過去の業績
2012年以前発表論文過去の学会・講演会
2012年以前発表論文
Spi-B is critical for plasmacytoid dendritic cell function and development.Sasaki I, Hoshino K, Sugiyama T, Yamazaki C, Yano T, Iizuka A, Hemmi H, Tanaka T, Saito M, Sugiyama M, Fukuda Y, Ohta T, Sato K, Ainai A, Suzuki T, Hasegawa H, Toyama-Sorimachi N, Kohara H, Nagasawa T, Kaisho T.
Blood. 2012 Dec 6;120(24):4733-43.
The solute carrier family 15A4 regulates TLR9 and NOD1 functions in the innate immune system and promotes colitis in mice.
Sasawatari S, Okamura T, Kasumi E, Tanaka-Furuyama K, Yanobu-Takanashi R, Shirasawa S, Kato N, Toyama-Sorimachi N.
Gastroenterology. 2011 May;140(5):1513-25.
The innate immune system in host mice targets cells with allogenic mitochondrial DNA.
Ishikawa K, Toyama-Sorimachi N, Nakada K, Morimoto M, Imanishi H, Yoshizaki M, Sasawatari S, Niikura M, Takenaga K, Yonekawa H, Hayashi J.
J Exp Med. 2010 Oct 25;207(11):2297-305.
Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy.
Ojima K, Kawabata Y, Nakao H, Nakao K, Doi N, Kitamura F, Ono Y, Hata S, Suzuki H, Kawahara H, Bogomolovas J, Witt C, Ottenheijm C, Labeit S, Granzier H, Toyama-Sorimachi N, Sorimachi M, Suzuki K, Maeda T, Abe K, Aiba A, Sorimachi H.
J Clin Invest. 120(8):2672-83, 2010
Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense.
Hata, S., Abe, M., Suzuki, H., Kitamura, F., Toyama-Sorimachi, N., Abe, K., Sakimura, K., and Sorimachi, H.
PLoS Genetics 6:e1001040, 2010
Ly49Q, an ITIM-bearing NK receptor, positively regulates osteoclast differentiation.
Hayashi M, Nakashima T, Kodama T, Makrigiannis AP, Toyama-Sorimachi N, Takayanagi H.
Biochem Biophys Res Commun. 393:432-438, 2010
The Ly49Q receptor plays a crucial role in neutrophil polarization and migration by regulating raft trafficking.
Sasawatari S, Yoshizaki M, Taya C, Tazawa A, Furuyama-Tanaka K, Yonekawa H, Dohi T, Makrigiannis AP, Sasazuki T, Inaba K, Toyama-Sorimachi N.
Immunity. 2010 Feb 26;32(2):200-13.
Spatiotemporal regulation of intracellular trafficking of Toll-like receptor 9 by an inhibitory receptor, Ly49Q.
Yoshizaki M, Tazawa A, Kasumi E, Sasawatari S, Itoh K, Dohi T, Sasazuki T, Inaba K, Makrigiannis AP, Toyama-Sorimachi N.
Blood. 2009 Aug 20;114(8):1518-27.
Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC.
Tai LH, Goulet ML, Belanger S, Toyama-Sorimachi N, Fodil-Cornu N, Vidal SM, Troke AD, McVicar DW, Makrigiannis AP.
J Exp Med. 2008 Dec 22;205(13):3187-99.
過去の学会・講演会
43rd Annual meeting of Japan Society for Immunology[Dec 2014, Kyoto, Japan].
Kobayashi T, Toyama-Sorimachi N.
SLC15A4 regulates TLR7/9-triggered type I interferon responses coordinating mTORC activity at lysosome.
[Oral/Poster]
Toyama-Sorimachi N, Kobayashi T.
A lysosomal oligopeptide transporter SLC15A4 regulates homeostasis and inflammatory responses of mast cells.
[Poster]
Handa Y, Toyama-Sorimachi N.
An ITIM-bearing receptor Ly49Q regulates actin cytoskeleton by controlling Rac activity.
[Oral/Poster]
42nd Annual meeting of Japan Society for Immunology
[Dec 2013 , Makuhari, Chiba, Japan].
Kobayashi T, Toyama-Sorimachi N.
SLC15A4 regulates IgG2a autoantibody production through IRF7-type I IFN activation loop in B cells.
[Oral/Poster]
15th International Congress of Immunology
[August 2013, Milan, Italy].
Toyama-Sorimachi N, Tanaka M, Kobayashi T, Makrigiannis AP, Inaba K.
The inhibitory NK receptor Ly49Q protects plasmacytoid dendritic cells from TLR9-triggering cell death by assuring lysosomal integrity.
[Oral]
Kobayashi T, Okamura T, Toyama-Sorimachi N.
Lysosomal oligopeptide transporter SLC15A4 regulates Toll-like receptor 7/9-mediated autoantibody production.
[Oral]
Kobayashi T, Toyama-Sorimachi N.
Lysosomal transporter SLC15A4 regulates TLR7/9-mediated antibody production.
Presented at Immunology 2013, May 2013, Honolulu, HI, USA.