『経口AMPA受容体拮抗剤による筋萎縮性側索硬化症(ALS)の治療法確立~孤発性ALS分子病態モデルマウスへの長期投与試験~』
Akamatsu M, Yamashita T, Hirose N, Teramoto S, Kwak S: The AMPA receptor antagonist perampanel robustly rescues amyotrophic lateral sclerosis (ALS) pathology in sporadic ALS model mice. Sci Rep. 6: 28649, 2016. doi: 10.1038/srep28649.
『マウスにおける筋萎縮側索硬化症の遺伝子治療実験に成功~孤発性筋萎縮側索硬化症の根本治療へ向けた大きなステップ』
Yamashita T, Chai HL, Teramoto S, Tsuji S, Shimazaki K, Muramatsu S, Kwak S: Rescue of amyotrophic lateral sclerosis phenotype in a mouse model by intravenous AAV9-ADAR2 delivery to motor neurons.EMBO Molecular Medicine
『筋萎縮側索硬化症ALSに特異的病理変化の謎解明~変異AMPA受容体により活性化されたカルパインが TDP-43を切断』
Yamashita T, Hideyama T, Hachiga K, Teramoto S, Takano J, Iwata N, Saido TC, and Kwak S: A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology. Nature Communications
『孤発性筋萎縮側索硬化症のモデルマウスの開発~グルタミン酸受容体のポストゲノム装飾(RNA編集)の缺陥』
Hideyama T, Yamashita T, Suzuki T, Tsuji S, Higuchi M, Seeburg PH, Takahashi R, Misawa H, Kwak S: Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2. The Journal of Neuroscience
Aizawa H, Sawada J, Hideyama T, Yamashita T, Katayama T, Hasebe N, KimuraT, Yahara O, Kwak S: TDP-43 pathology in sporadic ALS occurs in motor neurons lacking RNA editing enzyme ADAR2. Acta Neuropathologica
『微弱電流刺激で病状改善』
Yamamoto Y, Struzik ZR, Soma R, Ohashi K, Kwak S: Noisy vestibular stimulation improves autonomic and motor responsiveness in central neuro-degenerative disorders. Annals of Neurology
Kawahara Y, Ito K, Sun H, Aizawa H, Kanazawa I, Kwak S: RNA editing and death of motor neurons. Nature
Takuma H, Kwak S, Yoshizawa T, Kanazawa I: Reduction of GluR2 RNA editing, a molecular change that increases calcium influx through AMPA receptors, selective in the spinal ventral gray of patients with amyotrophic lateral sclerosis. Annals Neurology