原著論文・総説/日本語論文・総説(計画班)

A01: グリアアセンブリによる脳機能制御

池中一裕(山崎良彦、田中謙二、小林憲太、畑中伸彦、清水健史)
Ikenaka K (Yamazaki Y, Tanaka K, Kobayashi K, Hatanaka N, Shimizu T)

Ono K, Yoshii K, Tominaga H, Gotoh H, Nomura T, Takebayashi H, Ikenaka K. Oligodendrocyte precursor cells in the mouse optic nerve originate in the preoptic area. Brain Struct Funct in press.

Shinozaki Y, Shibata K, Yoshida K, Shigetomi E, Gachet C, Ikenaka K, Tanaka KF, Koizumi S. (2017) Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y1 Receptor Downregulation. Cell Rep 19: 1151-1164.

Shimizu T, Wisessmith W, Li J, Abe M, Sakimura K, Chetsawang B, Sahara Y, Tohyama K, Tanaka KF, Ikenaka K. (2017) The balance between Cathepsin C and Cystatin F controls remyelination in the brain of Plp1-overexpressing mouse, a chronic demyelinating disease model. Glia 65: 917-930.

Yoshimura T, Hayashi A, Handa-Narumi M, Yagi H, Ohno N, Koike T, Yamaguchi Y, Uchimura K, Kadomatsu K, Sedzik J, Kitamura K, Kato K, Trapp BD, Baba H, Ikenaka K. (2017) GlcNAc6ST-1 regulates sulfation of N-glycans and myelination in the peripheral nervous system. Sci Rep 7: 42257.

Yamazaki Y, Sumikawa K. (2017) Nicotine-induced neuroplasticity counteracts the effect of schizophrenia- linked neuregulin 1 signaling on NMDAR function in the rat hippocampus. Neuropharmacology 113: 386-395.

Natsubori A, Tsustui-Kimura I, Nishida H, Bouchekioua Y, Sekiya H, Uchigashima M, Watanabe M, de Kerchove d'Exaerde A, Mimura M, Takata N, Tanaka KF. (2017) Ventrolateral striatal medium spiny neurons positively regulate food-incentive, goal-directed behavior independently of D1 and D2 selectivity. J Neurosci 37: 2723-2733.

Tsutsui-Kimura I, Takiue H, Yoshida K, Xu M, Yano R, Ohta H, Nishida H, Bouchekioua Y, Okano H, Uchigashima M, Watanabe M, Takata N, Drew MR, Sano H, Mimura M, Tanaka KF. (2017) Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation. Nat Communications 8: 14304.

Shimizu T, Osanai Y, Tanaka KF, Abe M, Natsume R, Sakimura K, Ikenaka K. (2017) YAP functions as a mechanotransducer in oligodendrocyte morphogenesis and maturation. Glia 65: 360-374.

Osanai Y, Shimizu T, Mori M, Yoshimura Y, Hatanaka N, Nambu A, Kimori Y, Koyama S, Kobayashi K, Ikenaka K. (2017) Rabies virus-mediated oligodendrocyte labeling reveals a single oligodendrocyte myelinates axons from distinct brain regions. Glia 65: 93-105.

Sugio H, Tohyama K, Oku S, Fujiyoshi K, Yoshimura T, Hikishima K, Yano R, Fukuda T, Nakamura M, Okano H, Watanabe M, Fukata M, Ikenaka K, Tanaka KF. (2017) Astrocyte-mediated infantile-onset leukoencephalopathy mouse model. Glia 65: 150-168.

Shimizu T, Smits R, Ikenaka K. (2016) Microglia-induced activation of non-canonical Wnt signaling aggravates neurodegeneration in demyelinating disorders. Mol Cell Biol pii: MCB.00139-16 in press.

Fujii S, Yamazaki Y, Goto J, Fujiwara H, Mikoshiba K. (2016) Prior activation of inositol 1,4,5-trisphosphate receptors suppresses the subsequent induction of long-term potentiation in hippocampal CA1 neurons. Learning & Memory 23: 208-220.

Fujii S, Yamazaki Y, Goto J, Fujiwara H, Mikoshiba K. (2016) Prior activation of inositol 1,4,5-trisphosphate receptors suppresses the subsequent induction of long-term potentiation in hippocampal CA1 neurons. Learning & Memory 23: 208-220.

Yoshida K, Mimura Y, Ishihara R, Nishida H, Komaki Y, Minakuchi T, Tsurugizawa T, Mimura M, Okano H, Tanaka KF, Takata N. (2016) Physiological effects of a habituation procedure for functional MRI in awake mice using a cryogenic radiofrequency probe. J Neurosci Methods 274: 38-48.

Chiba T, Otani Y, Yamaguchi Y, Ishibashi T, Hayashi A, Tanaka KF, Yamazaki M, Sakimura K, Baba H. (2016) Microglial phospholipase D4 deficiency influences myelination during brain development. Proc Jpn Acad Ser B Phys Biol Sci 92: 237-54.

Nakayama R, Sasaki T, Tanaka KF, Ikegaya Y. (2016) Subcellular calcium dynamics during juvenile development in mouse hippocampal astrocytes. Eur J Neurosci 43: 923-932.

Zhou Z, Tanaka KF, Matsunaga S, Iseki M, Watanabe M, Matsuki N, Ikegaya Y, Koyama R. (2016) Photoactivated adenylyl cyclase (PAC) reveals novel mechanisms underlying cAMP-dependent axonal morphogenesis. Sci Rep 5: 19679.

Yamazaki Y, Fujii S, Goto JI, Fujiwara H, Mikoshiba K. (2015) Activation of inositol 1,4,5-trisphosphate receptors during preconditioning low-frequency stimulation suppresses subsequent induction of long-term potentiation in hippocampal CA1 neurons. Neuroscience 311: 195-206.

Chida K, Kaneko K, Fujii S, Yamazaki Y. (2015) Activity-dependent modulation of the axonal conduction of action potentials along rat hippocampal mossy fibers. Eur J Neurosci 41: 45-54.

Yamazaki Y, Fujii S. (2015) Extracellular ATP modulates synaptic plasticity induced by activation of metabotropic glutamate receptors in the hippocampus. Biomed Res 36: 1-9.

Yamazaki Y, Fujiwara H, Kaneko K, Hozumi Y, Xu M, Ikenaka K, Fujii S, Tanaka KF. (2014) Short- and long-term functional plasticity of white matter induced by oligodendrocyte depolarization in the hippocampus. Glia 62: 1299-1312.

Yamazaki Y, Fujiwara H, Kaneko K, Hozumi Y, Xu M, Ikenaka K, Fujii S, Tanaka KF. (2014) Short- and long-term functional plasticity of white matter induced by oligodendrocyte depolarization in the hippocampus. Glia 62: 1299-1312.

飯野正光(大久保洋平、金丸和典、関谷 敬)
Iino M (Okubo Y, Kanemaru K, Sekiya K)

Ino D, Iino M. (2017) Schwann cell mitochondria as key regulators in the development and maintenance of peripheral nerve axons. Cell Mol Life Sci 74: 827-835.

Suzuki J, Kanemaru K, Iino M. (2016) Genetically encoded fluorescent indicators for organellar calcium imaging. Biophys J 111: 1119–1131.

Ino D, Iino M. (2016) In vivo gene transfer to Schwann cells in the rodent sciatic nerve by electroporation. J Vis Exp 115: e54567.

Mikami Y, Kanemaru K, Okubo Y, Nakaune T, Suzuki J, Shibata K, Sugiyama H, Koyama R, Murayama T, Ito A, Yamazawa T, Ikegaya Y, Sakurai T, Saito N, Kakizawa S, Iino M. (2016) Nitric oxide-induced activation of the type 1 ryanodine receptor is critical for epileptic seizure-induced neuronal cell death. EBioMedicine 11: 253–261.

Kubota J, Mikami Y, Kanemaru K, Sekiya H, Okubo Y, Iino M. (2016) Whisker experience-dependent mGluR signaling maintains synaptic strength in the mouse adolescent cortex. Eur J Neurosci 44: 2004-2014.

Murayama T, Kurebayashi N, Ogawa H, Yamazawa T, Oyamada H, Suzuki J, Kanemaru K, Oguchi K, Iino M, Sakurai T. (2016) Genotype-phenotype correlations of malignant hyperthermia and central core disease mutations in the central region of the RYR1 channel. Hum Mutat 37: 1231–1241.

Okubo Y, Suzuki J, Kanemaru K, Nakamura N, Shibata T, Iino M. (2015) Visualization of Ca2+ filling mechanisms upon synaptic inputs in the endoplasmic reticulum of cerebellar Purkinje cells. J Neurosci 35: 15837–15846.

Murayama T, Kurebayashi N, Yamazawa T, Oyamada H, Suzuki J, Kanemaru K, Oguchi K, Iino M, Sakurai T. (2015) Divergent activity profiles of type 1 ryanodine receptor channels carrying malignant hyperthermia and central core disease mutations in the amino-terminal region. PLoS ONE 10: e0130606.

Ino D, Sagara H, Suzuki J, Kanemaru K, Okubo Y, Iino M. (2015) Neuronal regulation of Schwann cell mitochondrial Ca2+ Signaling during myelination. Cell Rep 12: 1951-1959.

Kanemaru K, Sekiya H, Xu M, Satoh K, Kitajima N, Yoshida K, Okubo Y, Sasaki T, Moritoh S, Hasuwa H, Mimura M, Horikawa K, Matsui K, Nagai T, Iino M, Tanaka KF. (2014) In vivo visualization of subtle, transient, and local activity of astrocytes using an ultrasensitive Ca2+ indicator. Cell Rep 10: 311-318.

Suzuki J, Kanemaru K, Ishii K, Ohkura M, Okubo Y, Iino M. (2014) Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA. Nat Commun 5:4153.

Kanemaru K, Kubota J, Sekiya H, Hirose K, Okubo Y, Iino M. (2013) Calcium-dependent N-cadherin up-regulation mediates reactive astrogliosis and neuroprotection after brain injury. Proc Natl Acad Sci USA 110: 11612-11617.

大木研一(根東 覚)
Ohki K (Kondo S)

Ohki K, Reid RC. (2014) In vivo two-photon calcium imaging in the visual system. Cold Spring Harb Protoc. pp. 402-416.

Kawashima T, Kitamura K, Suzuki K, Nonaka M, Kamijo S, Takemoto-Kimura S, Kano M, Okuno H, Ohki K, Bito H. (2013) Functional labeling of neurons and their projections using the synthetic activity-dependent promoter E-SARE. Nat Methods 10: 889-895.

Matsui T, Ohki K. (2013) Target dependence of orientation and direction selectivity of corticocortical projection neurons in the mouse V1. Front Neural Circuits 7: 143.

小泉修一(伊藤 啓、粟崎 健、繁冨英治)
Koizumi S (Ito K, Awasaki T, Shigetomi E)

Morizawa Y, Hirayama Y, Ohno N, Shibata S, Shigetomi E, Sui Y, Nabekura J, Sato K, Okajima F, Takebayashi H, Okano H, Koizumi S. (2017) Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway. Nature Commun 8: 28.

Shinozaki Y, Shibata K, Gachet C, Ikenaka, K, Tanaka, KF, Koizumi S. (2017) Transformation of neuroprotective astrocytes by microglia via P2Y1 receptor down-regulation. Cell Rep 19: 1151-1164 .

Hirayama, Y, Koizumi S. (2017) Hypoxia-independent mechanism for upregulation of hypoxia-inducible factor in astrocytes. GLIA 65: 523-530.

Kim SK, Hayashi H, Ishikawa T, Shibata K, Shigetomi E, Shinozaki Y, Shinozaki Y, Inada H, Roh SE, Kim SJ, Lee G, Bae H, Moorhouse AJ, Mikoshiba K, *Koizumi S, *Nabekura J. (2016) Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain. J Clin Invest 126: 1983-1997. *Co-correspondence author.

Taguchi M, Shinozaki Y, Kashiwagi K, Shigetomi E, Robaye B Koizumi S. (2016) Müller cell-mediated axon outgrowth of the retinal ganglion cells via P2Y6 receptor signals. J Neurochem 136: 741-751.

Hirayama Y, Ikeda-Matsuo Y, Notomi S, Enaida H, Kinouchi H Koizumi S. (2015) Astrocytes mediate ischemic tolerance in the brain. J Neurosci 35: 3794-3805.

Shinozaki Y, Nomura M, Iwatsuki K, Moriyama Y, Gachet C, Koizumi S. (2014) Microglia triggers astrocyte-mediated neuroprotection via purinergic gliotransmission. Sci Rep 4: 4329.

Imura Y, Morizawa Y, Komatus R, Shibata K, Shinozaki Y, Moriyama Y, Koizumi S. (2013) Microglia release ATP by exocytosis. GLIA 61: 1320-1330.

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A02: グリアアセンブリによる脳機能成熟

岡部繁男(橋本浩一、渡辺雅彦)
Okabe S (Hashimoto K, Watanabe M)

Hirai S, Hotta K, Kubo Y, Nishino A, Okabe S, Okamura Y, Okado H. (2017) AMPA glutamate receptors are required for sensory-organ formation and morphogenesis in the basal chordate.
Proc Natl Acad Sci USA 114: 3939-3944.

Parajuli LK, Tanaka S, Okabe S. (2017) Insights into age-old questions of new dendritic spines: From form to function. Brain Res Bull 129: 3-11.

Hayashi A, Asanuma, D, Kamiya M, Urano Y, Okabe S. (2016) High affinity receptor labeling based on basic leucine zipper domain peptides conjugated with pH-sensitive fluorescent dye: visualization of AMPA type glutamate receptor endocytosis in living neurons. Neuropharmacology 100: 66-75.

Matsumoto-Makidono Y, Nakayama H, Yamasaki M, Miyazaki T, Kobayashi K, Watanabe M, Kano M, Sakimura K, Hashimoto K. (2016) Ionic Basis for Membrane Potential Resonance in Neurons of the Inferior Olive. Cell Rep 16: 994-1004.

Ichikawa R, Hashimoto K, Miyazaki T, Uchigashima M, Yamasaki M, Aiba A, Kano M, Watanabe M. (2016) Territories of heterologous inputs onto Purkinje cell dendrites are segregated by mGluR1-dependent parallel fiber synapse elimination. Proc Natl Acad Sci USA 113: 2282-2287.

Oshiro H, Hirabayashi Y, Koretune H, Nakao K, Aizawa S, Okabe S, Gotoh Y. (2015) Upregulation of HP1γ expression during neuronal maturation promotes axonal and dendritic development in mouse embryonic neocortex. Genes Cells 20: 108-120.

Ageta-Ishihara N, Yamazaki M, Konno K, Nakayama H, Abe M, Hashimoto K, Nishioka T, Kaibuchi K, Hattori S, Miyakawa T, Tanaka K, Huda F, Hirai H, Hashimoto K, Watanabe M, Sakimura K, Kinoshita M. (2015) A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance. Nat Commun 6: 10090.

Isshiki M, Tanaka S, Kuriu T, Tabuchi K, Takumi T, Okabe S. (2014) Enhanced synapse remodelling as a common phenotype in mouse models of autism. Nat Commun 5: 4742.

Ebrahimi S, Okabe S. (2014) Structural dynamics of dendritic spines: molecular composition, geometry and functional regulation. Biochim Biophys Acta 1838: 2391-2398.

Ito-Ishida A, Kakegawa W, Kohda K, Miura E, Okabe S, Yuzaki M. (2014) Cbln1 down-regulates the formation and function of inhibitory synapses in mouse cerebellar Purkinje cells. Eur J Neurosci 39: 1268-1280.

Isshiki M, Okabe S. (2014) Evaluation of cranial window types for in vivo two-photon imaging of brain microstructures. Microscopy 63: 53-63.

Dai X, Iwasaki H, Watanabe M, Okabe S. (2014) Dlx1 transcription factor regulates dendritic growth and postsynaptic differentiation through inhibition of neuropilin-2 and PAK3 expression. Eur J Neurosci 39: 531-47.

Piochon C, Kloth AD, Grasselli G, Titley HK, Nakayama H, Hashimoto K, Wan V, Simmons DH, Eissa T, Nakatani J, Cherskov A, Miyazaki T, Watanabe M, Takumi T, Kano M, Wang SSH, Hansel C. (2014) Cerebellar plasticity and motor learning deficits in a copy number variation mouse model of autism. Nat Commun 5: 5586.

Kawata S, Miyazaki T, Yamazaki M, Mikuni T, Yamasaki M, Hashimoto K, Watanabe M, Sakimura K, Kano M. (2014) Global scaling down of excitatory postsynaptic responses in cerebellar purkinje cells impairs developmental synapse elimination. Cell Rep 8: 1119-1129.

Kawamura Y, Nakayama H, Hashimoto K, Sakimura K, Kitamura K, Kano M. (2013) Spike timing-dependent selective strengthening of single climbing fiber inputs to Purkinje cells during cerebellar development. Nat Commun 4: 2732.

高坂新一(一戸紀孝、内野茂夫)
Kohsaka S (Ichinohe N, Uchino S)

Kishikawa S, Sato S, Kaneto S, Uchino S, Kohsaka S, Nakamura S, Kiyono H. (2017) Allograft inflammatory factor 1 (Aif1) is a regulator of transcytosis in M cells. Nature Commun 8: 14509.

Mathews A, Ohsawa K, Buckland ME, Kesavadas C, Ratheesan K, Kusumakumary P, Burger PC, Kohsaka S, Graeber MB. (2016) Microglioma in a child - a further case in support of the microglioma entity and distinction from histiocytic sarcoma. Clin Neuropathol 35: 302-313.

Hayashi Y, Morinaga S, Zhang J, Satoh Y, Meredith AL, Nakata T, Wu Z, Kohsaka S, Inoue K, Nakanishi H. (2016) BK channels in microglia are required for morphine-induced hyperalgesia. Nat Commun 7: 11697.

Hashimoto R, Hori K, Owa T, Miyashita S, Dewa K, Masuyama N, Sakai K, Hayase Y, Seto Y, Inoue YU, Inoue T, Ichinohe N, Kawaguchi Y, Akiyama H, Koizumi S, Hoshino M. (2016) Origins of oligodendrocytes in the cerebellum, whose development is controlled by the transcription factor, Sox9. Mech Dev 140: 25-40.

Sudo K, Takezawa Y, Kohsaka S, Nakajima K. (2015) Involvement of nitric oxide in the induction of interleukin-1 beta in microglia. Brain Res 1625: 121-134.

Nakajima K, Kanamatsu T, Takezawa Y, Kohsaka S. (2015) Up-regulation of glutamine synthesis in microglia activated with endotoxin. Neurosci Lett 591: 99-104.

Hattori K, Ota M, Sasayama D, Yoshida S, Matsumura R, Miyakawa T, Yokota Y, Yamaguchi S, Noda T, Teraishi T, Hori H, Higuchi T, Kohsaka S, Goto Y, Kunugi H. (2015) Increased cerebrospinal fluid fibrinogen in major depressive disorder. Sci Rep 5: 11412.

Takezawa Y, Baba O, Kohsaka S, Nakajima K. (2015) Accumulation of glycogen in axotomized adult rat facial motoneurons. J Neurosci Res 93: 913-921.

Ito Y, Inoue N, Inoue YU, Nakamura S, Matsuda Y, Inagaki M, Ohkubo T, Asami J, Terakawa YW, Kohsaka S, Goto Y, Akazawa C, Inoue T, Inoue K. (2015) Additive dominant effect of a SOX10 mutation underlies a complex phenotype of PCWH. Neurobiol Dis 80: 1-14.

Takatsuru Y, Nabekura J, Ishikawa T, Kohsaka S, Koibuchi N. (2015) Early-life stress increases the motility of microglia in adulthood. J Physiol Sci 65: 187-194.

Sasaki T, Aoi H, Oga T, Fujita I, Ichinohe N. (2015) Postnatal development of dendritic structure of layer III pyramidal neurons in the medial prefrontal cortex of marmoset. Brain Struct Funct 220: 3245-3258.

Ichinohe N. (2015) On-going elucidation of mechanisms of primate specific synaptic spine development using the common marmoset (Callithrix jacchus). Neuroscience Res 93: 176-178.

Puentes S, Kaido T, Hanakawa T, Ichinohe N, Otsuki T, Seki K. (2015) Internal capsule stroke in the common marmoset. Neuroscience 284: 400-411.

Takezawa Y, Kohsaka S, Nakajima K. (2014) Transient down-regulation and restoration of glycogen synthase levels in axotomized rat facial motoneurons. Brain Res 1586: 34-45.

Masuda T, Nishimoto N, Tomiyama D, Matsuda T, Tozaki-Saitoh H, Tamura T, Kohsaka S, Tsuda M, Inoue K. (2014) IRF8 is a transcriptional determinant for microglial motility. Purinergic Signal 10: 515-521.

Ishikawa R, Kim R, Namba T, Kohsaka S, Uchino S, Kida S. (2014) Time-dependent enhancement of hippocampus-dependent memory after treatment with memantine: Implications for enhanced hippocampal adult neurogenesis. Hippocampus 24: 784-793.

Brawek B, Schwendele B, Riester K, Kohsaka S, Lerdkrai C, Liang Y, Garaschuk O. (2014) Impairment of in vivo calcium signaling in amyloid plaque-associated microglia. Acta Neuropathol 127: 495-505.

Waga C, Asano H, Sanagi T, Suzuki E, Nakamura Y, Tsuchiya A, Itoh M, Goto YI, Kohsaka S, Uchino S. (2014) Identification of two novel Shank3 transcripts in the developing mouse neocortex. J Neurochem 128: 280-293.

Sasaki T, Oga T, Nakagaki K, Sakai K, Sumida K, Hoshino K, Miyawaki I, Saito K, Suto F, Ichinohe N. (2014) Developmental expression profiles of axon guidance signaling and the immune system in the marmoset cortex: Potential molecular mechanisms of pruning of dendritic spines during primate synapse formation in late infancy and prepuberty (I). Biochem Biophys Res Commun 444: 302-306.

Sasaki T, Oga T, Nakagaki K, Sakai K, Sumida K, Hoshino K, Miyawaki I, Saito K, Suto F, Ichinohe N. (2014) Developmental genetic profiles of glutamate receptor system, neuromodulator system, protector of normal tissue and mitochondria, and reelin in marmoset cortex: Potential molecular mechanisms of pruning phase of spines in primate synaptic formation process during the end of infancy and prepuberty (II). Biochem Biophys Res Commun 444: 307-310.

Kawai N, Yasue M, Banno T, Ichinohe N. (2014) Marmoset monkeys evaluate third-party reciprocity. Biol Lett 10: 20140058.

Watakabe A, Ohsawa S, Ichinohe N, Rockland KS, Yamamori T. (2014) Characterization of claustral neurons by comparative gene expression profiling and dye-injection analyses. Front Syst Neurosci 8: 98.

Hayashi Y, Koyanagi S, Kusunose N, Okada R, Wu Z, Tozaki-Saitoh H, Ukai K, Kohsaka S, Inoue K, Ohdo S, Nakanishi H. (2013) The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S. Sci Rep 3: 2744.

Ikeda M, Tsuno S, Sugiyama T, Hashimoto A, Yamoto K, Takeuchi K, Kishi H, Mizuguchi H, Kohsaka S, Yoshioka T. (2013) Ca2+ spiking activity caused by the activation of store-operated Ca2+ channels mediates TNF-α release from microglial cells under chronic purinergic stimulation. Biochim Biophys Acta 1833: 2573-2585.

Hefendehl JK, Neher JJ, Suhs RB, Kohsaka S, Skodras A, Jucker M. (2013) Homeostatic and injury-induced microglia behavior in the aging brain. Aging Cell 12: 1-10.

Gonda Y, Andrews W. D, Tabata H, Namba T, Parnavelas J. G, Nakajima K, Kohsaka S, Hanashima C, Uchino S. (2013) Robo1 Regulates the Migration and Laminar Distribution of Upper-Layer Pyramidal Neurons of the Cerebral Cortex. Cereb Cortex 23: 1495-1508.

Ichimiya T, Yamamoto S, Honda Y, Kikuchi R, Kohsaka S, Nakajima K. (2013) Functional down-regulation of axotomized rat facial motoneurons. Brain Res 1507: 35–44.

竹林浩秀(榎戸 靖、千葉陽一、堀江正男)
Takebayashi H (Enokido Y, Chiba Y, Horie M)

Morizawa Y, Hirayama Y, Ohno N, Shibata S, Shigetomi E, Sui Y, Nabekura J, Sato K, Okajima F, Takebayashi H, Okano H, Koizumi S. (2017) Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway. Nature Commun 8: 28.

Hossain MI, Horie M, Takebayashi H. Reduced proliferation of oligodendrocyte progenitor cells in the postnatal brain of dystonia musculorum mice. Neurochem Res in press.

Ono K, Yoshii K, Tominaga H, Gotoh H, Nomura T, Takebayashi H, Ikenaka K. Oligodendrocyte precursor cells in the mouse optic nerve originate in the preoptic area. Brain Struct Funct in press.

Ikeda M, Hossain MI, Zhou L, Horie M, Ikenaka K, Horii A, Takebayashi H. Histological detection of dynamic glial responses in the dysmyelinating Tabby-jimpy mutant brain. Anat Sci Int in press.

Horie M, Mekada K, Sano H, Kikkawa Y, Chiken S, Someya T, Saito K, Hossain MD, Nameta M, Abe K, Sakimura K, Ono K, Nambu A, Yoshiki A, Takebayashi H. (2016) Characterization of novel dystonia musculorum mutant mice: implications for central nervous system abnormality. Neurobiol Dis 96: 271-283.

Tada M, Konno T, Tada M, Tezuka T, Miura T, Mezaki N, Okazaki KI, Arakawa M, Itoh K, Yamamoto T, Yokoo H, Yoshikura N, Ishihara K, Horie M, Takebayashi H, Toyoshima Y, Naito M, Onodera O, Nishizawa M, Takahashi H, Ikeuchi T, Kakita A. (2016) Characteristic microglial features in patients with hereditary diffuse leukoencephalopathy with spheroids. Ann Neurol 80: 554-565.

Fukushima S, Nishikawa K, Furube E, Muneoka S, Ono K, Takebayashi H, Miyata, S. (2015) Oligodendrogenesis in the fornix of adult mouse brain; the effect of LPS-induced inflammatory stimulation. Brain Res 1627: 520-69.

Takebayashi H, Ikenaka K. (2015) Oligodendrocyte Generation during Mouse Development. Glia 63: 1350-1356.

Horie M, Watanabe K, Bepari A K, Nashimoto J, Araki K, Sano H, Chiken S, Nambu A, Ono K, Ikenaka K, Kakita A, Yamamura K, Takebayashi H. (2014) Disruption of actin-binding domain-containing dystonin protein causes dystonia musculorum in mice. Eur J Neurosci 40: 3458-3471.

竹林浩秀, 堀江正男 (2015) ジストニア症状を示す遺伝性神経難病モデルマウスの作製と解析 新潟医学会雑誌 129: 491-497.

竹林浩秀 (2014) グリア細胞発生・分化機構の解析と生体内細胞系譜追跡実験系の確立・応用 神経化学 53: 41-46.

佐藤和彦, 堀江正男, 竹林浩秀, 高橋均, 柿田明美 (2014) ヒト脳病理切片におけるin situ hybridization 法を利用したニューロンおよびグリア細胞の同定 新潟医学会雑誌 128: 625-634.

福山秀直(植木孝俊)
Fukuyama H (Ueki T)

Inano R, Oishi N, Kunieda T, Arakawa Y, Kikuchi T, Fukuyama H, Miyamoto S. (2016) Visualization of heterogeneity and regional grading of gliomas by multiple features using magnetic resonance-based clustered images. Sci Rep 6: 30344.

Ota K, Oishi N, Ito K, Fukuyama H, SEAD-J Study Group, for the Alzheimer's Disease Neuroimaging Initiative. (2016) Prediction of Alzheimer's Disease in Amnestic Mild Cognitive Impairment Subtypes: Stratification Based on Imaging Biomarkers. J Alzheimers Dis 52: 1385-1401.

Inoue K, Sakuma E, Morimoto H, Asai H, Koide Y, Leng T, Wada I, Xiong ZG, Ueki T. (2016) Serum- and glucocorticoid-inducible kinases in microglia. Biochem Biophys Res Commun 478: 53-59.

Inoue K, Leng T, Yang T, Zeng Z, Ueki T, Xiong ZG. (2016) Role of serum- and glucocorticoid-inducible kinases in stroke. J Neurochem 138: 354-361.

Ota K, Oishi N, Ito K, Fukuyama H, SEAD-J Study Group, for the Alzheimer's Disease Neuroimaging Initiative. (2015) Effects of imaging modalities, brain atlases and feature selection on prediction of Alzheimer's disease. J Neurosci Methods 256: 168-183.

Hiyoshi-Taniguchi K, Oishi N, Namiki C, Miyata J, Murai T, Cichocki A, Fukuyama H. (2015) The Uncinate Fasciculus as a Predictor of Conversion from aMCI to Alzheimer Disease. J Neuroimaging 25: 748-753.

Inano R, Oishi N, Kunieda T, Arakawa Y, Yamao Y, Shibata S, Kikuchi T, Fukuyama H, Miyamoto S. (2014) Voxel-based clustered imaging by multiparameter diffusion tensor images for glioma grading. NeuroImage: Clinical 5: 396-407.

Ota K, Oishi N, Ito K, Fukuyama H. (2014) A comparison of three brain atlases for MCI prediction. J Neurosci Methods 221: 139-150.

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A03: グリア病: グリアアセンブリ破綻による精神・神経疾患

尾崎紀夫
Ozaki N

Yamamoto M, Kushima I, Kimura H, Hayashi A, Kawano N, Aleksic B, Iidaka T, Ozaki N. (2015) White matter microstructure between the pre-SMA and the cingulum bundle is related to response conflict in healthy subjects. Brain Behav 5: e00375.

Kimura H, Tanaka S, Kushima I, Koide T, Banno M, Kikuchi T, Nakumura Y, Shiino T, Yoshimi A, Oya-Ito T, Xing J, Wang C, Takasaki Y, Aleksic B, Okada T, Ikeda M, Inada T, Iidaka T, Iwata N, Ozaki N. (2015) Association study of BCL9 gene polymorphism rs583583 with schizophrenia and negative symptoms in Japanese population. Sci Rep 5: 15705.

Kimura H, Tsuboi D, Wang C, Kushima I, Koide T, Ikeda M, Iwayama Y, Toyota T, Yamamoto N, Kunimoto S, Nakamura Y, Yoshimi A, Banno M, Xing J, Takasaki Y, Yoshida M, Aleksic B, Uno Y, Okada T, Iidaka T, Inada T, Suzuki M, Ujike H, Kunugi H, Kato T, Yoshikawa T, Iwata N, Kaibuchi K, Ozaki N. (2015) Identification of Rare, Single-Nucleotide Mutations in NDE1 and Their Contributions to Schizophrenia Susceptibility. Schizophr Bull 41: 744-53.

Wang C, Aleksic B, Ozaki N. (2015) Glia-related genes and their contribution to schizophrenia. Psychiatry Clin Neurosci 69: 448-61.

Ikeda M, Yoshimura R, Hashimoto R, Kondo K, Saito T, Shimasaki A, Ohi K, Tochigi M, Kawamura Y, Nishida N, Miyagawa T, Sasaki T, Tokunaga K, Kasai K, Takeda M, Nakamura J, Ozaki N, Iwata N. (2015) Genetic Overlap Between Antipsychotic Response and Susceptibility to Schizophrenia. J Clin Psychopharmacol 35: 85-88.

Hida H, Mouri A, Mori K, Matsumoto Y, Seki T, Taniguchi M, Yamada K, Iwamoto K, Ozaki N, Nabeshima T, Noda Y. (2015) Blonanserin Ameliorates Phencyclidine-Induced Visual-Recognition Memory Deficits: the Complex Mechanism of Blonanserin Action Involving D3-5-HT2A and D1-NMDA Receptors in the mPFC. Neuropsychopharmacology 40: 601-613.

Xing J, Wang C, Kimura H, Takasaki Y, Kunimoto S, Yoshimi A, Nakamura Y, Koide T, Banno M, Kushima I, Uno Y, Okada T, Aleksic B, Ikeda M, Iwata N, Ozaki N. (2014) Resequencing and Association Analysis of PTPRA, a Possible Susceptibility Gene for Schizophrenia and Autism Spectrum Disorders. PLoS One 9: e112531.

Wang C., Koide T., Kimura H, Kunimoto S, Yoshimi A, Nakamura Y, Kushima I, Banno M, Kawano N, Takasaki Y, Xing J, Noda Y, Mouri A, Aleksic B, Ikeda M, Okada T, Iidaka T, Inada T, Iwata N, Ozaki N. (2014) Novel rare variants in F-box protein 45 (FBXO45) in schizophrenia. Schizophr Res 157: 149-156.

Shishido E, Aleksic B, Ozaki N. (2014) Copy-number variation in the pathogenesis of autism spectrum disorder. Psychiatry Clin Neurosci 68: 85-95.

Kido M, Nakamura Y, Nemoto K, Takahashi T, Aleksic B, Furuichi A, Nakamura Y, Ikeda M, Noguchi K, Kaibuchi K, Iwata N, Ozaki N, Suzuki M. (2014) The Polymorphism of YWHAE, a Gene Encoding 14-3-3Epsilon, and Brain Morphology in Schizophrenia: A Voxel-Based Morphometric Study. PLoS One 9: e103571.

井上和秀(齋藤秀俊、津田 誠、増田隆博)
Inoue K(Saitoh H, Tsuda M, Masuda T)

Shiratori-Hayashi M, Koga K, Tozaki-Saitoh H, Kohro Y, Toyonaga H, Yamaguchi C, Hasegawa A, Nakahara T, Hachisuka J, Akira S, Okano H, Furue M, Inoue K, Tsuda M. (2015) STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch. Nat Med 21: 927-931.

Kohro Y, Sakaguchi E, Tashima R, Tozaki-Saitoh H, Okano H, Inoue K, Tsuda M. (2015) A new minimally-invasive method for microinjection into the mouse spinal dorsal horn. Sci Rep 5: 14306.

Igawa T, Abe Y, Tsuda M, Inoue K, Ueda T. (2015) Solution structure of the rat P2X4 receptor head domain involved in inhibitory metal binding. FEBS Lett 589: 680-686.

Kobayakawa K, Kumamaru H, Saiwai H, Kubota K, Ohkawa Y, Kishimoto J, Yokota K, Ideta R, Shiba K, Tozaki-Saitoh H, Inoue K, Iwamoto Y, Okada S. (2014) Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans. Sci Transl Med 6: 256.

Masuda T, Iwamoto S, Yoshinaga R, Tozaki-Saitoh H, Nishiyama A, Mak TW, Tamura T, Tsuda M, Inoue K. (2014) Transcription factor IRF5 drives P2X4R+ reactive microglia gating neuropathic pain. Nat Commun 5: 3771.

Masuda T, Nishimoto N, Tomiyama D, Matsuda T, Tozaki-Saitoh H, Tamura T, Kohsaka S, Tsuda M, Inoue K. (2014) IRF8 is a transcriptional determinant for microglial motility. Purinergic Signal 10: 515-521.

Shimoyama H, Tsuda M, Masuda T, Yoshinaga R, Tsukamoto K, Tozaki-Saitoh H, Inoue K. (2014) Spinal cord is the primary site of action of the cannabinoid CB2 receptor agonist JWH133 that suppresses neuropathic pain: Possible involvement of microglia. The Open Pain Journal 7: 1-8.

Ochi-ishi R, Nagata K, Inoue T, Tozaki-Saitoh H, Tsuda M, Inoue K. (2014) Involvement of the chemokine CCL3 and the purinoceptor P2X7 in the spinal cord in aclitaxel-induced mechanical allodynia. Mol Pain 10: 53.

Akagi T, Matsumura Y, Yasui M, Minami E, Inoue H, Masuda T, Tozaki-Saitoh H, Tamura T, Mizumura K, Tsuda M, Kiyama H, Inoue K. (2014) Interferon regulatory factor 8 expressed in microglia contributes to tactile allodynia induced by repeated cold stress in rodents. J Pharmacol Sci 126: 172-176.

Kobayakawa K, Kumamaru H, Saiwai H, Kubota K, Ohkawa Y, Kishimoto J, Yokota K, Ideta R, Shiba K, Tozaki-Saitoh H, Inoue K, Iwamoto Y, Okada S. (2014) Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans. Sci Transl Med 6: 256.

神庭重信
Kanba S

Ohgidani M, Kato TA*, Sagata N, Hayakawa K, Shimokawa N, Sato-Kasai M, Kanba S. (2016) TNF-α from hippocampal microglia directly induces working memory deficits by acute stress in mice. Brain Behav Immun 55: 17-24.

Ohgidani M, Kato TA*, Kanba S. (2015) Introducing directly induced microglia-like (iMG) cells from fresh human monocytes: A novel translational research tool for psychiatric disorders. Front Cell Neurosci 9: 184.

Hayakawa K, Kato TA*, Kojiro M, Monji A, Kanba S. (2014) Minocycline, a microglial inhibitor, diminishes terminal patients’ delirium? Am J Geriatr Psychiatry 22: 314-315.

Ohgidani M, Kato TA, Setoyama D, Sagata N, Hashimoto R, Shigenobu K, Yoshida T, Hayakawa K, Shimokawa N, Miura D, Utsumi H, Kanba S. (2014) Direct induction of ramified microglia-like cells from human monocytes: Dynamic microglial dysfunction in Nasu-Hakola disease. Sci Rep 4: 4957.

Kato TA, Watabe M, Kanba S. (2013) Neuron-glia interaction as a possible glue to translate the mind-brain gap: A novel multi-dimensional approach toward psychology and psychiatry. Front Psychiatry 4: 139.

加藤隆弘, 神庭重信 (2014) ミクログリアと精神疾患 生命の科学 65: 37-42.

吉良潤一(河野祐治、山崎 亮、松瀬 大、真崎勝久、松下拓也、王 冰)
Kira J (Kawano Y, Yamasaki R, Matsuse D, Mazaki K, Matsushita T, Wang B)

Ogata H, Yamasaki R, Hiwatashi A, Oka N, Kawamura N, Matsuse D, Kuwahara M, Suzuki H, Kusunoki S, Fujimoto Y, Ikezoe K, Kishida H, Tanaka F, Matsushita T, Murai H, Kira J. (2015) Characterization of IgG4 anti-neurofascin 155 antibody-positive neuropathy. Ann Clin Transl Neurol 2: 960-971.

Hayashida S, Masaki K, Yonekawa T, Suzuki OS, Hiwatashi A, Matsushita T, Watanabe M, Yamasaki R, Suenaga T, Iwaki T, Murai H, Kira J. (2016) Early and extensive spinal white matter involvement in neuromyelitis optica. Brain Pathol 27: 249-265.

Nakamura Y, Matsushita T, Sato S, Niwa M, Fukazawa T, Yoshimura S, Hisahara S, Osobe N, Shimohama S, Watanabe M, Yoshida K, Houzen H, Miyazaki Y, Yamasaki R, Kikuchi S, Kira J, Japan Multiple Sclerosis Genetics Consortium. (2016) Latitude and HLA-DRBI* 04:05 independently influence disease severity in Japanese multiple sclerosis: a cross-sectional study. J Neuroinflammation 13: 239.

Yamasaki R, Fujii T, Wang B, Masaki K, Kido MA, Yoshida M, Matsushita T, Kira J. (2016) Allergic inflammation leads to neuropathic pain via glial cell activation. J Neurosci 36: 11929-11945.

Watanabe M, Masaki K, Yamasaki R, Kawanouchi J, Takeuchi H, Matsushita T, Suzumura A, Kira J. (2016) Th1 cells downregulate connexin 43 gap junctions in astrocytes via microglial activation. Sci Rep 6: 38387.

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