研究業績

2024

• Enomoto S, Nakatsuka S, Kuwayama T, Kawatsu K, Yokogawa M, and Osawa M. “NMR 1H, 13C, 15N backbone resonance assignments of 14-3-3ζ binding region of human FOXO3a (residues 1-284)”Biomolecular NMR Assignments (2024)1-9, doi:10.1007/s12104-024-10200-7

• Stillinovic M, Sarangdhar M. A., Andina N, Tardivel A, Greub F, Bombaci G, Ansermet C, Zatti M, Saha D, Xiong J, Sagae T, Yokogawa M, Osawa M, Heller M, Keogh A, Keller I, Angelillo-Scherrer A, and Allam R. “Ribonuclease inhibitor and angiogenin system regulates cell type-specific global translation”Science Advances(2024)10(22), doi:10.1126/sciadv.adl0320

2023

• Shimizu Y, Ohta M, Ishida S, Terayama K, Osawa M, Honma T, and Ikeda K. “AI-driven molecular generation of not-patented pharmaceutical compounds using world open patent data”Journal of Cheminformatics(2023)15(1), doi:10.1186/s13321-023-00791-z

• Tsuchiya Y, Yonezawa T, Yamamori Y, Inoura H, Osawa M, Ikeda K, and Tomii K. “PoSSuM v.3: A Major Expansion of the PoSSuM Database for Finding Similar Binding Sites of Proteins”Journal of Chemical Information and Modeling(2023) doi:10.1021/acs.jcim.3c01405.

• Miura M, Sakaue F, Matsuno H, Morita K, Yoshida A, Hara RI, Nishimura R, Nishida Y, Yokogawa M, Osawa M, and Yokota T. “TDP-43 N-terminal domain dimerisation or spatial separation by RNA binding decreases its propensity to aggregate”FEBS Letters(2023)doi: 10.1002/1873-3468.14635.

• Shimizu Y, Yonezawa T, Bao Y, Sakamoto J, Yokogawa M, Furuya T, Osawa M, and Ikeda K. “Applying deep learning to iterative screening of medium-sized molecules for protein-protein interaction-targeted drug discovery”Chemical Communications(2023)doi: 10.1039/d3cc01283b.

• 米澤朋起、池田和由、「化合物ライブラリーの情報検索におけるポイント」、『ケモインフォマティクスにおけるデータ収集の最適化と解析手法　-　組成予測や化学構造の生成、合成経路探索や反応条件最適化、毒性評価』 技術情報協会(2023)第８章 医薬品開発への活用事例　７節

2022

• Ikeda K, Maezawa Y, Yonezawa T, Shimizu Y, Tashiro T, Kanai S, Sugaya N, Masuda Y, Inoue N, Niimi T, Masuya K, Mizuguchi K, Furuya T and Osawa M. “DLiP-PPI library: An integrated chemical database of small-to-medium-sized molecules targeting protein-protein interactions”Frontiers in Chemistry(2022)10

• 清水祐吾、米澤朋起、池田和由、「AI創薬における適切な学習データとは？」、『革新的AI創薬 : 医療ビッグデータ、人工知能がもたらす創薬研究の未来像』 エヌ・ティー・エス(2022)小長谷明彦 監修、第2章　第5節

• Sagae T, Yokogawa M, Sawazaki R, Ishii Y, Hosoda N, Hoshino S, Imai S, Shimada I, and Osawa M. “Paip2A inhibits translation by competitively binding to the RNA recognition motifs of PABPC1 and promoting its dissociation from the poly(A) tail” Journal of Biological Chemistry(2022)298(5), 101844

2021

• Ikeda K, Kezuka Y, Nonaka T, Yonezawa T, Osawa M, and Katoh E. “Comprehensive Approach of 19F Nuclear Magnetic Resonance, Enzymatic, and In Silico Methods for Site-Specific Hit Selection and Validation of Fragment Molecules that Inhibit Methionine γ-Lyase Activity” Journal of Medicinal Chemistry(2021)64(19), 14299-14310

• Matsumura K, Yokogawa M, Osawa M. “Peptide Toxins Targeting KV Channels” Handbook of Experimental Pharmacology. Springer, Berlin, Heidelberg(2021)1-25

• Shimizu Y, Yonezawa T, Sakamoto J, Furuya T, Osawa M, Ikeda K. "Identification of novel inhibitors of Keap1/Nrf2 by a promising method combining protein-protein interaction-oriented library and machine learning" Scientific Reports(2021)7420

• Matsumura K, Shimomura T, Kubo Y, Oka T, Kobayashi N, Imai S, Yanase N, Akimoto M, Fukuda M, Yokogawa M, Ikeda K, Kurita J, Nishimura Y, Shimada I, Osawa M. "Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization" BMC Mol. Cell Biol.(2021)22:3

2020

• Iwahashi Y, Toyama Y, Imai S, Itoh H, Osawa M, Inoue M, Shimada I. "Conformational equilibrium shift underlies altered K+ channel gating as revealed by NMR" Nat Commun.(2020)Oct 14;11(1):5168. doi: 10.1038/s41467-020-19005-3. PMID: 33057011 Free PMC article.
• Kato Y, Kunimasa K, Takahashi M, Harada A, Nagasawa I, Osawa M, Sugimoto Y, Tomida A. "GZD824 Inhibits GCN2 and Sensitizes Cancer Cells to Amino Acid Starvation Stress" Mol Pharmacol.(2020)Dec;98(6):669-676. doi: 10.1124/molpharm.120.000070. Epub 2020 Oct 8. PMID: 33033108

2019

• Kano H, Toyama Y, Imai S, Iwahashi Y, Mase Y, Yokogawa M, Osawa M, and Shimada I. "Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel" Nat Commun. (2019)10, 1-13
• Yokogawa M, Fukuda M, and Osawa M. "Nanodiscs for Structural Biology in a Membranous Environment" Chem Pharm Bull (Tokyo) (2019)67(4), 321-326.

2018

• Maruyama T, Imai S, Kusakizako T, Hattori M, Ishitani R, Nureki O, Ito K, Maturana AD, Shimada I, and Osawa M. "Functional roles of Mg²⁺ binding sites in ion-dependent gating of a Mg²⁺ channel, MgtE, revealed by solution NMR" eLIFE (2018)7, e31596.
• Toyama Y, Kano H, Mase Y, Yokogawa M, Osawa M, and Shimada I. "Structural basis for the ethanol action on G-protein-activated inwardly rectifying potassium channel 1 revealed by NMR spectroscopy." Proc Natl Acad Sci USA (2018)115(15), 3858-3863.
• Sawazaki R, Imai S, Yokogawa M, Hosoda N, Hoshino S, Mio M, Mio K, Shimada I, and Osawa M. "Characterization of the multimeric structure of poly(A)-binding protein on a poly(A) tail."
  Sci. Rep.(2018) 8(1), 1455.
• Toyama Y, Mase Y, Kano H, Yokogawa M, Osawa M, and Shimada I. "Nuclear magnetic resonance approaches for characterizing protein-protein interactions", Methods Mol Biol. (2018) 1684, 115-128.
• 岡村康司, 大澤匡範　"脂質ーイオンチャネル相互連関"　実験医学増刊 Vol.36 No.10 脂質クオリティ~生命機能と健康を支える脂質の多様性 (2018)

2017

• Tomita A, Zhang M, Jin F, Zhuang W, Takeda H, Maruyama T, Osawa M, Hashimoto KI, Kawasaki H, Ito K, Dohmae N, Ishitani R, Shimada I, Yan Z, Hattori M, and Nureki O. "ATP-dependent modulation of MgtE in Mg²⁺ homeostasis."
  Nat Commun.(2017)8(1), 148.
• Toyama Y, Kano H, Mase Y, Yokogawa M, Osawa M, and Shimada I. "Dynamic regulation of GDP binding to G proteins revealed by magnetic field-dependent NMR relaxation analyses."Nat Commun.(2017) 8, 14523.

2016

• Nozaki T, Ozawa SI, Harada H, Kimura T, Osawa M, and Shimada I. "Disulfide mapping the voltage-sensing mechanism of a voltage-dependent potassium channel."Sci Rep.(2016) 6, 37303.
• Toyama Y, Osawa M, Yokogawa M, and Shimada I. "NMR Method for Characterizing Microsecond-to-Millisecond Chemical Exchanges Utilizing Differential Multiple-Quantum Relaxation in High Molecular Weight Proteins" J Am Chem Soc. (2016) 138(7), 2302-11.

2015

• Ozawa S, Kimura T, Nozaki T, Harada H, Shimada I, and Osawa M. "Structural basis for the inhibition of voltage-dependent K⁺ channel by gating modifier toxin" Sci Rep. (2015), 14226.
• Marshall C B, Nishikawa T, Osawa M, Stathopulos P B, and Ikura M. "Calmodulin and STIM proteins: Two major calcium sensors in the cytoplasm and endoplasmic reticulum" Biochem Biophys Res Commun. (2015) 460(1), 5-21

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