業績
2021年発表論文2020年発表論文
2019年発表論文
2018年発表論文
2017年発表論文
2016年発表論文
2015年発表論文
2014年発表論文
2013年発表論文
日本語総説
学会・講演会
2021年発表論文
SLC15A4 mediates M1-prone metabolic shift in macrophages and guards immune cells from metabolic stress. Kobayashi T, Nguyen-Tien D, Sorimachi Y, Sugiura Y, Suzuki T, Karyu H, Shimabukuro-Demoto S, Okamura T, Taguchi T, Ueki K, Kato N, Goda N, Dohmae N, Takubo K, Suematsu M, Toyama-Sorimachi N. Proc. Natl. Acad. Sci. USA (2021, in press)
Human SLC15A4 is crucial for TLR-mediated type I Interferon production and mitochondrial integrity.
Kobayashi T, Nguyen-Tien D, Ohshima D, Karyu H, Shimabukuro-Demoto S, Sugitani-Yoshida Y, Toyama-Sorimachi N. Int Immunol (2021), doi: 10.1093/intimm/dxab006
The inhibitory NK receptor Ly49Q protects plasmacytoid dendritic cells from pyroptotic cell death.
Sasawatari S, Karyu H, Nguyen-Tien D, Furuyama-Tanaka K, Toyama-Sorimachi N. Mol Immunol. (2021) 135;217-225. doi: 10.1016/j.molimm.2021.03.023.
The 49th Annual Meeting of the Japanese Society for Immunology: COVID-19 and Immunity.
Shinkura R, Kang S, Arase H, Toyama-Sorimachi N. Int Immunol (2021) Mar 31;33(4):193-196. doi: 10.1093/intimm/dxab004.
2020年発表論文
A common signaling pathway leading to degranulation in mast cells and its regulation by CCR1-ligand.Chang HW, Kanegasaki S, Jin F, Deng Y, You Z, Chang JH, Kim DY, Timilshina M, Jae-Ryong K, Lee YJ, Toyama-Sorimachi N, Tsuchiya T. Allergy. 2020 Jan 18.
Soluble SLAMF7 promotes the growth of myeloma cells via homophilic interaction with surface SLAMF7.
Kikuchi J, Hori M, Iha H, Toyama-Sorimachi N, Hagiwara S, Kuroda Y,Koyama D, Izumi T, Yasui H, Suzuki A, Furukawa Y. Leukemia. 2020 Jan;34(1):180-195.
2019年発表論文
Type I interferon limits mast-cell-mediated anaphylaxis by controlling secretory-granule homeostasis.Kobayashi T, Shimabukuro-Demoto S, Tsutsui H, Toyama-Sorimachi N. PLOS Biology. 2019 Nov 15;17(11):e3000530. doi: 10.1371/journal.pbio.3000530.
2018年発表論文
Exosome-associated Shiga toxin 2 is released from cells and causes severe toxicity in mice.Watanabe-Takahashi M, Yamasaki S, Murata M, Kano F, Motoyama J, Yamate J, Omi J, Sato W, Ukai H, Shimasaki K, Ikegawa M, Tamura-Nakano M, Yanoshita R, Nishino Y, Miyazawa A, Natori Y, Toyama-Sorimachi N, Nishikawa K.
Sci Rep. 2018 Jul 17;8(1):10776. doi: 10.1038/s41598-018-29128-9.
2017年発表論文
Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells.Kobayashi T, Tsutsui H, Shimabukuro-Demoto S, Sugitani-Yoshida R, Karyu H, Furuyama-Tanaka K, Ohshima D, Kato N, Okamura T, Toyama-Sorimachi N.
Int Immunol. 2017 Dec 31;29(12):551-566. doi: 10.1093/intimm/dxx063.
A Novel Role for PHT1 in the Disposition of L-Histidine in Brain: In Vitro Slice and In Vivo Pharmacokinetic Studies in Wildtype and Pht1 Null Mice.
Wang XX, Hu Y, Keep RF, Toyama-Sorimachi N, Smith DE.
Biochem Pharmacol. 2017 Jan 15;124:94-102. doi: 10.1016/j.bcp.2016.11.012.
2016年発表論文
2015年発表論文
Separation of Intracellular Vesicles for Immunoassays.Kobayashi T, Tanaka T, and Toyama-Sorimachi N.
Bio-protocol 5(16): e1571.
http://www.bio-protocol.org/e1571
The assembly of EDC4 and Dcp1a into processing bodies is critical for the translational regulation of IL-6.
Seto E, Yoshida-Sugitani R, Kobayashi T, Toyama-Sorimachi N.
PLoS One 2015 May 13;10(5):e0123223. doi: 10.1371/journal.pone.0123223.
2014年発表論文
Roles of ADAM8 in elimination of injured muscle fibers prior to skeletal muscle regeneration.Nishimura D, Sakai H, Sato T, Sato F, Nishimura S, Toyama-Sorimachi N, Bartsch JW, Sehara-Fujisawa A.
Mech Dev. 2015 Feb;135:58-67. doi: 10.1016/j.mod.2014.12.001.
The Histidine Transporter SLC15A4 Coordinates mTOR-dependent Inflammatory Responses and Pathogenic Antibody Production
Kobayashi T, Shimabukuro-Demoto S, Yoshida-Sugitani R, Furuyama-Tanaka K, Karyu H, Sugiura Y, Shimizu Y, Hosaka T, Goto M, Kato N, Okamura T, Suematsu M, Yokoyama S, Toyama-Sorimachi N.
Immunity. 2014 Sep 18; 41(3):375-388. doi: 10.1016/j.immuni.2014.08.011.
この論文はImmunity 2014年9月号表紙に採択されました.
Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility.
Jin H, Arase N, Hirayasu K, Kohyama M, Suenaga T, Saito F, Tanimura K, Matsuoka S, Ebina K, Shi K, Toyama-Sorimachi N, Yasuda S, Horita T, Hiwa R, Takasugi K, Ohmura K, Yoshikawa H, Saito T, Atsumi T, Sasazuki T, Katayama I, Lanier LL, Arase H.
Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3787-92. doi: 10.1073/pnas.1401105111. Epub 2014 Feb 24.
2013年発表論文
How do cells optimize luminal environments of endosomes/lysosomes for efficient inflammatory responses?Kobayashi T, Tanaka T, Toyama-Sorimachi N.
J Biochem. 2013 Dec;154(6):491-9. doi: 10.1093/jb/mvt099. Epub 2013 Oct 31.
Specific mtDNA mutations in mouse carcinoma cells suppress their tumor formation via activation of the host innate immune system.
Imanishi H, Takibuchi G, Kobayashi T, Ishikawa K, Nakada K, Mori M, Kikkawa Y, Takenaga K,Toyama-Sorimachi N, Hayashi J.
PLoS One. 2013 Sep 30;8(9):e75981. doi: 10.1371/journal.pone.0075981.
Polymorphic mutations in mouse mitochondrial DNA regulate a tumor phenotype.
Takibuchi G, Imanishi H, Morimoto M, Ishikawa K, Nakada K, Toyama-Sorimachi N, Kikkawa Y, Takenaga K, Hayashi J.
Mitochondrion. 2013 Nov;13(6):881-7. doi: 10.1016/j.mito.2013.07.117. Epub 2013 Aug 6.
A clonogenic progenitor with prominent plasmacytoid dendritic cell developmental potential.
Onai N, Kurabayashi K, Hosoi-Amaike M, Toyama-Sorimachi N, Matsushima K, Inaba K, Ohteki T.
Immunity. 2013 May 23;38(5):943-57. doi: 10.1016/j.immuni.2013.04.006. Epub 2013 Apr 25.
Ly49Q positively regulates type I IFN production by plasmacytoid dendritic cells in an immunoreceptor tyrosine-based inhibitory motif-dependent manner.
Rahim MM, Tai LH, Troke AD, Mahmoud AB, Abou-Samra E, Roy JG, Mottashed A, Ault N, Corbeil C, Goulet ML, Zein HS, Hamilton-Valensky M, Krystal G, Kerr WG, Toyama-Sorimachi N, Makrigiannis AP.
J Immunol. 2013 Apr 15;190(8):3994-4004. doi: 10.4049/jimmunol.1200873. Epub 2013 Mar 11.
2012年以前の発表論文はこちら
日本語総説
1.田口友彦、小林俊彦、反町典子、仁木隆裕：リポクオリティ認識プローブ
の開発と応用：実験医学増刊号 36巻10号 羊土社2018年6月
2. 反町典子、小林俊彦：エンドリソソーム環境に依存した自然免疫応答偏向 ：医学のあゆみ 第５土曜特集 265巻13号医歯薬出版 2018年6月
3. 小林俊彦、向井康治朗、田口友彦、反町典子：炎症・感染応答を担うオルガネラ：臨床免疫・アレルギー科69巻1号 pp99-106. 科学評論社 2018年1月
4. 小林俊彦、反町典子：リソソーム環境が担う炎症シグナルと自己免疫疾患の病態: 実験医学増刊号 33巻12号 羊土社2015年7月
5. 小林俊彦、反町典子：細胞内アミノ酸輸送に依存した新たなTLRシグナル制御機構: 細胞工学 34巻6号 pp557-561. 秀潤社2015年
学会・講演会
48 th Annual Meeting of Japan Society for Immunology[Dec 2019, Hamamatsu, Japan]
Nguyen-Tien D, Kobayashi T, Toyama-Sorimachi N. SLC15A3 inhibits autophagy in macrophage and dendritic cells
[Oral/Poster]
Toyama-Sorimachi N, Taguchi T. Cis-interaction between NK receptor and MHC class I mediates bulk phagocytosis in macrophages [Poster]
Kobayashi T, Nguyen-Tien Dat, Toyama-Sorimachi N. Unique role of an oligopeptide transporter SLC15A3 in the lung inflammation and resolution [Oral/Poster]
9 th FAOPS Congress
[Mar 2019, Kobe, Japan] Kobayashi T and Toyama-Sorimachi N. Controlling the innate immune responses by the lysosome-resident oligopeptide transporters. [Symposium]
47 th Annual Meeting of Japan Society for Immunology
[Dec 2018, Fukuoka, Japan] Kobayashi T, Tsutsui H, Toyama-Sorimachi N. Regulation of allergic inflammation by non-canonical type I interferon signaling [Oral/Poster]
6th Annual Meeting of the International Cytokine & Interferon Society (Cytokines 2018)
[Oct 2018, Boston, USA]
Kobayashi T, Tsutsui H, Toyama-Sorimachi N.
Regulation of the allergic inflammation by non-canonical type I interferon signaling. [Poster]
日本薬学会 第138年会
[2018.3.25-28 金沢]
反町典子
トランスポータータンパク質を標的とした自己免疫疾患治療薬の探索
[シンポジウム]
46th Annual Meeting of Japan Society for Immunology
[Dec 2017, Sendai, Japan]
Kobayashi T, Tsutsui H, Ohshima D, Toyama-Sorimachi N.
Regulatory role of an oligopeptide transporter SLC15A3 during the systemic inflammation. [Oral/Poster]
日本薬物動態学会 第32回年会
[2017.11.30 東京]
反町典子
全身性エリテマトーデスの治療標的としてのリソソーム局在型アミノ酸トランスポーターSLC15A4 [シンポジウム]
5th Annual Meeting of the International Cytokine and Interferon Society (Cytokines 2017)
[Oct-Nov 2017, Kanazawa, Japan]
Kobayashi T, Tsutsui H, Ohshima D, Toyama-Sorimachi N.
Regulatory role of a lysosome-resident oligopeptide transporter SLC15A4 in the inflammatory responses of mast cells. [Poster]
16th International Congress of Immunology
[Aug 2016, Melbourne Convention & Exhibition Centre, Melbourne, Australia]
Kobayashi T, Ohshima D, Toyama-Sorimachi N.
Regulatory role of an oligopeptide transporter SLC15A4 in the inflammatory responses in mast cells. [Oral]
Gordon Research Conference; Membrane Transport Proteins
[Jun 2016, Barga, Lucca, Italy]
Kobayashi T, Ohshima D, Toyama-Sorimachi N.
Oligopeptide transporter SLC15A4 regulates the allergic reactions by controlling mast cells’ homeostasis and inflammatory responses.
[Oral/Poster]
89th Annual Meeting of Japanese Society for Bacteriology
[Mar 2016, Osaka, Japan]
Handa Y, Toyama-Sorimachi N.
Role of inhibitory receptor Ly49Q on SCV formation and inflammatory response triggered by Salmonella
[Poster]
「オートファジーを誘導するペプチドとその治療薬としての可能性」
小路 早苗
2015.8.7 同志社大学
44th Annual meeting of Japan Society for Immunology
[Nov 2015, Sapporo, Japan].
Kobayashi T, Ohshima D, Toyama-Sorimachi N.
The Histidine transporter SLC15A4 regulates allergic responses by tuning the endo/lysosomal condition of mast cells.
[Oral/Poster]
Machida A, Kobayashi T, Toyama-Sorimachi N.
A possible involvement of endo-exocytosis coupling machinery in granule-dependent NK cytotoxicity.
[Poster]
Handa Y, Toyama-Sorimachi N.
A cis-interacting MHC class I receptor, Ly49Q mediates macropinocytic uptake of extracellular antigens.
[Oral/Poster]
Toyama-Sorimachi N, Handa Y.
MHC class I and its cis-interacting receptor shape GPCR signaling platform and orchestrate neutrophil chemotaxis.
[Oral/Poster]
43rd Annual meeting of Japan Society for Immunology
[Dec 2014, Kyoto, Japan].
Kobayashi T, Toyama-Sorimachi N.
SLC15A4 regulates TLR7/9-triggered type I interferon responses coordinating mTORC activity at lysosome.
[Oral/Poster]
Toyama-Sorimachi N, Kobayashi T.
A lysosomal oligopeptide transporter SLC15A4 regulates homeostasis and inflammatory responses of mast cells.
[Poster]
Handa Y, Toyama-Sorimachi N.
An ITIM-bearing receptor Ly49Q regulates actin cytoskeleton by controlling Rac activity.
[Oral/Poster]