Publications

  1. Early Growth Response Gene 2-Expressing CD4(+)LAG3(+) Regulatory T Cells: The Therapeutic Potential for Treating Autoimmune Diseases. 
    Okamura T, Yamamoto K, Fujio K.;
    Front Immunol. 2018;9:340.(2018)[PubMed]
  2. Egr2-independent, Klf1-mediated induction of PD-L1 in CD4+ T cells. 
    Teruya S, Okamura T, Komai T, Inoue M, Iwasaki Y, Sumitomo S, Shoda H, Yamamoto K, Fujio K.;
    Sci Rep. 2018;8(1):7021.(2018)[URL]
  3. Transforming Growth Factor-β and Interleukin-10 Synergistically Regulate Humoral Immunity via Modulating Metabolic Signals. 
    Komai T, Inoue M, Okamura T, Morita K, Iwasaki Y, Sumitomo S, Shoda H, Yamamoto K, Fujio K.;
    Front Immunol. 2018;9:1364.(2018)[PubMed]
  4. Reevaluation of Pluripotent Cytokine TGF-β3 in Immunity. 
    Komai T, Okamura T, Inoue M, Yamamoto K, Fujio K.;
    Int J Mol Sci. 2018;19(8). pii: E2261.(2018)[PubMed]
  5. Novel chemical compound SINCRO with dual function in STING-type I interferon and tumor cell death pathways.
    Kimura Y., Negishi H., Matsuda A., Endo N., Hangai S., Inoue A., Nishio J., Taniguchi T., Yanai H.;
    Cancer Sci.     2018 Jul 7. doi: 10.1111/cas.13726. [Epub ahead of print] [PubMed]
  6. Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice.
    Yanai H, Chiba S, Hangai S, Kometani K, Inoue A, Kimura Y, Abe T, Kiyonari H, Nishio J, Taguchi-Atarashi N, Mizushima Y, Negishi H, Grosschedl R, Taniguchi T.;
    Proc Natl Acad Sci U S A.     2018 May 15;115(20):5253-5258. doi: 10.1073/pnas.1803936115 [PubMed]
  7. The Interferon (IFN) Class of Cytokines and the IFN Regulatory Factor (IRF) Transcription Factor Family.
    Negishi H, Taniguchi T, Yanai H.;
    Cold Spring Harb Perspect Biol. 2017 Sep 29. pii: a028423. [Epub ahead of print]. doi: 10.1101/cshperspect.a028423 [CSH]
  8. Yanai H, Taniguchi T. (2017) Fine-tuning type I IFN signaling: A new chapter in the IFN saga.
    Cell Res.27:1407-1408. doi: 10.1038/cr.2017.118 [PubMed]
  9. Gallbladder-derived surfactant protein D regulates gut commensal bacteria for maintaining intestinal homeostasis.
    Sarashina-Kida H, Negishi H, Nishio J, Suda W, Nakajima Y, Yasui-Kato M, Iwaisako K, Kang S, Endo N, Yanai H, Asagiri M, Kida H, Hattori M, Kumanogo A, and Taniguchi T.;
    Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10178-10183. doi: 10.1073/pnas.1712837114. [PubMed]
  10. Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins.
    Hayashi T, Senda M, Suzuki N, Nishikawa H, Ben C, Tang C, Nagase L, Inoue K, Senda T, Hatakeyama M.;
    Cell Rep. 2017 Sep 19;20(12):2876-2890.doi:10.1016/j.celrep.2017.08.080. [PubMed]
  11. Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity. 
    Ban T., Sato G.R., Nishiyama A., Akiyama A., Takasuna M., Umehara M., Suzuki S., Ichino M., Matsunaga S., Kimura A., Kimura Y., Yanai H., Miyashita S., Kuromitsu J., Tsukahara K., Yoshimatsu K., Endo I., Yamamoto T., Hirano H., Ryo A., Taniguchi T., Tamura T;
    Immunity, 45, 319-332.(2016) doi: 10.1016/j.immuni.2016.07.015[PubMed]
  12. A novel pegylated IFN-β as strong suppressor of the malignant ascites in a peritoneal metastasis model of human cancer. (2017) 
    Iwamura T., Narumi H., Suzuki T., Yanai H., Mori K., Yamashita K., Tsushima Y., Asano T., Izawa A., Momen S., Nishimura K., Tsuchiyama H., Uchida M., Yamashita Y., Okano K., Taniguchi T.;
    Cancer Science, doi: 10.1111/cas.13176. [Epub ahead of print][PubMed]
  13. Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways
    Kikuchi I, Takahashi-Kanemitsu A, Sakiyama N, Tang C, Tang P, Noda S, Nakao K, Kassai H, Sato T, Aiba A & Hatakeyama M; 
    NATURE COMMUNICATIONS, 7:12887(2016) DOI: 10.1038/ncomms12887[PubMed] [PDF]
  14. Impact of structural polymorphism for the Helicobacter pylori CagA oncoprotein on binding to polarity-regulating kinase PAR1b
    Nishikawa H, Hayashi T, Arisaka F, Senda T & Hatakeyama M;
    Scientific Reports, 6:30031 (2016), DOI: 10.1038/srep30031[PubMed] [PDF]
  15. PGE2 induced in and released by dying cells functions as an inhibitory DAMP.
    Hangai S, Ao T, Kimura Y, Matsuki K, Kawamura T, Negishi H, Nishio J, Kodama T, Taniguchi T, and Yanai H.;
    Proc. Natl. Acad. Sci. U S A.2016 April 5;113(14):3844-49(2016).[PubMed]
  16. S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell Q:1 interferon-α autoamplification. 
    Teijaro JR, Studer S, Leaf N, Kiosses WB, Nguyen N, Matsuki K, Negishi H, Taniguchi T, Oldstone MB, Rosen H.;
    Proc. Natl. Acad. Sci. U S A.2016 Feb 2;113(5):1351-6. (2016).[PubMed]
  17. Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice.  
    Arai S, Kitada K, Yamazaki T, Takai R, Zhang X, Tsugawa Y, Sugisawa R, Matsumoto A, Mori M, Yoshihara Y, Doi K, Maehara N, Kusunoki S, Takahata A, Noiri E, Suzuki Y, Yahagi N, Nishiyama A, Gunaratnam L, Takano T and Miyazaki T; 
    Nat. Med. 2016 Feb;22(2):183-93. doi: 10.1038/nm.4012 (2016).[PubMed]
  18. Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin 
    Maike Frye, Martina Dierkes, Verena Küppers, Matthias Vockel, Janina Tomm,Dagmar Zeuschner, Jan Rossaint, Alexander Zarbock, Gou Young Koh,Kevin Peters, Astrid Fee Nottebaum, Dietmar Vestweber;
    JEM Vol.212, No.13. 2267-2287 (2015). [PubMed]
  19. Multi-facet contribution of the TLR4-activated IRF5 transcription factor in systemic sclerosis
    Ryosuke Saigusa, Yoshihide Asano, Takashi Taniguchi, Takashi Yamashita,Yohei Ichimura, Takehiro Takahashi, Tetsuo Toyama, Ayumi Yoshizaki, Koji Sugawara, Daisuke Tsuruta, Tadatsugu Taniguchi (corr-auth), Shinichi Sato;
    Proc. Natl. Acad. Sci. U S A.Dec 8;112(49):15136-41. [PubMed]
  20. Role of TGF-β3 in the regulation of immune responses.
    Okamura T, Morita K, Iwasaki Y, Inoue M, Komai T, Fujio K, Yamamoto K.;
    Clin Exp Rheumatol. 2015 Sep-Oct;33(4 Suppl 92):63-9. Epub 2015 Oct 12. Review. [PubMed]
  21. Requirement of full TCR repertoire for regulatory T cells to maintain intestinal homeostasis. 
    Nishio J, Baba M, Atarashi K, Tanoue T, Negishi H, Yanai H, Habu S, Hori S, Honda K and Taniguchi T.;
    Proc. Natl. Acad. Sci. U S A. 41.12770-12775 (2015) [PubMed]
  22. Quantitative Measurement of GPCR Endocytosis via Pulse-Chase Covalent Labeling.
    Kumagai H, Ikeda Y, Motozawa Y, Fujishiro M, Okamura T, Fujio K, Okazaki H, Nomura S, Takeda N, Harada M, Toko H, Takimoto E, Akazawa H, Morita H, Suzuki J, Yamazaki T, Yamamoto K, Komuro I, Yanagisawa M.;
    PLoS One. 2015 May 28;10(5):e0129394. doi: 10.1371/journal.pone.0129394. eCollection 2015. [PubMed]
  23. TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses.
    Okamura T, Sumitomo S, Morita K, Iwasaki Y, Inoue M, Nakachi S, Komai T, Shoda H, Miyazaki J, Fujio K, Yamamoto K.;
    Nat Commun. 2015 Feb 19;6:6329. doi: 10.1038/ncomms7329. [PubMed]
  24. Circulating AIM prevents hepatocellular carcinoma through complement activation. 
    Maehara N, Arai S, Mori M, Iwamura Y, Kurokawa J, Kai T, Kusunoki S, Taniguchi K, Ikeda K, Ohara O, Yamamura K and Miyazaki T.; 
    Cell Rep. 9: 61-74 (2014).[PubMed]
  25. Circulating AIM as an indicator of liver damage and hepatocellular carcinoma in humans. 
    Yamazaki T, Mori M, Arai S, Tateishi R, Abe M, Ban M, Nishijima A, Maeda M, Asano T, Kai T, Izumino K, Takahashi J, Aoyama K, Harada S, Takebayashi T, Gunji T, Ohnishi S, Seto S, Yoshida Y, Hiasa Y, Koike K, Yamamura K, Inoue K and Miyazaki T.;
    PLoS One. 9: e109123 (2014).[PubMed]
  26. Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses.
    Chiba S, Ikushima H, Ueki H, Yanai H, Kimura Y, Hangai S, Nishio J, Negishi H, Tamura T, Saijo S, Iwakura Y, Taniguchi T.;
    eLife 3. e04177 (2014). [PubMed]
  27. Nucleic acid sensing and beyond: virtues and vices of HMGB1.
    Yanai H, Taniguchi T.;
    J. Intern. Med. 276. 444-53. (2014). [PubMed]
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