研究結果

現在までの佐渡プロジェクトの研究成果です.

2017年
 
2016年
1.Watanabe Y, Kitamura K, Nakamura K, Sanpei K, Wakasugi M, Yokoseki A, Kabasawa K, Onodera O, Ikeuchi T, Kuwano R, Momotsu T, Narita I, Endo N.
Association between dialysis treatment and cognitive decline: A study from the Project in Sado for Total Health (PROST), Japan.
Geriatr Gerontol Int. 2016 Nov 21. doi: 10.1111/ggi.12937. [Epub ahead of print]
2.Kitamura K, Watanabe Y, Nakamura K, Sanpei K, Wakasugi M, Yokoseki A, Onodera O, Ikeuchi T, Kuwano R, Momotsu T, Narita I, Endo N.
Modifiable Factors Associated with Cognitive Impairment in 1,143 Japanese Outpatients: The Project in Sado for Total Health (PROST).
Dement Geriatr Cogn Dis Extra. 2016 Aug 12;6(2):341-349.
3.Watanabe Y, Kitamura K, Nakamura K, Sanpei K, Wakasugi M, Yokoseki A, Onodera O, Ikeuchi T, Kuwano R, Momotsu T, Narita I, Endo N.
Elevated C-Reactive Protein Is Associated with Cognitive Decline in Outpatients of a General Hospital: The Project in Sado for Total Health (PROST).
Dement Geriatr Cogn Dis Extra. 2016 Jan 19;6(1):10-9. doi: 10.1159/000442585.
4.Yagihara N, Watanabe H, Barnett P, Duboscq-Bidot L, Thomas AC, Yang P, Ohno S, Hasegawa K, Kuwano R, Chatel S, Redon R, Schott JJ, Probst V, Koopmann TT, Bezzina CR, Wilde AA, Nakano Y, Aiba T, Miyamoto Y, Kamakura S, Darbar D, Donahue BS, Shigemizu D, Tanaka T, Tsunoda T, Suda M, Sato A, Minamino T, Endo N, Shimizu W, Horie M, Roden DM, Makita N.
Variants in the SCN5A Promoter Associated With Various Arrhythmia Phenotypes.
J Am Heart Assoc. 2016 Sep 13;5(9). pii: e003644. doi: 10.1161/JAHA.116.003644.
5.Nozaki H, Kato T, Nihonmatsu M, Saito Y, Mizuta I, Noda T, Koike R, Miyazaki K, Kaito M, Ito S, Makino M, Koyama A, Shiga A, Uemura M, Sekine Y, Murakami A, Moritani S, Hara K, Yokoseki A, Kuwano R, Endo N, Momotsu T, Yoshida M, Nishizawa M, Mizuno T, Onodera O.
Distinct molecular mechanisms of HTRA1 mutants in manifesting heterozygotes with CARASIL.
Neurology. 2016 May 24;86(21):1964-74. doi: 10.1212/WNL.0000000000002694.
2015年
1.Watanabe H, Goto S, Miyashita A, Maruyama H, Wakasugi M, Yokoseki A, Kuwano R, Narita I.
Role of the p.E66Q variant of GLA in the progression of chronic kidney disease.
Clin Exp Nephrol. 2015 Apr;19(2):225-30. doi: 10.1007/s10157-014-0969-y.
2014年
1.Makita N, Yagihara N, Crotti L, Johnson CN, Beckmann BM, Roh MS, Shigemizu D, Lichtner P, Ishikawa T, Aiba T, Homfray T, Behr ER, Klug D, Denjoy I, Mastantuono E, Theisen D, Tsunoda T, Satake W, Toda T, Nakagawa H, Tsuji Y, Tsuchiya T, Yamamoto H, Miyamoto Y, Endo N, Kimura A, Ozaki K, Motomura H, Suda K, Tanaka T, Schwartz PJ, Meitinger T, Kääb S, Guicheney P, Shimizu W, Bhuiyan ZA, Watanabe H, Chazin WJ, George AL Jr.
Novel calmodulin mutations associated with congenital arrhythmia susceptibility.
Circ Cardiovasc Genet. 2014 Aug;7(4):466-74. doi: 10.1161/CIRCGENETICS.113.000459.
2.Sakuma M, Endo N, Oinuma T, Miyasaka D, Oguma Y, Imao K, Koga H, Tanabe N.
Incidence of osteoporotic fractures in Sado, Japan in 2010.
J Bone Miner Metab. 2014 Mar;32(2):200-5. doi: 10.1007/s00774-013-0486-1.
2013年
1.Bezzina CR, Barc J, Mizusawa Y, Remme CA, Gourraud JB, Simonet F, Verkerk AO, Schwartz PJ, Crotti L, Dagradi F, Guicheney P, Fressart V, Leenhardt A, Antzelevitch C, Bartkowiak S, Borggrefe M, Schimpf R, Schulze-Bahr E, Zumhagen S, Behr ER, Bastiaenen R, Tfelt-Hansen J, Olesen MS, Kääb S, Beckmann BM, Weeke P, Watanabe H, Endo N, Minamino T, Horie M, Ohno S, Hasegawa K, Makita N, Nogami A, Shimizu W, Aiba T, Froguel P, Balkau B, Lantieri O, Torchio M, Wiese C, Weber D, Wolswinkel R, Coronel R, Boukens BJ, Bézieau S, Charpentier E, Chatel S, Despres A, Gros F, Kyndt F, Lecointe S, Lindenbaum P, Portero V, Violleau J, Gessler M, Tan HL, Roden DM, Christoffels VM, Le Marec H, Wilde AA, Probst V, Schott JJ, Dina C, Redon R.
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.
Nat Genet. 2013 Sep;45(9):1044-9. doi: 10.1038/ng.2712.
2.Nakano Y, Chayama K, Ochi H, Toshishige M, Hayashida Y, Miki D, Hayes CN, Suzuki H, Tokuyama T, Oda N, Suenari K, Uchimura-Makita Y, Kajihara K, Sairaku A, Motoda C, Fujiwara M, Watanabe Y, Yoshida Y, Ohkubo K, Watanabe I, Nogami A, Hasegawa K, Watanabe H, Endo N, Aiba T, Shimizu W, Ohno S, Horie M, Arihiro K, Tashiro S, Makita N, Kihara Y.
A nonsynonymous polymorphism in semaphorin 3A as a risk factor for human unexplained cardiac arrest with documented ventricular fibrillation.
PLoS Genet. 2013 Apr;9(4):e1003364. doi: 10.1371/journal.pgen.1003364.
3.Wakasugi M, Kazama JJ, Yamamoto S, Kawamura K, Narita I.
A combination of healthy lifestyle factors is associated with a decreased incidence of chronic kidney disease: a population-based cohort study.
Hypertens Res. 2013 Apr;36(4):328-33. doi: 10.1038/hr.2012.186.
2012年
Wakasugi M, Kawamura K, Yamamoto S, Kazama JJ, Narita I.
High mortality rate of infectious diseases in dialysis patients: a comparison with the general population in Japan.
Ther Apher Dial. 2012 Jun;16(3):226-31. doi: 10.1111/j.1744-9987.2012.01062.x.
Wakasugi M, Kazama JJ, Narita I.
Differences in the local and national prevalences of chronic kidney disease based on annual health check program data.
Clin Exp Nephrol. 2012 Oct;16(5):749-54. doi: 10.1007/s10157-012-0628-0.
Wakasugi M, Kazama JJ, Narita I.
Use of Japanese Society for Dialysis Therapy dialysis tables to compare the local and national incidence of dialysis.
Ther Apher Dial. 2012 Feb;16(1):63-7. doi: 10.1111/j.1744-9987.2011.01030.x.
2011年
Shiga A, Nozaki H, Yokoseki A, Nihonmatsu M, Kawata H, Kato T, Koyama A, Arima K, Ikeda M, Katada S, Toyoshima Y, Takahashi H, Tanaka A, Nakano I, Ikeuchi T, Nishizawa M, Onodera O.
Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-β1 via cleavage of proTGF-β1.
Hum Mol Genet. 2011 May 1;20(9):1800-10. doi: 10.1093/hmg/ddr063.
2010年
Oinuma T, Sakuma M, Endo N.
Secular change of the incidence of four fracture types associated with senile osteoporosis in Sado, Japan: the results of a 3-year survey.
J Bone Miner Metab. 2010;28(1):55-9. doi: 10.1007/s00774-009-0097-z.
2008年
Sakuma M, Endo N, Oinuma T, Endo E, Yazawa T, Watanabe K, Watanabe S.
Incidence and outcome of osteoporotic fractures in 2004 in Sado City, Niigata Prefecture, Japan.
J Bone Miner Metab. 2008;26(4):373-8. doi: 10.1007/s00774-007-0841-1