichi Shinchi, Hiroaki Ikezaki,et al.
    Moderate-to-vigorous Physical Activity and Sedentary Behavior Are Independently Associated With Renal Function: A Cross-sectional Study.
    Journal of Epidemiology 2023;33(6):285-293. DOI:10.2188/jea.JE20210155
28. Aoki H, Higashi M, Okita M, Ando N, Murayama S, Ishikawa K, Yokota T.
    Thymidine Kinase 2 and Mitochondrial Protein COX I in the Cerebellum of Patients with Spinocerebellar Ataxia Type 31 Caused by Penta-nucleotide Repeats (TTCCA)_n.
    Cerebellum. 2023;22:70-84. DOI:10.1007/s12311-021-01364-2
29. Seino M, Nagase S, Ohta T, Yamagami W, Ebina Y, Kobayashi Y, Tabata T, Kaneuchi M, Enomoto T, Mikami M.
    Impact of adjuvant chemotherapy on the overall survival of patients with resectable bulky small cell neuroendocrine cervical cancer: a JSGO-JSOG joint study.
    J Gynecol Oncol. 2023;34(1):e4. DOI:10.3802/jgo.2023.34.e4
30. Song M, Rabkin CS, Ito H, Oze I, Koyanagi YN, Pfeiffer RM, Kasugai Y, Matsuo K, Camargo MC.
    Circulating immune- and inflammation-related biomarkers and early-stage noncardia gastric cancer risk.
    Eur J Cancer Prev 2022;31(3):270-273. DOI:10.1097/CEJ.0000000000000706
31. Shu X, Chen Z, Long J, Guo X, Yang Y, Kamatani Y, Kim DH, Kim J, Kweon SS, Le Marchand L, Matsuda K, Matsuo K, Peters U, Zheng W.
    Large-scale Integrated Analysis of Genetics and Metabolomic Data Reveals Potential Links Between Lipids and Colorectal Cancer Risk.
    Cancer Epidemiol Biomarkers Prev 2022;31:1216-1226. DOI:10.1158/1055-9965.EPI-21-1008
32. Wohlmuth C, Djedovic V, Kjaer SK, Matsuo K, Karlan BY, Lester J, Goodman MT, Thompson PJ, Pejovic T, Riggan MJ, Lajkosz K, Tone A, May T.
    CA-125 Levels Are Predictive of Survival in Low-Grade Serous Ovarian Cancer-A Multicenter Analysis.
    Cancers 2022;14(8):1954. DOI:10.3390/cancers14081954
33. Ho PJ, Khng AJ, Tan BK, Tan EY, Tan SM, Matsuo K, Mohd-Taib NA, Muir K, Murphy RA, Park SK, Shen CY, Shu XO, Easton DF, Pharoah PDP, Hartman M, Li J.
    Relevance of the MHC region for breast cancer susceptibility in Asians.
    Breast Cancer 2022;29:869-879. DOI:10.1007/s12282-022-01366-w
34. Yin X, Kim K, Suetsugu H, Bang SY, Wen L, Okada Y, Matsuda K, Matsuo K, Kochi Y, Zhang X, Terao C, Cui Y, Bae SC.
    Biological insights into systemic lupus erythematosus through an immune cell-specific transcriptome-wide association study.
    Annals of the Rheumatic Diseases 2022;81:1273-80. DOI:10.1136/annrheumdis-2022-222345
35. Ping J, Yang Y, Wen W, Kweon SS, Matsuda K, Jia WH, Shin A, Gao YT, Matsuo K, Kim J, Zheng W.
    Developing and validating polygenic risk scores for colorectal cancer risk prediction in East Asians.
    Int J Cancer 2022;151(10):1726-1736. DOI:10.1002/ijc.34194
36. Grootes I, Keeman R, Blows FM, Lambrechts D, Li J, Lubiński J, Manoochehri M, Margolin S, Matsuo K, Pharoah PDP.
    Incorporating progesterone receptor expression into the PREDICT breast prognostic model.
    Eur J Cancer 2022;173:178-193. DOI:10.1016/j.ejca.2022.06.011
37. Elshair M, Ugai T, Oze I, Kasugai Y, Koyanagi YN, Hara K, Ito H, Matsuo K.
    Impact of socioeconomic status and sibling number on the prevalence of Helicobacter pylori infection: a cross-sectional study in a Japanese population.
    Nagoya J Med Sci 2022;84(2):374-387. DOI:10.18999/nagjms.84.2.374
38. Pastorino R, Sassano M, Danilo Boffetta P, Matsuo K, Oze I, Brennan P, Boccia S.
    Plasma miR-151-3p as a Candidate Diagnostic Biomarker for Head and Neck Cancer: A Cross-sectional Study within the INHANCE Consortium.
    Cancer Epidemiol Biomarkers Prev 2022;31(12):2237-2243. DOI:10.1158/1055-9965.EPI-22-0376
39. Ishigaki K, Sakaue S, Terao C, Matsuo K, Louis Bridges S Jr, Padyukov L, Martin J, Klareskog L, Okada Y, Raychaudhuri S.
    Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis.
    Nat Genet 2022;54:1640-1651. DOI:10.1038/s41588-022-01213-w
40. Jia G, Ping J, Shu X, Yang Y, Cai Q, Matsuda K, Matsuo K, Kang D, Easton DF, Simard J, Shu XO, Long J, Zheng W.
    Genome- and transcriptome-wide association studies of 386,000 Asian and European-ancestry women provide new insights into breast cancer genetics.
    Am J Hum Genet 2022;109(12):2185-2195. DOI:10.1016/j.ajhg.2022.10.011
41. Phung MT, Webb PM, DeFazio A, Fasching PA, Goode EL, Goodman MT, Karlan BY, Lester J, Matsuo K, Berchuck A, Ramus SJ, Pearce CL.
    Lifestyle and personal factors associated with having macroscopic residual disease after ovarian cancer primary cytoreductive surgery.
    Gynecol Oncol 2022;168:68-75. DOI:10.1016/j.ygyno.2022.10.018
42. Fernandez-Rozadilla C, Timofeeva M, Matsuo K, Houlston R, Peters R.
    Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries.
    Nat Genet 2022;55:89-99. DOI:10.1038/s41588-022-01222-9
43. Yuji Saitoh, Etsuko Imabayashi, Masashi Mizutani, Tadashi Tsukamoto, Masato Hasegawa, Yuko Saito, Hiroshi Matsuda, Yuji Takahashi.
    ¹⁸F-THK5351 PET for visualizing predominant lesions of pathologically confirmed corticobasal degeneration presenting with frontal behavioral-spatial syndrome.
    J Neurol 2022;269:5157-5161. DOI:10.1007/s00415-022-11121-y
44. Borghammer P, Just MK, Horsager J, Skjærbæk C, Raunio A, Kok EH, Savola S, Murayama S, Saito Y, Myllykangas L, Van Den Berge N.
    A postmortem study suggests a revision of the dual-hit hypothesis of Parkinson's disease
    NPJ Parkinsons Dis 2022;8:166. DOI:10.1038/s41531-022-00436-2
45. Fujii R, Hishida A, Nakatochi M, et al.
    Associations of Genome-Wide Polygenic Risk Score and Risk Factors With Hypertension in a Japanese Population.
    Circ Genom Precis Med. 2022;15(4):e003612. DOI:10.1161/CIRCGEN.121.003612
46. Kushima I, Nakatochi M, Aleksic B, Okada T, Kimura H, Kato H, Morikawa M, Inada T, Ishizuka K, Torii Y, Ozaki N.
    Cross-Disorder Analysis of Genic and Regulatory Copy Number Variations in Bipolar Disorder, Schizophrenia, and Autism Spectrum Disorder.
    Biol Psychiatry 2022;92(5):362-374. DOI:10.1016/j.biopsych.2022.04.003
47. Kushima I, Imaeda M, Tanaka S, Kato H, Oya-Ito T, Nakatochi M, Aleksic B, Ozaki N.
    Contribution of copy number variations to the risk of severe eating disorders.
    Psychiatry Clin Neurosci 2022;76(8):423-428. DOI:10.1111/pcn.13430
48. Emiko Sawaguchi, Sho Nakamura, Kaname Watanabe, Kanami Tsuno, Hiromi Ikegami, Naoko Shinmura, Yoshinobu Saito, Hiroto Narimatsu.
    COVID-19-related stigma and its relationship with mental wellbeing: A cross-sectional analysis of a cohort study in Japan.
    Fronties in Public Health 2022;10:1010720. DOI:10.3389/fpubh.2022.1010720
49. Saito Y, Nakamura S, Tanaka A, Watanabe R, Narimatsu H, Chung UI.
    Checking the validity and reliability of the Japanese version of the Mini-Cog using a smartphone application.
    BMC Res Notes 2022;15:222. DOI:10.1186/s13104-022-06101-4
50. Saito Y, Nakamura S, Tanaka A, Watanabe R, Narimatsu H, Chung UI.
    Evaluation of the validity and reliability of the 10-meter walk test using a smartphone application among Japanese older adults.
    Front Sports Act Living 2022;4:904924. DOI:10.3389/fspor.2022.904924
51. Tarutani A, Adachi T, Akatsu H, Hashizume Y, Hasegawa K, Saito Y, Robinson AC, Mann DMA, Yoshida M, Murayama S, Hasegawa M.
    Ultrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43.
    Acta Neuropathol 2022;143:613-640. DOI:10.1007/s00401-022-02426-3
52. Reiko Okada, Masayuki Teramoto, Isao Muraki, Akiko Tamakoshi, Hiroyasu Iso.
    Sleep Duration and Daytime Napping and Risk of Type 2 Diabetes among Japanese Men and Women: the Japan Collaborative Cohort Study for Evaluation of Cancer Risk.
    Journal of Epidemiology 2022. DOI:10.2188/jea.JE20220118
53. Pascarella G, Hon CC, Hashimoto K, ..., Murayama S, Suzuki Y, Gustincich S, Frith M, Carninci P.
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     Correction to: Ultrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43.
     Acta Neuropathol 2022;144:165. DOI:10.1007/s00401-022-02439-y
129. Abdelhamid RF, Ogawa K, Beck G, Ikenaka K, Takeuchi E, Yasumizu Y, Jinno J, Kimura Y, Baba K, Nagai Y, Okada Y, Saito Y, Murayama S, Mochizuki H, Nagano S.
     piRNA/PIWI Protein Complex as a Potential Biomarker in Sporadic Amyotrophic Lateral Sclerosis.
     Molecular Neurobiology 2022;59:1693-1705. DOI:10.1007/s12035-021-02686-2
130. Riku Y, Iwasaki Y, Ishigaki S, Akagi A, Hasegawa M, Nishioka K, Li Y, Riku M, Ikeuchi T, Fujioka Y, .. Yoshida M, Katsuno M, Sobue G.
     Motor neuron TDP-43 proteinopathy in progressive supranuclear palsy and corticobasal degeneration.
     Brain 2022;145:2769-2784.. DOI:10.1093/brain/awac091
131. Li Y, Yatsuya H, Wang C, Uemura M, Matsunaga M, He Y, Khine M, Ota A.
     Dietary Patterns Derived from Reduced Rank Regression Are Associated with the 5-Year Occurrence of Metabolic Syndrome: Aichi Workers' Cohort Study.
     Nutrients 2022;14(15):3019. DOI:10.3390/nu14153019
132. Al-Shoaibi AAA, Li Y, Song Z, Chiang C, Hirakawa Y, Saif-Ur-Rahman KM, Shimoda M, Nakano Y, Matsunaga M, Aoyama A, Tamakoshi K, Ota A, Yatsuya H.
     Association of Low-Density Lipoprotein Cholesterol with Risk of Coronary Heart Disease and Stroke among Middle-Aged Japanese Workers: An Analysis using Inverse Probability Weighting.
     J Atheroscler Thromb 2022;30(5):455-466. DOI:10.5551/jat.63519
133. Song Z, He Y, Chiang C, Al-Shoaibi AAA, Saif-Ur-Rahman KM, Mamun MR, Aoyama A, Hirakawa Y, Matsunaga M, Ota A, Tamakoshi K, Li Y, Yatsuya H.
     Long-term variability and change trend of systolic blood pressure and risk of type 2 diabetes mellitus in middle-aged Japanese individuals: findings of the Aichi Workers' Cohort Study.
     Hypertens Res. 2022;45:1772-1780. DOI:10.1038/s41440-022-00993-2
134. Abe E, Fuwa TJ, Hoshi K, Saito T, Murakami T, Miyajima M, Ogawa N, Akatsu H, Hashizume Y, Hashimoto Y, Honda T.
     Expression of Transferrin Protein and Messenger RNA in Neural Cells from Mouse and Human Brain Tissue.
     Metabolites 2022;12(7):594. DOI:10.3390/metabo12070594
135. Shimizu S, Tojima I, Nakamura K, Kouzaki H, Kanesaka T, Ogawa N, Hashizume Y, Akatsu H, Hori A, Tooyama I, Shimizu T.
     A Histochemical Analysis of Neurofibrillary Tangles in Olfactory Epithelium, a Study Based on an Autopsy Case of Juvenile Alzheimer's Disease.
     Acta Histochem Cytochem 2022;55(3):93-98. DOI:10.1267/ahc.22-00048
136. Muguruma Y, Nagatomo R, Kamatsuki S, Miyabe K, Asano G, Akatsu H, Inoue K.
     Experimental design of a stable isotope labeling derivatized UHPLC-MS/MS method for the detection/quantification of primary/secondary bile acids in biofluids.
     J Pharm Biomed Anal. 2021;2021 Nov 25;209::114485. DOI:10.1016/j.jpba.2021.114485
137. Terada T, Therriault J, Kang MS, Savard M, Pascoal TA, Bezgin G, Matsudaira T, Bunai T, Obi T, Tsukada H, Ouchi Y, Rosa-Neto P.
     Mitochondrial complex I abnormalities underlie neurodegeneration and cognitive decline in Alzheimer's disease.
     Eur J Neurol. 2022;29(5):1324-1334. DOI:10.1111/ene.15246
138. 長谷川成人
     クライオ電顕が解き明かす神経変性疾患のメカニズム
     医学のあゆみ 2022;283(13):1109-1110, 1133-1137.
139. 岡澤 均
     加齢, 変性疾患とDNA損傷修復不全
     老年精神医学雑誌 2022;33(6):603-617.

2021年度

1. Nakamura Y, Tamura T, Narita A, Shimizu A, Sutoh Y, Takashima N, Matsui K, .. Kuirki K, et al.
   A genome-wide association study on adherence to low-carbohydrate diets in Japanese.
   Eur J Clin Nutr. 2022:in press. DOI:10.1038/s41430-022-01090-w
2. Chang SJ, Wakai K, Matsuo H et al.
   A meta-analysis of genome-wide association studies using Japanese and Taiwanese has revealed novel loci associated with gout susceptibility.
   Human Cell 2022;35:767-770. DOI:10.1007/s13577-021-00665-2
3. Mika Hayakawa, Tomoyasu Matsubara, Yoko Mochizuki, Chisen Takeuchi, Motoyuki Minamitani, Masayuki Imai, Kenjiro Kosaki, Tomio Arai, Shigeo Murayama
   An autopsied case report of spastic paraplegia with thin corpus callosum carrying a novel mutation in the SPG11 gene: widespread degeneration with eosinophilic inclusions.
   BMC Neurology 2022:in press. DOI:10.1186/s12883-021-02514-z
4. Beck G, Shigenobu K, Ukon K, Yamashita R, Yonenobu Y, Morii E, Hasegawa M, Ikeda M, Murayama S, Mochizuki H.
   An autopsy case of Alzheimer's disease with amygdala-predominant Lewy pathology presenting with frontotemporal dementia-like psychiatric symptoms.
   Neuropathology 2022;42:147-154. DOI:10.1111/neup.12786
5. Tadashi Sakaguchi, Yasumasa Kokubo, Kazuki Furuhashi, Yuki Nakamura, Yuta Suzuki, Kentaro Ito, Kentaro Fujiwara, Yoichi Nishii, Osamu Taguchi, Osamu Hataji
   An Extensive-stage Small-cell Lung Cancer Case With Preexisting Lambert-Eaton Myasthenic Syndrome Successfully Treated With an Immune Checkpoint Inhibitor.
   Clin Lung Cancer 2022;23(3):e273-e275. DOI:10.1016/j.cllc.2021.09.001
6. Kasugai Y, Kohmoto T, Taniyama Y, Koyanagi YN, Usui Y, Iwase M, Oze I, Yamaguchi R, Ito H, Imoto I, Matsuo K.
   Association between germline pathogenic variants and breast cancer risk in Japanese women: the HERPACC study.
   Cancer Sci. 2022:in press. DOI:10.1111/cas.15312
7. Naoyuki Takashima, Yasuyuki Nakamura, Naoko Miyagawa, Aya Kadota, Sachiko Tanaka-Mizuno, Kenji Matsui, Katsuyuki Miura, Hirotsugu Ueshima, Yoshikuni Kita
   Association between stress coping strategy and functional disability in the general older adult population: the Takashima study.
   Gerontology 2022;68(6):699-706. DOI:10.1159/000519194
8. Koga K, Hara M, Shimanoe C, Nishida Y, Furukawa T, Iwasaka C, Tanaka K, .., Kuriki K, et al.
   Association of perceived stress and coping strategies with the renal function in middle-aged and older Japanese men and women.
   Sci Rep. 2022;12(1):291. DOI:10.1038/s41598-021-04324-2
9. Katsuura-Kamano S, Arisawa K, Uemura H, Van Nguyen T, Takezaki T, Ibusuki R, Suzuki S, .., Kuriki K, et al.
   Association of skipping breakfast and short sleep duration with the prevalence of metabolic syndrome in the general Japanese population: Baseline data from the Japan Multi-Institutional Collaborative cohort study.
   Prev Med Rep. 2022;24:101613. DOI:10.1016/j.pmedr.2021.101613
10. Matsunaga T, Kadomatsu Y, Tsukamoto M, Kubo Y, Okada R, Nagayoshi M, Tamura T, .. Kuriki K, et al.
    Associations of breastfeeding history with metabolic syndrome and cardiovascular risk factors in community-dwelling parous women: The Japan Multi-Institutional Collaborative Cohort Study.
    PLoS One. 2022;17(1):e0262252. DOI:10.1371/journal.pone.0262252
11. Tomoyasu Matsubara,Masashi Kameyama,Noriko Tanaka,Renpei Sengoku,Makoto Orita,Ko Furuta,Atsushi Iwata,Tomio Arai,Hirofumi Maruyama,Yuko Saito,Shigeo Murayama
    Autopsy Validation of the Diagnostic Accuracy of 123 I-Metaiodobenzylguanidine Myocardial Scintigraphy for Lewy Body Disease.
    Neurology 2022:in press. DOI:10.1212/WNL.0000000000200110
12. Hashimoto I, Oshima T
    Claudins and Gastric Cancer: An Overview.
    Cancers 2022;14(2):290. DOI:10.3390/cancers14020290
13. Xue R, Lin W, Fujita H, Sun J, Kinoshita R, Ochiai K, Futami J, Watanabe M, Ohuchi H, Sakaguchi M, Tang Z, Huang P, Nasu Y, Kumon H
    Dkk3/REIC deficiency impairs spermiation, sperm fibrous sheath integrity and the sperm motility of mice.
    Genes 2022;13:285. DOI:10.3390/genes13020285
14. Yamazaki M, Yamada H, Munetsuna E, Maeda K, Ando Y, Mizuno G, Fujii R, Tsuboi Y, Ohashi K, Ishikawa H, Hashimoto S, Hamajima N, Suzuki K.
    DNA methylation level of the gene encoding thioredoxin-interacting protein in peripheral blood cells is associated with metabolic syndrome in the Japanese general population.
    Endocrine Journal 2022:in press. DOI:10.1507/endocrj.EJ21-0339
15. Furukawa T, Nishida Y, Hara M, Shimanoe C, Koga K, Iwasaka C, Higaki Y, .., Kuriki K, et al.
    Effect of the interaction between physical activity and estimated macronutrient intake on HbA1c: population-based cross-sectional and longitudinal studies.
    BMJ Open Diabetes Res Care. 2022;10(1):e002479. DOI:10.1136/bmjdrc-2021-002479
16. Wiratman W, Murakami T, Tiksnadi A, Kobayashi S, Hanajima R, Ugawa Y.
    Enhancement of LTD-like plasticity by associative pairing of quadripulse magnetic stimulation with peripheral nerve stimulation.
    Clin Neurophysiol 2022;138:9-17. DOI:10.1016/j.clinph.2022.03.009
17. Park H, Yamanaka T, Toyama Y, Fujita A, Doi H, Nirasawa T, Murayama S, Matsumoto N, Shimogori T, Ikegawa M, Haltia MJ, Nukina N.
    Hornerin deposits in neuronal intranuclear inclusion disease: direct identification of proteins with compositionally biased regions in inclusions.
    Acta Neuropathol Commun. 2022:in press. DOI:10.1186/s40478-022-01333-8
18. Arnaldo N S Silva, Yuichi Saito, Takaki Yoshikawa, Takashi Oshima, William Allum, Matthew G Nankivell, Gordon Hutchins, David Cunningham, Heike I Grabsch.
    Increasing frequency of gene copy number aberrations is associated with immunosuppression and predicts poor prognosis in gastric adenocarcinoma.
    The British journal of surgery 2022;109(3):291-297. DOI:10.1093/bjs/znab460
19. Hishida A, Yamada H, Ando Y, Okugawa Y, Shiozawa M, Miyagi Y, Daigo Y, Toiyama Y, Shirai Y, Tanaka K, Takeuchi K, Wakai K, et al.
    Investigation of miRNA expression profiles using cohort samples reveals potential early detectability of colorectal cancers by serum miR-26a-5p before clinical diagnosis.
    Oncology Letters 2022;23(3):87. DOI:10.3892/ol.2022.13207
20. Komaki K, Takano T, Sato Y, Asada A, Ikeda S, Yamada K, .., Murayama S, .., Fukuda M, Hisanaga SI.
    Lemur tail kinase 1 (LMTK1) regulates the endosomal localization of β-secretase BACE1.
    J Biochem 2022;170:729-738. DOI:10.1093/jb/mvab094.PMID:34523681
21. Koyanagi YN, Oze I, Kasugai Y, Kawakatsu Y, Taniyama Y, Hara K, Shimizu Y, Imoto I, Ito H, Matsuo K.
    New insights into the genetic contribution of ALDH2 rs671 in pancreatic carcinogenesis: Evaluation by mediation analysis.
    Cancer Sci. 2022:in press. DOI:10.1111/cas.15286
22. Fujiwara Y, Kabuta C, Sano T, Murayama S, Saito Y, Kabuta T.
    Pathology-associated change in levels and localization of SIDT2 in postmortem brains of Parkinson's disease and dementia with Lewy bodies patients.
    Neurochem Int 2022;152:105243. DOI:10.1016/j.neuint.2021.105243
23. Matsuda Y, Daigo Y, Miyagi Y, Yokose T, Oshima T, Ito H, Morinaga S, Kishida T, Minamoto T, et al.
    Phosphorylation ofhTERT at threonine 249 is a novel tumor biomarker of aggressive cancer with poorprognosis in multiple organs.
    the Journal of Pathology 2022;257(2):172-185. DOI:10.1002/path.5876
24. Kushima T, Yamagishi K, Kihara T, Tamakoshi A, Iso H
    Physical activity and risk of mortality from heart failure among Japanese population.
    J Atheroscler Thromb 2022;29(7):1076-1084. DOI:10.5551/jat.62843
25. Ohashi M, Miura K, Takashima N, Kadota A, Saito Y, Tsuji S, Murakami T, .. Kuriki K, et al.
    The association of reproductive history with hypertension and obesity according to menopausal status: the J-MICC Study.
    Hypertens Res. 2022;45(4):708-714. DOI:10.1038/s41440-021-00820-0
26. Sano T, Kawazoe T, Shioya A, Mori-Yoshimura M, Oya Y, Maruo K, Nishino I, Hoshino M, Murayama S, Saito Y.
    Unique Lewy pathology in myotonic dystrophy type 1.
    Neuropathology 2022:in press. DOI:10.1111/neup.12790
27. Hamada Y, Kanbayashi T, Takahashi K, Kamiya H, Kobayashi S, Sonoo M.
    Weak shoulder and arm sparing signs in amyotrophic lateral sclerosis.
    Muscle Nerve 2022;65(3):311-316. DOI:10.1002/mus.27480
28. 宇田川　潤
    胎生期環境と精神神経発達.
    BIO Clinica 2022;37:20-23.
29. Y. Nakamura, A. Narita, K. Miura, M. Nakatochi, H. Ikezaki, T. Takezaki, I. Oze, H. Mikami, S. Suzuki, K. Arisawa, Y. Momozawa, Y. Kita and K. Wakai.
    A genome-wide association study on meat consumption in a Japanese population: the Japan Multi-Institutional Collaborative Cohort study.
    J Nutr Sci 2021;10:e61. DOI:10.1017/jns.2021.49
30. Matsuda N, Ootsuki K, Kobayashi S, Nemoto A, Kubo H, Usami S, Kanai K.
    A novel case of concurrent occurrence of demyelinating-polyneuropathy-causing PMP22 duplication and SOX10 gene mutation producing severe hypertrophic neuropathy.
    BMC Neurol 2021;21:243. DOI:10.1186/s12883-021-02256-y
31. Daisuke, Hoshino; Katoh, Hisamori; Fukumura, Kazuhiro; Mayeda, Akila; Miyagi, Yohei; Seiki, Motoharu; Koshikawa, Naohiko
    A novel LAMC2 fusion protein has tumor promoting properties in ovarian carcinoma.
    Cancer Sci. 2021;112(12):4957-4967. DOI:10.1111/cas.15149
32. Oze I, Ito H, Kasugai Y, Yamaji T, Kijima Y, Ugai T, Kasuga Y, Ouellette TK, Taniyama Y, Koyanagi YN, Imoto I, Tsugane S, Koriyama C, Iwasaki M, Matsuo K.
    A Personal Breast Cancer Risk Stratification Model Using Common Variants and Environmental Risk Factors in Japanese Females.
    Cancers 2021;13:3796. DOI:10.3390/cancers13153796
33. Kawamura Y, Nakayama A, ., Takeuchi K, Takada T, Tsunoda M, Arisawa K, Takezaki T, Tanaka K, Ichida K, Wakai K, Shinomiya N, Matsuo H.
    A Proposal for Practical Diagnosis of Renal Hypouricemia: Evidenced from Genetic Studies of Nonfunctional Variants of URAT1/SLC22A12 among 30,685 Japanese Individuals.
    Biomedicines 2021;9:1012. DOI:10.3390/biomedicines9081012
34. Furusawa A, Takekuma M, Mori K, Usami T, Kondo E, Nishio S, Nishino K, Miyamoto Y, Yoshimura R, Watanabe M, Mikami M, Enomoto T.
    A randomized phase III trial of adjuvant chemotherapy versus concurrent chemoradiotherapy for postoperative cervical cancer: Japanese Gynecologic Oncology Group study (JGOG1082).
    Int J Gynecol Cancer 2021;31(4):623-626. DOI:10.1136/ijgc-2020-002344
35. Kobayashi E, Kanao H, Takekuma M, Nishio S, Kojima-Chiba A, Tozawa A, Yamaguchi S, Takeshima N, Nakatani E, Mikami M.
    A retrospective assessment of the safety and efficacy of laparoscopic radical hysterectomy in Japan during the early years following its introduction: a Japanese Gynecologic Oncology Group study (JGOG1081S).
    Int J Clin Oncol 2021;26(2):417-428. DOI:10.1007/s10147-020-01799-3
36. Sakai K, Yamagami W, Machida H, Ebina Y, Kobayashi Y, Tabata T, Kaneuchi M, Nagase S, Enomoto T, Aoki D, Mikami M.
    A retrospective study for investigating the outcomes of endometrial cancer treated with radiotherapy.
    Int J Gynaecol Obstet 2021;156(2):262-269. DOI:10.1002/ijgo.13725
37. Sogabe M, Kojima S, Kaya T, Tomioka A, Kaji H, Sato T, Chiba Y, Shimizu A, Tanaka N, Suzuki N, Hayashi I, Mikami M, Togayachi A, Narimatsu H.
    A Sensitive New Assay System for Serum Wisteria floribunda Agglutinin-reactive Ceruloplasmin that Distinguishes Ovarian Clear Cell Carcinoma from Endometrioma.
    Anal Chem 2021;94(5):2476-2484. DOI:10.1021/acs.analchem.1c04302
38. Asano T, Saito Y, Matsuoka N, Temmoku J, Fujita Y, Hattori K, Kobayashi S, Ojima A, Takahashi T, Matsumoto H, Yashiro-Furuya M, Sato S, Kobayashi H, Watanabe H, Yano K, Sasajima T, Fujihara K, Migita K.
    Acute retrobulbar optic neuritis with anti-myelin oligodendrocyte glycoprotein antibody-associated disease complicated with microscopic polyantitis: a case report.
    Medicine 2021;100(16):e24889. DOI:10.1097/MD.0000000000024889
39. Mitani TT, Beck G, Kido K, Yamashita R, Yonenobu Y, Ogawa T, Saeki C, Okuno T, Nagano S, Morii E, Hasegawa M, Saito Y, Murayama S, Mochizuki H.
    Amyotrophic lateral sclerosis with speech apraxia, predominant upper motor neuron signs, and prominent iron accumulation in the frontal operculum and precentral gyrus.
    Neuropathology 2021;41:324-331. DOI:10.1111/neup.12763
40. Matsubara T, Izumi Y, Oda M, Takahashi M, Maruyama H, Miyamoto R, Watanabe C, Tachiyama Y, Morino H, Kawakami H, Saito Y, Murayama S.
    An autopsy report of a familial amyotrophic lateral sclerosis case carrying VCP Arg487His mutation with a unique TDP-43 proteinopathy.
    Neuropathology 2021;41:118-126. DOI:10.1111/neup.12710
41. Y Kokubo, S Morimoto, R Sasaki, M Hasegawa, H Ishiura, S Tsuji, M Yoshida, N Yamazoe, M Miyazaki, S Kuzuhara
    An immigrant family with Kii Amyotrophic lateral sclerosis/parkinsonism–dementia complex.
    Neurol Sci 2021;43:1423- 1425. DOI:10.1007/s10072-021-05737-7
42. Nakatochi M, Toyoda Y, Kanai M, Nakayama A, Kawamura Y, Hishida A, Mikami H, Matsuo　K, Takezaki T, Shinomiya N, Yokota M, Wakai K, Okada Y, Matsuo H et al.
    An X chromosome-wide meta-analysis based on Japanese cohorts revealed that non-autosomal variations are associated with serum urate.
    Rheumatology 2021;60(9):4430-4432. DOI:10.1093/rheumatology/keab404
43. Hamada Y, Takahashi K, Kanbayashi T, Hatanaka Y, Kobayashi S, Sonoo M.
    Aquaporin-4-antibody-positive neuromyelitis optica spectrum disorder in a patient with Charcot-Marie-Tooth disease type 1A.
    Intern Med 2021;60(1):1611-1614. DOI:10.2169/internalmedicine.6153-20
44. Naoyuki Takashima, Yasuyuki Nakamura, Naoko Miyagawa, Aya Kadota, Yoshino Saito, Kenji Matsui, Katsuyuki Miura, Hirotsugu Ueshima and Yoshikuni Kita.
    Association between C-Reactive Protein Levels and Functional Disability in the General Older-Population: The Takashima Study.
    J Atheroscler Thromb 2021:in press.
45. Tohru Kobayashi, Wenjing Zhao, Shigekazu Ukawa, Kenji Wakai, Kazuyo Tsushita, Takashi Kawamura, Masahiko Ando, Akiko Tamakoshi
    Association between frequency of snacking and all-cause mortality among community-dwelling young-old adults: An age-specific prospective cohort study.
    Geriatr Gerontol Int 2021;21(8):697-704.
46. Machida H, Matsuo K, Oba K, Aoki D, Enomoto T, Okamoto A, Katabuchi H, Nagase S, Mandai M, Yaegashi N, Yamagami W, Mikami M.
    Association between hospital treatment volume and survival of women with gynecologic malignancy in Japan: a JSOG tumor registry-based data extraction study.
    J Gynecol Oncol 2021;33(1):e3. DOI:10.3802/jgo.2022.33.e3
47. Terabe M, Kitajima T, Ota A, Yatsuya H, Iwata N.
    Association between long-term alcohol consumption and insomnia symptoms in civil servants: Aichi Workers’ Cohort Study.
    Fujita Med J 2021:in press.
48. Ikeda M, Mikami M, Yasaka M, Enomoto T, Kobayashi Y, Nagase S, Yokoyama M, Katabuchi H.
    Association of menopause, aging and treatment procedures with positive margins after therapeutic cervical conization for CIN 3: a retrospective study of 8,856 patients by the Japan Society of Obstetrics and Gynecology.
    J Gynecol Oncol 2021;32(5):e68. DOI:10.3802/jgo.2021.32.e68
49. Camargo MC, Song M, Ito H, Oze I, Koyanagi YN, Kasugai Y, Rabkin CS, Matsuo K.
    Associations of circulating mediators of inflammation, cell regulation and immune response with esophageal squamous cell carcinoma.
    J Cancer Res Clin Oncol 2021;147:3885-2892. DOI:10.1007/s00432-021-03687-3
50. Shogo Yoshihara, Xuguang Jiang, Momo Morikawa, Tadayuki Ogawa, Sotaro Ichinose, Hirooki Yabe, Yasuto Kunii, Takeo Yoshikawa, Yosuke Tanaka, Nobutaka Hirokawa
    Betaine ameliorates schizophrenic traits by functionally compensating for KIF3-based CRMP2 transport.
    Cell Reports 2021;35:108971-108971. DOI:10.1016/j.celrep.2021.108971
51. Hermann P, Appleby B, Brandel JP, Caughey B, Collins S,Mead S, Nishida N, Pal S, Parchi P, Pocchiari M, Satoh K, Zanusso G, Zerr I.
    Biomarkers and diagnostic guidelines for sporadic Creutzfeldt-Jakob disease.
    Lancet Neurol. 2021;20(3):235-246. DOI:10.1016/S1474-4422(20)30477-4
52. Kawaguchi M, Nakayama A, Aoyagi Y, Nakamura T, ., Kawamura Y, Takao M, Tamura T, Hishida A, Nagayoshi M, Nagase M, Ooyama K, Ooyama H, Shinomiya N, Matsuo H.
    Both variants of A1CF and BAZ1B genes are associated with gout susceptibility: a replication study and meta-analysis in a Japanese population.
    Human Cell 2021;34:293-299. DOI:10.1007/s13577-021-00485-4
53. Iwai M, Tulafu M, Togo S, Kawaji H, Kadoya K, Namba Y, Jin J, Watanabe J, Okabe T, Hidayat M, Sumiyoshi I, Itoh M, Koyama Y, Ito Y, Orimo A, et.al
    Cancer-associated fibroblast migration in non-small cell lung cancers is modulated by increased integrin α11.
    Molecular Oncology 2021;15:1507-1527. DOI:10.1002/1878-0261.12937
54. Nishio S, Matsuo K, Matsuzaki S, Kato T, Kamiura S, Adachi H, Okadome M, Nakamura T, Mikami M, Enomoto T.
    Characteristics and outcomes of women with adenocarcinoma versus squamous cell carcinoma of the vulva: A Japanese Gynecologic Oncology Group study.
    Eur J Surg Oncol 2021;47:3188-3193. DOI:10.1016/j.ejso.2021.07.002
55. Kageyama Y, Irie Y, Matsushima Y, Segawa T, Bellier JP, Hidaka K, Sugiyama H, Kaneda D, Hashizume Y, Akatsu H, Miki K, Kita A, Walker DG, Irie K, Tooyama I
    Characterization of a Conformation-Restricted Amyloid β Peptide and Immunoreactivity of Its Antibody in Human AD brain.
    ACS Chem Neurosci 2021;12:3418-3432. DOI:10.1021/acschemneuro.1c00416
56. Ming Zhu Atsushi Takano Bayarbat Tsevegjav Yoshihiro Yoshitake Masanori Shinohara Yataro Daigo
    Characterization of Opa interacting protein 5 as a new biomarker and therapeutic target for oral cancer.
    International journal of oncology 2021;27:1791-2423. DOI:10.3892/ijo.2022.5317
57. Yamagishi M, Kubokawa M, Kuze Y, Suzuki A, Yokomizo A, Kobayashi S, Nakashima M, Makiyama J, Iwanaga M, Fukuda T, Watanabe T, Suzuki Y, Uchimaru K
    Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma.
    Nature Communications 2021;12:4821. DOI:10.1038/s41467-021-25101-9
58. Nagasawa S, Tsuchida K, Shiozawa M, Hiroshima Y, Kimura Y, Hashimoto I, Morinaga S, Yukawa N, Rino Y, Masuda M, Saeki H, Miyagi Y, Oshima T.
    Clinical Significance of Chemokine Receptor CXCR4 and CCR7 mRNA Expression in Patients With Colorectal Cancer.
    Anticancer Res 2021;41:4489-4495. DOI:10.21873/anticanres.15259
59. Nakahara Y, Matsutani T, Igarashi Y, Matsuo N, Himuro H, Saito H, Yamada K, Murotani K, Hoshino T, Azuma K, Sasada T.
    Clinical significance of peripheral TCR and BCR repertoire diversity in EGFR/ALK wild-type NSCLC treated with anti-PD-1 antibody.
    Cancer Immunol Immunother. 2021;70:2881-2892. DOI:10.1007/s00262-021-02900-z
60. Hatori S, Sakamaki K, Kimura Y, Hiroshima Y, Hashimoto I, Saeki H, Miyagi Y, Oshima T.
    Clinical Significance of PLA2G2A Expression in Gastric Cancer Patients who Receive Gastrectomy and Adjuvant S-1.
    Anticancer Res. 2021;41(7):3683-3588. DOI:10.21873/anticanres.15146
61. Watanabe T, Shiozawa M, Kimura Y, Hiroshima Y, Hashimoto I, Rino Y, Masuda M, Miyagi Y, Oshima T.
    Clinical Significance of Stanniocalcin2 mRNA Expression in Patients With Colorectal Cancer.
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138. 横山尚佑, 神林隆道, 小林俊輔, 石田毅,　園生　雅弘.
     亜急性の認知機能低下と尿閉で発症した 中枢神経原発移植後リンパ増殖性疾患の 1 例.
     臨床神経学 2021;61:750-755. DOI:10.5692/clinicalneurol.cn-001623
139. 池崎裕昭、Schaefer EJ、林　純
     総合診療医が担う脂質異常症診療.
     日本病院総合診療医学会雑誌 2021;17:326-334.
140. 郭帥，山海知子，山岸良匡，木原朋未，磯博康，玉腰暁子
     慢性腎臓病による死亡の危険因子の検討：JACC研究（総説）.
     日本循環器病予防学会誌 2021;57:55-57.

2020年度

1. Suzuki T, Nakamura Y, Doi Y, Narita A, Shimizu A, Imaeda N, Goto C, .. Kuriki K, et al.
   A Genome-wide Association Study on Confection Consumption in a Japanese Population- The Japan Multi-Institutional Collaborative Cohort study.
   Br J Nutr. -:2021, in press. DOI:10.1017/S0007114521000684
2. Kameyama, A., Thet Tin, WW., Nishijima, R., Yamakoshi, K.
   Alteration of mucins in the submandibular gland during aging in mice.
   Archives of Oral Biology 121:2021, 104967. DOI:10.1016/j.archoralbio.2020.104967
3. Hata K, Koyama T, Ozaki E, Kuriyama N, Mizuno S, Matsui D, Watanabe I, Uehara R, Watanabe Y.
   Assessing the Relationship between Helicobacter pylori and Chronic Kidney Disease.
   Healthcare 9:2021, 162. DOI:10.3390/healthcare9020162
4. Fujii R, Hishida A, Nishiyama T, Nakatochi M, Matsuo K, Ito H, Nishida Y, .. Kuriki K, et al.
   Assessing the relationship between high-sensitivity C-reactive protein and kidney function employing mendelian randomization in a Japanese community based J-MICC Study.
   J Epidemiol. -:2021, in press. DOI:10.2188/jea.JE20200540
5. Suzuki K, Yamada H, Fujii R, Munetsuna E, Ando Y, Ohashi K, Ishikawa H, Yamazaki M, Maeda K, Hashimoto S, Hamajima N.
   Association between circulating vascular-related microRNAs and an increase in blood pressure: a 5-year longitudinal population-based study.
   J Hypertens. 39(1):2021, 84-89. DOI:10.1097/HJH.0000000000002606
6. Nguyen Van Tien, Kokichi Arisawa, Hirokazu Uemura, Nahomi Imaeda, Chiho Goto, Sakurako Katsuura-Kamano
   Association between nutrient patterns and fatty liver index: Baseline survey of the Japan Multi-Institutional Collaborative Cohort Study in Tokushima, Japan.
   Journal of Epidemiology -:2021, in press. DOI:10.2188/jea.je20200447
7. Kameyama, A., Nishijima, R., Yamakoshi, K.
   Bmi-1 regulates mucin levels and mucin O-glycosylation in the submandibular gland of mice.
   PLoS One 16(1):2021, e0245607. DOI:10.1371/journal.pone.0245607
8. Suzuki S, Goto A, Nakatochi M, Narita A, Yamaji T, Sawada N, Katagiri R, …, Kuriki K, et al.
   Body mass index and colorectal cancer risk: A Mendelian randomization study.
   Cancer Sci. -:2021, in press. DOI:10.1111/cas.14824
9. Fujii R, Yamada H, Munetsuna E, Yamazaki M, Mizuno G, Ando Y, Maeda K, Tsuboi Y, Ohashi K, Ishikawa H, Hagiwara C, Wakai K, Hashimoto S, Hamajima N, Suzuki K.
   Dietary fish and ω-3 polyunsaturated fatty acids are associated with leukocyte ABCA1 DNA methylation levels.
   Nutrition 81:2021, 110951. DOI:10.1016/j.nut.2020.110951
10. Maeda J, Suhara T, Higuchi M, Sahara N. 他17名
    Distinct microglial response against Alzheimer’s amyloid and tau pathologies characterized by P2Y12 receptor.
    Brain Communications 3(1):2021, fcab011. DOI:10.1093/braincomms/fcab011
11. Yasuko Sagara, Hitomi Nakamura, Midori Yamamoto, Toshinobu Ezaki, Tomohide Koga, Masuhiro Shimamura, Masahiro Satake, Kazuo Irita
    Estimation of the window period of human T-cell leukemia virus type 1 and 2 tests by a lookback study of seroconverters among Japanese voluntary blood donors.
    Transfusion -:2021, in press. DOI:10.1111/trf.16213
12. Nakano M, Mitsuishi Y, Liu L, Watanabe N, Hibino E, Hata S, Saito T, Saido TC, Murayama S, Kasuga K, Ikeuchi T, Suzuki T, Nishimura M.
    Extracellular release of ILEI/FAM3C and amyloid-beta is associated with the activation of distinct synapse subpopulations.
    Journal of Alzheimer's Disease :2021, in press. DOI:10.3233/JAD-201174
13. Hishida A, Nakatochi M, Tamura T, Nagayoshi M, Okada R, Kubo Y, Tsukamoto M, .. Kuriki K, et al.
    Genome-wide association study of serum prostate-specific antigen levels based on 1000 Genomes imputed data in Japanese: the Japan Multi-Institutional Collaborative Cohort Study.
    Nagoya J Med Sci. 83(1):2021, 183-194. DOI:10.18999/nagjms.83.1.183
14. Teramoto M, Muraki I, Yamagishi K, Tamakoshi A, Iso H
    Green tea and coffee consumption and all-cause mortality among persons with and without stroke or myocardial infarction.
    Stroke 52:2021, 957-965. DOI:10.1161/STROKEAHA.120.032273
15. Tagai K, Suhara T, Sahara N, Higuchi M, Shimada H.他33名
    High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer's and Non-Alzheimer's Disease Tauopathies.
    Neuron 109:2021, 42-58. DOI:10.1016/j.neuron.2020.09.042
16. Takahashi Y, Wake H, Sakaguchi M, Yoshii Y, Teshigawara K, Wang D, Nishibori M.
    Histidine-rich glycoprotein stimulates human neutrophil phagocytosis and prolongs survival through CLEC1A.
    J Immunol 206:2021, 737-750. DOI:10.4049/jimmunol.2000817
17. Matsushita K, Jassal SK, Sang Y, Ballew SH, Grams ME, Yatsuya H, Zhang L, Schaeffner E, Coresh J, et al.
    Incorporating kidney disease measures into cardiovascular risk prediction: Development and validation in 9 million adults from 72 datasets.
    EClinicalMedicine -:2021, in press. DOI:10.1016/j.eclinm.2020.100552
18. Nakamura A, Miyoshi H, Ukawa S, Nakamura K, Nakagawa T, Terauchi Y, Tamakoshi A, Atsumi T.
    Inverse correlation between serum high-molecular-weight adiponectin and proinsulin level in a Japanese population: The Dynamics of Lifestyle and Neighborhood Community on Health Study.
    J Diabetes Investig 12(1):2021, 63-66. DOI:10.1111/jdi.13323
19. Wada H, Ikeda A, Maruyama K, Yamagishi K, Barnes PJ, Tanigawa T, Tamakoshi A, Iso H
    Low BMI and weight loss aggravate COPD mortality in men, findings from a large prospective cohort: the JACC study.
    Sci Rep 11:2021, 1531. DOI:10.1038/s41598-020-79860-4
20. Eshak ES, Muraki I, Imano H, Yamagishi K, Tamakoshi A, Iso H
    Manganese intake from foods and beverages is associated with a reduced risk of type 2 diabetes.
    Maturitas 143:2021, 127-131. DOI:10.1016/j.maturitas.2020.10.009
21. Sobue A, Kimine O, Hara Y, Endo F, Mizoguchi H, Watanabe S, Murayama S, Saito T, Saido T.C., Sahara N, Higuchi M, Ogi T, Yamanaka K.
    Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease.
    Acta Neuropathologica Communications 9:2021, 1. DOI:10.1186/s40478-020-01099-x
22. Koyama T, et al.
    Mid-regional pro-adrenomedullin is a novel biomarker for arterial stiffness as the criterion for vascular failure in a cross-sectional study.
    Sci Rep. 11:2021, 305. DOI:10.1038/s41598-020-79525-2
23. Shimanoe, C., Matsumoto A., Hara, M., Akao C., Nishida, Y., Horita, M.,Nanri H., Higaki, Y., Tanaka, K
    Perceived stress, depressive symptoms, and cortisol-to-cortisone ratio in spot urine in 6878 older adults.
    Psychoneuroendocrinology 125:2021, 105125. DOI:10.1016/j.psyneuen.2020.105125
24. Suzuki Y, Sasamoto Y, Koyama T, Yoshijima C, Oda A, Nakatochi M, Kubo M, Momozawa Y, Uehara R, Ohno K
    Relationship of Hemoglobin Level and Plasma Coproporphyrin-I Concentrations as an Endogenous Probe for Phenotyping OATP1B.
    Clin Transl Sci -:2021, in press. DOI:10.1111/cts.12996
25. Imaeda N, Goto C, Sasakabe T, Mikami H, Oze I, Hosono A, Naito M, .. Kuriki K, et al.
    Reproducibility and validity of food group intake in a short food frequency questionnaire for the middle-aged Japanese population.
    Environ Health Prev Med. 26(1):2021, in press. DOI:10.1186/s12199-021-00951-3
26. Suzuki Y, Sasamoto Y, Koyama T, Yoshijima C, Nakatochi M, Kubo M, Momozawa Y, Uehara R, Ohno K.
    Substantially Increased Plasma Coproporphyrin-I Concentrations Associated With OATP1B1*15 Allele in Japanese General Population.
    Clin Transl Sci 14(1):2021, 382-388. DOI:10.1111/cts.12889
27. Araki K, Kinoshita R, Tomonobu N, Yamamoto KI, Murata H, Suzawa K, Shien K, Yamamoto H, Okazaki M, Nishibori M, Miyahara N, Toyooka S, Sakaguchi M.
    The heterodimer S100A8/A9 is a potent therapeutic target for idiopathic pulmonary fibrosis.
    J Mol Med (Berl) 99:2021, 131-145. DOI:10.1007/s00109-020-02001-x
28. Horiuchi Y, Matsubayashi H, Kiyozumi Y, Nishimura S, Higashigawa S, Kado N, Nagashima T, Mizuguchi M, Ohnami S, Arai M, Urakami K, Kusuhara M, Yamaguchi K.
    Disclosure of secondary findings in exome sequencing of 2480 Japanese cancer patients.
    Hum Genet . -:2020, in press. DOI:10.1007/s00439-020-02207-6
29. Penova M, Kawaguchi S, Yasunaga JI, Kawaguchi T, Watanabe T, Uchimaru K, Iwanaga M, Utsunomiya A, Tabara Y, Paul R, Yamano Y, Matsuoka M, Matsuda F.
    Genome wide association study of HTLV-1-associated myelopathy/tropical spastic paraparesis in the Japanese population.
    Proc Natl Acad Sci U S A. 118:2020, e2004199118. DOI:10.1073/pnas.2004199118
30. Nakano K, Chihara Y, Kobayashi S, Iwanaga M, Utsunomiya A, Watanabe T, Uchimaru K.
    Kobayashi S, Iwanaga M, Utsunomiya A, Watanabe T, Uchimaru K. Overexpression of aberrant Wnt5a and its effect on acquisition of malignant phenotypes in adult T-cell leukemia/lymphoma (ATL) cells.
    Sci Rep. 11:2020, 4114. DOI:10.1038/s41598-021-83613-2
31. Suzuki H, Nakamura Y, Matsuo K, Imaeda N, Goto C, Narita A, Shimizu A, …, Kuriki K …
    A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern.
    Eur J Clin Nutr. -:2020, in press. DOI:10.1038/s41430-020-00823-z
32. Saito M, Hasegawa H, et al, Uchimaru K, Morishita K, Watanabe T, Miyazaki Y, Yanagihara K
    A high-throughput detection method for the clonality of Human T-cell leukemia virus type-1-infected cells in vivo.
    Int J Hematol 112(3):2020, 300-306. DOI:10.1007/s12185-020-02935-5
33. Masumichi Saito, Hiroo Hasegawa, Shunsuke Yamauchi, et al.
    A high-throughput detection method for the clonality of Human T-cell Leukemia Virus type-1-infected cells in vivo.
    International Journal of Hematology 112 (3):2020, 300-306. DOI:10.1007/s12185-020-02935-5
34. Okamoto N, Mikami H, Nakamura Y, Kusakabe M, Fujimoto S, Ueda M, Inagaki S, Miyagi Y, Nagase H. et al
    A nobel multivariate index for cancer risk detection based on the serum trace elements: Metallo-Balance Method.
    Journal of Cancer Epidemiology and Prevention 5:2020, 1-9. DOI:10.36648/cancer.5.1.4
35. Yoichi Sutoh, Tsuyoshi Hachiya, Yuji Suzuki, Shohei Komaki, Hideki Ohmomo, Keisuke Kakisaka, Ting Wang, Yasuhiro Takikawa & Atsushi Shimizu
    ALDH2 genotype modulates the association between alcohol consumption and AST/ALT ratio among middle-aged Japanese men: a genome-wide G × E interaction analysis.
    Scientific Reports 10:2020, 16227. DOI:10.1038/s41598-020-73263-1
36. Sakaguchi Y, Uchiyama J, Také A, Gotoh K, Sakaguchi M, Suzuki T, Yamamoto Y, Hosomi K, Kohda T, Mukamoto M, Kozaki S, Hayashi S, Oguma K.
    Analysis of a plasmid encoding botulinum neurotoxin type G gene in Clostridium argentinense.
    Anaerobe 66:2020, 102281. DOI:10.1016/j.anaerobe.2020.102281
37. Miyauchi S, Shien K, Takeda T, Araki K, Nakata K, Miura A, Tomida S, Yamane M, Sakaguchi M, Toyooka S.
    Antitumor Effects of Pan-RAF Inhibitor LY3009120 Against Lung Cancer Cells Harboring Oncogenic BRAF Mutation.
    Anticancer Res 40:2020, 2667-2673. DOI:10.21873/anticanres.14237
38. Amagasa S, Inoue S, Ukawa S, Sasaki S, Nakamura K, Yoshimura A, Tanaka A, Kimura T, Nakagawa T, Imae A, Ding D, Kikuchi H, Tamakoshi A.
    Are Japanese women less physically active than men? Findings from the DOSANCO Health Study.
    J Epidemiol. -:2020, in press. DOI:10.2188/jea.JE20200185
39. Sekiguchi M, Sobue A, Kushima I, et al.
    ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk.
    Transl Psychiatry. 10:2020, 247. DOI:10.1038/s41398-020-00917-z
40. Suzuki N, Matsuki E, Araumi A, Ashitomi S, Watanabe S, Kudo K, Ichikawa K, Inoue S, Watanabe M, Ueno Y, Ishizawa K, Kayama T, Konta T.
    Association among chronic kidney disease, airflow limitation, and mortality in a community-based population: The Yamagata (Takahata) study.
    Sci Rep. 10:2020, 5570. DOI:10.1038/s41598-020-62540-8
41. Suzuki K, ShivappaN, Kawado M, Yamada H, Hashimoto S, Wakai K, Iso H, Okada E, Fujii R, H?bert JR, Tamakoshi A.
    Association between dietary inflammatory index and serum C-reactive protein concentrations in the Japan Collaborative Cohort Study.
    Nagoya J Med Sci 82:2020, 237-249. DOI:10.18999/nagjms.82.2.237
42. Tamura T, Kuriyama N, Koyama T, Ozaki E, Matsui D, Kadomatsu Y, Tsukamoto M, …, Kuriki K …
    Association between plasma levels of homocysteine, folate, and vitamin B(12), and dietary folate intake and hypertension in a cross-sectional study.
    Sci Rep. 10(1):2020, 18499. DOI:10.1038/s41598-020-75267-3
43. Kawakatsu Y, Koyanagi YN, Oze I, Kasugai Y, Morioka H, Yamaguchi R, Ito H, Matsuo K.
    Association between Socioeconomic Status and Digestive Tract Cancers: A Case-Control Study.
    Cancers (Basel). 12:2020, in press. DOI:10.3390/cancers12113258
44. Arisawa K, Katsuura-Kamano S, Uemura H, Tien NV, Hishida A, Tamura T, Kubo Y, …, Kuriki K, et al.
    Association of Dietary Acid Load with the Prevalence of Metabolic Syndrome among Participants in Baseline Survey of the Japan Multi-Institutional Collaborative Cohort Study.
    Nutrients 12:2020, 1605. DOI:10.3390/nu12061605
45. Maeda K, Yamada H, Munetsuna E, Fujii R, Yamazaki M, Ando Y, Mizuno G, Ishikawa H, Ohashi K, Tsuboi Y, Hashimoto S, Hamajima N, Suzuki K.
    Association of smoking habits with TXNIP DNA methylation levels in leukocytes among general Japanese population.
    PLOS ONE 15(7):2020, e0235486. DOI:10.1371/journal.pone.0235486
46. Nakashima H, Ando K, Kobayashi K, Seki T, Ishizuka S, Fujii R, Takegami Y, Yamada H, Ando Y, Suzuki K, Hasegawa Y, Imagama S.
    Associations of Serum MicroRNA with Bone Mineral Density in Community-Dwelling Subjects: The Yakumo Study.
    Biomed Res Int. -:2020, 5047243. DOI:10.1155/2020/5047243
47. Takada M, Yamagishi K, Tamakoshi A, Iso H
    Body Mass Index and Mortality From Aortic Aneurysm and Dissection.
    J Atheroscler Thromb -:2020, in press. DOI:10.5551/jat.57232
48. Morimoto S, Ishikawa M, Watanabe H, Isoda M, Takao M, Nakamura S, Ozawa F, Hirokawa Y, Kuzuhara S, Okano H, Kokubo Y.
    Brain Transcriptome Analysis Links Deficiencies of Stress-Responsive Proteins to the Pathomechanism of Kii ALS/PDC.
    Antioxidants (Basel). 9(5):2020, 423. DOI:10.3390/antiox9050423
49. Nanumi Han, Delnur Anwar, Naoki Hama, Takuto Kobayashi Hidefumi Suzuki, Hidehisa Takahashi, Haruka Wada, Ryo Otsuka, Muhammad Baghdadi, Ken-ichiro Seino.
    Bromodomain-containing protein 4 regulates interleukin-34 expression in mouse ovarian cancer cells.
    Inflammation and Regeneration 40:25:2020, in press. DOI:10.1186/s41232-020-00129-4
50. Nakamura M, Takano A, Thang PM, Tsevegjav B, Zhu M, Yokose T, Yamashita T, Miyagi Y, Daigo Y
    Characterization of KIF20A as a prognostic biomarker and therapeutic target for different subtypes of breast cancer。.
    International Journal of Oncology 57(1):2020, 277-288. DOI:10.3892/ijo.2020.5060
51. Hashimoto I, Oue N, Kimura Y, Hiroshima Y, Yamada T, Tamagawa H, Yamamoto N, Ogata T, Shiozawa M, Morinaga S, Rino Y, Yasui W, Masuda M, Miyagi Y, Oshima T.
    Clinical Significance of Glioma-associated Oncogene 1 Expression in Patients With Locally Advanced Gastric Cancer Administered Adjuvant Chemotherapy With S-1 After Curative Surgery.
    Anticancer Res. 40:2020, 5815-5821. DOI:10.21873/anticanres.14599
52. Kametani F, Yoshida M, Matsubara T, Murayama S, Saito Y, Kawakami I, Onaya M, Tanaka H, Kakita A, Robinson A, Mann M, Hasegawa M.
    Comparison of common and disease-specific post-translational modifications of pathological tau associated with a wide range of tauopathies.
    Frontiers in Neuroscience 14:2020, 581936. DOI:10.3389/fnins.2020.581936
53. Tanabe K, Ikeda M, Hayashi M, Matsuo K, Yasaka M, Machida H, Shida M, Katahira T, Imanishi T, Hirasawa T, Sato K, Yoshida H, Mikami M.
    Comprehensive Serum Glycopeptide Spectra Analysis Combined with Artificial Intelligence (CSGSA-AI) to Diagnose Early-Stage Ovarian Cancer.
    Cancers (Basel) 12(9):2020, E2373. DOI:10.3390/cancers12092373
54. Miya A, Nakamura A, Miyoshi H, Ukawa S, Nakamura K, Nakagawa T, Terauchi Y, Tamakoshi A, Atsumi T
    Correlation between serum proinsulin levels and fatty liver: The Dynamics of Lifestyle and Neighborhood Community on Health Study.
    J Diabetes Investig 11(4):2020, 964-970. DOI:10.1111/jdi.13221
55. Yamamoto KI, Kagawa H, Arimoto S, Tan XW, Yasui K, Oshiki T, Sakaguchi M.
    Cytotoxic Effects of Alcohol Extracts from a Plastic Wrap (Polyvinylidene Chloride) on Human Cultured Liver Cells and Mouse Primary Cultured Liver Cells.
    Acta Med Okayama 74:2020, 327-334. DOI:10.18926/AMO/60371
56. Koyama T, Maekawa M, Ozaki E, Kuriyama N, Uehara R.
    Daily Consumption of Coffee and Eating Bread at Breakfast Time Is Associated with Lower Visceral Adipose Tissue and with Lower Prevalence of Both Visceral Obesity and Metabolic Syndrome in Japanese Populations: A Cross-Sectional Study.
    Nutrients. 12(10):2020, 3090. DOI:10.3390/nu12103090
57. Tanabe N, Seki N, Horikawa C, Yatsuya H, Yamagishi K, Iso H, Ukawa S, Tamakoshi A
    Depressive tendency and the risk of death from pneumonia: The JACC study.
    Intern Med -:2020, in press. DOI:10.2169/internalmedicine.5052-20
58. Fatmawati NND, Gotoh K, Mayura IPB, Nocianitri KA, Suwardana GNR, Komalasari NLGY, Ramona Y, Sakaguchi M, Matsushita O, Sujaya IN.
    Enhancement of intestinal epithelial barrier function by Weissella confusa F213 and Lactobacillus rhamnosus FBB81 probiotic candidates in an in vitro model of hydrogen peroxide-induced inflammatory bowel disease.
    BMC Res Notes 13:2020, 489. DOI:10.1186/s13104-020-05338-1
59. Shigeta S, Shida M, Nagase S, Ikeda M, Takahashi F, Shibata T, Yamagami W, Katabuchi H, Yaegashi N, Aoki D, Mikami M.
    Epidemiological guideline influence on the therapeutic trend and patient outcome of uterine cervical cancer in Japan: Japan society of gynecologic oncology guideline evaluation committee project.
    Gynecol Oncol -:2020, in press. DOI:10.1016/j.ygyno.2020.07.023
60. Kazu Okuma, Isao Hamaguchi, Isao Hamaguchi, Yasuko Sagara, Hitomi Nakamura, et al.
    Establishment of a novel diagnostic test algorithm for human T-cell leukemia virus type 1 infection with line immunoassay replacement of western blotting: a collaborative study for performance evaluation of diagnostic assays in Japan.
    Retrovirology 17(1):2020, 26. DOI:10.1186/s12977-020-00534-0
61. Li Y, Yatsuya H, Tanaka S, Iso H, Okayama A, Tsuji I, Sakata K, Miyamoto Y, Ueshima H, Miura K, Murakami Y, Okamura T
    Estimation of 10-Year Risk of Death from Coronary Heart Disease, Stroke, and Cardiovascular Disease in a Pooled Analysis of Japanese Cohorts: EPOCH-JAPAN.
    J Atheroscler Thromb -:2020, in press. DOI:10.5551/jat.58958
62. Komatsu H, Takeuchi H, Kikuchi Y, Ono C, Yu Z, Iizuka K, Takano Y, Kakuto Y, Funakoshi S, Ono T, Ito J, Kunii Y, Hino M, Nagaoka A, Iwasaki Y, Tomita H,et al.
    Ethnicity-Dependent Effects of Schizophrenia Risk Variants of the OLIG2 Gene on OLIG2 Transcription and White Matter Integrity.
    Schizophrenia Bulletin -:2020, sbaa049. DOI:10.1093/schbul/sbaa049
63. Osumi H, Muroi A, Koshikawa N, & Yao R.
    Evaluation of the RAS signaling network in response to MEK inhibition using organoids derived from a familial adenomatous polyposis patient.
    Sci Rep. 10(1):2020, 17455. DOI:10.1038/s41598-020-74530-x
64. Tomonobu N, Kinoshita R, Sakaguchi M.
    exMCAM-Fc, an S100A8/A9-mediated-metastasis blocker, efficiently reduced the number of circulating tumor cells that appeared in the blood flow.
    Mol Biol Rep 47:2020, 4879-4883. DOI:10.1007/s11033-020-05495-3
65. Lin Y, Nakatochi M, Hosono Y, Ito H, Kamatani Y, M, Sasahira N, Morimoto M, Kobayashi S, Fukushima T, Ueno M, Kikuchi S, Matsuo K, et al.
    Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer.
    Nature Communications 11(1):2020, 3175. DOI:10.1038/s41467-020-16711-w
66. Furukawa K, Igarashi M, Jia H, Nogawa S, Kawafune K, Hachiya T, Takahashi S, Saito K, Kato H
    Genome-Wide Association Study Identifies the Association between the 12q24 Locus and Black Tea Consumption in Japanese Populations.
    Nutrients 12:2020, 3182-3182. DOI:10.3390/nu12103182
67. Gao S, Wake H, Sakaguchi M, Wang D, Takahashi Y, Teshigawara K, Zhong H, Mori S, Liu K, Takahashi H, Nishibori M.
    Histidine-Rich Glycoprotein Inhibits High-Mobility Group Box-1-Mediated Pathways in Vascular Endothelial Cells Through CLEC-1A.
    iScience 23:2020, 101180. DOI:10.1016/j.isci.2020.101180
68. Komaki S, Sutoh Y, Kobayashi K, Saito S, Saito Tanaka C, Igawa T, Lau Q
    Hot spring frogs (Buergeria japonica) prefer cooler water to hot water.
    Ecology and Evolution 10:2020, 9466-9473. DOI:10.1002/ece3.6637
69. Kashiwagi H, Ishimoto H, Izumi SI, Seki T, Kinami R, Otomo A, Takahashi K, Kametani F, Hirayama N, Sasaki E, Shiina T, Sakabe K, Mikami M, Kametani Y.
    Human PZP and common marmoset A2ML1 as pregnancy related proteins.
    Sci Rep 10(1):2020, 5088. DOI:10.1038/s41598-020-61714-8
70. Y Kawamura, Y Toyoda, T Ohnishi, R Hisatomi, T Higashino, A Nakayama, S Shimizu, M Yanagi, I Kamimaki, R Fujimaru, H Suzuki, N Shinomiya, T Takada, H Matsuo
    Identification of a dysfunctional splicing mutation in SLC22A12/URAT1 gene causing renal hypouricemia type 1: A report on two families.
    Rheumatology 59:2020, 3988-3990. DOI:10.1093/rheumatology/keaa461
71. Murai U, Yamagishi K, Kishida R, Iso H
    Impact of seaweed intake on health.
    Eur J Clin Nutr -:2020, in press. DOI:10.1038/s41430-020-00739-8
72. Nakatochi M, Kushima I, Ozaki N.
    Implications of germline copy-number variations in psychiatric disorders: review of large-scale genetic studies.
    J Hum Genet -:2020, in press. DOI:10.1038/s10038-020-00838-1
73. Nakamura K, Akagi S, Ejiri K, Yoshida M, Miyoshi T, Sakaguchi M, Higashimoto Y, Fukami K, Matsubara H, Ito H.
    Inhibitory effects of RAGE-aptamer on development of monocrotaline-induced pulmonary arterial hypertension in rats.
    J Cardiol S0914-5087:2020, 30410-X. DOI:10.1016/j.jjcc.2020.12.009
74. Nagata E, Fujii N, Kohara S, Okada C, Satoh T, Takekoshi S, Takao M, Mihara B, Takizawa S.
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75. Umesawa M, Yamagishi K, Iso H
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76. N Hama, T Kobayashi, N Han, F Kitagawa, N Kajihara, R Otsuka, H Wada, H Lee, H Rhee, Y Hasegawa, H Yagita, M Baghdadi, K Seino.
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77. Nishio S, Murotani K, Nakao S, Takenaka M, Suzuki S, Aoki Y, Todo Y, Hosaka M, Nakai H, Katabuchi H, Nishi H, Takekuma M, Mikami M, Enomoto T.
    Investigation of clinicopathological features of vulvar cancer in 1068 patients: A Japanese Gynecologic Oncology Group (JGOG) nationwide survey study.
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78. Ishigaki K, Akiyama M, .., Kohno T, Shiraishi K, Momozawa Y,.., Matsuda K,.., Daigo Y, .., Kubo M, Kamatani Y.
    Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases.
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79. Chiyoda T, Sakurai M, Satoh T, Nagase S, Mikami M, Katabuchi H, Aoki D.
    Lymphadenectomy for primary ovarian cancer: a systematic review and meta-analysis.
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80. Sato H, Schoenfeld AJ, Siau E, Sakaguchi M, Toyooka S, Riely GJ, Ladanyi M, Somwar R.
    MAPK pathway alterations correlate with poor survival and drive resistance to therapy in patients with lung cancers driven by ROS1 fusions.
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81. Yoshida T, Suganuma N, Sato S, Toda S, Nakayama H, Masudo K, Okubo Y, Hayashi H, Yokose T, Koshikawa N, Rino Y, Iwasaki H, Miyagi Y, Masuda M, & Hoshino D.
    Membrane type 1 matrix metalloproteinase regulates anaplastic thyroid carcinoma cell growth and invasion into the collagen matrix.
    Biochem Biophys Res Commun. 529(4):2020, 1195-1200. DOI:10.1016/j.bbrc.2020.06.043
82. Koyama T, Kuriyama N, Uehara R.
    Midregional Proadrenomedullin Can Reflect the Accumulation of Visceral Adipose Tissue-A Key to Explaining the Obesity Paradox.
    Int J Environ Res Public Health. 17(11):2020, 3968. DOI:10.3390/ijerph17113968
83. Ohno M, Nishi K, Hiraoka Y, Niizuma S, Matsuda S, Iwasaki H, Kimura K, and Nishi E
    Nardilysin controls cardiac sympathetic innervation patterning through regulation of p75 neurotrophin receptor.
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84. Bajkowska K, Sumardika IW, Tomonobu N, Chen Y, Yamamoto KI, Kinoshita R, Murata H, Inoue Y, Sakaguchi M.
    Neuroplastinβ-mediated upregulation of solute carrier family 22 member 18 antisense (SLC22A18AS) plays a crucial role in the epithelial-mesenchymal transition, leading to lung cancer cells' enhanced motility.
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85. Nagano M, Hoshino D, Toshima J, Seiki M & Koshikawa N.
    NH2-terminal fragment of ZF21 protein suppresses tumor invasion via inhibiting the interaction of ZF21 with FAK.
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86. Nabeel Kajihara, Fumihito Kitagawa, Takuto Kobayashi, Haruka Wada, Ryo Otsuka, Ken-ichiro Seino.
    nterleukin-34 contributes to poor prognosis in triple negative breast cancer.
    Breast Cancer -:2020, in press. DOI:10.1007/s12282-020-01123-x
87. Ueki Y, Saito K, Iioka H, Sakamoto I, Kanda Y, Sakaguchi M, Horii A, Kondo E.
    PLOD2 Is Essential to Functional Activation of Integrin β1 for Invasion/Metastasis in Head and Neck Squamous Cell Carcinomas.
    iScience. 23:2020, 100850. DOI:10.1016/j.isci.2020.100850
88. Koyama S, Ito K, Terao C, Akiyama M, Horikoshi M, Momozawa Y, Matsunaga H, …, Kuriki K …
    Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease.
    Nat Genet. 52(11):2020, 1169-1177. DOI:10.1038/s41588-020-0705-3
89. Li Y, Yatsuya H, Hanibuchi T, Ota A, Naito H, Otsuka R, Murata C, Hirakawa Y, Chiang C, Uemura M, Tamakoshi K, Aoyama A
    Positive Association of Physical Activity with Both Objective and Perceived Measures of the Neighborhood Environment among Older Adults: The Aichi Workers' Cohort Study.
    Int J Environ Res Public Health 17:2020, 7971. DOI:10.3390/ijerph17217971
90. Machida H, Matsuo K, Matsuzaki S, Yamagami W, Ebina Y, Kobayashi Y, Tabata T, Kaneuchi M, Nagase S, Enomoto T, Mikami M.
    Proposal of a Two-Tier System in Grouping Adenocarcinoma of the Uterine Cervix.
    Cancers (Basel) 12(5):2020, E1251. DOI:10.3390/cancers12051251
91. Kato H, Kushima I, Mori D, Yoshimi A, Aleksic B, Nawa Y, et al.
    Rare genetic variants in the gene encoding histone lysine demethylase 4C (KDM4C) and their contributions to susceptibility to schizophrenia and autism spectrum disorder.
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92. Satoh JI, Kino Y, Yanaizu M, Ishida T, Saito Y
    Reactive astrocytes express Aggregatin ( FAM222A) in the brains of Alzheimer's disease and Nasu-Hakola disease.
    Intractable Rare Dis Res 9:2020, 217-221. DOI:10.5582/irdr.2020.03080
93. Koyama T, Kuriyama N, Ozaki E, Tomida S, Uehara R, Nishida Y, Shimanoe C, …, Kuriki K, et al.
    Sedentary Time is Associated with Cardiometabolic Diseases in A Large Japanese Population: A Cross-Sectional Study.
    J Atheroscler Thromb 27:2020, 1097-1107. DOI:10.5551/jat.54320
94. Iwao M, Suzuki Y, Tanaka R, Koyama T, Itoh H.
    Sensitive and selective quantification of mid-regional proadrenomedullin in human plasma using ultra-performance liquid chromatography coupled with tandem mass spectrometry.
    J Pharm Biomed Anal. 183:2020, 113168. DOI:10.1016/j.jpba.2020.113168
95. Ikezaki H, Furusyo N, Yokota Y, Ai M, Asztalos BF, Murata M, Hayashi J, Schaefer EJ.
    Small Dense Low-Density Lipoprotein Cholesterol and Carotid Intimal Medial Thickness Progression.
    Journal of Athersclerosis and Thrombosis 27:2020, 1108-1122. DOI:10.5551/jat.54130
96. Ukawa S, Tamakoshi A, Okada Y, Ito YM, Taniguchi R, Tani Y, Sasaki Y, Saito J, Haseda M, Kondo N, Kondo K
    Social participation patterns and the incidence of functional disability: The Japan Gerontological Evaluation Study.
    Geriatr Gerontol Int. 20(8):2020, 765-772. DOI:10.1111/ggi.13966
97. Schweighauser M, Shi Y, Tarutani A, Kametani F, Murzin AG, Ghetti B, Matsubara T, Tomita T, Ando T, Hasegawa K, Murayama S, Yoshida M, Hasegawa M, et al
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98. Takeuchi K, Momozawa Y, Tanaka K, Matsuo K, Oze I, Mikami H, Takezaki T, Suzuki S, Watanabe I, Kita Y, Arisawa K, Hamajima N, Tanaka H, Wakai K.
    Study profile of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study.
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99. Matsuo K, Nishio S, Matsuzaki S, Iwase H, Kagami S, Soeda S, Usui H, Nishikawa R, Mikami M, Enomoto T.
    Surgical margin status and recurrence pattern in invasive vulvar Paget's disease: A Japanese Gynecologic Oncology Group study.
    Gynecol Oncol -:2020, in press. DOI:10.1016/j.ygyno.2020.12.023
100. Kasano-Camones CI, Takizawa M, Iwasaki W, Sasaki S, Hamada M, Morimoto A, Sakaguchi M, Gonzalez FJ, Inoue Y.
     Synergistic Regulation of Hepatic Fsp27b Expression by HNF4α and CREBH.
     Biochem Biophys Res Commun 530:2020, 432-439. DOI:10.1016/j.bbrc.2020.05.070
101. Rie Kajino-Sakamoto, Teruaki Fujishita, Makoto Mark Taketo, Masahiro Aoki.
     Synthetic lethality between MyD88 loss and mutations in Wnt/β-catenin pathway in intestinal tumor epithelial cells.
     Oncogene 40:2020, 408-420. DOI:10.1038/s41388-020-01541-3
102. Ando S, Koyama T, Kuriyama N, Ozaki E, Uehara R.
     The Association of Daily Physical Activity Behaviors with Visceral Fat.
     Obes Res Clin Pract. 14:2020, 531-535. DOI:10.1016/j.orcp.2020.10.004
103. Nishida Y, Hara M, Fuku N, Taguchi N, Horita M, Shimanoe C, Higaki Y, Tanaka K
     The interaction between mitochondrial haplogroups (M7a/D) and physical activity on adiponectin in a Japanese population.
     Mitochondrion 53:2020, 234-242. DOI:10.1016/j.mito.2020.06.006
104. Wong JYY, Zhang H, Hsiung CA, Shiraishi K, .., Kohno T, Shen H, Chanock SJ, Rothman N, Lan Q.
     Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women.
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105. Nakano M, Riku Y, Nishioka K, Hasegawa M, Washimi Y, Arahata Y, Takeda A, Horibe K, Yamaoka A, Suzuki K, Tsujimoto M, Li Y, Yoshino H, Hattori N, et al
     Unclassified four-repeat tauopathy associated with familial parkinsonism and progressive respiratory failure.
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106. Matsuo K, Tanabe K, Hayashi M, Ikeda M, Yasaka M, Machida H, Shida M, Sato K, Yoshida H, Hirasawa T, Imanishi T, Mikami M.
     Utility of Comprehensive Serum Glycopeptide Spectra Analysis (CSGSA) for the Detection of Early Stage Epithelial Ovarian Cancer.
     Cancers (Basel) 12(9):2020, E2374. DOI:10.3390/cancers12092374
107. Matsuo K, Nusbaum DJ, Klar M, Matsuzaki S, Grubbs BH, Machida H, Konishi I, Mikami M, Roman LD.
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108. Minako Matsumoto, Sei Harada, Miho Iida,Tomonori Okamura, Toru Takebayashi
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109. Tomonobu N, Gede Yoni Komalasari NL, Sumardika IW, Jiang F, Chen Y, Yamamoto KI, Kinoshita R, Murata H, Inoue Y, Sakaguchi M.
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110. 郭　伸
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111. 保坂孝史、郭　伸
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112. 大谷　浩、宇田川　潤、八田　稔久
     第128回生涯教育講座 胎児科学をめざして(その2)出雲から展開した研究.
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113. 宇田川　潤
     妊娠期の環境要因により誘起される生後の脳機能変化.
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2019年度

1. Miura K, Adachi Y, Shirahase T, Nagashima Y, Suemune K, Sakaida N, Nakano Y, Sakai Y, Shimizu S, Ikehara S.
   A case of high-grade mucinous tubular and spindle cell carcinoma. .
   J Surg Case Rep 2020(2):2020 DOI:10.1093/jscr/rjaa014
2. Kazuya Takakuwa, Kaoru Mogushi, Min Han, Tomoaki Fujii, Masaki Hosoya, Arina Yamanami, Tomomi Akita, Chicamasa Yamashita, Shunsuke Kato, and Shigeo Yamaguchi
   A novel diagnostic system to evaluate the impact of epidermal growth factor receptor as a prognostic and therapeutic indicator for lung adenocarcinoma.
   Scientific Reports 10:2020, 6214. DOI:10.1038/s41598-020-63200-7
3. Yamagami W, Nagase S, Takahashi F, Ino K, Hachisuga T, Mikami M, Enomoto T, Katabuchi H, Aoki D.
   A retrospective study for investigating the relationship between old and new staging systems with prognosis in ovarian cancer using gynecologic cancer registry of Japan Society of Obstetrics and Gynecology (JSOG): disparity between serous carcinoma and clear cell carcinoma.
   J Gynecol Oncol :2020, in press. DOI:10.3802/jgo.2020.31.e45
4. Koyanagi YN, Suzuki E, Imoto I, Kasugai Y, Oze I, Ugai T, Iwase M, Usui Y, Kawakatsu Y, Sawabe M, Tanaka T, Abe T, Ito S, Tajika M, Ito H, Matsuo K
   Across-site differences in the mechanism of alcohol-induced digestive tract carcinogenesis: an evaluation by mediation analysis.
   Cancer Research 80(7):2020, 1601-1610. DOI:10.1158/0008-5472.CAN-19-2685
5. Ikebe E, Matsuoka S, Tezuka K, Kuramitsu M, Okuma K, Nakashima M, Seiichiro Kobayashi S, Makiyama J, Yamagishi M, Oyadomari S, Uchimaru K, Hamaguchi I
   Activation of PERK-ATF4-CHOP pathway as a novel therapeutic approach for efficient elimination of HTLV-1-infected cells.
   Blood adv 4(9):2020, 1845-1858. DOI:10.1182/bloodadvances.2019001139
6. Kawakita D, Abdelaziz S, Chen Y, Rowe K, Snyder J, Fraser A, Smith K, Herget K, Deshmukh V, Newman M, Monroe M, Hashibe M.
   Adverse respiratory outcomes among head and neck cancer survivors in the Utah Cancer Survivors Study.
   Cancer 126(4):2020, 879-885. DOI:10.1002/cncr.32617
7. Nagaoka A, Kunii Y, Hino M, Izumi R, Nagashima C, Takeshima A, Sainouchi M, Nawa H, Kakita A, Yabe H.
   ALDH4A1 expression levels are elevated in postmortem brains of patients with schizophrenia and are associated with genetic variants in enzymes related to proline metabolism.
   J Psychiatr Res 123:2020, 119-127. DOI:10.1016/j.jpsychires.2020.02.001
8. Suzuki K, ShivappaN, Kawado M, Yamada H, Hashimoto S, Wakai K, Iso H, Okada E, Fujii R, Hebert JR, Tamakoshi A.
   Association between dietary inflammatory index and serum C-reactive protein concentrations in the Japan Collaborative Cohort Study.
   Nagoya J Med Sci 82:2020
9. Furuya M, Hasumi H, Yao M, Nagashima Y.
   Birt-Hogg-Dube syndrome-associated renal cell carcinoma: Histopathological features and diagnostic conundrum. .
   Cancer Sci 111:2020, 15-22. DOI:10.1111/cas.14255
10. Roberts JA, Varma VR, Huang CW, An Y, Oommen A, Tanaka T, Ferrucci L, Elango P, Takebayashi T, Harada S, Iida M, Thambisetty M.
    Blood Metabolite Signature of Metabolic Syndrome Implicates Alterations in Amino Acid Metabolism: Findings from the Baltimore Longitudinal Study of Aging (BLSA) and the Tsuruoka Metabolomics Cohort Study (TMCS).
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11. Camargo MC, Kim KM, Matsuo K, Torres J, Liao LM, Morgan D, Michel A, Waterboer T, Song M, Gulley ML, Pawlita M, Rabkin CS.
    Circulating Antibodies against Epstein-Barr Virus (EBV) and p53 in EBV-Positive and -Negative Gastric Cancer.
    Cancer Epidemiol Biomarkers Prev 29:2020, 414-419. DOI:10.1158/1055-9965.EPI-19-0790
12. Nakahata S, Syahrul C, Morishita K. et al
    Clinical significance of soluble CADM1 as a novel marker for adult T-cell leukemia/lymphoma.
    Haematologica :2020, in press. DOI:10.3324/haematol.2019.234096
13. Masanori Kurihara, Tatsuo Mano, Yuko Saito, Shigeo Murayama, Tatsushi Toda, Atsushi Iwata
    Colocalization of BRCA1 with Tau Aggregates in Human Tauopathies.
    Brain Sciences 10(1):2020, E7. DOI:10.3390/brainsci10010007
14. Okada R、Kadomatsu Y, Tsukamoto M, Sasakabe T, Kawai S, Tamura T, Hishida A, Kuriki K, Wakai K, et al.
    Combined effect of weight gain within normal weight range and parental hypertension on the prevalence of hypertension; from the J-MICC Study.
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15. Banno T, Takagi T, Kondo T, Yoshida K, Iizuka J, Okumi M, Ishida H, Morita S, Nagashima Y, Tanabe K.
    Computed tomography imaging characteristics of clear cell papillary renal cell carcinoma.
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16. Nozaki, Y. Kato, Y. Uike, K. Yamamura, K. Kikuchi, M. Yasuda, M. Ohno, S. Horie, M. Murayama, T. Kurebayashi, N. Horigome, H.
    Co-Phenotype of Left Ventricular Non-Compaction Cardiomyopathy and Atypical Catecholaminergic Polymorphic Ventricular Tachycardia in Association With R169Q, a Ryanodine Receptor Type 2 Missense Mutation.
    Circulation Journal 84:2020, 226-234. DOI:10.1253/circj.CJ-19-0720
17. Arakawa A, Saito Y, Seki T, Mitsutake A, Sato T, Katsumata J, Maekawa R, Hideyama T, Tamura K, Hasegawa M, Shiio Y.
    Corticobasal degeneration with deep white matter lesion diagnosed by brain biopsy.
    Neuropathology :2020, in press. DOI:10.1111/neup.12638
18. Sumimoto H, Takano A, Teramoto K, Daigo Y
    Detection of neoantigen-reactive T cell clones based on the clonal expansion using next-generation sequencing of T cell receptor β complementarity-determining region 3.
    J Immunol Methods. 476:2020, 112679. DOI:10.1016/j.jim.2019.112679
19. Iwase M, Matsuo K, Nakatochi M, Oze I, Ito H, Koyanagi Y, Ugai T, Kasugai Y, Kuriki K, wakai K, et al.
    Differential effect of polymorphisms on body mass index across the life course of Japanese: the Japan Multi-Institutional Collaborative Cohort Study.
    J Epidemiol :2020, in press. DOI:10.2188/jea.JE20190296
20. Kubo A, Misonou H, Matsuyama M, Nomori A, Wada-Kakuda S, Takashima A, Kawata M, Murayama S, Ihara Y, Miyasaka T
    Distribution of endogenous normal tau in the mouse brain.
    Journal of Comparative Neurology 527:2020, 985-998. DOI:10.1002/cne.24577
21. Kazama K, Otake J, Satoyoshi T,... ,Sasada T, Masuda M.
    Distribution of Regulatory T-Cells and Other Phenotypes of T-Cells in Tumors and Regional Lymph Nodes of Colorectal Cancer Patients.
    In Vivo. 34:2020, 849-856. DOI:10.21873/invivo.11848
22. Hata S, Hu A, Piao Y, Nakaya T, Taru H, Morishima-Kawashima M, Murayama S, Nishimura M. and Suzuki T.
    Enhanced amyloid-β generation by y-secretase complex in detergent-resistant membrane microdomain accompanied by the reduced cholesterol level.
    Human. Mol. Gene. 29:2020, 382-393. DOI:10.1093/hmg/ddz297
23. Machida H, Iwata T, Okugawa K, Matsuo K, Saito T, Tanaka K, Morishige K, Kobayashi H, Yoshino K, Tokunaga H, Ikeda T, Shozu M, Yaegashi N, Enomoto T, Mikami M.
    Fertility-sparing trachelectomy for early-stage cervical cancer: A proposal of an ideal candidate.
    Gynecol Oncol 156(2):2020, 341-348. DOI:10.1016/j.ygyno.2019.11.021
24. Fachal L, Aschard H, Beesley J, Matsuo K, Chenevix-Trench G, Simard J, Easton DF, Kraft P, Dunning AM.
    Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes.
    Nat Genet 52:2020, 56-73. DOI:10.1038/s41588-019-0537-1
25. Kishida R, Yamagishi K, Muraki I, Sata M, Tamakoshi A, Iso H; for the JACC Study Group
    Frequency of Seaweed Intake and Its Association with Cardiovascular Disease Mortality: The JACC Study.
    J Atheroscler Thromb :2020, in press. DOI:10.5551/jat.53447
26. Sawada Y, Kikugawa T, Iio H, Sakakibara I, Yoshida S, Ikedo A, Yanagihara Y, Saeki N, Gyorffy B, Kishida T, Okubo Y, Nakamura Y, Miyagi Y, Saika T, Imai Y.
    GPRC5A facilitates cell proliferation through cell cycle regulation and correlates with bone metastasis in prostate cancer.
    Int J Cancer. 146(5):2020, 1369-1382. . DOI:10.1002/ijc.32554
27. Maezawa Y, Sakamaki K, Oue N, Kimura Y, Rino Y, Yasui W, Masuda M, Miyagi Y, Oshima T.
    High gamma-glutamyl hydrolase and low folylpolyglutamate synthetase expression as prognostic biomarkers in patients with locally advanced gastric cancer who were administrated postoperative adjuvant chemotherapy with S-1.
    J Cancer Res Clin Oncol. 146:2020, 75-86. DOI:10.1007/s00432-019-03087-8
28. Fukuyama M, Ohno S, Ozawa J, Kato K, Makiyama T, Nakagawa Y and Horie M.
    High Prevalence of Late-Appearing T-Wave in Patients With Long QT Syndrome Type 8.
    Circulation Journal 84:2020, 559-568. DOI:10.1253/circj.CJ-19-1101
29. Sakai K, Tanikawa C, Hirasawa A, Terao C, Kamatani Y, Takahashi A, Momozawa Y, Hirata M, Kubo M, Wakai K, Matsuda K. et al.
    Identification of a novel uterine leiomyoma GWAS locus in a Japanese population.
    Scientific Reports 10(1):2020, 1197. DOI:10.1038/s41598-020-58066-8
30. Shu X, Long J, Cai Q, Kweon SS, Choi JY, Kubo M, Low SK, Mariapun S, Matsuda K, Matsuo K, Shu XO, Kang D, Easton DF, Simard J, Zheng W.
    Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants.
    Nat Commun 11:2020, 1217. DOI:10.1038/s41467-020-15046-w
31. Kano K, Sakamaki K, Oue N, Kimura Y, Rino Y, Yasui W, Masuda M, Miyagi Y, Oshima T.
    Impact of the ESM-1 Gene Expression on Outcomes in Stage II/III Gastric Cancer Patients Who Received Adjuvant S-1 Chemotherapy.
    In Vivo 34:2020, 461-467. DOI:10.21873/invivo.11796
32. Tatsuhiro Terada, Tomokazu Obi, Tomoyasu Bunai, Takashi Matsudaira, Etsuji Y. Ichiro A., Masami F., Hideo Tsukada, Yasuomi Ouchi
    In vivo mitochondrial and glycolytic impairments in Alzheimer's disease.
    Neurology 94(15):2020, e1592-e1604. DOI:10.1212/WNL.0000000000009249
33. Shinohara M, Tashiro Y, Shinohara M, Hirokawa J, Suzuki K, Onishi-Takeya M, Mukouzono M, Takeda S, Saito T, Fukumori A, Saido TC, Morishita R, Sato N.
    Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes.
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34. Shinohara M, Tashiro Y, Suzuki K, Fukumori A, Guojun Bu, Sato N
    Interaction between APOE genotype and diabetes in cognitive decline.
    Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 12:2020, e12006. DOI:10.1002/dad2.12006
35. Yamagami W, Mikami M, Nagase S, Tabata T, Kobayashi Y, Kaneuchi M, Kobayashi H, Yamada H, Hasegawa K, Fujiwara H, Katabuchi H, Aoki D
    Japan Society of Gynecologic Oncology 2018 guidelines for treatment of uterine body neoplasms.
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36. Matsuzaki S, Klar M, Mikami M, Shimada M, Grubbs BH, Fujiwara K, Roman LD, Matsuo K.
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116. Ohnishi T, Balan S, Toyoshima M, Maekawa M, Ohba H, Watanabe A, Iwayama Y, Hisano Y, Nagaoka A, Hino M, Kunii Y, Kakita A, Yabe H, Yoshikawa T.
     Investigation of betaine as a novel psychotherapeutic for schizophrenia.
     EBioMedicine 45:2019, 432-446. DOI:10.1016/j.ebiom.2019.05.062
117. Tanaka K, Kiguchi K, Mikami M, Aoki D, Iwamori M.
     Involvement of the MDR1 gene and glycolipids in anticancer drug-resistance of human ovarian carcinoma-derived cells.
     Hum Cell 32(4):2019, 447-452. DOI:10.1007/s13577-019-00261-5
118. Akihiro Kawatsuki, Shin-Ya Morita, Naoki Watanabe, Emi Hibino, Yachiyo Mitsuishi, Takuma Sugi, Shigeo Murayama, Masaki Nishimura
     Lipid class composition of membrane and raft fractions from brains of individuals with Alzheimer's disease.
     Biochemistry and biophysics reports 20:2019, 100704-100704. DOI:10.1016/j.bbrep.2019.100704
119. Okumura Y, Adachi Y, Shirahase T, Nagashima Y, Tanaka Y, Taki Y, Watanabe J, Uegaki M, Sakatani T, Ikehara S.
     Malignant rhabdoid tumour in an adult kidney: A case report.
     Mol Clin Oncol 11(1):55-58. doi: 10.3892/mco.2019.1848.:2019, 55-58. DOI:10.3892/mco.2019.1848
120. Chen Y, Sumardika IW, Tomonobu N, Kinoshita R, Kondo E, Inoue Y, Yamauchi A, Nishibori M, Toyooka S, Sakaguchi M.
     Melanoma cell adhesion molecule is the driving force behind the dissemination of melanoma upon S100A8/A9 binding in the original skin lesion.
     Cancer Lett 452:2019, 178-190. DOI:10.1016/j.canlet.2019.03.023
121. Playdon MC, Joshi AD, Tabung FK, Cheng S, Henglin M, Kim A, Lin T, van Roekel EH, Huang J, Krumsiek J, Wang Y, Mathe E, Temprosa M, Moore S, Harada S et al.
     Metabolomics Analytics Workflow for Epidemiological Research: Perspectives from the Consortium of Metabolomics Studies (COMETS).
     Metabolites 19:2019, E145. DOI:10.3390/metabo9070145
122. Satoh JI, Kino Y, Yanaizu M, Ishida T, Saito Y.
     Microglia express GPNMB in the brains of Alzheimer's disease and Nasu-Hakola disease.
     Intractable & Rare Diseases Research 8:2019, 120-128. DOI:10.5582/irdr.2019.01049
123. Satoh J, Kino Y, Yanaizu M, Ishida T, Saito Y.
     Microglia express TMEM119 in the brains of Nasu-Hakola disease.
     Intractable & Rare Diseases Research 8:2019, 260-265. DOI:10.5582/irdr.2019.01123
124. Machida H, Matsuo K, Enomoto T, Mikami M.
     Neoadjuvant chemotherapy for epithelial ovarian cancer in Japan: a JSGO-JSOG joint study.
     J Gynecol Oncol 30(6):2019, e113. DOI:10.3802/jgo.2019.30.e113
125. Sumardika IW, Chen Y, Tomonobu N, Kinoshita R, Kondo E, Inoue Y, Yamauchi A, Nishibori M, Toyooka S, Sakaguchi M.
     Neuroplastin-β mediates S100A8/A9-induced lung cancer disseminative progression.
     Mol Carcinog 58:2019, 980-995. DOI:10.1002/mc.22987
126. Kinoshita R, Sato H, Yamauchi A, Inoue Y, Nishibori M, Kondo E, Toyooka S, Sakaguchi M.
     Newly developed anti-S100A8/A9 monoclonal antibody efficiently prevents lung tropic cancer metastasis.
     Int J Cancer 145:2019, 569-575. DOI:10.1002/ijc.31982
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     Novel Risk Loci Identified in a Genome-Wide Association Study of Urolithiasis in a Japanese Population.
     J Am Soc Nephrol. 30(5):2019, 855-864. DOI:10.1681/ASN.2018090942
128. Matsuo K, Shimada M, Nakamura K, Takei Y, Ushijima K, Sumi T, Ohara T, Yahata H, Mikami M, Sugiyama T.
     Predictors for pathological parametrial invasion in clinical stage IIB cervical cancer.
     Eur J Surg Oncol 45(8):2019, 1417-1424. DOI:10.1016/j.ejso.2019.02.019
129. Kobayashi T, Baghdadi M, Han N , Murata T, Hama N, Otsuka R, Wada H, Shiozawa M, Yokose T, Miyagi Y, Takano A, Daigo Y, Seino K.
     Prognostic value of IL-34 in colorectal cancer patients.
     Immunological Medicine 42:2019, 169-175. DOI:10.1080/25785826.2019.1691429
130. Nakahara Y, Kouro T, Igarashi Y, Kawahara M, Sasada T.
     Prospects for a personalized peptide vaccine against lung cancer.
     Expert Rev Vaccines. 18:2019, 703-709. DOI:10.1080/14760584.2019.1635461
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     RBM10-TFE3 renal cell carcinoma characterised by paracentric inversion with consistent closely split signals in break-apart fluorescence in-situ hybridisation: study of 10 cases and a literature review. .
     Histopathology 75:2019, 254-265. DOI:10.1111/his.13866
132. Matsuo K, Cripe JC, Kurnit KC, Kaneda M, Garneau AS, Glaser GE, Nizam A, Schillinger RM, Kuznicki ML, Yabuno A, Yanai S, Shida M, Mikami M,et al.
     Recurrence, death, and secondary malignancy after ovarian conservation for young women with early-stage low-grade endometrial cancer.
     Gynecol Oncol. 155(1):2019, 39-50. DOI:10.1016/j.ygyno.2019.08.007
133. Akimoto S, Goto C, Kuriki K.
     Relationship between ethanol consumption and TBL2 rs17145738 on LDL-C concentration in Japanese adults: a four season 3-day weighed diet record study.
     BMC Nutr :2019 DOI:10.1186/s40795-019-0315-6,
134. Tanigawa K, Ikehara S, Kimura T, Imano H, Muraki I, Shirai K, Tamakoshi A,Iso H.
     Relationships between reproductive history and mortality from cardiovascular diseases among Japanese women: the Japan Collaborative Cohort (JACC) Study.
     J Epidemiol :2019, in press. DOI:10.2188/jea.JE20190020
135. Nakanishi K, Mizuno T, Sakakura N, Kuroda H, Shimizu J, Hida T, Yatabe Y, Sakao Y.
     Salvage surgery for small cell lung cancer after chemoradiotherapy.
     Jpn J Clin Oncol 49:2019, 389-392. DOI:10.1093/jjco/hyz010
136. Yamazaki Y, Shinohara M, Shinohara M, Yamazaki A, Murray ME, Liesinger AM, Heckman MG, Lesser ER, Parisi JE, Petersen RC, Dickson DW, Kanekiyo T, Bu G.
     Selective loss of cortical endothelial tight junction proteins during Alzheimer's disease progression.
     Brain 142:2019, 1077-1092. DOI:10.1093/brain/awz011
137. Matsuo K, Shimada M, Matsuzaki S, Machida H, Nagase Y, Saito T, Kamiura S, Iwata T, Sugiyama T, Mikami M
     Significance of Malignant Peritoneal Cytology on the Survival of Women with Early-Stage Cervical Cancer: A Japanese Gynecologic Oncology Group Study.
     J Clin Med 8(11):2019, E1822. DOI:10.3390/jcm8111822
138. Kato A, Li Y, Ota A, Naito H, Yamada H, Nihashi T, Hotta Y, Chiang C, Hirakawa Y, Aoyama A, Tamakoshi K, Yatsuya H.
     Smoking results in accumulation of ectopic fat in the liver.
     Diabetes Metab Syndr Obes 12:2019, 1075-1080. DOI:10.2147/DMSO.S212495
139. Zhong L, Xu Y, Zhuo R, Wang T, Wang K, Huang R, Wang D, Gao Y, Zhu Y, Sheng X, Chen K, Wang N, Zhu L, Can D, Marten Y, Shinohara M, et al.
     Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model.
     Nat Commun 10:2019, 1365. DOI:10.1038/s41467-019-09118-9
140. Nishioka M, Bundo M, Iwamoto K, Kato T
     Somatic mutations in the human brain: implications for psychiatric research.
     Molecular Psychiatry 24:2019, 839-856. DOI:10.1038/s41380-018-0129-y
141. Matsumura Y, Daigo Y, Takano A, Orimo A, et.al.
     Stromal fibroblasts induce metastatic tumor cell clusters via epithelial-mesenchymal plasticity.
     Life Sci Alliance 2(4):2019, in press. DOI:10.26508/lsa.201900425
142. Machida H, Tokunaga H, Matsuo K, Matsumura N, Kobayashi Y, Tabata T, Kaneuchi M, Nagase S, Mikami M.
     Survival outcome and perioperative complication related to neoadjuvant chemotherapy with carboplatin and paclitaxel for advanced ovarian cancer: A systematic review and meta-analysis.
     Eur J Surg Oncol :2019, in press. DOI:10.1016/j.ejso.2019.11.520
143. Yamagishi M, Uchimaru K et al.
     Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas.
     Cell Reports 29:2019, 2321-2337. DOI:10.1016/j.celrep.2019.10.083
144. Hatsuta H, Takao M, Nogami A, Uchino A, Sumikura H, Takata T, Morimoto S, Kanemaru K, Adachi T, Arai T, Hasegawa, M and Murayama S.
     Tau and TDP-43 accumulation of the basal nucleus of Meynert in individuals with cerebral lobar infarcts or hemorrhage.
     Acta Neuropathol Commun 7:2019, 49. DOI:10.1186/s40478-019-0700-z
145. Sharma, G., Hisanaga, S., et al.,
     Tau isoform expression and phosphorylation in marmoset brains.
     J. Biol. Chem. 294:2019, 11433-11444. DOI:10.1074/jbc.RA119.008415
146. Cao J, Eshak ES, Liu K, Muraki I, Cui R, Iso H, Tamakoshi A; JACC Study Group.
     Television Viewing Time and Breast Cancer Incidence for Japanese Premenopausal and Postmenopausal Women: The JACC Study.
     Cancer Res Treat. 51:2019, 1509-1517. DOI:10.4143/crt.2018.705
147. Baba M, Furuya M, Motoshima T, Nagashima Y, Schmidt LS, Linehan WM et al.
     TFE3 Xp11.2 Translocation Renal Cell Carcinoma Mouse Model Reveals Novel Therapeutic Targets and Identifies GPNMB as a Diagnostic Marker for Human Disease.
     Mol Cancer Res 17:2019, 1613-1626. DOI:10.1158/1541-7786.MCR-18-1235
148. Kon S, Konta T, Ichikawa K, Watanabe M, Sato H, Ishizawa K, Ueno Y, Yamashita H, Kayama T.
     The association between genotypes of urate transporter-1, Serum uric acid, and mortality in the community-based population: the Yamagata (Takahata) Study.
     Clin Exp Nephrol 23:2019, 1357-1363. DOI:10.1007/s10157-019-01781-y
149. Kawakami I, Arai T, Hasegawa M.
     The basis of clinicopathological heterogeneity in TDP-43 proteinopathy.
     Acta Neuropathol 138:2019, 751-770. DOI:10.1007/s00401-019-02077-x
150. Yu B, Zanetti KA, Temprosa M, .., Harada S, .., Takebayashi T, .., Moore SC.
     The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies.
     American Journal of Epidemiology 188:2019, 991-1012. DOI:10.1093/aje/kwz028
151. Katsuya H, Islam S, Tan B, Ito J, Miyazato P, Matsuo M, Iwase S, Uchiyama Y, Yamagishi M, Watanabe T, Uchimaru K, Fujisawa J, Utsunomiya A, Yamano Y, Satou Y
     The nature of HTLV-1 provirus in naturally infected individuals analyzed by viral DNA-capture-seq approach.
     Cell Reports, 29:2019, 724-735. DOI:10.1016/j.celrep.2019.09.016
152. Machida H, Mastuo K, Yamagami W, Ebina Y, Kobayashi Y, Tabata T, Kanauchi M, Nagase T, Enomoto T, Mikami M.
     Trends and characteristics of epithelial ovarian cancer in Japan between 2002 and 2015 : A JSGO-JSOG joint study.
     Gynecol Oncol 153(3):2019, 589-596. DOI:10.1016/j.ygyno.2019.03.243
153. Yasuda H, Nakagawa M, Kiyokawa H, Yoshida E, Yoshimura T, Koshikawa N, Itoh F, Seiki M
     Unique Biological Activity and Potential Role of Monomeric Laminin-γ2 as a Novel Biomarker for Hepatocellular Carcinoma.
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154. Mitsui Y, Tomonobu N, Watanabe M, Kinoshita R, Yamauchi A, Inoue Y, Kondo E, Nishibori M, Toyooka S, Yamamoto Y, Nasu Y, Sakaguchi M.
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2018年度

1. Mizukoshi K, Okazawa Y, Haeno H, Koyama Y, Sulidan K, Komiyama H, Saeki H, Ohtsuji N, Ito Y, Kojima Y, Goto M, Habu S, Hino O, Sakamoto K,＊ Orimo A.
   Metastatic seeding of human colon cancer cell clusters expressing the hybrid epithelial/mesenchymal state.
   International Journal of Cancer, published as early view. 146(9):2547-2562, 2020. DOI:10.1002/ijc.32672
2. Shinohara M, Shinohara M, Zhao J, Fu Y, Liu C C, Kanekiyo T, Bu G.
   5-HT3 Antagonist Ondansetron Increases ApoE Secretion by Modulating the LXR-ABCA1 Pathway.
   Int. J. Mol. Sci 20(6):1488, 2019. DOI:10.3390/ijms20061488
3. Shimanoe C, Hachiya T, Hara M, Nishida Y, Tanaka K, Sutoh Y, Shimizu A, Hishida A, Kawai S, Okada R, Suzuki S, Watanabe M, Kuriki K, Endoh K, Mikami H, Nakamura Y, Momozawa Y, Kubo M, Nakatochi M, Naito M, Wakai K et al.
   A genome-wide association study of coping behaviors suggests FBXO45 is associated with emotional expression.
   Genes, Brain and Behavior 18(2):e12481, 2019. DOI:10.1111/gbb.12481
4. Baghdadi M, Ishikawa K, Nakanishi S, Murata T, Umeyama Y, Kobayashi T, Kameda Y, Endo H, Wada H, Bogen B, Yamamoto S, Yamaguchi K, Kasahara I, Iwasaki H, Takahata M, Ibata M, Takahashi S, Goto H, Teshima T, Seino K
   A role for IL-34 in osteolytic disease of multiple myeloma.
   Blood advances 3(4):541-551, 2019. DOI:10.1182
5. Hosaka T, Yamashita T, Teramoto S, Hirose N, Tamaoka A, Kwak S
   ADAR2-dependent A-to-I RNA editing in the extracellular linear and circular RNAs.
   Neurosci Res 147:48-57, 2019. DOI:10.1016/j.neures.2018.11.005
6. Kamoi K, Okayama A, Izumo S, Hamaguchi I, Uchimaru K, Tojo A, Ohno-Matsui K.
   Adult T-Cell Leukemia/Lymphoma-Related Ocular Manifestations: Analysis of the First Large-Scale Nationwide Survey.
   Front Microbiol. 9:3240, 2019. DOI:10.3389/fmicb.2018.03240
7. Tachibana M, Holm ML, Liu CC, Shinohara M, Aikawa T, Oue H, Yamazaki Y, Martens YA, Murray ME, Sullivan PM, Weyer K, Glerup S, Dickson DW, Bu G, Kanekiyo T.
   APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1.
   J Clin Invest 129(3):1272-1277, 2019. DOI:10.1172/JCI124853
8. Matsuo N, Azuma K, Hattori S, Ohtake J, Kawahara A, Ishii H, Tokito T, Yamada K, Shibata Y, Shimokawaji T, Kondo T, Kato T, Saito H, Yamada K, Sasada T, Hoshino T.
   Association between soluble immune mediators and tumor responses in patients with nonsmall cell lung cancer treated with anti-PD-1 inhibitor.
   Int J Cancer. 144(5):1170-1179, 2019. DOI:10.1002/ijc.31923
9. Fujii R, Hishida A, Nakatochi M, Furusyo N, Murata M, Tanaka K, Shimanoe C, Suzuki S, Watanabe M, Kuriyama N, Koyama T, Takezaki T, Shimoshikiryo I, Arisawa K, Katsuura-Kamano S, Takashima N, Turin TC, Kuriki K, Endoh K, Mikami H, Nakamura Y, Oze I, Ito H, Kubo M, Momozawa Y, Kondo T, Naito M, Wakai K.
   Association of genetic risk score and chronic kidney disease in a Japanese population.
   Nephrology (Carlton) 24(6):670-673, 2019. DOI:10.1111/nep.13479
10. Suzuki W, Wuren, Kuriki K.
    Associations between family factors and body weight gain from 20 years old.
    BMC Women’s Health. 19(1):33, 2019. DOI:10.1186/s12905-019-0719-0
11. Ukawa S, Zhao W, Yatsuya H, Yamagishi K, Tanabe N, Iso H, Tamakoshi A.
    Associations of Daily Walking Time With Pneumonia Mortality Among Elderly Individuals With or Without a Medical History of Myocardial Infarction or Stroke: Findings From the Japan Collaborative Cohort Study.
    J Epidemiol 29(6):233-237, 2019. DOI:10.2188/jea.JE20170341
12. Kondo M, Yamada H, Munetsuna E, Yamazaki M, Hatta T, Iwahara A, Ohashi K, Ishikawa H, Tsuboi Y, Inoue T, Fujii R, Suzuki K
    Associations of serum microRNA-20a, -27a, and -103a with cognitive function in a Japanese population: the Yakumo Study.
    Archives of Gerontology and Geriatrics 82:155-160, 2019. DOI:10.1016/j.archger.2019.01.007
13. Yamagishi K, Sawachi S, Tamakoshi A, Iso H
    Blood pressure levels and risk of cardiovascular disease mortality among Japanese men and women: The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study).
    J Hypertens 37(7):1366-1371, 2019. DOI:10.1097/HJH.0000000000002073
14. Naruse H,?Ishiura H, Mitsui J, Takahashi Y, Matsukawa T, Tanaka M, Doi K, Yoshimura J, Morishita S, Goto J, Toda T, Tsuji S.
    Burden of rare variants in causative genes for amyotrophic lateral sclerosis (ALS) accelerates age at onset of ALS.
    J Neurol Neurosurg Psychiatry. 90(5):537-542, 2019. DOI:10.1136/jnnp-2018-318568
15. Mezawa Y, Daigo Y, Takano A, Miyagi Y, Yokose T, Yamashita T, Morimoto T, Hino O, Orimo A.
    CD26 expression is attenuated by TGF-β and SDF-1 autocrine signaling on stromal myofibroblasts in human breast cancers.
    Cancer Med. 8:3936-3948, 2019. DOI:10.1002/cam4.2249
16. Mai Mochizuki, Mao Nakamura, Rie Sibuya, Toshimasa Okazaki, Jiro Abe, Takayuki Nakagawa, Satomi Takahashi, Tomoko Yamazaki, Takayuki Imai, Atsushi Takano, Hiroyuki Ito, Tomoyuki Yokose, Yohei Miyagi, Yataro Daigo, Ikuro Sato, Kennichi Satoh, Kazuo Sugamura, Kazunori Yamaguchi, Keiichi Tamai
    CD271 is a negative prognostic factor and essential for cell proliferation in lung squamous cell carcinoma.
    Laboratory Investigation 99(9):1349-1362, 2019. DOI:10.1038/s41374-019-0246-5
17. Yamashita T, Kwak S
    Cell death cascade and molecular therapy in ADAR2-deficient motor neurons of ALS.
    Neurosci Res 144:4-13, 2019. DOI:10.1016/j.neures.2018.06.004
18. (20) Tago T, Toyohara J, Harada R, Furumoto S, Okamura N, Kudo Y, Takahashi-Fujigasaki J, Murayama S, Ishii K.
    Characterization of the binding of tau imaging ligands to melanine-containing cells: putative off-target-binding site.
    Ann. Nucl. Med. 33(6):375-382, 2019. DOI:10.1007/s12149-019-01344-x
19. Ishikawa M, Osaki M, Yamagishi M, Onuma K, Ito H, Okada F, Endo H
    Correlation of two distinct metastasis-associated proteins, MTA1 and S100A4, in angiogenesis for promoting tumor growth.
    Oncogene 38(24):4715-4728, 2019. DOI:10.1038/s41388-019-0748-z
20. H. Yoda, T. Inoue, Y. Shinozaki, J. Lin, T. Watanabe, N. Koshikawa, A. Takatori, H. Nagase
    Direct targeting of MYCN gene amplification by site-specific DNA alkylation in neuroblastoma.
    Cancer Research 79(4):830-840, 2019. DOI:10.1158/0008-5472.CAN-18-1198
21. Wuren, Endoh K, Kuriki K, Shizuoka-Sakuragaoka J-MICC Study group.
    Eating rate as risk for body mass index and waist circumference obesity with appropriate confounding factors: a cross-sectional analysis of the Shizuoka-Sakuragaoka J-MICC Study.
    Asia Pac J Clin Nutr 28(1):79-91, 2019. DOI:10.6133/apjcn.201903_28(1).0012
22. J. Lin, S. Krishnamurthy, H. Yoda, Y. Shinozaki, T. Watanabe, N. Koshikawa, A. Takatori, P. Horton, H. Nagase
    Estimating genome-wide off-target effects for pyrrole-imoidazole polyamide binding by a pathway-based expression profiling approach.
    PLoS ONE 14(4):e0215247, 2019. DOI:10.1371/journal.pone.0215247
23. Takahira Shirahase,Yoshihisa Watanabe,Atsushi Tsujimura,Shin Kwak,Toshiro Yamamoto,Narisato Kanamura and Masaki Tanaka
    Ethanol Preference and Drinking Behavior Are Controlled by RNA Editing in the Nucleus Accumbens.
    Front.Behav.Neurosci 12:331, 2019. DOI:10.1.10.3389/fnbeh.2018.00331
24. Yamagishi K, Iso H, Shimazu T, Tamakoshi A, Sawada N, Matsuo K, Ito H, Wakai K, Nakayama T, Kitamura Y, Sado J, Tsuji I, Sugawara Y, Mizoue T, Inoue M, Nagata C, Sadakane A, Tanaka K, Tsugane S, Sasazuki S
    Fish intake and risk of mortality due to aortic dissection and aneurysm: A pooled analysis of the Japan cohort consortium.
    Clin Nutr 38(4):1678-1683, 2019. DOI:10.1016/j.clnu.2018.08.007
25. Morita E, Kadomatsu Y, Tsukamoto M, Kubo Y, Okada R, Sasakabe T, Kawai S, Hishida A, Naito M, Wakai K.
    Frequency of forest walking is not associated with prevalence of hypertension based on cross-sectional studies of a general Japanese population: A reconfirmation by the J-MICC Daiko Study.
    Nagoya Journal of Medical Science :in press, 2019.
26. Nishiyama T, Nakatochi M, Goto A, Iwasaki M, Hachiya T, Sutoh Y, Shimizu A, Wang C, Tanaka H, Watanabe M, Hosono A, Tamai Y, Yamada T, Yamaji T, Sawada N, Fukumoto K, Otsuka K, Tanno K, Tomita H, Kojima K, Nagasaki M, Hozawa A, Hishida A, Sasakabe T, Nishida Y, Hara M, Ito H, Oze I, Nakamura Y, Mikami H, Ibusuki R, Takezaki T, Koyama T, Kuriyama N, Endoh K, Kuriki K, Turin T C, Takashima N, Katsuura-Kamano S, Uemura H, Okada R, Kawai S, Naito M, Momozawa Y, Kubo M, Sasaki M, Yamamoto M, Tsugane S, Wakai K, Suzuki S
    Genome-wide association meta-analysis and Mendelian randomization analysis confirm ALDH2 influencing on sleep duration in the Japanese population.
    Sleep 42(6):zsz046, 2019. DOI:10.1093/sleep/zsz046
27. Lawrenson K, Song F, Hazelett DJ, Kar SP, Tyrer J, Phelan CM, Corona RI, Rodr?guez-Malav? NI, Seo JH, Adler E, Coetzee SG, Segato F, Fonseca MAS, Amos CI, Carney ME, Chenevix-Trench G, Choi J, Doherty JA, Jia W, Jin GJ, Kim BG, Le ND, Lee J, Li L, Lim BK, Adenan NA, Mizuno M, Park B, Pearce CL, Shan K, Shi Y, Shu XO, Sieh W; Australian Ovarian Cancer Study Group, Thompson PJ, Wilkens LR, Wei Q, Woo YL, Yan L, Karlan BY, Freedman ML, Noushmehr H, Goode EL, Berchuck A, Sellers TA, Teo SH, Zheng W, Matsuo K, Park S, Chen K, Pharoah PDP, Gayther SA, Goodman MT.
    Genome-wide association studies identify susceptibility loci for epithelial ovarian cancer in east Asian women.
    Gynecol Oncol :30133-30137, 2019. DOI:10.1016/j.ygyno.2019.02.023
28. Takeuchi F, Kukimoto I, Li Z, Li S, Li N, Hu Z, Takahashi A, Inoue S, Yokoi S, Chen J, Hang D, Kuroda M, Matsuda F, Mizuno M, Mori S, Wu P, Tanaka N, Matsuo K, Kamatani Y, Kubo M, Ma D, Shi Y.
    Genome-wide association study of cervical cancer suggests a role for ARRDC3 gene in human papillomavirus infection.
    Hum Mol Genet 28(2):341-348, 2019. DOI:10.1093/hmg/ddy390
29. Nakatochi M, Kanai M, Nakayama A, Hishida A, Kawamura Y, Kamatani Y, Shinomiya N, Yokota M, Wakai K, Okada Y, Matsuo H (他38名)
    Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals.
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     Trogocytosis of ligand-receptor complex and its intracellular transport in CD30 signalling.
     Biol Cell 110(5):109-124, 2018. DOI:10.1111/boc.201800002
148. Ito Y, Nakamura S, Sugimoto N, Shigemori T, Kato Y, Ohno M, Sakuma S, Ito K, Kumon H, Hirose H, Okamoto H, Nogawa M, Iwasaki M, Kihara S, Fujio K, Matsumoto T, Higashi N, Hashimoto K, Sawaguchi A, Harimoto KI, Nakagawa M, Yamamoto T, Handa M, Watanabe N, Nishi E, Arai F, Nishimura S, Eto K
     Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production.
     Cell 174(3):636-648, 2018. DOI:10.1016/j.cell.2018.06.011.?
149. Morimoto S, Hatsuta H, Kokubo Y, Nakano Y, Hasegawa M, et al
     Unusual tau pathology of the cerebellum in patients with amyotrophic lateral sclerosis/parkinsonism-dementia complex from the Kii Peninsula, Japan.
     Brain Pathol 28:287-291, 2018. DOI:10.1111/bpa.12500
150. Earp M, Tyrer JP, Winham SJ, Lin HY, Chornokur G, Dennis J, Aben KKH, Anton-Culver H, Antonenkova N, Bandera EV, Bean YT, Beckmann MW, Bjorge L, Bogdanova N, Brinton LA, Brooks-Wilson A, Bruinsma F, Bunker CH, Butzow R, Campbell IG, Carty K, Chang-Claude J, Cook LS, Cramer DW, Cunningham JM, Cybulski C, Dansonka-Mieszkowska A, Despierre E, Doherty JA, D?rk T, du Bois A, D?rst M, Easton DF, Eccles DM, Edwards RP, Ekici AB, Fasching PA, Fridley BL, Gentry-Maharaj A, Giles GG, Glasspool R, Goodman MT, Gronwald J, Harter P, Hein A, Heitz F, Hildebrandt MAT, Hillemanns P, Hogdall CK, H?gdall E, Hosono S, Iversen ES, Jakubowska A, Jensen A, Ji BT, Jung AY, Karlan BY, Kellar M, Kiemeney LA, Kiong Lim B, Kjaer SK, Krakstad C, Kupryjanczyk J, Lambrechts D, Lambrechts S, Le ND, Lele S, Lester J, Levine DA, Li Z, Liang D, Lissowska J, Lu K, Lubinski J, Lundvall L, Massuger LFAG, Matsuo K, McGuire V, McLaughlin JR, McNeish I, Menon U, Milne RL, Modugno F, Moysich KB, Ness RB, Nevanlinna H, Odunsi K, Olson SH, Orlow I, Orsulic S, Paul J, Pejovic T, Pelttari LM, Permuth JB, Pike MC, Poole EM, Rosen B, Rossing MA, Rothstein JH, Runnebaum IB, Rzepecka IK, Schernhammer E, Schwaab I, Shu XO, Shvetsov YB, Siddiqui N, Sieh W, Song H, Southey MC, Spiewankiewicz B, Sucheston-Campbell L, Tangen IL, Teo SH, Terry KL, Thompson PJ, Thomsen L, Tworoger SS, van Altena AM, Vergote I, Vestrheim Thomsen LC, Vierkant RA, Walsh CS, Wang-Gohrke S, Wentzensen N, Whittemore AS, Wicklund KG, Wilkens LR, Woo YL, Wu AH, Wu X, Xiang YB, Yang H, Zheng W, Ziogas A, Lee AW, Pearce CL, Berchuck A, Schildkraut JM, Ramus SJ, Monteiro ANA, Narod SA, Sellers TA, Gayther SA, Kelemen LE, Chenevix-Trench G, Risch HA, Pharoah PDP, Goode EL, Phelan CM.
     Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility.
     PLoS ONE 13(7):e0197561, 2018. DOI:10.1371/journal.pone.0197561
151. Cui R, Iso H, Eshak ES, Maruyama K, Tamakoshi A
     Water intake from foods and beverages and risk of mortality from CVD: the Japan Collaborative Cohort (JACC) Study.
     Public Health Nutr 21(16):3011-3017, 2018. DOI:10.1017/S1368980018001386
152. 北川善康、奥村和弘、鈴木拓人、渡部隆義、篠崎喜脩、早田浩明、傳田忠道、山口武人、永瀬浩喜
     ピロールイミダゾール含有ポリアミドによる 大腸がん患者血液由来のKRAS 変異アレル濃縮法の検討.
     調査研究ジャーナル Vol.7 No.2:106-110, 2018.
153. Sawabe M, Ito H, Takahara T, Oze I, Kawakita D, Yatabe Y, Hasegawa Y, Murakami S, Matsuo K.
     喫煙と唾液腺癌リスクに関する研究.
     Cancer 124(2):118-125, 2018. DOI:10.1002/cncr.30958
154. 栗山長門，渡邊能行.
     血管性認知症に関する疫学研究.
     京都府立医科大学雑誌 127:435-449, 2018.
155. 村上友太、齋藤　清、高橋浩一、荒木信夫、橋本康弘
     髄液バイオマーカーとしての“脳型”トランスフェリン.
     自律神経 :in press, 2018.
156. 村上友太、高橋浩一、星 京香、伊藤浩美、齋藤 清、宮嶋雅一、新井 一、美馬達夫、橋本康弘
     脳脊髄液減少症（特発性低髄液圧症候群）と脳型トランスフェリン.
     日本頭痛学会誌 45(1):25-33, 2018.
157. Makoto Yamagishi, Kaoru Uchimaru
     ATL、HTLV-1キャリアに対する新規治療法の開発及び薬効評価.
     Current Opinion in Oncology 29:375-381, 2017.
158. Kawakita D, Matsuo K, Boffetta P, Hashibe M, La Vecchia C, Edefonti V, et al.
     Dietary fiber intake and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology consortium.
     International Journal of Cancer 141(9):1811-1821, 2017. DOI:10.1002/ijc.30886
159. Kawakita D, Lee YA, Hashibe M, et al.
     Impact of oral hygiene on head and neck cancer risk in a Chinese population.
     Head & Neck 39(12):2549-2557, 2017. DOI:10.1002/hed.24929

2017年度

1. Eshak ES, Iso H, Muraki I, Tamakoshi A
   Fat-soluble vitamins from diet in relation to risk of type 2 diabetes mellitus in Japanese population.
   Br J Nutr 20:1-18, 2018. DOI:10.1017/S000711451800377X
2. Okada E, Nakamura K, Ukawa S, Wakai K, Date C, Iso H, Tamakoshi A
   The Japanese food score and risk of all-cause, CVD and cancer mortality: the Japan Collaborative Cohort Study.
   Br J Nutr 120:464-471, 2018. DOI:10.1017/S000711451800154X
3. Nakamura Y, Narita A, Hachiya T, Sutoh Y, Shimizu A, Ohno S, Takashima N, Suzuki H, Tanaka K, Hara M, Kuriki K, Endoh K, Oze I, Ito H, Uemura H, Katsuura-Kamano S, Mikami H, Nakamura Y, Shimoshikiryo I, Takezaki T, Suzuki S, Watanabe M, Kuriyama N, Koyama T, Furusyo N, Ikezaki H, Nakatochi M, Kawai S, Hishida A, Okada R, Tamura T, Naito M, Wakai K, Momozawa Y, Kubo M, Ueshima H, Kita Y.
   A Genome-wide Association Study in the Diabetic Patients Finds the 13q35.43-35.46 Locus Associated with Estimated Glomerular Filtration Rate: The Japan Multi-Institutional Collaborative Cohort study.
   J Clin Diabetes. 2:102, 2018.
4. Nakagawa-Senda H, Hachiya T, Shimizu A, Hosono S, Oze I, Watanabe M, Matsuo K, Ito H, Hara M, Nishida Y, Endoh K, Kuriki K, Katsuura-Kamano S, Arisawa K, Nindita Y, Ibusuki R, Suzuki S, Hosono A, Mikami H, Nakamura Y, Takashima N, Nakamura Y, Kuriyama N, Wakai K, et al.
   A genome-wide association study in the Japanese population identifies the 12q24 locus for habitual coffee consumption: The J-MICC Study.
   Scientific Reports 8(1):1493, 2018. DOI:10.1038/s41598-018-19914-w
5. Ukawa S, Tamakoshi A, Mori M, Ikehara S, Shirakawa T, Yatsuya H, Iso H.
   Association between average daily television viewing time and the incidence of ovarian cancer: findings from the Japan Collaborative Cohort Study.
   Cancer Causes Control 29:213-219, 2018. DOI:10.1007/s10552-018-1001-8
6. Kuriyama Nagato, Ozaki Etsuko, Mizuno Toshiki, Ihara Masafumi, Mizuno Shigeto, Koyama Teruhide, Matsui Daisuke, Watanabe Isao, Akazawa Kentaro, Takeda Kazuo, Takada Akihiro, Inaba Masaaki, Yamada Shinsuke, Motoyama Koka, Takeshita Wakiko, Iwai Komei, Hashiguchi Kanae, Kobayashi Daiki, Kondo Masaki, Tamura Aiko, Yamada Kei, Nakagawa Masanori, Watanabe Yoshiyuki
   Association between α-Klotho and Deep White Matter Lesions in the Brain: A Pilot Case Control Study Using Brain MRI.
   J Alzheimers Dis 61(1):145-155, 2018. DOI:10.3233/JAD-170466
7. Etsuko Ozaki, Shinsuke Yamada, Nagato Kuriyama, Daisuke Matsui, Isao Watanabe,Teruhide Koyama, Yasuo Imanishi, Masaaki Inaba & Yoshiyuki Watanabe
   Association of BAP with urinary albumin excretion in postmenopausal, but not premenopausal, non-CKDJapanese women.
   Scientific Reports 8(1):82, 2018. DOI:10.1038/s41598-017-1473-w
8. Seiki T, Naito M, Hishida A, Takagi S, Matsunaga T, Sasakabe T, Hattori Y, Kawai S, Okada R, Yin G, Hamajima N, Wakai K
   Association of genetic polymorphisms with erythrocyte traits: Verification of SNPs reported in a previous GWAS in a Japanese population.
   Gene 642:172-177, 2018. DOI:10.1016/j.gene.2017.11.031
9. Liu Y, Shu XO, Wen W, Saito E, Rahman MS, Tsugane S, Tamakoshi A, Xiang YB, Yuan JM, Gao YT, Tsuji I, Kanemura S, Nagata C, Shin MH, Pan WH, Koh WP, Sawada N, Cai H, Li HL, Tomata Y, Sugawara Y, Wada K, Ahn YO, Yoo KY, Ashan H, Chia KS, Boffetta P, Inoue M, Kang D, Potter JD, Zheng W.
   Association of leisure-time physical activity with total and cause-specific mortality: a pooled analysis of nearly a half million adults in the Asia Cohort Consortium.
   Int J Epidemiol :Epub ahead of print, 2018. DOI:10.1093/ije/dyy024
10. Eshak ES, Iso H, Yamagishi K, Maruyama K, Umesawa M, Tamakoshi A.
    Associations between copper and zinc intakes from diet and mortality from cardiovascular disease in a large population-based prospective cohort study.
    J Nutr Biochem 56:126-132, 2018. DOI:10.1016/j.jnutbio.2018.02.008
11. Daigo K, Takano A, Thang PM, Yoshitake Y, Shinohara M, Tohnai I, Murakami Y, Maegawa J, Daigo Y.
    Characterization of KIF11 as a novel prognostic biomarker and therapeutic target for oral cancer.
    Int J Oncol. 52(1):155-165, 2018. DOI:10.3892/ijo.2017.4181
12. Y. Horiuchi, J. Lin, Y. Shinojima, K. Fujiwara, M. Moriyama, H. Nagase
    Characterizing key nucleotide polymorphisms of hepatitis C virus-disease associations via mass-spectrometric genotyping.
    International Journal of Oncology 52(2):441-452, 2018. DOI:10.3892/ijo.2017.4209
13. Kashino I, Akter S, Mizoue T, Sawada N, Kotemori A, Matsuo K, Oze I, Ito H, Naito M, Nakayama T, Kitamura Y, Tamakoshi A, Tsuji I, Sugawara Y, Inoue M, Nagata C, Sadakane A, Tanaka K, Tsugane S, Shimazu T; Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan.
    Coffee drinking and colorectal cancer and its subsites: A pooled analysis of 8 cohort studies in Japan.
    Int J Cancer 143:307-316, 2018. DOI:10.1002/ijc.31320
14. Kenta Tezuka, Kazu Okuma, Madoka Kuramitsu, Sahoko Matsuoka, Reiko Tanaka, Yuetsu Tanaka, Isao Hamaguchi
    Control of HTLV-1 Infection by Eliminating Envelope Protein-Positive Cells with Recombinant Vesicular Stomatitis Viruses Encoding HTLV-1 Primary Receptor.
    Journal of Virology 92(4):e01885-17, 2018. DOI:10.1128/JVI.01885-17
15. Shimanoe C, Hara M, Nishida Y, Nanri H, Otsuka Y, Horita M, Yasukata J, Miyoshi N, Yamada Y, Higaki Y, Tanaka K
    Coping strategy and social support modify the association between perceived stress and C-reactive protein: a longitudinal study of healthy men and women.
    Stress 21(3):237-246, 2018. DOI:10.1080/10253890.2018.1435638
16. Eshak ES, Iso H, Yamagishi K, Cui R, Tamakoshi A.
    Dietary intakes of fat soluble vitamins as predictors of mortality from heart failure in a large prospective cohort study.
    Nutrition 47:50-55, 2018. DOI:10.1016/j.nut.2017.09.009
17. Miho Ogawa, Kazuaki Yokoyama, Mitsuhito Hirano, Koji Jimbo, Kiyosumi Ochi, Toyotaka Kawamata, Nobuhiro Ohno, Eigo Shimizu,Nozomi Yokoyama,Rui Yamaguchi,Seiya Imoto, Kaoru Uchimaru, Satoru Miyano,Yoichi Imai, Arinobu Tojo.
    Different Clonal Dynamics of Chronic Myeloid Leukaemia between Bone Marrow and the Central Nervous System.
    Journal: British Journal of Haematology. 183(5):842-845, 2018. DOI:10.1111/bjh.15065
18. Kenichi Nagata, Tatsuo Mano, Shigeo Murayama, Takaomi C. Saido, Atsushi Iwata
    DNA methylation level of the neprilysin promoter in Alzheimer's disease brains.
    Neuroscience Letters 670:8-13, 2018. DOI:10.1016/j.neulet.2018.01.003
19. Ishiura H, Doi K, Mitsui J, Yoshimura J, Shimizu J (67名中46番目), Hanajima R, Hayashi T, Terao Y, Inomata-Terada S, Hamada M, Shirota Y, Kubota A, Ugawa Y, Koh K, Takiyama Y, Ohsawa-Yoshida N, Ishiura S, Yamasaki R, Tamaoka A, Akiyama H, Otsuki T, Sano A, Ikeda A, Goto J, Morishita S, Tsuji S.
    Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy.
    Nat Genet 5:Epub ahead of prin, 2018. DOI:10.1038/s41588-018-0067-2
20. Fujii R, Hishida A, Michael C Wu, Kondo T, Hattori Y, Naito M, Endoh K, Nakatochi M, Hamajima N, Kubo M, Kuriki K, Wakaki K.
    Genome-wide association study for pollinosis identified two novel loci in interleukin (IL)-1B in a Japanese population.
    Nagoya J Med Sci. 80(1):109-120, 2018. DOI:10.18999/nagjms.80.1.109
21. Shiga Y, Akiyama M, Nishiguchi K M, Sato K, Shimozawa N, Takahashi A, Momozawa Y, Hirata M, Matsuda K, Yamaji T, Iwasaki M, Tsugane S, Oze I, Mikami H, Naito M, Wakai K, Yoshikawa M, Miyake M, Yamashiro K, Wakai K, et al.
    Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma.
    Human Molecular Genetics 27(8):1486-1496, 2018. DOI:10.1093/hmg/ddy053
22. Hara M, Hachiya T, Sutoh Y, Matsuo K, Nishida Y, Shimanoe C, Tanaka K, Shimizu A, Ohnaka K, Kawaguchi T, Oze I, Matsuda F, Ito H, Kawai S, Hishida A, Okada R, Sasakabe T, Hirata A, Ibusuki R, Nindita Y, Furusyo N, Ikezaki H, Kuriyama N, Ozaki E, Mikami H, Nakamura Y, Suzuki S, Hosono A, Katsuura-Kamano S, Arisawa K, Kuriki K, Endoh K, Takashima N, Kadota A, Nakatochi M, Momozawa Y, Kubo M, Naito M, Wakai K.
    Genome-wide Association Study of Leisure-Time Exercise Behavior in Japanese Adults.
    Med Sci Sports Exerc. 50(12):2433-2441, 2018. DOI:10.1249/MSS.0000000000001712
23. Tanikawa C, Kamatani Y, Takahashi A, Momozawa Y, Leveque K, Nagayama S, Mimori K, Mori M, Ishii H, Inazawa J, Yasuda J, Tsuboi A, Shimizu A, Sasaki M, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Naito M, Wakai K, Koyama T, Takezaki T, Yuji K, Murakami Y, Wakai K, et al.
    GWAS Identifies Two Novel Colorectal Cancer Loci at 16q24.1 and 20q13.12.
    Carcinogenesis 39(5):652-660, 2018. DOI:10.1093/carcin/bgy026
24. Nishizuka SS, Tamura G, Nakatochi M, Fukushima N, Ohmori Y, Sumida C, Iwaya T, Takahashi T, Koeda K; Northern Japan Gastric Cancer Study Consortium
    Helicobacter pylori infection is associated with favorable outcome in advanced gastric cancer patients treated with S-1 adjuvant chemotherapy.
    Journal of Surgical Oncology 117:947-956, 2018. DOI:10.1002/jso.24977
25. Yu Okazawa, Kosuke Mizukoshi, Yu Koyama, Shoki Okubo, Hiromitsu Komiyama, Yutaka Kojima, Michitoshi Goto, Sonoko Habu, Okio Hino, Kazuhiro Sakamoto* and Akira Orimo*
    High-sensitivity detection of micrometastases in GFP-labelled colon tumor organoids extracted from patient-derived tumor xenografts.
    Journal of Visualized Experiments (JoVE), :136, 2018. DOI:10.3791/57374
26. Shirafuji N,?Hamano?T, Yen SH, Kanaan NM,?Yoshida?H, Hayashi K, Ikawa M, Yamamura O, Kuriyama M, Nakamoto Y.
    Homocysteine Increases?Tau?Phosphorylation, Truncation and Oligomerization.
    International Journal of Molecular Science 19(3):?E891, 2018. DOI:10.3390/ijms19030891
27. Yoko Kataoka, Yasuhiko Ohshio, Koji Teramoto, Tomoyuki Igarashi, Tohru Asai, Jun Hanaoka
    Hypoxia-induced galectin-3 enhances RhoA function to activate the motility of tumor cells in non-small cell lung cancer.
    Oncology Reports 41:853-862, 2018. DOI:10.3892/or.2018.6915
28. Sasakabe T, Wakai K, Kawai S, Hishida A, Naito M, Suzuki S, Nindita Y, Arisawa K, Kita Y, Hara M, Kuriyama N, Hirata A, Mikami H, Oze I, Kubo M, Tanaka H, Hamajima N
    Modification of the associations of alcohol intake with serum low-density lipoprotein cholesterol and triglycerides by ALDH2 and ADH1B polymorphisms in Japanese men.
    Journal of Epidemiology 28(4):185-193, 2018. DOI:10.2188/jea.JE20160189
29. Sato T, Coler-Reilly ALG, Yagishita N, Araya N, Inoue E, Furuta R, Watanabe T, Uchimaru K, Matsuoka M, Matsumoto N, Hasegawa Y, Yamano Y.
    Mogamulizumab (Anti-CCR4) in HTLV-1-Associated Myelopathy.
    N Engl J Med. 378(6):529-538, 2018. DOI:10.1056/NEJMoa1704827
30. Yamaguchi S, Takahashi S, Mogushi K, Izumi Y, Nozaki Y, Nomizu T, Kakugawa Y, Ishida T, Ohuchi N, Ishioka C, Kato S.
    Molecular and clinical features of the TP53 signature gene expression profile in early-stage breast cancer.
    Oncotarget 9(18):14193-14206, 2018. DOI:10.18632/oncotarget.24447
31. Naruse H,?Ishiura H, Mitsui J, Date H, Takahashi Y, Matsukawa T, Tanaka M, Ishii A, Tamaoka A, Hokkoku K, Sonoo M, Segawa M, Ugawa Y, Doi K, Yoshimura J, Morishita S, Goto J, Tsuji S.
    Molecular epidemiological study of familial amyotrophic lateral sclerosis in Japanese population by whole-exome sequencing and identification of novel HNRNPA1 mutation.
    Neurobiol Aging 61:e9-255, 2018. DOI:10.1016/j.neurobiolaging.2017.08.030
32. Yukiko Hata, Ning Ma, Misao Yoneda, Satoru Morimoto, Hideyuki Okano, Shigeo Murayama, Shosuke Kawanishi, Shigeki Kuzuhara, Yasumasa Kokubo
    Nitrative Stress and Tau Accumulation in Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC) in the Kii Peninsula, Japan.
    Front Neurosci.? 11:751, 2018. DOI:10.3389/fnins.2017.00751
33. Tirani Bahari, Hirokazu Uemura, Sakurako Katsuura-Kamano, Miwa Yamaguchi, Mariko Nakamoto, Keisuke Miki, Masashi Ishizu, Kokichi Arisawa
    Nutrient-derived dietary patterns and their association with metabolic syndrome in a Japanese population.
    Journal of Epidemiology 28(4):194-201, 2018. DOI:10.2188/jea.JE20170010
34. Fujii R, Ueyama J, Aoi A, Ichino N, Osakabe K, Sugimoto K, Suzuki K, Hamajima N, Wakai K, Kondo T.
    Oxidized human serum albumin as a possible correlation factor for atherosclerosis in a rural Japanese population: the results of the Yakumo Study.
    Environmental health and preventive medicine 23(1), 2018. DOI:10.1186/s12199-017-0690-z
35. Shimanoe C; Hara M; Nishida Y; Nanri, H; Horita, M; Yamada, Y; Li, Y S; Kasai, H; Kawai, K; Higaki, Y; Tanaka, K
    Perceived Stress, Depressive Symptoms, and Oxidative DNA Damage.
    Psychosomatic Medicine 80(1):28-33, 2018. DOI:10.1097/PSY.0000000000000513
36. Ukawa S, Tamakoshi A, Murakami Y, Kiyohara Y, Yamada M, Nagai M, Satoh A, Miura K, Ueshima H, Okamura T, EPOCH-JAPAN Research Group
    Pooled Analysis of the Associations between Body Mass Index, Total Cholesterol, and Liver Cancer-related Mortality in Japan.
    Asian Pac J Cancer Prev 19:2089-2095, 2018.
37. Tanabe A, Nakano K, Nakakido M, Nagatoishi S, Tanaka Y, Tsumoto K, Uchimaru K, Watanabe T.
    Production and characterization of a novel site-specific-modifiable anti-OX40-receptor single-chain variable fragment for targeted drug delivery.
    Biochem Biophys Res Commun. 496(2):614-620, 2018. DOI:10.1016/j.bbrc.2018.01.051
38. Urayama KY, Takagi M, Kawaguchi T, Matsuo K, Tanaka Y, Ayukawa Y, Arakawa Y, Hasegawa D, Yuza Y, Kaneko T, Noguchi Y, Taneyama Y, Ota S, Inukai T, Yanagimachi M, Keino D, Koike K, Toyama D, Nakazawa Y, Kurosawa H, Nakamura K, Moriwaki K, Goto H, Sekinaka Y, Morita D, Kato M, Takita J, Tanaka T, Inazawa J, Koh K, IshidaY, Ohara A, Mizutani S, Matsuda F, Manabe A.
    Regional Evaluation of Childhood Acute Lymphoblastic Leukemia Genetic Susceptibility Loci Among Japanese.
    Sci Rep 8(1):789, 2018. DOI:10.1038/s41598-017-19127-7
39. Fuji S, Kurosawa S, Inamoto Y, Murata T, Utsunomiya A, Uchimaru K, Yamasaki S, Inoue Y, Moriuchi Y, Choi I, Ogata M, Hidaka M, Yamaguchi T, Fukuda T.
    Role of up-front allogeneic hematopoietic stem cell transplantation for patients with aggressive adult T-cell leukemia-lymphoma: a decision analysis.
    Bone Marrow Transplant 53(7):905-908, 2018. DOI:10.1038/s41409-017-0082-4
40. Ugai T, Matsuo K, Oze I, Ito H, Wakai K, Wada K, Nagata C, Nakayama T, Liu R, Kitamura Y, Tamakoshi A, Tsuji I, Sugawara Y, Sawada N, Sadakane A, Tanaka K, Mizoue T, Inoue M, Tsugane S, Shimazu T; Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan.
    Smoking and subsequent risk of acute myeloid leukaemia: A pooled analysis of 9 cohort studies in Japan.
    Hematol Oncol 36:262-268, 2018. DOI:10.1002/hon.2457
41. Kochi Y, Kamatani Y, Kondo Y, Shimizu J (48名31番目), Fujio K, Amano H, Mimori A, Kawakami A, Umehara H, Takeuchi T, Sano H, Muro Y, Atsumi T, Mimura T, Kawaguchi Y, Mimori T, Takahashi A, Kubo M, Kohsaka H, Sumida T, Yamamoto K.
    Splicing variant of WDFY4 augments MDA5 signalling and the risk of clinically amyopathic dermatomyositis.
    Ann Rheum Dis 77(4):602-611, 2018. DOI:10.1136/annrheumdis-2017-212149
42. Fujita K, Chen X, Homma H, Tagawa K, Amano M, Saito A, Imoto S, Akatsu H, Hashizume Y, Kaibuchi K, Miyano S, Okazawa H.
    Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology.
    Nat Commun. 30;9(1):433, 2018. DOI:10.1038/s41467-018-02821-z
43. 間野かがり，岩田淳
    パーキンソン病・アルツハイマー病のエピゲノム.
    Clinical Neuroscience 36(2):227-229, 2018.
44. 間野達雄，岩田淳
    神経細胞特異的メチル化解析から明らかになったアルツハイマー病におけるDNA修復の障害.
    実験医学 36(4):556-559, 2018.
45. Nishimura K, Takagi T, Toda N, Yamamoto T, Kondo T, Ishida H, Nagashima Y, Tanabe K.
    A case of metastatic Xp11.2 translocation renal cell carcinoma successfully managed by cytoreductive nephrectomy followed by axitinib therapy. .
    Mol Clin Oncol 6:362-364, 2017. DOI:10.3892/mco.2017.1142
46. Kubota A, Ishiura H, Mitsui J, Sakuishi K, Iwata A, Yamamoto T, Nishino I, Tsuji S, Shimizu J
    A Homozygous LAMA2 Mutation of c.818G>A Caused Partial Merosin Deficiency in a Japanese patient.
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     British Journal of Nutrition 118(6):463-472, 2017. DOI:10.1017/S0007114517002239
115. Satoh JI, Kino Y,?Yanaizu M, Tosaki Y, Sakai K, Ishida T, Saito Y.
     Microglia express ABI3 in the brains of Alzheimer’s disease and Nasu-Hakola disease.
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     Mint3-mediated L1CAM expression in fibroblasts promotes cancer cell proliferation via integrin α5β1 and tumour growth.
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117. Tanaka K, Kim SE, Yano H, Matsumoto G, Ohuchida R, Ishikura Y, Araki M, Araki K, Park S, Komatsu T, Hayashi H, Ikematsu K, Tanaka K, Hirano A, Martin P, Shimokawa I, Mori R
     MiR-142 Is Required for Staphylococcus aureus Clearance at Skin Wound Sites via Small GTPase-Mediated Regulation of the Neutrophil Actin Cytoskeleton.
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     Mitochondrial-Associated Membranes in Parkinson's Disease.
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     Mucin-poor and aggressive mucinous tubular and spindle cell carcinoma of the kidney: Two case reports.
     Mol Clin Oncol 7:777-782, 2017. DOI:10.3892/mco.2017.1400
120. Farmanbar A, Firouzi S, Park SJ, Nakai K, Uchimaru K, Watanabe T.
     Multidisciplinary insight into clonal expansion of HTLV-1-infected cells in adult T-cell leukemia via modeling by deterministic finite automata coupled with high-throughput sequencing.
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121. Yamashita C, Funayama M, Li Y, Yoshino H, Yamada H, Seino Y, Tomiyama H, Hattori N.
     Mutation screening of PLA2G6 in Japanese patients with early onset dystonia-parkinsonism.
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122. Chen PM*, Ohno M*, Hiwasa T, Nishi K, Saijo S, Sakamoto J, Morita Y, Matsuda S, Watanabe S, Kuwabara Y, Ono K, Imai M, Inoue K, Murai T, Inada T, Tanaka M, Kita T, Kimura T, Nishi E. * equally first
     Nardilysin is a promising biomarker for the early diagnosis of acute coronary syndrome.
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123. Fujii T, Nishi E, Ito H, Yoshitomi H, Furu M, Okabe N, Ohno M, Nishi K, Morita Y, Morita Y, Azukizawa M, Okahata A, Tomizawa T, Kimura T, Matsuda S.
     Nardilysin is involved in autoimmune arthritis via the regulation of tumour necrosis factor alpha secretion.
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124. Kasai Y, Toriguchi K, Hatano E, Nishi K, Ohno M, Yoh T, Fukuyama K, Nishio T, Okuno M, Iwaisako K, Seo S, Taura K, Kurokawa M, Kunichika M, Uemoto S, Nishi E.
     Nardilysin promotes hepatocellular carcinoma through activation of signal transducer and activator of transcription 3.
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     Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease.
     PNAS 11:E9645-E9654, 2017. DOI:10.1073/pnas.1707151114
127. Miki Y, Yoshizawa T, Morohashi S, Seino Y, Kijima H, Shoji M, Mori A, Yamashita C, Hatano T, Hattori N, Wakabayashi K
     Neuropathology of PARK14 is identical to idiopathic Parkinson's disease.
     Mov Disord. 32:799-800, 2017. DOI:10.1002/mds.26952
128. Eguchi E, Iso H, Honjo K, Yatsuya H, Tamakoshi A.
     No modifying effect of education level on the association between lifestyle behaviors and cardiovascular mortality: the Japan Collaborative Cohort Study.
     Sci Rep 7:39820, 2017. DOI:10.1038/srep39820
129. Kurihara M, Ishiura H, Sasaki T, Otsuka J, Hayashi T, Terao Y, Matsukawa T,Mitsui J, Kaneko J, Nishiyama K, Doi K, Yoshimura J, Morishita S, Shimizu J,Tsuji S
     Novel De Novo KCND3 Mutation in a Japanese Patient with Intellectual Disability.
     Cerebellum 17(2):237-242, 2017. DOI:10.1007/s12311-017-0883-4
130. Sato NS, Maekawa R, Ishiura H, Mitsui J, Naruse H, Tokushige SI, Sugie K, Tate G, Shimizu J, Goto J, Tsuji S, Shiio Y
     Partial duplication of DHH causes minifascicular neuropathy: A novel mutation detection of DHH.
     Ann Clin Transl Neurol 4(6):415-421, 2017. DOI:10.1002/acn3.417
131. Kihara T, Yamagishi K, Iso H, Tamakoshi A
     Passive smoking and mortality from aortic dissection or aneurysm.
     Atherosclerosis 263:145-150, 2017. DOI:10.1016/j.atherosclerosis.2017.06.022
132. Nishiura K, Ichikawa-Tomikawa N, Sugimoto K, Kunii Y, Kashiwagi K, Tanaka M, Yokoyama Y, Hino M, Sugino T, Yabe H, Takahashi H, Kakita A, Imura T, Chiba H
     PKA activation and endothelial claudin-5 breakdown in the schizophrenic prefrontal cortex.
     Oncotarget 8(55):93382-93391, 2017. DOI:10.18632/oncotarget.21850
133. Kuramitsu M, Sekizuka T, Yamochi T, Firouzi S, Sato T, Umeki K, Sasaki D, Hasegawa H, Kubota R, Sobata R, Matsumoto C, Kaneko N, Momose H, Araki K, Saito M, Nosaka K, Utsunomiya A, Koh KR, Ogata M, Uchimaru K, Iwanaga M, Sagara Y, Yamano Y, Okayama A, Miura K, Satake M, Saito S, Itabashi K, Yamaguchi K, Kuroda M, Watanabe T, Okuma K, Hamaguchi I.
     Proviral features of human T cell leukemia virus type 1 in carriers with indeterminate western blot results.
     J Clin Microbiol. 55(9):2838-2849, 2017. DOI:10.1128/JCM.00659-17
134. Mai T, Takano A, Suzuki H, Hirose T, Mori T, Teramoto K, Kiyotani K, Nakamura Y, Daigo Y.
     Quantitative analysis and clonal characterization of T-cell receptor β repertoires in patients with advanced non-small cell lung cancer treated with cancer vaccine.
     Oncol Lett. 14(1):283-292, 2017. DOI:10.3892/ol.2017.6125
135. Sonoda K, Ohno S, Otuki S, Kato K, Yagihara N, Watanabe H, Makiyama T, Minamino T and Horie M.
     Quantitative analysis of PKP2 and neighbouring genes in a patient with arrhythmogenic right ventricular cardiomyopathy caused by heterozygous PKP2 deletion.
     Europace 19:644-650., 2017. DOI:10.1093/europace/euw038
136. Yamada K, Iso H, Cui R, Tamakoshi A.
     Recurrent Pregnancy Loss and Cardiovascular Disease Mortality in Japanese Women: A Population-Based, Prospective Cohort Study.
     J Stroke Cerebrovasc Dis 26(5):1047-1054, 2017. DOI:10.1016/j.jstrokecerebrovasdis.2016.12.018
137. Ishiguro T, Sato N, Ueyama M, Fujikake N, Sellier C,.., Yokota T, Wada K, Taylor JP, Pearson CE, Charlet-Berguerand N, Mizusawa H, Nagai Y*, Ishikawa K*
     Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31.
     Neuron 94(1):108-124, 2017. DOI:10.1016/j.neuron.2017.02.046
138. Hirokazu Uemura, Sakurako Katsuura-Kamano, Miwa Yamaguchi, Tirani Bahari, Masashi Ishizu, Miho Fujioka, Kokichi Arisawa
     Relationships of serum high-sensitivity C-reactive protein and body size with insulin resistance in a Japanese cohort.
     PLoS One 12(6):e0178672, 2017. DOI:10.1371/journal.pone.0178672
139. Kiyokawa H, Yasuda H, Oikawa R, Okuse C, Matsumoto N, Ikeda H, Watanabe T, Yamamoto H, Itoh F, Otsubo T, Yoshimura T, Yoshida E, Nakagawa M, Koshikawa N & Seiki M
     Serum monomeric laminin-gamma2 as a novel biomarker for hepatocellular carcinoma.
     Cancer Sci. 108:1432-1439, 2017. DOI:10.1111/cas.13261
140. Matsunaga M, Yatsuya H, Iso H, Yamashita K, Li Y, Yamagishi K, Tanabe N, Wada Y, Wang C, Ota A, Tamakoshi K, Tamakoshi A; JACC Study Group.
     Similarities and differences between coronary heart disease and stroke in the associations with cardiovascular risk factors: The Japan Collaborative Cohort Study.
     Atherosclerosis 261:124-130, 2017. DOI:10.1016/j.atherosclerosis.2017.03.003
141. Saito E, Inoue M, Tsugane S, Ito H, Matsuo K, Wakai K, Wada K, Nagata C, Tamakoshi A, Sugawara Y, Tsuji I, Mizoue T, Tanaka K, Sasazuki S; Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan.
     Smoking cessation and subsequent risk of cancer: A pooled analysis of eight population-based cohort studies in Japan.
     Cancer Epidemiol 51:98-108, 2017. DOI:10.1016/j.canep.2017.10.013
142. Koshikawa N, Minegishi T, Kiyokawa H, and Seiki M
     Specific detection of soluble EphA2 fragments in blood as a new biomarker for pancreatic cancer.
     Cell Death Dis 8:e3134, 2017. DOI:10.1038/cddis.2017.545
143. Iwashita H, Okudela K, Matsumura M, Nagashima Y, Ohashi K et al.
     Succinate dehydrogenase B-deficient renal cell carcinoma: A case report with novel germline mutation.
     Pathol Int 67:585-589, 2017. DOI:10.1111/pin.12587
144. Hirokazu Uemura, AHMAD AMMAR GHAIBEH, Sakurako Katsuura-Kamano, Miwa Yamaguchi, Bahari Tirani, Masashi Ishizu, Hiroki Moriguchi and Kokichi Arisawa
     Systemic inflammation and family history in relation to the prevalence of type 2 diabetes based on an alternating decision tree.
     Scientific Reports 7:45502, 2017. DOI:10.1038/srep45502
145. Yamagishi M, Uchimaru K.
     Targeting EZH2 in cancer therapy.
     Curr. Opin. Oncol. 29(5):375-381, 2017. DOI:10.1097/CCO.0000000000000390
146. Tsuiji H*, Inoue I, Takeuchi M, Furuya A, Yamakage Y, Watanabe S, Koike M, Hattori M, Yamanaka K*.
     TDP-43 accelerates age-dependent degeneration of interneurons.
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147. Park S, Mori R, Shimokawa I
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     Aging (Albany NY) 9(11):2243-2244, 2017. DOI:10.18632/aging.101338
148. Tomokatsu Omoto, Joo-ri Kim-Kaneyama, Xiao-Feng Lei, Akira Orimo, Koji Ohnishi, Kosuke Yoshihara, Aya Miyauchi, Shuo Li, Lin Gao, Takahiro Umemoto, Junichi Tanaka, Kenta Nakahara, Motohiro Takeya, Fumio Ishida, Shin-ei Kudo, Shogo Haraguchi, Takuro Miyazaki and Akira Miyazaki.,
     The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling.
     Oncogene, , 2017. DOI:10.1038/s41388-017-0033-y
149. Tomoyuki Igarashi, Koji Teramoto, Mitsuaki Ishida, Jun Hanaoka, Yataro Daigo
     The mechanism of de novo expression of programmed cell death-ligand 1 in squamous cell carcinoma of the lung.
     Oncology Reports 38(4):2189-2196, 2017. DOI:10.3892/or.2017.5876
150. Abe M, Ito H, Oze I, Nomura M, Ogawa Y, Matsuo K
     The more from East-Asian, the better: risk prediction of colorectal cancer risk by GWAS-identified SNPs among Japanese.
     Journal of cancer research and clinical oncology 143(12):2481-92, 2017. DOI:10.1007/s00432-017-2505-4
151. Kato Y, Furusyo N, Tanaka Y, Ueyama T, Yamasaki S, Murata M, Hayashi J.
     The Relation between Serum Endostatin Level and Carotid Atherosclerosis in Healthy Residents of Japan: Results from the Kyushu and Okinawa Population Study (KOPS).
     J Atheroscler Thromb 24:1023-1030, 2017. DOI:10.5551/jat.39735
152. Shimada N, Ohno N, Tanosaki R, Fuji S, Suzuki Y, Yuji K, Uchimaru K, Tojo A.
     Therapy-related Acute Myeloid Leukemia after the Long-term Administration of Low-dose Etoposide for Chronic-type Adult T-cell Leukemia-lymphoma: A Case Report and Literature Review.
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153. Yada E, Wada S, Yoshida S, Sasada T.
     Use of patient-derived xenograft mouse models in cancer research and treatment.
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154. Inoshita T, Arano T, Hosaka Y, Meng H, Umezaki Y, Kosugi S, Morimoto T, Koike M, Chang HY, Imai Y, Hattori N
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     β-N-methylamino-L-alanine analysis in the brains of patients with Kii ALS/PDC.
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2016年度

1. Koyanagi YN, Matsuo K, Ito H, Tamakoshi A, Sugawara Y, Hidaka A, Wada K, Oze I, Kitamura Y, Liu R, Mizoue T, Sawada N, Nagata C, Wakai K, Nakayama T, Sadakane A, Tanaka K, Inoue M, Tsugane S, Sasazuki S.
   Body-Mass Index and Pancreatic Cancer Incidence: A Pooled Analysis of Nine Population-Based Cohort Studies With More Than 340,000 Japanese Subjects.
   J Epidemiol 28:245-252, 2018. DOI:10.2188/jea.JE20160193
2. Endoh K, Matsui Y, Takeshita M, Katashima, Yasunaga, Kuriki K.
   Actual Daily Intakes of Tea Catechins and Their Estimation According to Four Season 3 Day Weighed Dietary Records and a Short Food Frequency Questionnaire among Japanese Men and Women.
   Asian Pac J Cancer Prev 18(10):2875-2881, 2017. DOI:10.22034/APJCP.2017.18.10.2875
3. Chen Y, Wu F, Saito E, Lin Y, Song M, Luu HN, Gupta PC, Sawada N, Tamakoshi A, Shu XO, Koh WP, Xiang YB, Tomata Y, Sugiyama K, Park SK, Matsuo K, Nagata C, Sugawara Y, Qiao YL, You SL, Wang R, Shin MH, Pan WH, Pednekar MS, Tsugane S, Cai H, Yuan JM, Gao YT, Tsuji I, Kanemura S, Ito H, Wada K, Ahn YO, Yoo KY, Ahsan H, Chia KS, Boffetta P, Zheng W, Inoue M, Kang D, Potter JD.
   Association between type 2 diabetes and risk of cancer mortality: a pooled analysis of over 771,000 individuals in the Asia Cohort Consortium.
   Diabetologia 60:1022-1032, 2017. DOI:10.1007/s00125-017-4229-z
4. Iso H, Maruyama K, Eshak ES, Ikehara S, Yamagishi K, Tamakoshi A.
   Blood soluble Fas levels and mortality from cardiovascular disease in middle-aged Japanese: The JACC study.
   Atherosclerosis 260:97-101, 2017. DOI:10.1016/j.atherosclerosis.2017.03.020
5. Takenari Yamashita, Hitoshi Aizawa, Sayaka Teramoto, Megumi Akamatsu & Shin Kwak
   Calpain-dependent disruption of nucleo-cytoplasmic transport in ALS motor neurons.
   Scientific Reports 7:39994, 2017. DOI:10.1038/srep39994
6. Ishii Y, Ishihara J, Takachi R, Shinozawa Y, Imaeda N, Goto C, Wakai K, Takahashi T, Iso H, Nakamura K, Tanaka J, Shimazu T, Yamaji T, Sasazuki S, Sawada N, Iwasaki M, Mikami H, Kuriki K, et al.
   Comparison of weighed food record procedures for the reference methods in two validation studies of food frequency questionnaires.
   J Epidemiol 27(7):331-337, 2017. DOI:10.1016/j.je.2016.08.008
7. Matsumoto J, Nakanishi H, Kunii Y, Sugiura Y, Yuki D, Wada A, Hino M, Niwa SI, Kondo T, Waki M, Hayasaka T, Sato S, Setou M, Yabe H.
   Decreased 16:0/20:4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia.
   Scientific Reports 7:45050, 2017. DOI:10.1038/srep45050
8. Fuji S, Yamaguchi T, Inoue Y, Utsunomiya A, Moriuchi Y, Uchimaru K, Owatari S, Miyagi T, Taguchi J, Choi I, Otsuka E, Nakachi S, Yamamoto H, Kurosawa S, Tobinai K, Fukuda T.
   Development of a modified prognostic index of patients with aggressive adult T-cell leukemia-lymphoma aged 70 years or younger: a possible risk-adapted management strategies including allogeneic transplantation.
   Haematologica 102(7):1258-1265, 2017. DOI:10.3324/haematol.2017.164996
9. Hirayama-Kurogi M, Takizawa Y, Kunii Y, Matsumoto J, Wada A, Hino M, Akatsu H, Hashizume Y, Yamamoto S, Kondo T, Ito S, Tachikawa M, Niwa SI, Yabe H, Terasaki T, Setou M, Ohtsuki S
   Downregulation of GNA13-ERK network in prefrontal cortex of schizophrenia brain identified by combined focused and targeted quantitative proteomics.
   J Proteomics 31;158:31-42, 2017. DOI:10.1016/j.jprot.2017.02009
10. Keiko Akasaka-Manya, Masaki Kawamura, Hiroki Tsumoto, Yuko Saitoh, Shinobu Kitazume, Hiroyuki Hatsuda, Yuri Miura, Shinichi Hisanaga, Shigeo Murayama, Yasuhiro Hashimoto, Hiroshi Manya and Tamao Endo
    Excess APP O-glycosylation by GalNAc-T6 decreases Ab production.
    Jourmal of Biochemistry 161:99-111, 2017. DOI:10.1093/jb/mvw056.Epub2016Oct19
11. Hachiya T, Kamatani Y, Takahashi A, Hata J, Furukawa R, Shiwa Y, Yamaji T, Hara M, Tanno K, Ohmomo H, Ono K, Takashima N, Matsuda K, Wakai K, Sawada N, Iwasaki M, Yamagishi K, Ago T, Ninomiya T, Fukushima A, Hozawa A, Minegishi N, Satoh M, Endo R, Wakai K, et al.
    Genetic predisposition to ischemic stroke: a polygenic risk score.
    Stroke 48(2):253-258, 2017. DOI:10.1161/STROKEAHA.116.014506
12. Koyama T, Kuriyama N, Ozaki E, Matsui D, Watanabe I, Takeshita W, Iwai K, Watanabe Y, Nakatochi M, Shimanoe C, Tanaka K, Oze I, Ito H, Uemura H, Katsuura-Kamano S, Ibusuki R, Shimoshikiryo I, Takashima N, Kadota A, Kawai S, Sasakabe T, Okada R, Hishida A, Naito M, Kuriki K, et al.
    Genetic Variants of RAMP2 and CLR are Associated with Stroke.
    J Atheroscler Thromb 24(12):1267-1281, 2017. DOI:10.5551/jat.41517
13. Vu HT, Akatsu H, Hashizume Y, Setou M, Ikegami K.
    Increase in α-tubulin modifications in the neuronal processes of hippocampal neurons in both kainic acid-induced epileptic seizure and Alzheimer's disease.
    Sci Rep 9;7:40205, 2017. DOI:10.1038/srep40205
14. Okada R, Naito M, Hattori Y, Seiki T, Wakai K, Nanri H, Watanabe M, Suzuki S, Kairupan T, Takashima N, Mikami H, Ohnaka K, Watanabe Y, Katsuura-Kamano S, Kubo M, Hamajima N, Tanaka H, The Japan Multi-institutional Collaborative Cohort Study Group
    Matrix metalloproteinase 9 gene polymorphisms are associated with a multiple family history of gastric cancer.
    Gastric Cancer 20(2):246-253, 2017. DOI:10.1007/s10120-016-0608-2
15. Ukawa S, Tamakoshi A, Yatsuya H, Yamagishi K, Ando M, Iso H.
    Passive smoking and chronic obstructive pulmonary disease mortality: findings from the Japan collaborative cohort study.
    Int J Public Health 62:489-494, 2017. DOI:10.1007/s00038-016-0938-1
16. Kikuchi N, Nishiyama T, Sawada T, Wang C, Lin Y, Watanabe Y, Tamakoshi A, Kikuchi S.
    Perceived Stress and Colorectal Cancer Incidence: The Japan Collaborative Cohort Study.
    Sci Rep. 7:40363, 2017. DOI:10.1038/srep40363
17. Koyama T, et al.
    Serum albumin to globulin ratio is related to cognitive decline via reflection of homeostasis: a nested case-control study.
    BMC Neurol 16(1):253, 2017. DOI:10.1186/s12883-016-0776-z
18. Morimoto T, Mineharu Y, Ono K, Nakatochi M, Ichihara S, Kabata R, Takagi Y, Cao Y, Zhao L, Kobayashi H, Harada KH, Takenaka K, Funaki T, Yokota M, Matsubara T, Yamamoto K, Izawa H, Kimura T, Miyamoto S, Koizumi A
    Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease.
    PLoS ONE 12(4):e0175649, 2017. DOI:10.1371/journal.pone.0175649
19. Yamashita T, Kwak S
    [Abnormal RNA editing and treatment strategy in neurological diseases; towards cure for ALS].
    Seikagaku 88:600-608, 2016. DOI:10.14952/SEIKAGAKU.2016.880600
20. Hayashi H, Ohtani H, Yamaguchi J, Shimokawa I
    A case of malignant transformation of ductal adenoma: a diagnostic pitfall.
    Malays J Pathol 37:281-285, 2016.
21. Hosono S, Ito H, Oze I, Watanabe M, Komori K, Yatabe Y, Shimizu Y, Tanaka H, Matsuo K
    A risk prediction model for colorectal cancer using genome-wide association study-identified polymorphisms and established risk factors among Japanese: results from two independent case-control studies.
    European journal of cancer prevention 25(6):500-7, 2016. DOI:10.1097/CEJ.0000000000000213
22. Yin G, Naito M, Wakai K, Morita E, Kawai S, Hamajima N, Suzuki S, Kita Y, Takezaki T, Tanaka K, Morita M, Uemura H, Ozaki E, Hosono S, Mikami H, Kubo M, Tanaka H, for the Japan Multi-institutional Collaborative Cohort (J-MICC) Study Group
    ALDH2 polymorphism is associated with fasting blood glucose through alcohol consumption in Japanese men.
    Nagoya Journal of Medical Science 78(2):183-193, 2016.
23. Yin G, Naito M, Wakai K, Morita E, Kawai S, Hamajima N, Suzuki S, Kita Y, Takezaki T, Tanaka K, Morita M, Uemura H, Ozaki E, Hosono S, Mikami H, Kubo M, Tanaka H; Japan Multi-institutional Collaborative Cohort (J-MICC) Study Group.
    ALDH2 polymorphism is independently associated with fasting blood glucose from alcohol consumption in Japanese men.
    Nagoya J Med Sci 78(2):183-193, 2016.
24. Hida A, Yamashita T, Hosono Y, Inoue M, Kaida K, Kadoya M, Miwa Y, Yajima N, Maezawa R, Arai S, Kurosawa K, Ito K, Shimada H, Iwanami T, Sonoo M, Hatanaka Y, Murayama S, Uchibori A, Chiba A, Aizawa H, Momoo T, Nakase Y, Sakurai Y, Shiio Y, Hashida H, Yoshizawa T, Sakiyama Y, Oda A, Inoue K, Takeuchi S, Iwata NK, Date H, Masuda N, Mikata T, Motoyoshi Y, Uesaka Y, Maeda M, Nakashima R, Tsuji S, Kwak S, Mimori T, Shimizu J
    Anti-TIF1-γ antibody and cancer-associated myositis:a clinicohistopathological study.
    Neurology 87:299-308, 2016. DOI:10.1212/WNL.0000000000002863
25. Miyazato P, Katsuya H, Fukuda A, Uchiyama Y, Matsuo M, Tokunaga M, Hino S, Nakao M, Satou Y.
    Application of targeted enrichment to next-generation sequencing of retroviruses integrated into the host human genome.
    Sci Rep 6, 2016. DOI:10.1038/srep28324
26. Shiraishi K, Okada Y, Takahashi A, .., Matsuda F, Matsuo K, Daigo Y, Kubo M, Kohno T.
    Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma.
    Nat Commun. 9:12451, 2016. DOI:10.1038/ncomms12451
27. Nanri H, Nishida Y, Nakamura K, Tanaka K, et al.
    Associations between dietary patterns, ADRβ2 Gln27Glu and ADRβ3 Trp64Arg with regard to serum triglyceride levels: J-MICC Study.
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