研究業績

原著論文

2015年度

  • Yasui M., Matsushima M., Omura A., Mori K., Ogasawara N., Kodera Y., Shiga M., Ito K, Kojima S., Kawabe T. The suppressive effect of quercetin on Toll-like receptor 7-mediated activation in alveolar macrophages. Pharmacology. 96 (5-6): 201-209, 2015. doi:10.1159/000438993
  • Kusunose M, Hashimoto N, Kimura M, Ogata R, Aoyama D, Sakamoto K, Miyazaki S, Ando A, Omote N, Imaizumi K, Kawabe T, Hasegawa Y. Direct regulation of TGFβ-induced EMT by the protein phosphatase activity of unphosphorylated PTEN in lung cancer cells. Cancer Sci. 2015 in press doi: 10.1111/cas.12831

2014年度

  • Yamamoto A., Hioki S., Tanada C., Miwa T., Inoue Y., Yamamoto R., Matsushima M. and Kawabe T.　Design and development of a suitable adsorbent to capture theophylline for non-invasive therapeutic drug monitoring with exhaled breath. Anal. Methods, 2015, 7, 423-427 14 Nov 2014, DOI: 10.1039/C4AY02243B
  • Takashima K, Matsushima M, Hashimoto K, Nose H, Sato M, Hashimoto N, Hasegawa Y, Kawabe T. Protective effects of intratracheally administered quercetin on lipopolysaccharide-induced acute lung injury. Respir Res. 2014 Nov 21;15(1):150 PMID: 25413579, doi: 10.1186/s12931-014-0150-x
  • Shikida M, Yoshikawa K, Matsuyama T, Yamazaki Y, Matsushima M, Kawabe T. Catheter flow sensor with temperature compensation for tracheal intubation tube system. Sensors and Actuators A: Physical. [0924-4247] 2014 Aug; 215:155-160. doi: 10.1016/j.sna.2013.08.004
  • Nagai D, Nishiboria M, Itoha T, Kawabe T, Sato K, Shin W. Ppm level methane detection using micro-thermoelectric gas sensors with Pd/Al2O3 combustion catalyst films. Sensors and Actuators B: Chemical 2015 Jan; 206, 488-494. doi: 10.1016/j.snb.2014.09.059
  • 武田直也、伊藤　理、指尾豊和、平松哲夫、木村智樹、大林浩幸、馬場研二、若原恵子、若山尚士、今泉和良、川部　勤、長谷川好規　呼吸器内科医を対象とした喘息治療ステップダウンの実態調査　　2014年4月号(Vol.21 No.4) アレルギー・免疫　平成26(2014)年3月15日
  • Iida Y, Yamazaki T, Kawabe T, Usui A, Yamada S. Postoperative muscle proteolysis affects systemic muscle weakness in patients undergoing cardiac surgery. Int J Cardiol. 2014 Apr 1;172(3):595-7. doi: 10.1016/j.ijcard.2014.01.062. PMID: 24485621

2013年度

  • Shikida M, Yoshikawa K, Matsuyama T, Yamazaki Y, Matsushima M, Kawabe T. Catheter flow sensor with temperature compensation for trachealintubation tube system. Sensors and Actuators A: Physical. in press
  • Shikida M, Shikano T, Matsuyama T, Yamazaki Y, Matsushima M, Kawabe T. Micromachined catheter flow sensor and its applications in breathing measurements in animal experiments. Microsyst Technol. in press DOI 10.1007/s00542-013-1855-3
  • Enokibori Y., Ito Y., Ikeda K., Suzuki A., Shimakami Y., Kawabe T., Mase K. Respiratory Volume Estimation by a Stretchable Textile Sensor. Advances in Science and Technology 80: 136-41, 2013 doi: 10.4028/www.scientific.net/AST.80.136

2012年度

  • Hashimoto I, Imaizumi K, Hashimoto N, Furukawa H, Noda Y, Kawabe T, Honda T, Ogawa T, Matsuo M, Imai N, Ito S, Sato M, Kondo M, Shimokata K, Hasegawa Y. An aqueous fraction of Sauropus androgynus might be responsible for bronchiolitis obliterans. Respirology in press PMID: 23062110
  • Ohno T, Okamoto M, Hara T, Hashimoto N, Imaizumi K, Matsushima M, Nishimura M, Shimokata K, Hasegawa Y, Kawabe T. Detection of loci for allergic asthma using SMXA recombinant inbred strains of mice. Immunogenetics. 65(1):17-24, 2013
  • Sakamoto K, Hashimoto N, Kondoh Y, Imaizumi K, Aoyama D, Kohnoh T, Kusunose M, Kimura M, Kawabe T, Taniguchi H, Hasegawa Y. Differential modulation of surfactant protein D under acute and persistent hypoxia in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 303(1):L43-53, 2012 July PMID: 22561461
  • Matsuo M, Hashimoto N, Usami N, Imaizumi K, Wakai K, Kawabe T, Yokoi K, Hasegawa Y. Inspiratory capacity as a preoperative assessment of patients undergoing thoracic surgery. Interact Cardiovasc Thorac Surg. 14(5):560-4, 2012 May PMID: 22307392
  • Nakashima H, Hashimoto N, Aoyama D, Kohnoh T, Sakamoto K, Kusunose M, Imaizumi K, Takeyama Y, Sato M, Kawabe T, Hasegawa Y. Involvement of the transcription factor twist in phenotype alteration through epithelial-mesenchymal transition in lung cancer cells. Mol Carcinog. 51(5):400-10, 2012 May PMID: 21594904

2011年度

  • Ishida S, Nishizawa N, Kitatsuji M, Ohshima H, Hasegawa Y, Matsushima M, Kawabe T. Observation of Fine Lung Structure by Ultrahigh-Resolution Optical Coherence Tomography Using 800, 1060, and 1300nm Supercontinua. Jpn. J. Appl. Phys. 51: 047001, 2012 March
  • Ito K, Futamura M, Movérare R, Tanaka A, Kawabe T, Sakamoto T, Borres MP. The usefulness of casein-specific IgE and IgG4 antibodies in cow's milk allergic children. Clin Mol Allergy. 10(1):1, 2012 January PMID: 22212305
  • Hayashi Y, Matsushima M, Nakamura T, Shibasaki M, Hashimoto N, Imaizumi K, Shimokata K, Hasegawa Y, Kawabe T. Quercetin protects against pulmonary oxidant stress via heme oxygenase-1 induction in lung epithelial cells. Biochem. Biophys. Res. Commun. 417(1):169-74, 2012 January
  • 片山　真、杉田智哉、加藤竜司、大河内美奈、松島充代子、川部　勤、高瀬智和、吉田安子、川瀬三雄、本多裕之．ミルクタンパク質全網羅ペプチドアレイを用いたIgG結合ペプチドの探索．化学工学論文集，37 (6): 546-550, 2011 September
  • Kawabe T, Matsushima M, Hashimoto N, Imaizumi K, Hasegawa Y. CD40/CD40 ligand interactions in immune responses and pulmonary immunity. Nagoya J Med Sci. 73 (3-4): 69-78, 2011 August
  • Nakamura T, Matsushima M, Hayashi Y, Shibasaki M, Imaizumi K, Hashimoto N, Shimokata K, Hasegawa Y, Kawabe T. Attenuation of TGF- -Stimulated Collagen Production in Fibroblasts by Quercetin-Induced HO-1. Am J Respir Cell Mol Biol. 44(5):614-620. 2011 May

2010年度

  • Takahashi Y, Tamakoshi K, Matsushima M, Kawabe T. Comparison of salivary cortisol, heart rate, and oxygen saturation between early skin-to-skin contact with different initiation and duration times in healthy, full-term infants. Early Hum. Dev, 87 (3) 151-157. 2011 March
  • Shikida M, Yokota T, Kawabe , Funaki T, Matsushima M, Iwai S, Matsunaga N, Sato K. Characteristics of an optimized catheter-type thermal flow sensor for measuring reciprocating airflows in bronchial pathways. J. Micromech. Microen, 20 (12)1-11, 2010 December
  • Hirayama T, Kawabe T, Matsushima M, Nishimura Y, Kobe Y, Ota Y, Baba K, Takagi K. Ghrelin and obestatin promote the allergic action in rat peritoneal mast cells as basic secretagogues. Peptides, 31 (11) 2109-2113, 2010 November
  • Hashimoto N, Phan SH, Imaizumi K, Matsuo M, Nakashima H, Kawabe T, Shimokata K, Hasegawa Y. Endothelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis. Am. J. Respir. Cell Mol. Biol. 43 (2) 161-72, 2010 August

2009年度

  • Honda T, Imaizumi K, Yokoi T, Hashimoto N, Hashimoto I, Kawabe T, Matsuo M, Iwano S, Shimokata K, Hasegawa Y. Differential Th1/Th2 chemokine expression in interstitial pneumonia. Am. J. Med. Sci. 339 (1) 41-8, 2010 January
  • Matsushima M., Takagi K., Ogawa M., Hirose E., Ota Y., Abe F., Baba K., Hasegawa T., Hasegawa Y., Kawabe T. Heme Oxygenase-1 Mediates the Anti-allergic Actions of Quercetin in Rodent Mast Cells. Inflammation Research, 58 (10)705-15. 2009 October
  • Takagi Y, Hashimoto N, Phan SH, Imaizumi K, Matsuo M, Nakashima H, Hashimoto I, Hayashi Y, Kawabe T, Shimokata K, Hasegawa Y. Erythromycin-induced CXCR4 expression on microvascular endothelial cells. Am. J. Physiol. Lung Cell Mol. Physiol., 297 (3)L420-31. 2009 September PMID: 19502290
  • Matsumoto N., Okochi M., Matsushima M., Ogawa A., Takase T., Yohida Y., Kawase M., Isobe K., Kawabe T., Honda H. Development of peptide arrays for detection of IgE-binding epitopes in cow's milk allergens. Journal of Bioscience and Bioengineering, 107 (3) 324-330, 2009 October
  • Ogasawara N., Oguro T., Sakabe T., Matsushima M., Takikawa O., Isobe KI., Nagase F. Hemoglobin induces the expression of indoleamine 2,3-dioxygenase in dendritic cells through the activation of PI3K, PKC, and NF-kappaB and the generation of reactive oxygen species. J. Cell. Biochem., 108 (3)716-25. 2009 August
  • Shibasaki M, Yagi T, Yatsuya H, Okamoto M, Nishikawa M, Baba H, Hashimoto N, Senda K, Kawabe T, Nakashima K, Imaizumi K, Shimokata K, Hasegawa Y. An influence of Interferon-gamma gene polymorphisms on treatment response to tuberculosis in Japanese population. J. Infect., 58 (6)467-9. 2009 June
  • Matsumoto N, Okochi M, Matsushima M, Kato R, Takase T, Yoshida Y, Kawase M, Isobe KI, Kawabe T, Honda H. Peptide array-based analysis of the specific IgE and IgG4 in cow's milk allergens and its use in allergy evaluation. Peptides, 30 (10)1840-7. 2009 May
  • Shibasaki M, Hashimoto K, Okamoto M, Hayashi Y, Imaizumi K, Hashimoto N, Ozaki N, Yokoi T, Takagi K, Hasegawa Y, Shimokata K, Kawabe T. Up-regulation of surfactant protein production in a mouse model of secondary pulmonary alveolar proteinosis. Am. J. Respir. Cell Mol. Biol., 40 (5)536-42. 2009 May
  • Matsushima M., Hirose E., Takagi K., Ota Y., Ishigami K., Hirayama T., Hayashi Y., Nakamura T., Hashimoto N., Imaizumi K., Baba K., Hasegawa Y., Kawabe T. Involvement of Heme Oxygenase-1 in Kaempferol-induced Anti-allergic Actions in RBL-2H3 Cells. Inflammation, 32 (2) 99-108, 2009 April
  • Ota Y., Matsushima M., Ogawa M., Hirose E., Hirayama T., Yuasa E., Yabuta K., Baba K., Hasegawa Y., Takagi K., Kawabe T. Inhibition of Degranulation by Myricetin-induced Heme Oxygenase-1 in Mast Cells. Occupational and Environmental Allergy, 16 (2) 61-73. 2009
  • Shikida M, Naito J, Yokota T, Kawabe T, Hayashi Y and K Sato. A catheter-type flow sensor for measurement of aspirated- and inspired-air characteristics in the bronchial region. Journal of Micromechanics and Microengineering. 査読(有) 19: 1-9, 2009

2008年度

  • Sumida A, Hasegawa Y, Okamoto M, Hashimoto N, Imaizumi K, Yatsuya H, Yokoi T, Takagi K, Shimokata K, Kawabe T. TH1/TH2 immune response in lung fibroblasts in interstitial lung disease. Arch Med Res. 39(5):503-10, 2008 July PMID: 18514095

2007年度

  • Hara T, Yamakura F, Takikawa O, Hiramatsu R, Kawabe T, Isobe K, Nagase F. Diazotization of kynurenine by acidified nitrite secreted from indoleamine 2,3-dioxygenase-expressing myeloid dendritic cells. J Immunol Methods. 332(1-2):162-9, 2008 March PMID: 18158157
  • Hara T, Ogasawara N, Akimoto H, Takikawa O, Hiramatsu R, Kawabe T, Isobe K, Nagase F. High-affinity uptake of kynurenine and nitric oxide-mediated inhibition of indoleamine 2,3-dioxygenase in bone marrow-derived myeloid dendritic cells. Immunol Lett. 116(1):95-102, 2008 February PMID: 18179826
  • Hiramatsu R, Hara T, Akimoto H, Takikawa O, Kawabe T, Isobe K, Nagase F. Cinnabarinic acid generated from 3-hydroxyanthranilic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspase. J Cell Biochem. 103(1):42-53, 2008 January PMID: 17476692
  • Okamoto M, Imaizumi K, Hasegawa Y, Hashimoto N, Sumida A, Shibazaki M, Takagi K, Shimokata K, Kawabe T. Macrophage-derived chemokine in malignant and tuberculous pleural effusions. Respirology. 12(4):581-4, 2007 July PMID: 17587426
  • Matsushima M., Kitaichi k., Kawabe T., Suzuki R., Baba K., Hasegawa T., Takagi K. Xenin and xenopsin induce histamine release from rat peritoneal mast cells. Occupational and Environmental Allergy, 14 (2) 60-67. 2007

2006年度

  • Nakanishi T, Imaizumi K, Hasegawa Y, Kawabe T, Hashimoto N, Okamoto M, Shimokata K. Expression of macrophage-derived chemokine (MDC)/CCL22 in human lung cancer. Cancer Immunol Immunother. 55(11):1320-9, 2006 November PMID: 16453150
  • Hashimoto N, Imaizumi K, Honda T, Kawabe T, Nagasaka T, Shimokata K, Hasegawa Y. Successful re-treatment with gefitinib for carcinomatous meningitis as disease recurrence of non-small-cell lung cancer. Lung Cancer. 53(3):387-90, 2006 September PMID: 16824645
  • Imaizumi K, Sugishita M, Usui M, Kawabe T, Hashimoto N, Hasegawa Y. Pulmonary infectious complications associated with anti-TNFalpha therapy (infliximab) for rheumatoid arthritis. Intern Med. 45(10):685-8, 2006 June PMID: 16778341
  • Kataoka K, Taniguchi H, Hasegawa Y, Kondoh Y, Kimura T, Nishiyama O, Imaizumi K, Kawabe T, Kume H, Shimokata K. Interstitial lung disease associated with gefitinib. Respir Med. 100(4):698-704, 2006 April PMID: 16137874

2005年度

  • Okamoto M, Hasegawa Y, Hara T, Hashimoto N, Imaizumi K, Shimokata K, Kawabe T. T-helper type 1/T-helper type 2 balance in malignant pleural effusions compared to tuberculous pleural effusions. Chest. 128(6):4030-5, 2005 December PMID: 16354877

2004年度

  • Okamoto M, Kawabe T, Iwasaki Y, Hara T, Hashimoto N, Imaizumi K, Hasegawa Y, Shimokata K. Evaluation of interferon-gamma, interferon-gamma-inducing cytokines, and interferon-gamma-inducible chemokines in tuberculous pleural effusions. J Lab Clin Med. 145(2):88-93, 2005 February PMID: 15746651
  • Okamoto M, Kawabe T. [Fecal occult blood test]. Nihon Rinsho. 62 Suppl 11:190-2, 2004 November PMID: 15628372
  • Ito G, Uchiyama M, Kondo M, Mori S, Usami N, Maeda O, Kawabe T, Hasegawa Y, Shimokata K, Sekido Y. Krüppel-like factor 6 is frequently down-regulated and induces apoptosis in non-small cell lung cancer cells. Cancer Res. 64(11):3838-43, 2004 June
  • Hashimoto N, Kawabe T, Imaizumi K, Hara T, Okamoto M, Kojima K, Shimokata K, Hasegawa Y. CD40 plays a crucial role in lipopolysaccharide-induced acute lung injury. Am J Respir Cell Mol Biol. 30(6):808-15, 2004 June PMID: 14693668

2002年度

  • Matsushima M., Kitaichi K., Tatsumi Y., Hasegawa T., Takagi K. The mRNA expression of calcitonin receptor-like receptor/receptor activity modifying proteins in rat peritoneal mast cells. Eur J Pharmacol, 464 111-114. 2003. March
  • Kitaichi K., Morishita Y., Doi Y., Ueyama J., Matsushima M., Takagi K., Hasegawa T. Increased plasma concentration and brain penetration of methamphetamine in behaviorally sensitized rats. Eur J Pharmacol, 464 39-48. 2003. March
  • Suzuki R., Kimura T., Kitaichi K., Tatsumi Y., Matsushima M., Shibata E., Zhao Y. L., Baba K., Hasegawa T., Takagi K. Platelet factor 4 fragment induces histamine release from rat peritoneal mast cells Peptides. 23 1713-1717. 2002. October
  • Hasegawa Y, Imaizumi K, Sekido Y, Iinuma Y, Kawabe T, Hashimoto N, Shimokata K. Perfusion and ventilation isotope lung scans in constrictive bronchiolitis obliterans. A series of three cases. Respiration. 69(6):550-5, 2002 PMID: 12457011
  • Inagaki-Ohara K, Kawabe T, Hasegawa Y, Hashimoto N, Nishiyama Y. Critical involvement of CD40 in protection against herpes simplex virus infection in a murine model of genital herpes. Arch Virol. 147(1):187-94, 2002 PMID: 11855631

2001年度

  • Yoshida M., Kimura T., Kitaichi K., Suzuki R., Baba K., Matsushima M., Tatsumi Y., Shibata E., Takagi K., Hasegawa T., Takagi K. Induction of histamine release from rat peritoneal mast cells by histatins. Biol Pharm Bull, 24, 1267-1270, 2001.
  • Noguchi M, Imaizumi K, Kawabe T, Wakayama H, Horio Y, Sekido Y, Hara T, Hashimoto N, Takahashi M, Shimokata K, Hasegawa Y. Induction of antitumor immunity by transduction of CD40 ligand gene and interferon-gamma gene into lung cancer. Cancer Gene Ther. 8(6):421-9, 2001 June PMID: 11498762

2000年度

  • Hashimoto N, Kawabe T, Hara T, Imaizumi K, Wakayama H, Saito H, Shimokata K, Hasegawa Y. Effect of erythromycin on matrix metalloproteinase-9 and cell migration. J Lab Clin Med. 137(3):176-83, 2001 March PMID: 11241027
  • Hashimoto N, Kawabe T, Hara T, Imaizumi K, Wakayama H, Shimokata K, Hasegawa Y. [Effects of erythromycin on matrix metalloproteinase-9(MMP-9)and cell migration]. Jpn J Antibiot. 54 Suppl A:137-8, 2001 February PMID: 11439893
  • Wakayama H, Hasegawa Y, Kawabe T, Hara T, Matsuo S, Mizuno M, Takai T, Kikutani H, Shimokata K. Abolition of anti-glomerular basement membrane antibody-mediated glomerulonephritis in FcRgamma-deficient mice. Eur J Immunol. 30(4):1182-90, 2000 April PMID: 10760808

1999年度

  • Imaizumi K, Kawabe T, Ichiyama S, Kikutani H, Yagita H, Shimokata K, Hasegawa Y. Enhancement of tumoricidal activity of alveolar macrophages via CD40-CD40 ligand interaction. Am J Physiol. 277(1 Pt 1):L49-57, 1999 July PMID: 10409230
  • Pearse RN, Kawabe T, Bolland S, Guinamard R, Kurosaki T, Ravetch JV. SHIP recruitment attenuates Fc gamma RIIB-induced B cell apoptosis. Immunity. 10(6):753-60, 1999 June PMID: 10403650

1998年度

  • Wakayama H, Hasegawa Y, Kawabe T, Saito H, Kikutani H, Shimokata K. IgG-mediated anaphylaxis via Fc gamma receptor in CD40-deficient mice. Clin Exp Immunol. 114(2):154-60, 1998 November PMID: 9822270
  • Ohara H, Hasegawa Y, Kawabe T, Ichiyama S, Hara T, Shimono Y, Saito H, Shimokata K. Effect of gene transfer of tumor necrosis factor receptors into human lung carcinoma cell line. Jpn J Cancer Res. 89(5):589-95, 1998 May PMID: 9685865
  • Shores EW, Ono M, Kawabe T, Sommers CL, Tran T, Lui K, Udey MC, Ravetch J, Love PE. T cell development in mice lacking all T cell receptor zeta family members (Zeta, eta, and FcepsilonRIgamma). J Exp Med. 187(7):1093-101, 1998 April PMID: 9529325

1997年度

  • Imaizumi K, Hasegawa Y, Kawabe T, Emi N, Saito H, Naruse K, Shimokata K. Bystander tumoricidal effect and gap junctional communication in lung cancer cell lines. Am J Respir Cell Mol Biol. 18(2):205-12, 1998 February PMID: 9476907

1996年度

  • Yasui T, Fujiwara H, Kamanaka M, Kawabe T, Yoshida N, Kishimoto T, Kikutani H. The roles of CD40 and CD23 in IgE regulation. Adv Exp Med Biol. 409:349-54, 1996 PMID: 9095264

1995年度

  • Kamanaka M, Yu P, Yasui T, Yoshida K, Kawabe T, Horii T, Kishimoto T, Kikutani H. Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity. Immunity. 4(3):275-81, 1996 Mach PMID: 8624817

1994年度

  • Kawabe T, Naka T, Yoshida K, Tanaka T, Fujiwara H, Suematsu S, Yoshida N, Kishimoto T, Kikutani H. The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity. 1(3):167-78, 1994 June PMID: 7534202

1993年度

  • Hasegawa Y, Emi N, Shimokata K, Abe A, Kawabe T, Hasegawa T, Kirioka T, Saito H. Gene transfer of herpes simplex virus type I thymidine kinase gene as a drug sensitivity gene into human lung cancer cell lines using retroviral vectors. Am J Respir Cell Mol Biol. 8(6):655-61, 1993 June PMID: 8391827

1992年度

  • Kawabe T, Isobe KI, Hasegawa Y, Nakashima I, Shimokata K. Immunosuppressive activity induced by nitric oxide in culture supernatant of activated rat alveolar macrophages. Immunology. 76(1):72-8, 1992 May PMID: 1385798