Publications

2018 | 2017 | 2016 | 2015 | 2014 |2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007−

2018

Nakamura Y, Kimura S, Hase K. M cell-dependent antigen uptake on follicle-associated epithelium for mucosal immune surveillance. Inflamm Regen. 3;38:15, 2018
Zai K, Hirota M, Yamada T, Ishihara N, Mori T, Kishimura A, Suzuki K, Hase K, Katayama Y. Therapeutic effect of vitamin D₃-containing nanostructured lipid carriers on inflammatory bowel disease. J Control Release. 28:286:94-102, 2018
Zai K, Ishihara N, Oguchi H, Hirota M, Kishimura A, Mori T, Hase K, Katayama Y. Regulation of inflammatory response of macrophages and induction of regulatory T cells by using retinoic acid-loaded nanostructured lipid carrier. J Biomater Sci Polym Ed. 26:1-22, 2018
Kikuchi K, Iida M, Ikeda N, Moriyama S, Hamada M, Takahashi S, Kitamura H, Watanabe T, Hasegawa Y, Hase K, Fukuhara T, Sato H, Kobayashi EH, Suzuki T, Yamamoto M, Tanaka M, Asano K. Macrophages Switch Their Phenotype by Regulating Maf Expression during Different Phases of Inflammation. J Immunol. 16;43(1):25-39, 2018
Suzuki K, Yamada T, Yamazaki K, Hirota M, Ishihara N, Sakamoto M, Hase K. Intestinal Epithelial Cell-specific Deletion of α-Mannosidase II Ameliorates Experimental Colitis. Cell Struct Funct. 16;43(1):25-39, 2018
Okubo K, Kurosawa M, Kamiya M, Urano Y, Suzuki A, Yamamoto K, Hase K, Homma K, Sasaki J, Miyauchi H, Hoshino T, Hayashi M, Mayadas TN, Hirahashi J. Macrophage extracellular trap formation promoted by platelet activation is a key mediator of rhabdomyolysis-induced acute kidney injury. Nat Med. 24:232-238, 2018

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2017

Date Y, Ebisawa M, Fukuda S, Shima H, Obata Y, Takahashi D, Kato T, Hanazato M, Nakato G, Williams IR, Hase K, Ohno H. NALT M cells are important for immune induction for the common mucosal immune system. Int Immunol. 18;29(10):471-478, 2017
Jinnohara T, Kanaya T, Hase K, Sakakibara S, Kato T, Tachibana N, Sasaki T, Hashimoto Y, Sato T, Watarai H, Kunisawa J, Shibata N, Williams I, Kiyono H, Ohno H. IL-22BP dictates characteristics of Peyer's patch follicle-associated epithelium for antigen uptake. J. Exp. Med. 214(6):1607-1618, 2017
Kim YG, Sakamoto K, Seo SU, Pickard JM, Gillilland MG 3rd, Pudlo NA, Hoostal M, Li X, Wang TD, Feehley T, Stefka AT, Schmidt TM, Martens EC, Fukuda S, Inohara N, Nagler CR, Núñez G. Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens. Science. 356(6335):315-319, 2017
Sakamoto K, Kim YG, Hara H, Kamada N, Caballero-Flores G, Tolosano E, Soares MP, Puente JL, Inohara N, Núñez G. IL-22 controls iron-dependent nutritional immunity against systemic bacterial infections. Science Immunol. 2(8), 2017
Kim YG. Microbiota Influences Vaccine and Mucosal Adjuvant Efficacy. Immune Network. 17(1):20-24.
Yang JY, Lee YS, Kim Y, Lee SH, Ryu S, Fukuda S, Hase K, Yang CS, Lim HS, Kim MS, Kim HM, Ahn SH, Kwon BE, Ko HJ, Kweon MN. Gut commensal Bacteroides acidifaciens prevents obesity and improves insulin sensitivity in mice. Mucosal Immunol. 10: 104-116, 2017

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2016

Ohashi W, Kimura S, Iwanaga T, Furusawa Y, Irié T, Izumi H, Watanabe T, Hijikata A, Hara T, Ohara O, Koseki H, Sato T, Robine S, Mori H, Hattori Y, Watarai H, Mishima K, Ohno H, Hase K, Fukada T. Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress.PLoS Genet. 12: e1006349, 2016
Kimura S, Yamashita M, Yamakami-Kimura M, Sato Y, Yamagata A, Kobashigawa Y, Inagaki F, Amada T, Hase K, Iwanaga T, Ohno H, Fukai S. Distinct Roles for the N- and C-terminal Regions of M-Sec in Plasma Membrane Deformation during Tunneling Nanotube Formation. 2016 Sep 15;6:33548. doi0.1038/srep33548Sci Rep. 2016 Sep 15;6:33548. doi0.1038/srep33548
Nagai M, Obata Y, Takahashi D, Hase K. Fine-tuning of the mucosal barrier and metabolic systems using the diet-microbial metabolite axis. Int. Immunopharmacol.2016 Aug;37:79-86.
Yamada T, Takahashi D, Hase K. The diet-microbiota-metabolite axis regulates the host physiology. J. Biochem. 160(1):1-10, 2016.
Hashimoto M, Bhuyan F, Hiyoshi M, Noyori O, Nasser H, Miyazaki M, Saito T,Kondoh Y, Osada H, Kimura S, Hase K, Ohno H, Suzu S. Potential Role of the Formation of Tunneling Nanotubes in HIV-1 Spread in Macrophages. J Immunol. 196: 1832-41, 2016.
Nakato G, Hase K, Sato T, Kimura S, Sakakibara S, Sugiyama M, Obata Y,Hanazato M, Iwanaga T, Ohno H. Epithelium-Intrinsic MicroRNAs Contribute to Mucosal Immune Homeostasis by Promoting M-Cell Maturation. PLoS One. 11(3):e0150379, 2016.
Li Y, Takahashi Y, Fujii S, Zhou Y, Hong R, Suzuki A, Tsubata T, Hase K, Wang JY. EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity. Nat. Commun. 7:10836, 2016.

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2015

Ohnmacht C, Park JH, Cording S, Wing JB, Atarashi K, Obata Y, Gaboriau-Routhiau V, Marques R, Dulauroy S, Fedoseeva M, Busslinger M, Cerf-Bensussan N, Boneca IG, Voehringer D, Hase K, Honda K, Sakaguchi S, Eberl G. The microbiota regulates type 2 immunity through RORγt+ T cells. Science 349: 989-93, 2015.
Matsumura T, Sugawara Y, Yutani M, Amatsu S, Yagita H，Kohda T, Fukuoka S-I, Nakamura Y, Hase K, *Ohno H and *Fujinaga Y. Botulinum toxin A complex exploits intestinal M cells to enter the host and exert neurotoxicity. Nat. Commun., 6: 6255, 2015
Nakato G, Hase K, Ohno H. Distinct microRNA expression profiles in follicle-associated epithelium and villous epithelium. Genom Data. 5:388-90, 2015.
Takahashi D and *Hase K. Commensal microbiota-derived signals regulate host immune system epigenetics. Inflammation and Regeneration 35: 129-136. 2015.
Obata Y, Furusawa Y, Hase K. Epigenetic modifications of the immune system in health and disease. Immunol. Cell Biol. 93: 226-32, 2015.
Furusawa Y, Obata Y, Hase K. Commensal microbiota regulates T cell fate decision in the gut. Semin Immunopathol. 37:17-25, 2015.
Kimura S, Yamakami-Kimura M, Obata Y, Hase K, Kitamura H, Ohno H, *Iwanaga T. Visualization of the entire differentiation process of murine M cells: suppression of their maturation in cecal patches. Mucosal Immunol. 8: 650-60, 2015.
Obata Y and Hase K. Mucosal Barriology: The molecular machinery and physiological significance of multiple epithelial barriers. Inflammation and Regeneration 35: 3-13, 2015.

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2014

Obata Y, Furusawa Y, Endo TA, Sharif J, Takahashi D, Atarashi K, Onawa S, Fujimura Y, Takahashi M, Ikawa T, Otsubo T, Kawamura YI, Dohi T, Tajima S, Ohara O, Honda K, Hori S, Ohno H, Koseki H and *Hase K. Epigenetic regulator Uhrf1 is critical for functional expansion of colonic regulatory T cells. Nat. Immunol. 15: 571-579, 2014.
Lee WJ and Hase K, Gut microbiota-generated metabolites in animal health and disease. Nat. Chem. Biol. 10:416-24, 2014.
Hanazato M, Nakato G, Nishikawa F, Hase K, Nishikawa S and Ohno H. Selection of an aptamer against mouse GP2 by SELEX. Cell Struct Funct 39: 23-29, 2014.
Furusawa Y, Endo TA, Obata Y, Ohara O, Ohno H, *Hase K. Pitfalls in global normalization of ChIP-seq data in CD4(+) T cells treated with butyrate: A possible solution strategy. Genom Data. 2014 Jun 27;2:176-80.
*Nakatsu F, Hase K, Ohno H. The Role of the Clathrin Adaptor AP-1: Polarized Sorting and Beyond. Membranes. 4: 747-63, 2014.
Obata Y, Kimura S, Nakato G, Iizuka K, Miyagawa Y, Nakamura Y, Furusawa Y, Sugiyama M, Suzuki K, Ebisawa M, Fujimura Y, Yoshida H, Iwanaga T, *Hase K, *Ohno H. Epithelial-stromal interaction via Notch signaling is essential for the full maturation of gut-associated lymphoid tissues. EMBO Rep. 15:1297-304, 2014.

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2013

Furusawa Y, Obata Y, *Fukuda S, Endo TA, Nakato G, Takahashi D, Nakanishi Y, Uetake C, Kato K, Kato T, Takahashi M, Fukuda NR, Murakami M, Miyauchi E, Hubi S, Atarashi K, Onawa S, Fujimura Y, Lockett T, Clarke JM, Topping DL, Tomita M, Hori S, Ohara O, Morita T, Koseki H, Kikuchi J, Honda K, *Hase K & *Ohno H. Commensal Microbe-derived butyrate induces colonic regulatory T cells. Nature 2013, 504:446-450, 2013.
Atarashi K, Tanoue T, Oshima K, Suda W, Nagano Y, Nishikawa H, Fukuda S, Saito T, Narushima S, Hase K, Kim S, Fritz JV, Wilmes P, Ueha S, Matsushima K, Ohno H, Olle B, Sakaguchi S, Taniguchi T, Morita H, *Hattori M, *Honda K. Treg induction by a rationally selected Clostridia cocktail from the human microbiota. Nature 500: 232-236, 2013.
Okada T, Fukuda S, Hase K, Nishiumi S, Izumi Y, Yoshida M, Hagiwara T, Kawashima R, Yamazaki M, Oshio T, Otsubo T, Inagaki-Ohara K, Kakimoto K, Higuchi K, Kawamura Y.I., Ohno H and *Dohi H. Microbiota-derived lactate accelerates colon epithelial cell turnover in starvation-refed mice. Nat. Commun. 4: 1654, 2013.
Hase K, Nakatsu F, Ohmae M, Sugihara K, Shioda N, Takahashi D, Obata Y, Furusawa Y, Fujimura Y, Yamashita T, Fukuda S, Okamoto H, Asano M, Yonemura S and Ohno H. AP-1ーmediated protein sorting regulates polarity and proliferation of intestinal epithelial cells in mice. Gastroenterology. 145: 625-635, 2013

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2012

Nakato G, Hase K, Suzuki M, Kimura M, Ato M, Hanazato M, Tobiume M, Horiuchi M, Atarashi R, Nishida N, Watarai M, Imaoka K and Ohno H. Cutting Edge: Brucella abortus exploits a cellular prion protein on intestinal M cells as an invasive receptor. J. Immunol. 189: 1540-1544, 2012.
Kanaya T, Hase K, Takahashi D, Fukuda S, Hoshino K, Sasaki I, Hemmi H, Knoop KA, Kumar N, Sato M, Katsuno T, Yokosuka O, Toyooka K, Nakai K, Sakamoto A, Kitahara Y, Jinnohara T, McSorley SJ, Kaisho T, Williams IR and Ohno H, The Ets Transcription factor Spi-B is essential for the differentiation of intestinal microfold (M) Cells. Nat. Immunol. 13: 729-736, 2012.
Ouchida R, Mori H, Hase K, Takatsu H, Kurosaki T, Tokuhisa T, Ohno H and Wang J-Y, Critical role of the IgM Fc receptor in IgM homeostasis, B-cell survival, and humoral immune responses. Proc. Natl. Acad. Sci. USA., 109: E2699-706.
Obata Y, Takahashi D, Ebisawa M, Kakiguchi M, Yonemura S, Jinnohara T, Kanaya T, Fujimura Y, Ohmae M, *Hase K (corresponding author) and Ohno H. Epithelial cell-intrinsic Notch signaling plays an essential role in the maintenance of gut immune homeostasis. J. Immunol. 188: 2427-36, 2012.
Mimura M, Masuda A, Nishiumi S, Kawakami K, Fujishima Y, Yoshie T, Mizuno S, Miki I, Ohno H, Hase K, Minamoto T, Azuma T and Yoshida M, AP1B plays an important role in intestinal tumorigenesis with the truncating mutation of an APC gene. Int. J. Cancer 130: 1011-20, 2012.

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2011

Takahashi D, *Hase K (corresponding author), Kimura S, Nakatsu F, Ohmae M, Mandai Y, Sato T, Date Y, Ebisawa M, Kato T, Obata Y, Fukuda S, Kawamura Y. I, Dohi T, Katsuno T, Yokosuka O, Waguri S and Ohno H. The Epithelia-specific membrane trafficking factor AP-1B controls gut immune homeostasis in mice. Gastroenterology 141: 621-32, 2011.
Ebisawa M, Hase K, Takahashi D, Kitamura H, Knoop KA, Williams IR, Ohno H. CCR6hiCD11cint B cells promote M-cell differentiation in Peyer's patch. Int. Immunol. 23: 261-9, 2011.
Ito M, Kitamura H, Kikuguchi C, Hase K, Ohno H and Ohara O, SP600125 inhibits cap-dependent translation independently of the c-Jun N-terminal kinase pathway. Cell Struct. Funct. 36: 27-33, 2011.
Fukuda S, Toh H, Hase K, Oshima K, Nakanishi Y, Yoshimura K, Tobe T, Clarke JM, Topping DM, Suzuki T, Taylor TD, Itoh K, Kikuchi J, Morita H, Hattori M and Ohno H. Bifidobacteria protect host from enteropathogenic infection through production of acetate. Nature 469: 543-7, 2011.

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2010

Shima H, Takatsu H, Fukuda S, Ohmae M, Hase K, Kubagawa H, Wang JY, Ohno H. Identification of TOSO/FAIM3 as an Fc receptor for IgM. Int. Immunol. 22: 149-56, 2010.

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2009

Hase K, Kawano K, Nochi T, Pontes GS, Fukuda S, Ebisawa M, Kadokura K, Tobe T, Fujimura Y, Kawano S, Yabashi A, Waguri S, Nakato G, Kimura S, Murakami T, Iimura M, Hamura K, Fukuoka S, Lowe AW, Itoh K, Kiyono H, Ohno H.　Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response. Nature. 462: 226-30, 2009.
Hase K, Kimura S, Takatsu H, Ohmae M, Kawano S, Kitamura H, Ito M, Watarai H, Hazelett CC, Yeaman C, Ohno H. M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex. Nat. Cell Biol. 11: 1427-32, 2009.
Nakato G, Fukuda S, Hase K, Goitsuka R, Cooper MD, Ohno H. New approach for M-cell-specific molecules screening by comprehensive transcriptome analysis. DNA Res. 16: 227-235, 2009.

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2008

Terashima　A, Watarai H, Inoue S, Sekine E, Nakagawa R, Hase K, Iwamura C, Nakajima H, Nakayama T and TaniguchiM, A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity. J. Exp. Med. 205: 2727-33, 2008.
Zhu　G, Okada　M, Yoshida　N, Ueno　S, Mori F, Takahara　T, Saito R, Miura Y, Kishi A, Tomiyama M, Sato A, Kojima T, Fukuma G, Wakabayashi K, Hase K, Ohno H, Kijima H, Takano Y, Mitsudome A, Kaneko S, and Hirose S. Rats harboring S284L Chrna4 mutation show attenuation of synaptic and extrasynaptic GABAergic transmission and exhibit the nocturnal frontal lobe epilepsy phenotype. J. Neuroscience 28:12465-76, 2008.
Hase K, Takahashi D, Ebisawa M, Kawano S, Itoh K and Ohno H. Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease. PLoS ONE 3: e3033, 2008.
Terahara K, Yoshida M, Igarashi O, Nochi T, Pontes GS, Hase K, Ohno H, Kurokawa S, Mejima M, Takayama N, Yuki Y, Lowe AW, Kiyono H. Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells. J Immunol. 180: 7840-6, 2008.
Dann SM, Spehlmann ME, Hammond DC, Iimura M, Hase K, Choi LJ, Hanson E, Eckmann L. IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens. J Immunol. 180: 6816-26, 2008.
Kamijuku H., Nagata Y., Jiang X., Ichinohe T., Tashiro T., Mori K., Taniguchi M., Hase K, Ohno H., Shimaoka T., Yonehara S., Odagiri T., Tahiro M., Sata T., Hasegawa H., Seino K-i. Mechanism of NKT cell activation by intranasal coadministration of α-galactosylceramide, which can induce cross-protection against influenza. Mucosal Immunol. 1(3): 208-218, 2008.

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2007-

Hijikata A, Kitamura H, Kimura Y, Yokoyama R, Aiba Y, Bao Y, Fujita S, Hase K, Hori S, Kanagawa O, Kawamoto H, Kawano K, Koseki H, Kubo M, Kurita Miki A, Kurosaki T, Masuda K, Nakata M, Oboki K, Ohno H, Okamoto M, Okayama Y, O-Wang J, Saito H, Saito T, Sakuma M, Sato K, Sato K, Seino KI, Setoguchi R, Tamura Y,Tanaka M, Taniguchi M, Taniuchi I, Teng A, Watanabe T, Watarai H, Yamasaki S, Ohara O., Construction of an open-access database that integrates cross-reference information from the transcriptome and immune cells. Bioinformatics,23: 2934-41. 2007.
Kawano K, Ebisawa M, Hase K, Fukuda S, Hijikata A, Kawano S, Date Y, Itoh K and Ohno H, Psg18 is specifically expressed in follicle-associated epithelium. Cell Struct. Funct. 32: 115-26, 2007.
Murakami T, Chen X, Hase K, Sakamoto A, Nishigaki C, Ohno H. Splenic CD19-CD35+B220+ cells function as an inducer of follicular dendritic cell network formation. Blood 110: 1215-24, 2007.
Takatsu H, Hase K, Ohmae M, Ohshima S, Hashimoto K, Taniura N, Yamamoto A and Ohno H. CD300 antigen like family member G: A novel Ig receptor like protein exclusively expressed on capillary endothelium. Biochem Biophys Res Commun. 348: 183-191, 2006.
Takano-Maruyama M, Hase K, Fukamachi H, Kato Y, Koseki H and Ohno H, Foxl1-deficient mice exhibit aberrant epithelial cell positioning due to dysregulated EphB/EphrinB expression in the small intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 291: G163-G170, 2006.
Hase K, Murakami T, Takatsu T, Shimaoka T, Iimura M, Hamura K, Kawano K, Ohshima S, Chihara R, Itoh K, Yonehara S and Ohno H, The membrane-bound chemokine CXCL16 expressed on follicle-associated epithelium and M cells mediates lympho-epithelial interaction in GALT. J. Immunol. 176: 43-51, 2006.
Hase K, Ohshima S, Kawano K, Hashimoto N, Matsumoto K, Saito H and Ohno H, Distinct gene expression profiles characterize cellular phenotypes of follicle-associated epithelium and M cells. DNA Res. 12: 127-137, 2005.
Iimura M, Gallo RL, Hase K, Miyamoto Y, Eckmann L and Kagnoff MF, Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogens. J. Immunol. 174: 4901-4907, 2005.
Hase K, Murakami M, Iimura M, Cole SP, Horibe Y, Ohtake T, Obonyo M, Gallo RL, Eckmann L, and Kagnoff MF, Expression of LL-37/hCAP18 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pylori. Gastroenterology, 125: 1613-1625, 2003.
Hase K, Eckmann L., Leopard JD, Varki N and Kagnoff MF, Cell differentiation is a key determinant of cathelicidin LL-37/hCAP18 expression by human colon epithelium. Infection immunity70: 953-963, 2002.
Kasaoka S, Hase K, Morita T and Kiriyama S, Green tea flavonoids inhibit the LDL oxidation in osteogenic disordered rats fed a marginal ascorbic acid in diet. J. Nutr. Biochem 13: 96-102, 2002.
Xiong Q, Tezuka Y, Kaneko T, Li H, Tran LQ, Hase K, Namba T and Kadota S, Inhibition of nitric oxide by phenylethanoids in activated macrophages. Eur. J. Pharmacol. 400:137-44, 2000.
Banskota AH, Tezuka Y, Adnyana IK, Xiong Q, Hase K, Tran KQ, Tanaka K, Saiki I and Kadota S, Hepatoprotective effect of Combretum quadrangulare and its constituents.Biol. Pharm. Bul. 23: 456-60, 2000.
Xiong Q, Hase K, Tezuka Y, Namba T and Kadota S, Acteoside inhibits apoptosis in D-Galactosamine and lipopolysaccharide-induced liver injury. Life Science 65: 421-430, 1999.
Hase K, Xiong Q, Basnet P, Namba T and Kadota S, Inhibitory effect of tetrahydroswertianolin on TNF-α-dependent hepatic apoptosis in mice. Biochem Pharmacol 57: 1431-1437, 1999.
Morita T, Kasaoka S, Hase K, Kiriyama S, Psyllium shifts the fermentation site of high-amylose cornstarch toward the distal colon and increases fecal butyrate concentration in rats. J Nutr 129: 2081-2087, 1999.
Morita T, Kasaoka S, Hase K, Kiriyama S, Oligo-L-methionine and resistant protein promote cecal butyrate production in rats fed resistant starch and fructooligosaccharide. J Nutr 129: 1333-1339, 1999.
Ohsugi M, Fan W, Hase K, Xiong Q, Tezuka K, Komatsu K, Namba T, Saitoh T, Tazawa K and Kadota S, Active-oxygen scavenging activity of traditional nourishing-tonic herbal medicines and active constituents of Rhodiola sacra. J Ethnopharmacol 67:111-9, 1999.
Watanabe C, Satoh T, Tahara E, Murakami K, Hayashi K, Hase K, Andoh T, Kuraishi Y, Kadota S, Nagai H and Saiki I, Inhibitory effect of glycoprotein fraction derived from Miscanthus sinensis for the immediate phase response of an IgE-mediated cutaneous reaction. Biol Pharm Bull 22: 26-30, 1999.
Hayakawa Y, Fujii H, Hase K, Ohnishi Y, Sakukawa R, Kadota S, Namba T and Saiki I, Anti-metastatic and immunomodulating properties of the water extract from Celosia argentea seeds. Biol Pharm Bull21: 1154-1159, 1998.
Prasain JK, Tezuka Y, Hase K, Basnet P, Dong H, Namba T and Kadota S, Inhibitory effect of diarylheptanoids on nitric oxide production in activated murine macrophages.Biol Pharm Bull21:　371-374, 1998.
Watanabe C, Hase K, Oku T, Koizumi F, Kadota S, Nagai H, Namba T and Saiki I, Effect of spiklets of Miscanthus sinensis on IgE-mediated biphasic cutaneous reaction in mice. Planta Med 64: 12-17, 1998.
Xiong Q, Hase K, Tezuka Y, Tani T, Namba T and Kadota S, Hepatoprotective activity of phenylethanoids from Cistanche deserticola. Planta Med 64: 120-125, 1998.
Hase K, Ohsugi M, Xigong Q, Basnet P, Kadota S and Namba T, Hepatoprotective effect of Hovenia dulcis Thunb. on experimental liver injuries induced by carbon tetrachloride or D-galactosamine/lipopolysaccharide. Biol Pharm Bull 20: 381-385, 1997.
Hase K, Kadota S, Basnet P, Li J, Xiong Q, Takamura S and Namba T, Hepatoprotective principles of Swertia japonica Makino on D-galactosamine/lipopolysaccharide-induced liver injury in mice. Chem Pharm Bull 45: 1823-1827, 1997.
Hase K, Kadota S, Basnet P, Li J, Takamura S and Namba T, Tetrahydroswertianolin: A potent hepatoprotective agent from Swertia japonica. Chem Pharm Bull 45: 567-569, 1997.
Hase K, Basnet P, Kadota S and Namba T, Immunostimulating activity of celosian, an antihepatotoxic polysaccharide isolated from Celosia argentea. Planta Med 63: 216-219, 1997.
Hase K, Basnet P, Kadota S and Namba T, Effect of Hovenia dulcis on lipopolysaccharide-induced liver injury in chronic alcohol-fed rats. J Trad Med 14: 28-33, 1997.
Basnet P, Matsushige K, Hase K, Kadota S and Namba T, Four di-O-caffeoyl quinic acid derivatives from propolis. Potent hepatoprotective activity in experimental liver injury models. Biol Pharm Bull 19: 1479-1484, 1996.
Basnet P, Matsushige K, Hase K, Kadota S, Namba T, Potent antihepatotoxic activity of dicaffeoyl quinic acids from propolis. Biol Pharm Bull 19: 655-657, 1996.
Matsushige K, Basnet P, Hase K, Kadota S, Tanaka K and Namba T, Propolis protects pancreatic beta-cells against the toxicity of streptozotocin (STZ). Phytomedicine 3: 203-209, 1996.
Prasain JK, Kadota S, Basnet P, Hase K and Namba T, Hepatoprotective effects of Panax notoginseng: Ginsenosides-Re and -Rg1 as its active constituents in D-galactosamine/lipopolysaccharide-induced liver injury. Phytomedicine2: 297-303, 1996.
Hase K, Kasimu R, Basnet P, Kadota S and Namba T, Preventive effect of lithospermate B from Salvia miltiorhiza on experimental hepatitis induced by carbon tetrachloride or D-galactosamine/lipopolysaccharide. Planta Med 63: 22-26, 1997.
Hase K, Kadota S, Basnet P, Takahashi T and Namba T, Protective effect of celosian, an acidic polysacchride, on chemically and immunologically induced liver injuries. Biol Pharm Bull 19: 567-572, 1996.
Hase K, Kadota S, Basnet P, Namba T and Takahashi T, Hepatoprotective effects of traditional medicines. Isolation of the active constituent from seeds of Celosia argentea. Phytother Res10: 387-392, 1996.
Iida K, Hase K, Shimomura K, Sudo S, Kadoata S and Namba T, Potent inhibitors of tyrosinase activity and melanin biosynthesis from Rheum officinale.Planta Med 61: 425-428, 1995.
Basnet P, Kadota S, Hase K and Namba T, Five new C-methyl flavonoids, the potent aldose reductase inhibitors from Matteuccia orientalis Trev. Chem Pharm Bull 43: 1558-1564, 1995.
Kadota S, Basnet P, Hase K and Namba T, Matteuorienate A and B, two new and potent aldose reductase inhibitors from Matteuccia orientalis (Hook.) Trev. Chem Pharm Bull 42: 1712-1714, 1994.

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