Research

Our aim is to develop mechanism-based specific therapy for sporadic amyotrophic lateral sclerosis (ALS), in which RNA editing activity is efficient in the motor neurons.

News＆Topics

  • November, 2018
    Presentation on the title of ”Target therapy for ALS with RNA aptamers ?rescue of ALS phenotype resulting from loss of motor neurons with TDP-43 pathology in ALS model mice ”at The 49th Annual Meeting Society for Neuroscience San Diego, 2018.11.4. (Akamatsu, M)
  • November, 2018
    Presentation on the title of ”ADAR2-mediated RNA editing of extracellular liner and circular RNAs: a potential biomarker of amyotrophic lateral sclerosis ”at the The 49th Annual Meeting Society for Neuroscience San Diego, 2018.11.3.(Hosaka, T)
  • November, 2018
    Presentation on the title of ”A aptamer as a potential drug candidate for ALS ? rescue of clinicopathologic ALS phenotype in model mice ”at the Neurobiology of Disease, San Diego, 1-2 November 2018.(Akamatsu, M)
  • November, 2018
    Presentation on the title of ”ADAR2-dependent A-to-I RNA editing in the extracellular linear and circular RNAs ” Neurobiology of Disease,at the Neurobiology of Disease, San Diego, 1-2 November 2018.(Hosaka, T)
  • June, 2018
    Presentation on the title of ”Development of ALS therapy using AMPA receptor RNA aptamers ”at the 4th EAN Congress, Lisbon 16-19 (16) . 2018.6. (Kwak, S)
  • September, 2017
    Presentation on the title of ”SEARCH FOR ALS-ASSOCIATED EXTRACELLULAR RNA AS A BIOMARKER ” at the WCN2017: XXIII World Congress of Neurology, Kyoto International Conference Center, Japan, September 17, 2017. (Hosaka, T)
  • September, 2017
    【Press Release】”Calpain-dependent disruption of nucleo-cytoplasmic transport in ALS motor neurons "January 18, 2017. (Yamashita, T)
  • December, 2016
    Presentation on the title of ”ROBUST BENEFICIAL EFFECTS OF A NON-COMPETITIVE AMPA RECEPTOR ANTAGONIST IN AN ALS MOUSE MODEL "at The 27thInternational Symposium on ALS/MND, Convention Centre Dublin, Ireland, December 8, 2016. (Akamatsu, M)
  • November, 2016
    Presentation on the title of ”A selective non-competitive AMPA receptor antagonist as a potential drug for sporadic amyotrophic lateral sclerosis (ALS) -rescue of motor dysfunctions and loss of motor neurons with TDP-43 pathology in ALS model mice ” at the Society for Neuroscience 2016, San Diego Convention Center, USA, November 13, 2016. (Akamatsu, M)
  • November, 2016
    Presentation on the title of ”Death of motor neurons caused by failure of GluA2 RNA editing was robustly rescued by a selective AMPA receptor antagonist in the mechanistic ALS model mice: a potential drug for sporadic amyotrophic lateral scleroses(ALS) ” at the 10th , Paradise Point, USA, November 10, 2016. (Akamatsu, M)
  • July, 2016
    【Press Release】”The AMPA receptor antagonist perampanel robustly rescues amyotrophic lateral sclerosis (ALS) pathology in sporadic ALS model mice ”July 13, 2016. (Akamatsu, M)
  • February, 2016
    Special Lecture on the title of ”Development of specific therapy for sporadic ALS“ at【3rd World Centenarians Initiative】International Symposium on Amyotrophic Lateral Sclerosis, at Senri Life Science Center , JAPAN, February 19, 2016. (Kwak, S)
  • December, 2014
    Presentation on the title of ”ADAR2 down-regulation, a pathogenesis of ALS and a target for therapy "The Batsheva de Rothschild Seminar on RNA Editing-From Prediction to Function" in RNA editing workshop, at Ein Gedi Resort Hotel, Israel, December 7-10, 2014. (Kwak, S)
  • September, 2014
    Updated the link.
  • August, 2014
    Special Lecture on the title of ”Mechanism-based gene therapy for ALS“ at the 5th ALS Forum, at Sheraton Miyako Hotel Tokyo, Tokyo, August 23, 2014. (Kwak, S)
  • June, 2014
    Presentation on the tiile of ”Calpain Plays a Crucial Role in TDP-43 Pathology “ in the symposium of ”Progress of TDP-43 research“ at 55th Annual Meeting of the Japanese Society of Neurology, Fukuoka, May 21,2014.(Yamashita, T)
  • March, 2014
    Special lecture on the title of ”A Step for Mechanism-Based ALS Therapy“ at the International Symposium of ”New Frontier of Molecular Neuropathology 2014“, Tokyo, March 16-17, 2014. (Kwak, S)