原著論文・総説【公募班】

A01: グリアアセンブリによる脳機能制御

柴崎貢志 Shibasaki Koji (2014-2015)

Iijima K, Kurachi M, Shibasaki K, Naruse M, Puentes S, Imai H, Yoshimoto Y, Mikuni M, Ishizaki Y. (2015) Transplanted microvascular endothelial cells promote oligodendrocyte precursor cell survival in ischemic demyelinating lesions. J Neurochem 135: 539-550.

Shibasaki K, Sugio S, Takao K, Yamanaka A, Miyakawa T, Tominaga M, Ishizaki Y. (2015) TRPV4 activation at the physiological temperature is a critical determinant of neuronal excitability and behavior. Pflügers Archiv 467: 2495-2507.

Shibasaki K, Tominaga M, Ishizaki Y. (2015) Hippocampal neuronal maturation triggers post-synaptic clustering of brain temperature-sensor TRPV4. Biochem Biophys Res Commun 458: 168-173.

Kusakari S, Saitow F, Ago Y, Shibasaki K, Sato-Hashimoto M, Matsuzaki Y, Kotani T, Murata Y, Hirai H, Matsuda T, Suzuki H, Matozaki T, Ohnishi H. (2015) Shp2 in forebrain neurons regulates synaptic plasticity, locomotion, and memory formation in mice. Mol Cell Biol 35: 1557-1572.

Shibasaki K, Ikenaka K, Tamalu F, Tominaga M, Ishizaki Y. (2014) A novel subtype of astrocytes expressing TRPV4 (transient receptor potential vanilloid 4) regulates neuronal excitability via release of gliotransmitters. J Biol Chem 289: 14470-14480.

Takayama Y, Shibasaki K, Suzuki Y, Yamanaka A, Tominaga M. (2014) Modulation of water efflux through functional interaction between TRPV4 and TMEM16A/anoctamin 1. FASEB J 28: 2238-2248.

尾藤晴彦 Bito Haruhiko (2014-2017)

Inoue M, Takeuchi A, Horigane S, Ohkura M, Gengyo-Ando K, Fujii H, Kamijo S, Takemoto-Kimura S, Kano M, Nakai J, Kitamura K, Bito H. (2015) Rational design of a high-affinity, fast, red calcium indicator R-CaMP2. Nat Methods 12: 64-70.

坂内博子 Bannai Hiroko (2014-2015)

匂坂敏朗 Sakisaka Toshiro (2014-2015)

Yamamoto Y, Sakisaka T. (2015) The emerging role of calcium-modulating cyclophilin ligand in posttranslational insertion of tail-anchored proteins into the endoplasmic reticulum membrane. J Biochem 157: 419-429.

Yamamoto Y, Sakisaka T. (2015) Roles of tomosyn in neurotransmitter release, Presynaptic Terminals pp. 129-140.

Fujiwara Y, Goda N, Tamashiro T, Narita H, Satomura K, Tenno T, Nakagawa A, Oda M, Suzuki M, Sakisaka T, Takai Y, Hiroaki H. (2015) Crystal structure of afadin PDZ domain-nectin-3 complex shows the structural plasticity of the ligand-binding site. Protein Sci 24: 376-385.

Yunus J, Setsu T, Kikkawa S, Sakisaka T, Terashima T. (2014) Cytoarchitecture of the olfactory bulb in the laggard mutant mouse. Neuroscience 275: 259-271.

Urade T, Yamamoto Y, Zhang X, Ku Y, Sakisaka T. (2014) Identification and Characterization of TMEM33 as a Reticulon-binding Protein. Kobe J Med Sci 60: E57-65.

Hantan D, Yamamoto Y, Sakisaka T. (2014) VAP-B Binds to Rab3GAP1 at the ER: Its Implication in Nuclear Envelope Formation through the ER-Golgi Intermediate Compartment. Kobe J Med Sci 60: E48-E56.

日浅未来 Hiasa Miki (2014-2015)

Togawa N, Juge N, Miyaji T, Hiasa M, Omote H, Moriyama Y. (2015) Wide expression of type I Na+/phosphate cotransporter 3 (NPT3/SLC17A2), a membrane potential-driven organic anion transporter. Am J Physiol Cell Physiol 309: C71-80.

Sakamoto S, Miyaji T, Hiasa M, Ichikawa R, Uematsu A, Iwatsuki K, Shibata A, Uneyama H, Takayanagi R, Yamamoto A, Omote H, Nomura M, Moriyama Y. (2014) Impairment of vesicular ATP release affects glucose metabolism and increases insulin sensitivity. Sci Rep 4: 6689.

Hiasa M*, Togawa N, Miyaji T, Omote H, Yamamoto A, Moriyama Y. (2014) Essential role of vesicular nucleotide transporter in vesicular storage and release of nucleotides in platelets. Physiol Rep 2: e12034.

Hiasa M, Miyaji T, Haruna Y, Takeuchi T, Harada Y, Moriyama S, Yamamoto A, Omote H, Moriyama Y. (2014) Identification of a mammalian vesicular polyamine transporter. Sci Rep 4: 6836.

掛川 渉 Kakegawa Wataru (2014-2015)

Kakegawa W, Yuzaki M. (2016) Physiological functions of d-serine mediated through δ2 glutamate receptors in the cerebellum. Physiology, Metabolism, and Application, Springer Books. d-Amino Acids pp. 65-80.

Kakegawa W, Mitakidis N, Miura E, Abe M, Matsuda K, Takeo HY, Kohda K, Motohashi J, Takahashi A, Nagao S, Muramatsu S, Watanabe M, Sakimura K, Aricescu AR, Yuzaki M. (2015) Anterograde C1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum. Neuron 85: 316-329.

掛川 渉 (2015) 記憶・学習をささえる脳内d-アミノ酸の機能 d-アミノ酸学会誌 3: 1-6.

掛川 渉, 柚﨑 通介 (2014) d-アミノ酸の神経生理:脳内d-セリンによる記憶・学習制御 生物工学会誌 92: 657-660.

宮田信吾 Miyata Shingo (2014-2015)

Miyata S*, Yoshikawa K, Taniguchi M, Ishikawa T, Tanaka T, Shimizu S, Tohyama M. (2015) Sgk1 regulates desmoglein 1 expression levels in oligodendrocytes in the mouse corpus callosum after chronic stress exposure. Biochem Biophys Res Commun 14: 76-82. *Corresponding author

Shimizu S, Tanaka T, Tohyama M, Miyata S*. (2015) Yokukansan normalizes glucocorticoid receptor protein expression in oligodendrocytes of the corpus callosum by regulating microRNA-124a expression after stress exposure. Brain Res Bull 114: 49-55. *Corresponding author

Shimizu S, Tanaka T, Takeda T, Tohyama M, Miyata S*. (2015) The Kampo medicine Yokukansan decreases microRNA-18 expression and recovers glucocorticoid receptors protein expression in the hypothalamus of stressed mice. Biomed Res Int 2015: 1-8. *Corresponding author

Miyata S*, Hattori T, Shimizu S, Ito A, Tohyama M. (2015) Disturbance of oligodendrocyte function plays a key role in the pathogenesis of schizophrenia and major depressive disorder. Biomed Res Int 2015: 492367. *Corresponding author

Tohyama M, Miyata S, Hattori T, Shimizu S, Matsuzaki S. (2015) Molecular basis of major psychiatric diseases such as schizophrenia and depression. Anat Sci Int 90: 137-143.

Shimizu S, Koyama Y, Hattori T, Tachibana T, Yoshimi T, Emoto H, Matsumoto Y, Miyata S, Katayama T, Ito A, Tohyama M. (2014) DBZ, a CNS-specific DISC1 binding protein, positively regulates oligodendrocyte differentiation. Glia 62: 709-24.

宮田信吾, 田中貴士, 清水尚, 遠山正彌 (2015) 遺伝子操作の新しい手法-double-nicking strategyによる標的特異的なゲノム編集の可能性 脳21 18: 203-210.

平瀬 肇 Hirase Hajime(2014-2015)

Nagai Y, Takata N, Shinohara Y, Hirase H. (2015) Adaptive changes of extracellular amino acid concentrations in mouse dorsal striatum by 4-AP-induced cortical seizures. Neuroscience 295: 229-236.

Hirase H, Shinohara Y. (2014) Transformation of cortical and hippocampal neural circuit by environmental enrichment. Neuroscience 280: 282–298.

松井 広 Matsui Ko (2016-2017)

森 郁恵 Mori Ikue (2016-2017)

木下 専 Kinoshita Makoto (2016-2017)

上野太郎 Ueno Taro (2016-2017)

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A02: グリアアセンブリによる脳機能成熟

今吉 格 Imayoshi Itaru (2014-2015)

Imayoshi I, Ishidate F, Kageyama R. (2015) Real-time imaging of bHLH transcription factors reveals their dynamic control in the multipotency and fate choice of neural stem cells. Front Cell Neurosci 9: 288.

馬場広子 Baba Hiroko (2014-2015)

Chiba T, Otani Y, Yamaguchi Y, Ishibashi T, Hayashi A, Tanaka KF, Yamazaki M, Sakimura K, Baba H. (2016) Microglial phospholipase D4 deficiency influences myelination during brain development. Proc Jpn Acad Ser B Phys Biol Sci 92: 237-254.

竹居光太郎 Takei Kohtaro (2016-2017)

大海雄介 Ohmi Yuhsuke (2016-2017)

和氣弘明 Wake Hiroaki (2016-2017)

小山隆太 Koyama Ryuta (2016-2017)

今井啓雄 Imai Hiroo (2016-2017)

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A03: グリア病: グリアアセンブリ破綻による精神・神経疾患

松井 広 Matsui Ko (2014-2015)

Kanemaru K, Sekiya H, Xu M, Satoh K, Kitajima N, Yoshida K, Okubo Y, Sasaki T, Moritoh S, Hasuwa H, Mimura M, Horikawa K, Matsui K, Nagai T, Iino M, Tanaka KF. (2014) In vivo visualization of subtle, transient, and local activity of astrocytes using an ultrasensitive Ca2+ indicator. Cell Rep 8: 311–318.

小山隆太 Koyama Ryuta (2014-2015)

Hiragi T, Andoh M, Araki T, Shirakawa T, Ono T, Koyama R, Ikegaya Y. (2017) Differentiation of human induced pluripotent stem cell (hiPSC)-derived neurons in mouse hippocampal slice cultures. Front Cell Neurosci 11: 143.

Luo C, Koyama R, Ikegaya Y. (2016) Microglia engulf viable newborn cells in the epileptic dentate gyrus. Glia 64: 1508-1517.

Andoh M, Koyama R, Ikegaya Y. (2016) Severity of kainic acid-induced seizures is not aggravated in the maternal immune activation mouse model of gestational poly(I:C) exposure. J Autism Epilepsy 1: 1013.

Kasahara Y, Koyama R, Ikegaya Y. (2016) Depth and time-dependent heterogeneity of microglia in mouse hippocampal slice cultures. Kasahara Y, Koyama R, Ikegaya Y. (2016) Depth and time-dependent heterogeneity of microglia in mouse hippocampal slice cultures. Neurosci Res 111: 64-69. 111: 64-69.

Zhou Z, Tanaka KF, Matsunaga S, Iseki M, Watanabe M, Matsuki N, Ikegaya Y, Koyama R. (2016) Photoactivated adenylyl cyclase (PAC) reveals novel mechanisms underlying cAMP-dependent axonal morphogenesis. Sci Rep 5: 19679.

Sajo M, Sugiyama H, Yamamoto H, Tanii T, Matsuki N, Ikegaya Y, Koyama R. (2016) Neuraminidase-dependent degradation of polysialic acid is required for the lamination of newly generated neurons. PLoS One 11: e0146398.

Luo C, Ikegaya Y, Koyama R. (2016) Microglia and neurogenesis in the epileptic dentate gyrus. Neurogenesis 3: e1235525.

Koyama R. (2016) Dentate circuitry as a model to study epileptogenesis. Biol Pharm Bull 39: 1-6.

Koyama R, Ikegaya Y. (2015) Microglia in the pathogenesis of autism spectrum disorders. Neurosci Res 100: 1-5.

池内 健 Ikeuchi Takeshi (2014-2017)

Konno T, Yoshida K, Mizuno T, Kawarai T, Tada M, Nozaki H, Ikeda S, Nishizawa M, Onodera O, Wszolek ZK, Ikeuchi T. (2017) Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia associated with CSF1R mutation. Eur J Neurol 24: 37-45.

Konno T, Broderick DF, Mezaki N, Isami A, Kaneda D, Tashiro Y, Tokutake T, Keegan M, Woodruff BK, Miura T, Nozaki H, Nishizawa M, Onodera O, Wszolek ZK, Ikeuchi T. (2017) Diagnostic value of brain calcifications in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia. Ame J Neuroradiol 38: 77-83.

Tada M, Konno T, Tada M, Tezuka T, Miura T, Mezaki N, Okazaki KI, Arakawa M, Itoh K, Yamamoto T, Yokoo H, Yoshikura N, Ishihara K, Horie M, Takebayashi H, Toyoshima Y, Naito M, Onodera O, Nishizawa M, Takahashi H, Ikeuchi T, Kakita A. (2016) Characteristic microglial features in patients with hereditary diffuse leukoencephalopathy with spheroids. Ann Neurol 80: 554-565.

宝田剛志 Takarada Takeshi (2014-2017)

Takarada T, Ogura M, Nakamichi N, Kakuda T, Nakazato R, Kokubo H, Ikeno S, Nakamura S, Kutsukake T, Hinoi E, Yoneda Y. (2016) Upregulation of Slc38a1 gene along with promotion of neurosphere growth and subsequent neuronal specification in undifferentiated neural progenitor cells exposed to theanine. Neurochem Res 41: 5-15.

Iezaki T, Onishi Y, Ozaki K, Fukasawa K, Takahata Y, Nakamura Y, Fujikawa K, Takarada T, Yoneda Y, Yamashita Y, Shioi G, Hinoi E. (2016) The transcriptional modulator interferon-related developmental regulator 1 in osteoblasts suppresses bone formation and promotes bone resorption. J Bone Miner Res 31: 573-584.

Takarada T, Nakamichi N, Nakazato R, Kakuda T, Kokubo H, Ikeno S, Nakamura S, Kuramoto K, Hinoi E, Yoneda Y. (2016) Possible activation by the green tea amino acid theanine of mammalian target of rapamycin signaling in undifferentiated neural progenitor cells in vitro. Biochem Biophys Rep 5: 89-95.

Fujikawa K, Fukumori R, Nakamura S, Kutsukake T, Takarada T, Yoneda Y. (2015) Potential interactions of calcium-sensitive reagents with zinc ion in different cultured cells. PLoS One 10: e0127421.

Wei J, Shimazu J, Makinistoglu MP, Maurizi A, Kajimura D, Zong H, Takarada T, Iezaki T, Pessin JE, Hinoi E, Karsenty G. (2015) Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation. Cell 161: 1576-1591.

Takarada T, Nakamichi N, Kakuda T, Nakazato R, Kokubo H, Ikeno S, Nakamura S, Hinoi E, Yoneda Y. (2015) Daily oral intake of theanine prevents the decline of 5-bromo-2'-deoxyuridine incorporation in hippocampal dentate gyrus with concomitant all eviation of behavioral abnormalities in adult mice with severe traumatic stress. J Pharmacol Sci 127: 292-297.

Nakazato R*, Takarada T*, Ikeno S, Nakamura S, Kutsukake T, Hinoi E, Yoneda Y. (2015) Upregulation of runt-related transcription factor-2 through CCAAT enhancer binding protein-beta signaling pathway in microglial BV-2 cells exposed to ATP. J Cell Physiol 230: 2510-21. *Equally contributed.

Nakazato R*, Takarada T*, Watanabe T, Nguyen BT, Ikeno S, Hinoi E, Yoneda Y. (2014) Constitutive and functional expression of runt-related transcription factor-2 by microglial cells. Neurochem Int 74: 24-35. *Equally contributed.

今井啓雄 Imai Hiroo (2014-2015)

Suzuki-Hashido N, Hayakawa T, Matsui A, Go Y, Ishimaru Y, Misaka T, Abe K, Hirai H, Satta Y, and Imai H. (2015) Rapid Expansion of Phenylthiocarbamide Non-Tasters among Japanese Macaques. PLoS One 10: e0132016.

安井正人 Yasui Masato (2014-2015)

Kato J, Takai Y, Kato Hayashi M, Kato Y, Tanaka M, Sohma Y, Abe Y, and Masato Yasui. (2014) Expression and localization of aquaporin-4 in sensory ganglia. Biochem Biophys Res Commun 451: 562-567.

北爪しのぶ Kitazume Shinobu (2014-2015)

Sakuda K, Kizuka Y, Yamaguchi Y, Tanaka K, Ogiwara K, Segawa T, Hagiwara Y, Matsuo I, Ogawa H, Taniguchi N, Kitazume S. (2017) Reactivity of anti-HNK-1 antibodies to branched O-mannose glycans associated with demyelination. BBRC 487: 450-456.

Kizuka Y, Nakano M, Kitazume S*, Saito T, Saido TC, Taniguchi N*. (2016) Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions. Biochem J 473: 21-30. *corresponding author.

山内淳司 Yamauchi Junji (2014-2015)

Torii T, Miyamoto Y, Yamamoto M, Ohbuchi K, Tsumura H, Kawahara K, Tanoue A, Sakagami H, Yamauchi J. (2015) Data supporting Arf6 regulation of Schwann cell differentiation and myelination. Data Brief 5: 388-395.

Miyamoto Y, Torii T, Takada S, Ohno N, Saitoh Y, Nakamura K, Ito A, Ogata T, Terada N, Tanoue A, Yamauchi J. (2015) Involvement of the Tyro3 receptor and its intracellular partner Fyn signaling in Schwann cell myelination. Mol Biol Cell 26: 3489-3503.

Torii T, Miyamoto Y, Yamamoto M, Ohbuchi K, Tsumura H, Kawahara K, Tanoue A, Sakagami H, Yamauchi J. (2015) Arf6 mediates Schwann cell differentiation and myelination. Biochem Biophys Res Commun 465: 450-457.

Miyamoto Y, Eguchi T, Kawahara K, Hasegawa N, Nakamura K, Funakoshi-Tago M, Tanoue A, Tamura H, Yamauchi J. (2015) Hypomyelinating leukodystrophy-associated missense mutation in HSPD1 blunts mitochondrial dynamics. Biochem Biophys Res Commun 462: 275-281.

Torii T, Ohno N, Miyamoto Y, Kawahara K, Saitoh Y, Nakamura K, Takashima S, Sakagami H, Tanoue A, Yamauchi J. (2015) Arf6 guanine-nucleotide exchange factor cytohesin-2 regulates myelination in nerves. Biochem Biophys Res Commun 460: 819-825.

Torii T, Miyamoto Y, Tago K, Sango K, Nakamura K, Sanbe A, Tanoue A, Yamauchi J*. (2014) Arf6 guanine-nucleotide exchange factor cytohesin-2 binds to CCDC120 and is transported along neurites to mediate neurite growth. J Biol Chem 289: 33887-33903. *Corresponding author

Torii T, Miyamoto Y, Takada S, Tsumura H, Arai M, Nakamura K, Ohbuchi K, Yamamoto M, Tanoue A, Yamauchi J*. (2014) In vivo knockdown of ErbB3 in mice inhibits Schwann cell precursor migration. Biochem Biophys Res Commun 452: 782-788. *Corresponding author

Miyamoto Y, Eguchi T, Torii T, Nakamura K, Tanoue A, Yamauchi J*. (2014) Hypomyelinating leukodystrophy-associated missense mutant of FAM126A/hyccin/DRCTNNB1A aggregates in the endoplasmic reticulum. J Clin Neurosci 21: 1033-1039. *Corresponding author

Miyamoto Y, Yamamori N, Torii T, Tanoue A, Yamauchi J*. (2014) Rab35, acting through ACAP2 switching off Arf6, negatively regulates oligodendrocyte differentiation and myelination. Mol Biol Cell 25: 1532-1542. *Corresponding author Picked up as ‘cover image’

Global Medical Discovery

Yamauchi J. (2015) Arf6 as the potential therapeutic target of neuropathies.

Yamauchi J. (2015) Hereditary hypomyelinating leukodystrophy 4 (HLD4)-associated mutation of mitochondrial heat shock protein HSPD1 causes blunted dynamics of mitochondria in cells and in turn apoptotic cell death.

Yamauchi J. (2015) Arf6-specific guanine-nucleotide exchange factor cytohesin-2 could be a new molecular target for promoting myelination.

Yamauchi J. (2015) Cytohesin-2 and CCDC120 could be new targets for helping neuronal process elongation or proper vesicle transport after degeneration or injury.

Yamauchi J. (2014) Schwann cell precursor ErbB3 could be a target for peripheral nerve regeneration after injury.

Yamauchi J. (2014) Rab35 as a Potential Therapeutic Target of the CNS Demyelinating Disorders.

Yamauchi J. (2014) Hypomyelinating leukodystrophy phenotype in disease-associated FAM126A L53P transgenic mice.

池田匡志 Ikeda Masashi (2014-2015)

Hatano M, Ikeda M, Kondo K, Saito T, Shimasaki A, Esaki K, Umene-Nakano W, Yoshimura R, Nakamura J, Ozaki N, Iwata N. (2015) No support for replication of the genetic variants identified by a recent mega-analysis of the treatment response to antidepressants. J Hum Genet 60: 343-344.

立川正憲 Tachikawa Masanori (2016-2017)

山中宏二 Yamanaka Koji (2016-2017)

中西 博 Nakanishi Hiroshi (2016-2017)

Wu Z, Ni J, Liu Y, Teeling JL, Takayama F, Collcutt A, Ibbett P, Nakanishi H. Cathepsin B plays a critical role in inducing Alzheimer’s disease-like phenotypes following chronic systemic exposure to lipopolysaccharidefrom Porphyromonas gingivalis in mice. Behav Brain Immun in press.

Takayama F, Zhang X, Hayashi Y, Wu Z, Nakanishi H. (2017) Dysfunction in diurnal synaptic responses and social behavior abnormalities in cathepsin S-deficient mice. Biochem Biophys Res Commun 490: 447-452.

Harada Y, Takayama F, Tanabe K, Ni J, Hayashu Y, Yamamoto K, Wu Z, Nakanishi H. (2017) Overexpression of cathepsin E interferes with neuronal differentiation of P19 embryonal teratocarcinoma cells by degradation of N-cadherin. Cell Mol Neurobiol 37: 437-443.

Takayama F, Hayashi Y, Wu Z, Liu Y, Nakanishi H. (2016) Diurnal dynamic behavior of microglia in response to infected bacteria through the UDP-P2Y6 receptor system. Sci Rep 6: 30006.

Hayashi Y, Morinaga S, Zhang J, Satoh Y, Meredith A, Nakata T, Wu Z, Kohsaka S, Inoue K, Nakanishi H. (2016) BK channels in microglia are required for morphine-induced hyperalgesia. Nat Commun 7: 11687.

Hayashi Y, Morinaga S, Liu X, Zhang J, Wu Z, Yokoyama T, Nakanishi H. (2016) An EP2 agonist facilitates NMDA-induced outward currents and inhibits dendritic beading through activation of BK channels in mouse cortical neurons. Mediators Inflamm 2016: 5079597.

Wu Z, Yu J, Zhu A, Nakanishi H. (2016) Nutrients, Microglia Aging, and Brain Aging. Oxid Med Cell Longev 2016: 7498528.

武 洲, 中西 博 (2017) 古くて新しいアルツハイマー病の脳炎症仮説と感染症仮説:鍵を握るミクログリアの老化と慢性的脳炎症 日薬理誌(総説) 150: 1-7.

武 洲, 中西 博 (2017) 歯周病のアルツハイマー病における関与メカニズム:慢性全身性炎症からミクログリア活性化脳炎症へ BIO Clinica 32: 75-80.

西山正章 Nishiyama Masaaki (2016-2017)

宮田麻理子 Miyata Mariko (2016-2017)

貫名信行 Nukina Nobuyuki (2016-2017)

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