SAVE-J II study本邦における院外心停止患者に対するExtracorporeal Cardiopulmonary Resuscitation (ECPR)

About the study

Title Study of Advanced Cardiac Life Support for Ventricular Fibrillation with Extracorporeal Circulation in Japan
Acronym SAVE-J II study
Study design A multicenter retrospective observational study.
Objective The objective of this study is to examine the efficacy of extracorporeal cardiopulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest (OHCA) patients in Japan.

Trial Registration: UMIN-ID, UMIN000036490

Study Population

All OHCA patients receiving ECPR from January 2013 to December 2018.
Inclusion criteria: 18 years and older, OHCA, receiving ECPR
Exclusion criteria: Family or other agents refuse to the registry of patient

Outcome measures

Primary outcome: Favorable outcome at hospital discharge which is defined as Cerebral Performance Category (CPC) of 1 or 2.

Secondary outcome: Favorable outcome at 1 month, Survival rate at hospital discharge and 1 month, Complications.


  • This study was supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI (Grant-in-Aid for Scientific Research [C]) grant number JP19K09419.
  • Public relations support by Japan Resuscitation Council


Akihiko Inoue, MD, PhD. Department of Emergency and Critical Care Medicine, Hyogo Emergency Medical Center
Toru Hifumi, MD, PhD. Department of Emergency and Critical Care Medicine, St. Luke’s International Hospital
Tetsuya Sakamoto, MD, PhD. Department of Emergency Medicine, Teikyo University
Yasuhiro Kuroda, MD, PhD. Department of Emergency, Disaster and Critical Care Medicine, Faculty of Medicine, Kagawa University


Akihiko Inoue, Hyogo Emergency Medical Center, Kobe, Japan