243研究室では、以下のような研究を行っています。

呼吸器疾患における転写共役因子TAZ/YAPの機能解析

Hippo pathwayは進化的に保存された経路で、発生・分化・腫瘍形成などにおいて重要な役割を果たす。転写活性因子であるTAZおよびYAPはこのHippo pathwayの重要なエフェクターであり、当研究室では、これらの分子の肺における役割についての研究を行っている。遺伝子改変マウスなどを用いた解析により、これまでにTAZの肺胞形成や肺癌、肺線維症における役割などについて報告を行ってきた。

遺伝子改変マウスを用いた呼吸器疾患の病態解明

肺の炎症性疾患の複雑な病態を解明するのに、マウスモデルは非常に強力なツールである。当研究室では、当科517研究室との共同研究にて、ブレオマイシンを用いた肺線維症モデル、OVA感作による気管支喘息モデル、エラスターゼやLPSを用いたCOPDモデルなどを作成している。様々な遺伝子改変マウスを用いて特定の遺伝子の機能を解明したり、薬剤投与による効果の検証などを行っている。

DPCデータベースを用いた研究

　Diagnosis Procedure Combination (DPC)データベースは退院時情報や診療報酬データなどから構成され、診断名・入院時併存症および入院時合併症、手術処置名、使用された薬剤、在院日数や転帰といった情報が含まれ、我が国の全入院患者の約50％をカバーする。本研究室では、本学公共健康医学専攻臨床疫学・経済学（康永秀生教授）との共同研究にて、DPCデータベースを用いた呼吸器疾患に関する研究を行っている。

肺癌診断における胸水エクソソーム中miRNAの有効性

　近年、血液や胸水などの体液中に、細胞から分泌された膜小胞であるエクソソームが豊富に含まれていることが明らかになった。このエクソソームには、マイクロRNA(miRNA)やサイトカインなどの液性因子が豊富に含まれ、体液中のエクソソームが細胞に再び取り込まれることで、様々な細胞応答を引き起こしている可能性が示唆されている。現在、肺癌の悪性胸水中のエクソソームを分離し、診断における意義について研究を行っている。

肺抗酸菌症に関わる宿主側因子の解析

　近年増加傾向にある肺非結核性抗酸菌症は、緩徐に進行する難治性の肺疾患であり、病因の解明と新たな治療法の開発が望まれている。当研究室では、国立国際医療研究センター研究所 呼吸器疾患研究部（慶長直人部長、現 結核予防会結核研究所 副所長）との共同研究のもとに宿主側の疾患感受性に関わる遺伝因子などについての研究を行ってきた。

業績

論文（海外誌） [CLICK]

2024年

Isago H., Watanabe K., Satoh Y., Kurano M. Correlation between variant call accuracy and quality parameters in comprehensive cancer genomic profiling tests. Pract Lab Med. 2024;39:e00369.

Hideaki Isago, Baasanjav Uranbileg, Akihisa Mitani, Makoto Kurano. Understanding the modulations of glycero-lysophospholipids in an elastase-induced murine emphysema model. Biochem Biophys Res Commun.2024 Jan 29:694:149419.

Nishiyama A, Shimizu M, Narita T, Kodera N, Ozeki Y, Yokoyama A, Mayanagi K, Yamaguchi T, Hakamata M, Shaban AK, Tateishi Y, Ito K, Matsumoto S. Dynamic action of an intrinsically disordered protein in DNA compaction that induces mycobacterial dormancy. Nucleic Acids Res. 2024 Jan 25;52(2):816-830.

Kimura Y, Suzukawa M, Jo T, Hashimoto Y, Kumazawa R, Ishimaru M, Matsui H, Yokoyama A, Tanaka G, Yasunaga H. Epidemiology of severe childhood asthma in Japan: A nationwide descriptive study. Allergy. 2024 Jan 7. Epub ahead of print..

Fukuda K, Matsuzaki H, Hiraishi Y, Miyashita N, Ishii T, Yuki M, Isago H, Tamiya H, Mitani A, Saito A, Jo T, Nagase T. Anti-Inflammatory Effects of Japanese Herbal Medicine Hochuekkito in a Mouse Model of Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Pharmacology 2024 Feb 12:1-6 (Online ahead of print)

2023年

Yokoyama A, Jo T, Sakamoto Y, Urushiyama H, Tamiya H, Tanaka G, Kumazawa R, Matsui H, Fushimi K, Yasunaga H, Nagase T. Effectiveness and safety of the co-administration of Yokukan-San (Japanese herbal medicine) with antipsychotics in hospitalized older patients with pneumonia. Geriatr Gerontol Int. 2023 Nov;23(11):849-854.

Tamiya H, Abe M, Nagase T, Mitani A. The Link between Periodontal Disease and Asthma: How Do These Two Diseases Affect Each Other? J Clin Med. 2023;12(21):6747

Yoshida Y, Nishiyama A, Suameitria Dewi DNS, Yamazaki T, Yokoyama A, Kobayashi D, Kondo H, Ozeki Y, Matsumoto S. Limited proteolysis of mycobacterial DNA-binding protein 1 with an extended, lysine-rich, intrinsically disordered region to unveil posttranslational modifications. Biochem Biophys Res Commun. 2023 Nov 12;681:111-119.

Tamiya H, Mitani A, Abe M, Nagase T. Putative Bidirectionality of Chronic Obstructive Pulmonary Disease and Periodontal Disease: A Review of the Literature. J Clin Med. 2023;12(18):5935

Kato H, Kimura S, Taguchi M, Sunouchi T, Hoshino Y, Hidaka N, Edvige Foligno N, Koga M, Manaka K, Tamiya H, Kawakami M, Kage H, Yasunaga Y, Nangaku M, Makita N, Ito N. FGF23-related hypophosphatemia in a patient with small cell lung cancer: a case report and literature review. Endocr J. 2023 Jul 20. doi: 10.1507/endocrj.EJ23-0086. Online ahead of print

Tamiya H, Mitani A, Abe T, Nagase Y, Isago H, Saito M, Yokoyama A, Ishimori T, Jo T, Tanaka G, Suzuki H, Nagase T. Practices of Inhaler Instruction to Patients with Obstructive Lung Diseases in Community Pharmacies: A Questionnaire Survey. Japanese Journal of Pharmaceutical Health Care and Sciences Vol. 49, No. 06, 2023

2022年

Tamiya H, Mitani A, Abe T, Nagase Y, Suzuki H, Jo T, Tanaka G, Nagase T. Association between Inhalation Instruction Method in Community Pharmacies and Inhaler Device Handling Error in Patients with Obstructive Lung Disease: An Evaluation of the Impact of Practical Demonstration by Pharmacists. Biol Pharm Bull. 2022;45(12):1764

Kato T, Radicioni G, Papanikolas MJ, Stoychev GV, Markovetz MR, Aoki K, Porterfield M, Okuda K, Barbosa Cardenas SM, Gilmore RC, Morrison CB, Ehre C, Burns KA, White KK, Brennan TA, Goodell HP, Thacker H, Loznev HT, Forsberg LJ, Nagase T, Rubinstein M, Randell SH, Tiemeyer M, Hill DB, Kesimer M, O'Neal WK, Ballard ST, Freeman R, Button B, Boucher RC. Mucus concentration-dependent biophysical abnormalities unify submucosal gland and superficial airway dysfunction in cystic fibrosis. Sci Adv 2022;8:eabm9718.

Mitani A, Hamada K, Yoshikawa N, Morita Y, Horie T, Inoue Y, Saito M, Ishii T, Sunohara M, Takahashi R, Emoto N, Nishimoto N, Murano Y, Okazaki S, Tateishi S, Yao A, Shimura T, Kurano M, Yatomi Y, Yanagimoto S. Epidemiological study using igm and igg antibody titers against sars-cov-2 in the university of tokyo, japan (ut-cats). J Infect Chemother 2021;27:1342-1349.


2021年

Tamiya H, Mitani A, Isago H, Ishimori T, Saito M, Jo T, Tanaka G, Yanagimoto S, Nagase T. Measurement of chest wall motion using a motion capture system with the one-pitch phase analysis method. Sci Rep. 2021 Nov 2;11(1):21497

Yokoyama A, Sakamoto Y, Jo T, Urushiyama H, Tamiya H, Tanaka G, Matsui H, Fushimi K, Yasunaga H, Nagase T. Pulmonary disease as a risk factor for transfusion-related acute lung injury. ERJ Open Res. 2021 Aug 31;7(3).

Abe M, Mitani A, Zong L, Zhang CD, Hoshi K, Yanagimoto S. High frequency and long duration of toothbrushing can potentially reduce the risk of common systemic diseases in late adolescence. Spec Care Dentist 2021.

Mitani A, Hamada K, Yoshikawa N, Morita Y, Horie T, Inoue Y, Saito M, Ishii T, Sunohara M, Takahashi R, Emoto N, Nishimoto N, Murano Y, Okazaki S, Tateishi S, Yao A, Shimura T, Kurano M, Yatomi Y, Yanagimoto S. Epidemiological study using igm and igg antibody titers against sars-cov-2 in the university of tokyo, japan (ut-cats). J Infect Chemother 2021;27:1342-1349.

Matsuda K, Jo T, Miyauchi M, Toyama K, Nakazaki K, Matsui H, Fushimi K, Yasunaga H, Kurokawa M. Difference of preventing effects of G-CSF according to age in patients with malignant lymphoma: A nation-wide analysis in Japan. J Infect Chemother. 2021 Aug;27(8):1151-1155.

Kobayashi K, Jo T, Mimura W, Suzukawa M, Ohshima N, Tanaka G, Akazawa M, Matsui H, Fushimi K, Yasunaga H, Nagase T, Nagai H. Interrupted time-series analyses of routine vaccination program for elderly pneumonia patients in japan; an ecological study using aggregated nationwide inpatient data. Hum Vaccin Immunother 2021:1-9.

Kurokawa R, Inui S, Gonoi W, Nakai Y, Ishida M, Watanabe Y, Kubo T, Amano Y, Okamoto K, Kage H, Harada S, Tanaka G, Kawahara T, Nagase T, Moriya K, Abe O. Standardized reporting systems of chest computed tomography in a population with low coronavirus disease 2019 prevalence: A retrospective comparative study. Heliyon 2021;7:e07743.

Ikushima H, Hiraishi Y, Toriumi K, Ando T, Tamiya H, Ishida J, Amano Y, Kage H, Tanaka G, Nagase T. Multiple cerebral infarctions in ros1-rearranged lung adenocarcinoma. Respirol Case Rep 2021;9:e0831.

Yokoyama A, Sakamoto Y, Jo T, Urushiyama H, Tamiya H, Tanaka G, Matsui H, Fushimi K, Yasunaga H, Nagase T. Pulmonary disease as a risk factor for transfusion-related acute lung injury. ERJ Open Res 2021;7.

Amano Y, Kage H, Tanaka G, Gonoi W, Nakai Y, Kurokawa R, Inui S, Okamoto K, Harada S, Iwabu M, Morizaki Y, Abe O, Moriya K, Nagase T. Diagnostic prediction of covid-19 based on clinical and radiological findings in a relatively low covid-19 prevalence area. Respir Investig 2021;59:446-453.

Tanaka G, Jo T, Tamiya H, Sakamoto Y, Hasegawa W, Matsui H, Fushimi K, Yasunaga H, Nagase T. Factors affecting in-hospital mortality of non-tuberculous mycobacterial pulmonary disease. BMC Infect Dis 2021;21:698.

Urushiyama H, Jo T, Hasegawa W, Ando T, Sakamoto Y, Uda K, Matsui H, Fushimi K, Yasunaga H, Nagase T. Preoperative use of pirfenidone and reduced risk of postoperative severe respiratory complications in patients with idiopathic pulmonary fibrosis: Propensity score-matched analysis using a nationwide database in japan. Respirology 2021;26:590-596.

Kaneko H, Yano Y, Itoh H, Morita K, Kiriyama H, Kamon T, Fujiu K, Michihata N, Jo T, Takeda N, Morita H, Node K, Carey RM, Lima JAC, Oparil S, Yasunaga H, Komuro I. Association of Blood Pressure Classification Using the 2017 American College of Cardiology/American Heart Association Blood Pressure Guideline With Risk of Heart Failure and Atrial Fibrillation. Circulation. 2021 Jun 8;143(23):2244-2253.

Awano N, Jo T, Yasunaga H, Inomata M, Kuse N, Tone M, Morita K, Matsui H, Fushimi K, Nagase T, Izumo T. Body mass index and in-hospital mortality in patients with acute exacerbation of idiopathic pulmonary fibrosis. ERJ Open Res 2021;7.

Shinozaki N, Morita K, Matsui H, Jo T, Yasunaga H. Semisolid vs Liquid Nutrients and 30-Day Readmission in Gastrostomy Tube-Fed Patients: A Propensity-Matched Analysis. JPEN J Parenter Enteral Nutr. 2021 May;45(4):720-728.

Okuda K, Dang H, Kobayashi Y, Carraro G, Nakano S, Chen G, Kato T, Asakura T, Gilmore RC, Morton LC, Lee RE, Mascenik T, Yin WN, Barbosa Cardenas SM, O'Neal YK, Minnick CE, Chua M, Quinney NL, Gentzsch M, Anderson CW, Ghio A, Matsui H, Nagase T, Ostrowski LE, Grubb BR, Olsen JC, Randell SH, Stripp BR, Tata PR, O'Neal WK, Boucher RC. Secretory cells dominate airway cftr expression and function in human airway superficial epithelia. Am J Respir Crit Care Med 2021;203:1275-1289.

Itoh H, Kaneko H, Kiriyama H, Kamon T, Fujiu K, Morita K, Michihata N, Jo T, Takeda N, Morita H, Yasunaga H, Komuro I. Metabolically Healthy Obesity and the Risk of Cardiovascular Disease in the General Population　- Analysis of a Nationwide Epidemiological Database. Circ J. 2021 May 25;85(6):914-920.

Ando T, Kawashima M, Jo T, Yasunaga H, Nagase T. The authors reply. Crit Care Med 2021;49:e466-e467.

Kiriyama H, Kaneko H, Itoh H, Kamon T, Morita K, Jo T, Fujiu K, Daimon M, Takeda N, Morita H, Yasunaga H, Komuro I. Surgical treatment for infective endocarditis in the ageing society: a nationwide retrospective study in Japan. Open Heart. 2021 Apr;8(1):e001627.

Jo T, Michihata N, Yamana H, Morita K, Ishimaru M, Yamauchi Y, Hasegawa W, Urushiyama H, Uda K, Matsui H, Fushimi K, Yasunaga H, Nagase T. Risk of drug-induced interstitial lung disease in hospitalised patients: A nested case-control study. Thorax 2021.

Katsuki R, Jo T, Yasunaga H, Kumazawa R, Uda K. Outcomes of laparoscopic versus open pancreatoduodenectomy: A nationwide retrospective cohort study. Surgery. 2021 Jun;169(6):1427-1434

Kaneko H, Itoh H, Kiriyama H, Kamon T, Fujiu K, Morita K, Michihata N, Jo T, Takeda N, Morita H, Yasunaga H, Komuro I. Possible association between eating behaviors and cardiovascular disease in the general population: Analysis of a nationwide epidemiological database. Atherosclerosis. 2021 Mar;320:79-85.

Abe M, Mitani A, Yao A, Zhang CD, Hoshi K, Yanagimoto S. Close association between awareness of teeth-alignment disorder and systemic disorders in late adolescence. Healthcare (Basel) 2021;9.

Yamana H, Iba A, Tomio J, Ono S, Jo T, Yasunaga H. Treatment of latent tuberculosis infection in patients receiving biologic agents. J Infect Chemother. 2021 Feb;27(2):243-249.

Kaneko H, Itoh H, Kiriyama H, Kamon T, Fujiu K, Morita K, Michihata N, Jo T, Takeda N, Morita H, Yasunaga H, Komuro I. Fasting plasma glucose and subsequent cardiovascular disease among young adults: Analysis of a nationwide epidemiological database. Atherosclerosis. 2021 Feb;319:35-41.

Fukuda K, Matsuzaki H, Mikami Y, Makita K, Miyakawa K, Miyashita N, Hosoki K, Ishii T, Noguchi S, Urushiyama H, Horie M, Mitani A, Yamauchi Y, Shimura E, Nakae S, Saito A, Nagase T, Hiraishi Y. A mouse model of asthma-chronic obstructive pulmonary disease overlap induced by intratracheal papain. Allergy 2021;76:390-394.

Isago H, Mitani A, Kohno S, Nagoshi S, Ishimori T, Saito M, Tamiya H, Miyashita N, Ishii T, Matsuzaki H, Yatomi Y, Nagase T, Jo T. The japanese herbal (kampo) medicine hochuekkito attenuates lung inflammation in lung emphysema. Biol Pharm Bull 2021;44:39-45.

Ohbe H, Jo T, Matsui H, Fushimi K, Yasunaga H. Effect of Daikenchuto for Mechanically Ventilated Patients With Enteral Feeding Intolerance: A Propensity Score-Matched Analysis Using a Nationwide Administrative Inpatient Database. JPEN J Parenter Enteral Nutr. 2021 Jan 22

Kaneko H, Itoh H, Kiriyama H, Kamon T, Fujiu K, Morita K, Michihata N, Jo T, Takeda N, Morita H, Yasunaga H, Komuro I. Lipid Profile and Subsequent Cardiovascular Disease among Young Adults Aged < 50 Years. Am J Cardiol. 2021 Mar 1;142:59-65.


2020年

Miyashita N, Horie M, Suzuki HI, Saito M, Mikami Y, Okuda K, Boucher RC, Suzukawa M, Hebisawa A, Saito A, Nagase T. Foxl1 regulates lung fibroblast function via multiple mechanisms. Am J Respir Cell Mol Biol 2020;63:831-842.

Kamon T, Kaneko H, Kiriyama H, Itoh H, Fujiu K, Kumazawa R, Morita K, Michihata N, Jo T, Miura M, Kodera S, Uehara M, Ando J, Inoue T, Kinoshita O, Yamauchi H, Mori Y, Nakao T, Daimon M, Takeda N, Morita H, Ono M, Yasunaga H, Komuro I. Transcatheter Aortic Valve Implantation and Surgical Aortic Valve Replacement for Aortic Stenosis in Japan　- Analysis of a Nationwide Inpatient Database. Circ Rep. 2020 Dec 1;2(12):753-758

Yamana H, Ono S, Michihata N, Jo T, Yasunaga H. Outpatient Prescriptions of Kampo Formulations in Japan. Intern Med. 2020 Nov 15;59(22):2863-2869.

Ikeda Kurakawa K, Okada A, Jo T, Ono S, Bessho K, Michihata N, Matsui H, Yamaguchi S, Fushimi K, Kadowaki T, Yasunaga H. Effects of Prophylactic Antibiotics on Length of Stay and Total Costs for Pediatric Acute Pancreatitis: A Nationwide Database Study in Japan. Pancreas. 2020 Nov/Dec;49(10):1321-1326.

Kaneko H, Itoh H, Kamon T, Fujiu K, Morita K, Michihata N, Jo T, Morita H, Yasunaga H, Komuro I. Association of Cardiovascular Health Metrics With Subsequent Cardiovascular Disease in Young Adults. J Am Coll Cardiol. 2020 Nov 17;76(20):2414-2416

Papadaki V, Asada K, Watson JK, Tamura T, Leung A, Hopkins J, Dellett M, Sasai N, Davaapil H, Nik-Zainal S, Longbottom R, Nakakido M, Torii R, Veerakumarasivam A, Kaneko S, Sagoo MS, Murphy G, Mitani A, Tsumoto K, Kelly JD, Hamamoto R, Ohnuma SI. Two secreted proteoglycans, activators of urothelial cell-cell adhesion, negatively contribute to bladder cancer initiation and progression. Cancers (Basel) 2020;12.

Ando T, Kawashima M, Jo T, Masuda K, Yamauchi Y, Tanaka G, Kage H, Suzukawa M, Nagai H, Matsui H, Fushimi K, Yasunaga H, Nagase T. Early arterial embolization and mortality in mechanically ventilated patients with hemoptysis: A nationwide retrospective cohort study. Crit Care Med 2020;48:1480-1486.

Kaneko H, Itoh H, Yotsumoto H, Kiriyama H, Kamon T, Fujiu K, Morita K, Michihata N, Jo T, Takeda N, Morita H, Yasunaga H, Komuro I. Association of Isolated Diastolic Hypertension Based on the Cutoff Value in the 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines With Subsequent Cardiovascular Events in the General Population. J Am Heart Assoc. 2020 Oct 20;9(19):e017963.

Hosoki K, Mikami Y, Urushiyama H, Souma K, Kawamura G, Uchida K, Nagase T, Jo T. Predictors of postoperative acute exacerbation of interstitial lung disease: A case-control study. BMJ Open Respir Res 2020;7.

Mouri H, Jo T, Matsui H, Fushimi K, Yasunaga H. Impact of glucocorticoid supplementation on reducing perioperative complications in patients on long-term glucocorticoid medication: A propensity score analysis using a nationwide inpatient database. Am J Surg 2020.

Kaneko H, Itoh H, Yotsumoto H, Kiriyama H, Kamon T, Fujiu K, Morita K, Michihata N, Jo T, Takeda N, Morita H, Yasunaga H, Komuro I. Association of Cancer With Outcomes in Patients Hospitalized for Heart Failure. Circ J. 2020 Sep 25;84(10):1771-1778.

Itoh H, Kaneko H, Kiriyama H, Kamon T, Fujiu K, Morita K, Yotsumoto H, Michihata N, Jo T, Takeda N, Morita H, Yasunaga H, Komuro I. Reverse J-shaped relationship between body mass index and in-hospital mortality of patients hospitalized for heart failure in Japan. Heart Vessels. 2021 Mar;36(3):383-392.

Kato T, Hiraishi Y, Kaseda K, Suzuki S, Tanaka G, Yamauchi Y, Yasui M, Shinozaki-Ushiku A, Ushiku T, Yamaji O, O'Neal WK, Nagase T. A 79-year-old man with progressive dyspnea and multiple pulmonary nodules. Chest 2020;158:e79-e84.

Abe M, Mitani A, Yao A, Zong L, Hoshi K, Yanagimoto S. Awareness of malocclusion is closely associated with allergic rhinitis, asthma, and arrhythmia in late adolescents. Healthcare (Basel) 2020;8.

Saito M, Mitani A, Ishimori T, Miyashita N, Isago H, Mikami Y, Noguchi S, Tarui M, Nagase T. Active mtor in lung epithelium promotes epithelial-mesenchymal transition and enhances lung fibrosis. Am J Respir Cell Mol Biol 2020;62:699-708.

Abe M, Mitani A, Yao A, Takeshima H, Zong L, Hoshi K, Yanagimoto S. Close associations of gum bleeding with systemic diseases in late adolescence. Int J Environ Res Public Health 2020;17.

Abe M, Mitani A, Hoshi K, Yanagimoto S. Large gender gap in oral hygiene behavior and its impact on gingival health in late adolescence. Int J Environ Res Public Health 2020;17.

Oki R, Hirakawa Y, Kimura H, Honda K, Hinata M, Abe H, Domoto Y, Tanaka G, Nagase T, Nangaku M. Renal effects after pembrolizumab treatment for non-small cell lung carcinoma. Intern Med 2020;59:977-981.

Kawata M, Jo T, Taketomi S, Inui H, Yamagami R, Matsui H, Fushimi K, Yasunaga H, Tanaka S. Type of bone graft and primary diagnosis were associated with nosocomial surgical site infection after high tibial osteotomy: Analysis of a national database. Knee Surg Sports Traumatol Arthrosc 2020.

Ohbe H, Goto T, Yamazaki R, Jo T, Matsui H, Fushimi K, Yasunaga H. Clinical trajectories of suicide attempts and self-harm in patients admitted to acute-care hospitals in japan: A nationwide inpatient database study. J Epidemiol 2020.

Watanabe K, Kage H, Nagoshi S, Toyama K, Ohno Y, Shinozaki-Ushiku A, Nakazaki K, Suzuki H, Kurokawa M, Nagase T. Dual egfr and abl tyrosine kinase inhibitor treatment in a patient with concomitant egfr-mutated lung adenocarcinoma and bcr-abl1-positive cml. Case Rep Oncol Med 2020;2020:4201727.

Muroyama Y, Tamiya H, Tanaka G, Tanaka W, Huang AC, Oldridge DA, Matsusaka K, Takazawa Y, Jo T, Ushiku T, Nagase T. Alpha-fetoprotein-producing lung hepatoid adenocarcinoma with brain metastasis treated with s-1. Case Rep Oncol 2020;13:1552-1559.

Ohbe H, Jo T, Matsui H, Fushimi K, Yasunaga H. Differences in effect of early enteral nutrition on mortality among ventilated adults with shock requiring low-, medium-, and high-dose noradrenaline: A propensity-matched analysis. Clin Nutr 2020;39:460-467.

Mouri H, Jo T, Matsui H, Fushimi K, Yasunaga H. Effect of sugammadex on postoperative myasthenic crisis in myasthenia gravis patients: Propensity score analysis of a japanese nationwide database. Anesth Analg 2020;130:367-373.

Isago H, Mitani A, Mikami Y, Horie M, Urushiyama H, Hamamoto R, Terasaki Y, Nagase T. Epithelial expression of yap and taz is sequentially required in lung development. Am J Respir Cell Mol Biol 2020;62:256-266.

Mikami Y, Jo T, Matsuzaki H, Ishimori T, Saito M, Sakamoto Y, Yamauchi Y, Takai D, Yatomi Y, Nagase T. Preoperative intervention with long-acting bronchodilators for the reduction of postoperative pulmonary complications in untreated patients with obstructive lung disease. Clin Respir J 2020;14:92-101.

Ohbe H, Jo T, Matsui H, Fushimi K, Yasunaga H. Early enteral nutrition in patients with severe traumatic brain injury: A propensity score-matched analysis using a nationwide inpatient database in japan. Am J Clin Nutr 2020;111:378-384.

Jo T, Yasunaga H, Yamauchi Y, Mitani A, Hiraishi Y, Hasegawa W, Sakamoto Y, Matsui H, Fushimi K, Nagase T. Inhaled corticosteroid withdrawal may improve outcomes in elderly patients with copd exacerbation: A nationwide database study. ERJ Open Res 2020;6.


2019年

Hiraishi Y, Jo T, Michihata N, Hasegawa W, Sakamoto Y, Urushiyama H, Matsui H, Fushimi K, Nagase T, Yasunaga H, Yamauchi Y. Hospital volume and mortality following diagnostic bronchoscopy in lung cancer patients: Data from a national inpatient database in japan. Respiration 2019;97:264-272.

Ohbe H, Isogai S, Jo T, Matsui H, Fushimi K, Yasunaga H. Extracorporeal membrane oxygenation improves outcomes of accidental hypothermia without vital signs: A nationwide observational study. Resuscitation 2019;144:27-32.

Ohbe H, Isogai S, Jo T, Matsui H, Fushimi K, Yasunaga H. Treatment with antithrombin or thrombomodulin and mortality from heatstroke-induced disseminated intravascular coagulation: A nationwide observational study. Semin Thromb Hemost 2019;45:760-766.

Goto T, Jo T, Matsui H, Fushimi K, Hayashi H, Yasunaga H. Machine learning-based prediction models for 30-day readmission after hospitalization for chronic obstructive pulmonary disease. Copd 2019;16:338-343.

Kumazawa R, Jo T, Matsui H, Fushimi K, Yasunaga H. ssociation between AngiotensinConverting Enzyme Inhibitors and Post-Stroke Aspiration Pneumonia.

Kumazawa R, Jo T, Matsui H, Fushimi K, Yasunaga H. Association between angiotensin-converting enzyme inhibitors and post-stroke aspiration pneumonia. J Stroke Cerebrovasc Dis 2019;28:104444.

Ohbe H, Jo T, Matsui H, Fushimi K, Yasunaga H. Early enteral nutrition in patients undergoing sustained neuromuscular blockade: A propensity-matched analysis using a nationwide inpatient database. Crit Care Med 2019;47:1072-1080.

Saito A, Hakamata Y, Yamada Y, Sunohara M, Tarui M, Murano Y, Mitani A, Tanaka K, Nagase T, Yanagimoto S. Pleural thickening on screening chest x-rays: A single institutional study. Respir Res 2019;20:138.

Urushiyama H, Terasaki Y, Nagasaka S, Kokuho N, Endo Y, Terasaki M, Kunugi S, Makita K, Isago H, Hosoki K, Souma K, Ishii T, Matsuzaki H, Hiraishi Y, Mikami Y, Noguchi S, Tamiya H, Mitani A, Yamauchi Y, Shimizu A, Nagase T. Naftopidil reduced the proliferation of lung fibroblasts and bleomycin-induced lung fibrosis in mice. J Cell Mol Med 2019;23:3563-3571.

Michihata N, Shigemi D, Sasabuchi Y, Matsui H, Jo T, Yasunaga H. Safety and effectiveness of japanese herbal kampo medicines for treatment of hyperemesis gravidarum. Int J Gynaecol Obstet 2019;145:182-186.

Saito M, Kage H, Ando T, Sawada R, Amano Y, Goto Y, Shinoda Y, Nagase T. Prevalence of bone pain decreases as lymph node stage increases in nonsmall cell lung cancer patients. Curr Probl Cancer 2019;43:86-91.

Ota K, Sasabuchi Y, Matsui H, Jo T, Fushimi K, Yasunaga H. Age distribution and seasonality in acute eosinophilic pneumonia: Analysis using a national inpatient database. BMC Pulm Med 2019;19:38.

Ohbe H, Isogai S, Nakajima M, Jo T, Matsui H, Fushimi K, Yasunaga H. Physician-manned prehospital emergency care in tertiary emergency centers in japan. Acute Med Surg 2019;6:165-172.

Mouri H, Jo T, Michihata N, Matsui H, Fushimi K, Yasunaga H. Continuous neuromuscular blockade and mortality in subjects with exacerbation of idiopathic interstitial pneumonias. Respir Care 2019;64:34-39.

Takeshima H, Horie M, Mikami Y, Makita K, Miyashita N, Matsuzaki H, Noguchi S, Urushiyama H, Hiraishi Y, Mitani A, Borok Z, Nagase T, Yamauchi Y. Cish is a negative regulator of il-13-induced ccl26 production in lung fibroblasts. Allergol Int 2019;68:101-109.


2018年

Tamiya H, Mitani A, Saito A, Ishimori T, Saito M, Isago H, Jo T, Yamauchi Y, Tanaka G, Nagase T. Exosomal microrna expression profiling in patients with lung adenocarcinoma-associated malignant pleural effusion. Anticancer Res 2018;38:6707-6714.

Jo T, Michihata N, Yamana H, Sasabuchi Y, Matsui H, Urushiyama H, Mitani A, Yamauchi Y, Fushimi K, Nagase T, Yasunaga H. Reduction in exacerbation of copd in patients of advanced age using the japanese kampo medicine dai-kenchu-to: A retrospective cohort study. Int J Chron Obstruct Pulmon Dis 2019;14:129-139.

Hiraishi Y, Jo T, Michihata N, Hasegawa W, Sakamoto Y, Urushiyama H, Matsui H, Fushimi K, Nagase T, Yasunaga H, Yamauchi Y. Hospital volume and mortality following diagnostic bronchoscopy in lung cancer patients: Data from a national inpatient database in japan. Respiration 2018:1-9.

Hiyama N, Sasabuchi Y, Jo T, Hirata T, Osuga Y, Nakajima J, Yasunaga H. The three peaks in age distribution of females with pneumothorax: A nationwide database study in japan. Eur J Cardiothorac Surg 2018;54:572-578.

Jo T, Yasunaga H, Michihata N, Sasabuchi Y, Hasegawa W, Takeshima H, Sakamoto Y, Matsui H, Fushimi K, Nagase T, Yamauchi Y. Influence of parkinsonism on outcomes of elderly pneumonia patients. Parkinsonism Relat Disord 2018;54:25-29.

Ohbe H, Jo T, Matsui H, Fushimi K, Yasunaga H. Cholinergic crisis caused by cholinesterase inhibitors: A retrospective nationwide database study. J Med Toxicol 2018;14:237-241.

Nakaharai K, Morita K, Jo T, Matsui H, Fushimi K, Yasunaga H. Early prophylactic antibiotics for severe acute pancreatitis: A population-based cohort study using a nationwide database in japan. J Infect Chemother 2018;24:753-758.

Takeshima H, Horie M, Mikami Y, Makita K, Miyashita N, Matsuzaki H, Noguchi S, Urushiyama H, Hiraishi Y, Mitani A, Borok Z, Nagase T, Yamauchi Y. Cish is a negative regulator of il-13-induced ccl26 production in lung fibroblasts. Allergol Int 2018.

Ando T, Kage H, Saito M, Amano Y, Goto Y, Nakajima J, Nagase T. Early stage non-small cell lung cancer patients need brain imaging regardless of symptoms. Int J Clin Oncol 2018;23:641-646.

Ohbe H, Jo T, Yamana H, Matsui H, Fushimi K, Yasunaga H. Early enteral nutrition for cardiogenic or obstructive shock requiring venoarterial extracorporeal membrane oxygenation: A nationwide inpatient database study. Intensive Care Med 2018;44:1258-1265.

Urushiyama H, Jo T, Yasunaga H, Michihata N, Matsui H, Hasegawa W, Takeshima H, Sakamoto Y, Hiraishi Y, Mitani A, Fushimi K, Nagase T, Yamauchi Y. Oral fluorouracil vs vinorelbine plus cisplatin as adjuvant chemotherapy for stage ii-iiia non-small cell lung cancer: Propensity score-matched and instrumental variable analyses. Cancer Med 2018;7:4863-4869.

Urushiyama H, Jo T, Yasunaga H, Michihata N, Yamana H, Matsui H, Hasegawa W, Hiraishi Y, Mitani A, Fushimi K, Nagase T, Yamauchi Y. Effect of hangeshashin-to (japanese herbal medicine tj-14) on tolerability of irinotecan: Propensity score and instrumental variable analyses. J Clin Med 2018;7.

Mitani A, Jo T, Yasunaga H, Sakamoto Y, Hasegawa W, Urushiyama H, Yamauchi Y, Matsui H, Fushimi K, Nagase T. Venous thromboembolic events in patients with lung cancer treated with cisplatin-based versus carboplatin/nedaplatin-based chemotherapy. Anticancer Drugs 2018;29:560-564.

Maemura K, Kage H, Isago H, Takeshima H, Makita K, Amano Y, Takai D, Ohishi N, Nagase T. Cerebral arterial air embolism after diagnostic flexible fiberoptic bronchoscopy: A case report and review of the literature. Case Rep Pulmonol 2018;2018:7108215.

Sasabuchi Y, Matsui H, Lefor AK, Jo T, Michihata N, Fushimi K, Yasunaga H. Japanese herbal kampo hochu-ekki-to or juzen-taiho-to after surgery for hip fracture does not reduce infectious complications. Evid Based Complement Alternat Med 2018;2018:8620198.

Sato C, Okuda K, Tamiya H, Yamamoto K, Hoshina K, Narumoto O, Urushiyama H, Noguchi S, Amano Y, Watanabe K, Mitani A, Kage H, Tanaka G, Yamauchi Y, Takai D, Nagase T. Acute arterial thrombosis during postoperative adjuvant cisplatin-based chemotherapy for completely resected lung adenocarcinoma. Intern Med 2018;57:557-561.

Shinno Y, Kage H, Chino H, Inaba A, Arakawa S, Noguchi S, Amano Y, Yamauchi Y, Tanaka G, Nagase T. Old age and underlying interstitial abnormalities are risk factors for development of ards after pleurodesis using limited amount of large particle size talc. Respirology 2018;23:55-59.

Mitani A. Asthma and stress. In: Gellman M, editor. Encyclopedia of behavioral medicine. New York, NY: Springer New York; 2018. p. 1-2.

Mitani A. Asthma. In: Gellman M, Turner JR, editors. Encyclopedia of behavioral medicine. New York, NY: Springer New York; 2018. p. 1-2.

Mitani A. Chronic obstructive pulmonary disease. In: Gellman M, Turner JR, editors. Encyclopedia of behavioral medicine. New York, NY: Springer New York; 2018. p. 1-2.


2017年

Mitani A, Azam A, Vuppusetty C, Ito K, Mercado N, Barnes PJ. Quercetin restores corticosteroid sensitivity in cells from patients with chronic obstructive pulmonary disease. Exp Lung Res 2017;43:417-425.

Mitani A, Hakamata Y, Hosoi M, Horie M, Murano Y, Saito A, Yanagimoto S, Tsuji S, Yamamoto K, Nagase T. The incidence and risk factors of asymptomatic primary spontaneous pneumothorax detected during health check-ups. BMC Pulm Med 2017;17:177.

Jo T, Yasunaga H, Sasabuchi Y, Michihata N, Morita K, Yamauchi Y, Hasegawa W, Takeshima H, Sakamoto Y, Matsui H, Fushimi K, Nagase T. Association between dementia and discharge status in patients hospitalized with pneumonia. BMC Pulm Med 2017;17:128.

Urushiyama H, Jo T, Yasunaga H, Yamauchi Y, Matsui H, Hasegawa W, Takeshima H, Hiraishi Y, Mitani A, Fushimi K, Nagase T. Adjuvant chemotherapy versus chemoradiotherapy for small cell lung cancer with lymph node metastasis: A retrospective observational study with use of a national database in japan. BMC Cancer 2017;17:613.

Hasegawa W, Yamauchi Y, Yasunaga H, Takeshima H, Sakamoto Y, Jo T, Sasabuchi Y, Matsui H, Fushimi K, Nagase T. Prognostic nomogram for inpatients with asthma exacerbation. BMC Pulm Med 2017;17:108.

Matsuki R, Okuda K, Mitani A, Yamauchi Y, Tanaka G, Kume H, Homma Y, Hinata M, Hayashi A, Shibahara J, Fukayama M, Nagase T. A case of delayed exacerbation of interstitial lung disease after discontinuation of temsirolimus. Respir Med Case Rep 2017;22:158-163.

Sakamoto Y, Yamauchi Y, Yasunaga H, Takeshima H, Hasegawa W, Jo T, Sasabuchi Y, Matsui H, Fushimi K, Nagase T. Development of a nomogram for predicting in-hospital mortality of patients with exacerbation of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2017;12:1605-1611.

Matsui H, Jo T, Fushimi K, Yasunaga H. Outcomes after early and delayed rehabilitation for exacerbation of chronic obstructive pulmonary disease: A nationwide retrospective cohort study in japan. Respir Res 2017;18:68.

Noguchi S, Saito A, Mikami Y, Urushiyama H, Horie M, Matsuzaki H, Takeshima H, Makita K, Miyashita N, Mitani A, Jo T, Yamauchi Y, Terasaki Y, Nagase T. Taz contributes to pulmonary fibrosis by activating profibrotic functions of lung fibroblasts. Sci Rep 2017;7:42595.

Sakamoto Y, Yamauchi Y, Yasunaga H, Takeshima H, Hasegawa W, Jo T, Matsui H, Fushimi K, Nagase T. Guidelines-concordant empiric antimicrobial therapy and mortality in patients with severe community-acquired pneumonia requiring mechanical ventilation. Respir Investig 2017;55:39-44.

Kido Y, Mitani A, Isago H, Takeshima H, Narumoto O, Tanaka G, Yamauchi Y, Takai D, Ohishi N, Nagase T. Successful treatment of pulmonary injury after nitrogen oxide exposure with corticosteroid therapy: A case report and review of the literature. Respir Med Case Rep 2017;20:107-110.

Mitani A. Lung function. In: Gellman M, Turner JR, editors. Encyclopedia of behavioral medicine. New York, NY: Springer New York; 2017. p. 1-2.


2016年

Kage H, Goto Y, Amano Y, Makita K, Isago H, Kobayashi K, Narumoto O, Okudaira R, Tanaka G, Takami K, Ohishi N, Nagase T. Development of pulmonary artery aneurysms due to behcet's disease and resolution after treatment. Intern Med 2016;55:3337-3340.

Yamauchi Y, Yasunaga H, Sakamoto Y, Hasegawa W, Takeshima H, Urushiyama H, Jo T, Matsui H, Fushimi K, Nagase T. Mortality associated with bone fractures in copd patients. Int J Chron Obstruct Pulmon Dis 2016;11:2335-2340.

Chino H, Amano Y, Yamauchi Y, Matsuda J, Takeda N, Tanaka G, Takai D, Nagase T. Cardiogenic syncope possibly related to bevacizumab-containing combination chemotherapy for advanced non-small cell lung cancer. J Thorac Dis 2016;8:2646-2650.

Yamauchi Y, Yasunaga H, Hasegawa W, Sakamoto Y, Takeshima H, Jo T, Matsui H, Fushimi K, Nagase T. Effect of outpatient therapy with inhaled corticosteroids on decreasing in-hospital mortality from pneumonia in patients with copd. Int J Chron Obstruct Pulmon Dis 2016;11:1403-1411.

Okuda K, Noguchi S, Narumoto O, Ikemura M, Yamauchi Y, Tanaka G, Takai D, Fukayama M, Nagase T. A case of meigs' syndrome with preceding pericardial effusion in advance of pleural effusion. BMC Pulm Med 2016;16:71.

Mitani A, Ito K, Vuppusetty C, Barnes PJ, Mercado N. Restoration of corticosteroid sensitivity in chronic obstructive pulmonary disease by inhibition of mammalian target of rapamycin. Am J Respir Crit Care Med 2016;193:143-153.

Horie M, Tamiya H, Goto Y, Suzuki M, Matsuzaki H, Hasegawa WT, Noguchi S, Kawakami M, Matsuta K, Nagase T, Sakamoto Y. Nonspecific elevation of serum aspergillus galactomannan antigen levels in patients with rheumatoid arthritis. Respir Investig 2016;54:44-49.


2015年以前

Matsuzaki H, Mikami Y, Makita K, Takeshima H, Horie M, Noguchi S, Jo T, Narumoto O, Kohyama T, Takizawa H, Nagase T, Yamauchi Y. Interleukin-17a and toll-like receptor 3 ligand poly(i:C) synergistically induced neutrophil chemoattractant production by bronchial epithelial cells. PLoS One 2015;10:e0141746.

Yamauchi Y, Yasunaga H, Matsui H, Hasegawa W, Jo T, Takami K, Fushimi K, Nagase T. Comparison of clinical characteristics and outcomes between aspiration pneumonia and community-acquired pneumonia in patients with chronic obstructive pulmonary disease. BMC Pulm Med 2015;15:69.

Hasegawa W, Yamauchi Y, Yasunaga H, Sunohara M, Jo T, Matsui H, Fushimi K, Takami K, Nagase T. Factors that predict in-hospital mortality in eosinophilic granulomatosis with polyangiitis. Allergy 2015;70:585-590.

Yamauchi Y, Yasunaga H, Matsui H, Hasegawa W, Jo T, Takami K, Fushimi K, Nagase T. Comparison of in-hospital mortality in patients with copd, asthma and asthma-copd overlap exacerbations. Respirology 2015;20:940-946.

Hasegawa W, Yamauchi Y, Yasunaga H, Sunohara M, Jo T, Matsui H, Fushimi K, Takami K, Nagase T. Clinical features of 280 hospitalized patients with lymphangioleiomyomatosis in japan. Respirology 2015;20:160-165.

Tamiya H, Ochiai E, Kikuchi K, Yahiro M, Toyotome T, Watanabe A, Yaguchi T, Kamei K. Secondary metabolite profiles and antifungal drug susceptibility of aspergillus fumigatus and closely related species, aspergillus lentulus, aspergillus udagawae, and aspergillus viridinutans. J Infect Chemother 2015;21:385-391.

Mikami Y, Matsuzaki H, Horie M, Noguchi S, Jo T, Narumoto O, Kohyama T, Takizawa H, Nagase T, Yamauchi Y. Lymphotoxin beta receptor signaling induces il-8 production in human bronchial epithelial cells. PLoS One 2014;9:e114791.

Yamauchi Y, Hasegawa W, Yasunaga H, Sunohara M, Jo T, Takami K, Matsui H, Fushimi K, Nagase T. Paradoxical association between body mass index and in-hospital mortality in elderly patients with chronic obstructive pulmonary disease in japan. Int J Chron Obstruct Pulmon Dis 2014;9:1337-1346.

Horie M, Saito A, Yamauchi Y, Mikami Y, Sakamoto M, Jo T, Nakajima J, Takizawa H, Nagase T, Kohyama T. Histamine induces human lung fibroblast-mediated collagen gel contraction via histamine h1 receptor. Exp Lung Res 2014;40:222-236.

Risse PA, Lavoie-Lamoureux A, Jo T, Tsuchiya K, Siddiqui S, Martin JG. Airway arginase expression and nomega-hydroxy-nor-arginine effect on methacholine-induced bronchoconstriction differentiate lewis and fischer rat strains. J Appl Physiol (1985) 2014;116:621-627.

Siddiqui S, Novali M, Tsuchiya K, Hirota N, Geller BJ, McGovern TK, Risse PA, Jo T, Zeroual MA, Martin JG. The modulation of large airway smooth muscle phenotype and effects of epidermal growth factor receptor inhibition in the repeatedly allergen-challenged rat. Am J Physiol Lung Cell Mol Physiol 2013;304:L853-862.

Mikami Y, Yamauchi Y, Horie M, Kase M, Jo T, Takizawa H, Kohyama T, Nagase T. Tumor necrosis factor superfamily member light induces epithelial-mesenchymal transition in a549 human alveolar epithelial cells. Biochem Biophys Res Commun 2012;428:451-457.

Shalaby KH, Jo T, Nakada E, Allard-Coutu A, Tsuchiya K, Hirota N, Qureshi ST, Maghni K, Rioux CR, Martin JG. Icos-expressing cd4 t cells induced via tlr4 in the nasal mucosa are capable of inhibiting experimental allergic asthma. J Immunol 2012;189:2793-2804.

Sapkota BR, Hijikata M, Matsushita I, Tanaka G, Ieki R, Kobayashi N, Toyota E, Nagai H, Kurashima A, Tokunaga K, Keicho N. Association of slc11a1 (nramp1) polymorphisms with pulmonary mycobacterium avium complex infection. Hum Immunol 2012;73:529-536.

Yamauchi Y, Kohyama T, Jo T, Nagase T. Dynamic change in respiratory resistance during inspiratory and expiratory phases of tidal breathing in patients with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2012;7:259-269.

Venkatesan N, Siddiqui S, Jo T, Martin JG, Ludwig MS. Allergen-induced airway remodeling in brown norway rats: Structural and metabolic changes in glycosaminoglycans. Am J Respir Cell Mol Biol 2012;46:96-105.

Tanaka G, Aminuddin F, Akhabir L, He JQ, Shumansky K, Connett JE, Anthonisen NR, Abboud RT, Pare PD, Sandford AJ. Effect of heme oxygenase-1 polymorphisms on lung function and gene expression. BMC Med Genet 2011;12:117.

Risse PA, Jo T, Suarez F, Hirota N, Tolloczko B, Ferraro P, Grutter P, Martin JG. Interleukin-13 inhibits proliferation and enhances contractility of human airway smooth muscle cells without change in contractile phenotype. Am J Physiol Lung Cell Mol Physiol 2011;300:L958-966.

Hijikata M, Matsushita I, Tanaka G, Tsuchiya T, Ito H, Tokunaga K, Ohashi J, Homma S, Kobashi Y, Taguchi Y, Azuma A, Kudoh S, Keicho N. Molecular cloning of two novel mucin-like genes in the disease-susceptibility locus for diffuse panbronchiolitis. Hum Genet 2011;129:117-128.

Fujimoto C, Ozeki H, Uchijima Y, Suzukawa K, Mitani A, Fukuhara S, Nishiyama K, Kurihara Y, Kondo K, Aburatani H, Kaga K, Yamasoba T, Kurihara H. Establishment of mice expressing egfp in the placode-derived inner ear sensory cell lineage and facs-array analysis focused on the regional specificity of the otocyst. J Comp Neurol 2010;518:4702-4722.

Siddiqui S, Jo T, Tamaoka M, Shalaby KH, Ghezzo H, Bernabeu M, Martin JG. Sites of allergic airway smooth muscle remodeling and hyperresponsiveness are not associated in the rat. J Appl Physiol (1985) 2010;109:1170-1178.

Tsuchiya K, Jo T, Takeda N, Al Heialy S, Siddiqui S, Shalaby KH, Risse PA, Maghni K, Martin JG. Egf receptor activation during allergic sensitization affects il-6-induced t-cell influx to airways in a rat model of asthma. Eur J Immunol 2010;40:1590-1602.

Hassan M, Jo T, Risse PA, Tolloczko B, Lemiere C, Olivenstein R, Hamid Q, Martin JG. Airway smooth muscle remodeling is a dynamic process in severe long-standing asthma. J Allergy Clin Immunol 2010;125:1037-1045 e1033.

Mitani A, Nagase T, Fukuchi K, Aburatani H, Makita R, Kurihara H. Transcriptional coactivator with pdz-binding motif is essential for normal alveolarization in mice. Am J Respir Crit Care Med 2009;180:326-338.

Shojima J, Tanaka G, Keicho N, Tamiya G, Ando S, Oka A, Inoue Y, Suzuki K, Sakatani M, Okada M, Kobayashi N, Toyota E, Kudo K, Kajiki A, Nagai H, Kurashima A, Oketani N, Hayakawa H, Takemura T, Nakata K, Ito H, Morita T, Matsushita I, Hijikata M, Sakurada S, Sasazuki T, Inoko H. Identification of mica as a susceptibility gene for pulmonary mycobacterium avium complex infection. J Infect Dis 2009;199:1707-1715.

Nakajima T, Kubota N, Tsutsumi T, Oguri A, Imuta H, Jo T, Oonuma H, Soma M, Meguro K, Takano H, Nagase T, Nagata T. Eicosapentaenoic acid inhibits voltage-gated sodium channels and invasiveness in prostate cancer cells. Br J Pharmacol 2009;156:420-431.

Tamaoka M, Hassan M, McGovern T, Ramos-Barbon D, Jo T, Yoshizawa Y, Tolloczko B, Hamid Q, Martin JG. The epidermal growth factor receptor mediates allergic airway remodelling in the rat. Eur Respir J 2008;32:1213-1223.

Nakajima T, Jo T, Meguro K, Oonuma H, Ma J, Kubota N, Imuta H, Takano H, Iida H, Nagase T, Nagata T. Effect of dexamethasone on voltage-gated na+ channel in cultured human bronchial smooth muscle cells. Life Sci 2008;82:1210-1215.

Makita R, Uchijima Y, Nishiyama K, Amano T, Chen Q, Takeuchi T, Mitani A, Nagase T, Yatomi Y, Aburatani H, Nakagawa O, Small EV, Cobo-Stark P, Igarashi P, Murakami M, Tominaga J, Sato T, Asano T, Kurihara Y, Kurihara H. Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking taz. Am J Physiol Renal Physiol 2008;294:F542-553.

Martin JG, Jo T. Genetic differences in airway smooth muscle function. Proc Am Thorac Soc 2008;5:73-79.

Tanaka G, Shojima J, Matsushita I, Nagai H, Kurashima A, Nakata K, Toyota E, Kobayashi N, Kudo K, Keicho N. Pulmonary mycobacterium avium complex infection: Association with nramp1 polymorphisms. Eur Respir J 2007;30:90-96.

Mai HN, Hijikata M, Inoue Y, Suzuki K, Sakatani M, Okada M, Kimura K, Kobayashi N, Toyota E, Kudo K, Nagai H, Kurashima A, Kajiki A, Oketani N, Hayakawa H, Tanaka G, Shojima J, Matsushita I, Sakurada S, Tokunaga K, Keicho N. Pulmonary mycobacterium avium complex infection associated with the ivs8-t5 allele of the cftr gene. Int J Tuberc Lung Dis 2007;11:808-813.

Tanaka G, Sandford AJ, Burkett K, Connett JE, Anthonisen NR, Pare PD, He JQ. Tumour necrosis factor and lymphotoxin a polymorphisms and lung function in smokers. Eur Respir J 2007;29:34-41.

Iida H, Jo T, Iwasawa K, Morita T, Hikiji H, Takato T, Toyo-Oka T, Nagai R, Nakajima T. Molecular and pharmacological characteristics of transient voltage-dependent k+ currents in cultured human pulmonary arterial smooth muscle cells. Br J Pharmacol 2005;146:49-59.

Jo T, Iida H, Kishida S, Imuta H, Oonuma H, Nagata T, Hara H, Iwasawa K, Soma M, Sato Y, Nagase T, Nagai R, Nakajima T. Acute and chronic effects of eicosapentaenoic acid on voltage-gated sodium channel expressed in cultured human bronchial smooth muscle cells. Biochem Biophys Res Commun 2005;331:1452-1459.

Kamio K, Matsushita I, Hijikata M, Kobashi Y, Tanaka G, Nakata K, Ishida T, Tokunaga K, Taguchi Y, Homma S, Nakata K, Azuma A, Kudoh S, Keicho N. Promoter analysis and aberrant expression of the muc5b gene in diffuse panbronchiolitis. Am J Respir Crit Care Med 2005;171:949-957.

Tanaka G, Matsushita I, Ohashi J, Tsuchiya N, Ikushima S, Oritsu M, Hijikata M, Nagata T, Yamamoto K, Tokunaga K, Keicho N. Evaluation of microsatellite markers in association studies: A search for an immune-related susceptibility gene in sarcoidosis. Immunogenetics 2005;56:861-870.

Ma J, Iida H, Jo T, Takano H, Oonuma H, Morita T, Toyo-Oka T, Omata M, Nagai R, Okuda Y, Yamada N, Nakajima T. Ursodeoxycholic acid inhibits endothelin-1 production in human vascular endothelial cells. Eur J Pharmacol 2004;505:67-74.

Kamio K, Matsushita I, Tanaka G, Ohashi J, Hijikata M, Nakata K, Tokunaga K, Azuma A, Kudoh S, Keicho N. Direct determination of muc5b promoter haplotypes based on the method of single-strand conformation polymorphism and their statistical estimation. Genomics 2004;84:613-622.

Jo T, Nagata T, Iida H, Imuta H, Iwasawa K, Ma J, Hara K, Omata M, Nagai R, Takizawa H, Nagase T, Nakajima T. Voltage-gated sodium channel expressed in cultured human smooth muscle cells: Involvement of scn9a. FEBS Lett 2004;567:339-343.

Mitani A, Saku N, Hironaka M, Ohno S, Sohara Y, Saito K, Sugiyama Y. [a case of metastatic lung tumor from an occult thyroid oncocytic carcinoma growing into the bronchial lumen]. Nihon Kokyuki Gakkai Zasshi 2003;41:822-826.

Ma J, Nakajima T, Iida H, Iwasawa K, Terasawa K, Oonuma H, Jo T, Morita T, Imuta H, Suzuki J, Hirose K, Okuda Y, Yamada N, Nagai R, Omata M. Inhibitory effects of ursodeoxycholic acid on the induction of nitric oxide synthase in vascular smooth muscle cells. Eur J Pharmacol 2003;464:79-86.

Terasawa K, Nakajima T, Iida H, Iwasawa K, Oonuma H, Jo T, Morita T, Nakamura F, Fujimori Y, Toyo-oka T, Nagai R. Nonselective cation currents regulate membrane potential of rabbit coronary arterial cell: Modulation by lysophosphatidylcholine. Circulation 2002;106:3111-3119.

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論文（国内誌）

- 作成中

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海外学会・講演会　[CLICK]

2021年

Akihisa Mitani. Educational Lecture: How do we use mice in medical research?
26th Congress of the Asian Pacific Society of Respirology Kyoto 2021: symposium

Akira Yokoyama. Yokukansan and in-hospital mortality in patients with pneumonia
26th Congress of the Asian Pacific Society of Respirology Kyoto 2021: poster

Saki Nagoshi. Effect of autophagy in human alveolar epithelial cells on pulmonary fibrosis
26th Congress of the Asian Pacific Society of Respirology Kyoto 2021: poster

Hiroyuki Tamiya. Role of early intrapleural fibrinolytic therapy for thoracic empyema: an analysis of the nationwide inpatient database
26th Congress of the Asian Pacific Society of Respirology Kyoto 2021: poster

Masaaki Yuki. The Japanese herbal medicine Hochuekkito (TJ-41) reduces lung inflammation in COPD exacerbation mouse model.
26th Congress of the Asian Pacific Society of Respirology Kyoto 2021: poster

Taro Ishimori. Sirtuin3 suppresses lung inflammation of COPD exacerbation mouse model
26th Congress of the Asian Pacific Society of Respirology Kyoto 2021: poster

Minako Saito. The roles of Angiopoietin-like 4 in lung fibrosis
26th Congress of the Asian Pacific Society of Respirology Kyoto 2021: poster


2020年

Hiroyuki Tamiya. Prevalence and predictors of incorrect use of inhaler device in patients with obstructive lung diseases
Japanese Society of Allergology / World Allergy Organization Joint Congress Kyoto 2020: poster

Hiroyuki Tamiya. Measurement of Chest Wall Motion by High-Speed Whole-Field Three-Dimensional Motion Capture
American Thoracic Society (ATS) Conference 2020: poster


2019年

Akihisa Mitani. Molecular Mechanism undelying COPD
24th Congress of the Asian Pacific Society of Respirology Hanoi 2019: symposium

Taisuke Jo. Prophylactic use of goshajinkigan (TJ107) for prevention of taxane-based chemotherapyinduced peripheral neuropathy in patients with non-small cell lung cancer
24th Congress of the Asian Pacific Society of Respirology Hanoi 2019: poster

Goh Tanaka. Factors affecting in-hospital mortality of non-tuberculous mycobacterial pulmonary disease
24th Congress of the Asian Pacific Society of Respirology Hanoi 2019: poster

Minako Saito. Mechanistic target of rapamycin enhances fibrosis in lung by promoting epithelial mesenchymal transition
European-Respiratory-Society (ERS) International Congress 2019 Madrid: oral presentation

Hideaki Isago. Japanese herbal medicine Hochu-ekki-to (TJ-41) attenuates lung inflammation in lung emphysema
European-Respiratory-Society (ERS) International Congress 2019 Madrid: poster

Hideaki Isago. The Hippo pathway effectors TAZ and YAP are sequentially required in lung development (ERS Travel Awards)
European-Respiratory-Society (ERS) International Congress 2019 Madrid: oral presentation

Taro Ishimori. Sirtuin3 reduces acute lung inflammation and emphysematous aggravation in COPD exacerbation mouse model
European-Respiratory-Society (ERS) International Congress 2019 Madrid: poster

Taisuke Jo. Safety of Inhaled corticosteroid withdrawal in elderly patients hospitalized for chronic obstructive pulmonary disease exacerbation: a nationwide cohort study in Japan
American Thoracic Society (ATS) Conference 2019 Dalas: poster


2018年

Taisuke Jo. Effect of Dai-Kenchu-To on COPD Exacerbations in Elderly Patients: A retrospective Study Using a Nationwide Database in Japan
23rd Congress of the Asian Pacific Society of Respirology 2018 Taipei: poster

Hiroyuki Tamiya. MicroRNA expression profiling for identifying malignant pleural effusion in patients with lung adenocarcinoma
23rd Congress of the Asian Pacific Society of Respirology 2018 Taipei: poster

Taisuke Jo. Impact of Parkinsonism on elderly patients hospitalized for pneumonia
American Thoracic Society (ATS) Conference 2018 San Diego: poster


2017年以前

Hideaki Isago. Hippo pathway effectors Taz and Yap functioning at different stages of lung development
22nd Congress of the Asian Pacific Society of Respirology 2017 Sydney: poster

Hiroyuki Tamiya. Diagnostic Significance of microRNA Features in Patient with Malignant Pleural Effusion
22nd Congress of the Asian Pacific Society of Respirology 2017 Sydney: poster

Akihisa Mitani. The Incidence and Risk Factors of Asymptomatic Spontaneous Pneumothorax (ASP) Detected during Health Check-ups.
American Thoracic Society (ATS) Conference 2017 Washington, DC: poster

Minako Saito. Clinically N0 Non-Small Cell Lung Cancer Patients Without Bone Pain Do Not Need Bone Imaging
American Thoracic Society (ATS) Conference 2017 Washington, DC: poster

Akihisa Mitani. Inhibition of mTOR restores corticosteroid sensitivity in chronic obstructive pulmonary disease (APSR Travel Awards)
20th Congress of the Asian Pacific Society of Respirology 2015 Kuala Lumpur: oral presentation

Goh Tanaka. A retrospective analysis of patient data for management of tuberculosis in Hanoi
19th Congress of the Asian Pacific Society of Respirology 2014 Bali: poster

Taisuke Jo. The influence of bronchial asthma as a comorbidity of COPD on the COPD assessment test (CAT)
European-Respiratory-Society (ERS) International Congress 2014 Munich: poster

Akihisa Mitani. A role of mTOR in cigarette smoke-induced corticosteroid insensitivity
European-Respiratory-Society (ERS) International Congress 2012 Vienna: poster

Taisuke Jo. Analysis of the airway transcriptome in two rat strains of differing airway responsiveness
European-Respiratory-Society (ERS) International Congress 2010 Barcelona: poster

Akihisa Mitani. TAZ IS ESSENTIAL FOR NORMAL ALVEOLARIZATION IN MICE
14th Congress of the Asian Pacific Society of Respirology 2009 Seoul: poster

Taisuke Jo. Investigation of the Molecular Regulation in the Airways of Two Highly Inbred Rat Strains
American Thoracic Society (ATS) Conference 2009 San Diego: poster

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国内学会・講演会　[CLICK]

2023年

田宮浩之．口頭「One-pitch phase analysis法を用いたモーションキャプチャーシステムによる胸郭運動解析」（第25回IREF）IREF Young Investigator’s Award

横山晃．ポスター「3次病院の外来玄関における赤外線サーモグラフィと問診による発熱者スクリーニング」（第38回日本環境感染学会学術集会）

田宮浩之．口頭「地域薬局における閉塞性肺疾患患者に対する吸入指導についてのアンケート調査」（第63回日本呼吸器学会学術講演会）


2022年

石森太郎．口頭「COPDにおけるSIRT3の役割の研究」（第23回IREF）IREF Young Investigator’s Award

三谷明久．ポスター「本学における新型コロナウイルス抗体疫学研究」（第62回日本呼吸器学会学術講演会）


2020年

齋藤美奈子．口演「肺上皮細胞におけるmTOR活性化が肺線維症の病態に及ぼす影響についての解析」（第22回IREF）IREF Young Investigator’s Award

田中　剛．ポスター「肺非結核性抗酸菌症の在院死亡についての検討」（第95回日本結核・非結核性抗酸菌症学会）


2019年

城　大祐．口演「高齢非小細胞肺癌のタキサン系抗癌剤治療における末梢神経障害に対する牛車腎気丸の予防的投与の効果」（第3回日本臨床疫学会）

齋藤美奈子．口演「肺上皮細胞におけるmTOR活性化が肺線維症の病態に及ぼす影響についての解析」（第16回東京呼吸器リサーチフォーラム）


2018年

城　大祐．口演「大建中湯の慢性閉塞性肺疾患後期高齢患者における再増悪入院または死亡リスク低下効果の検討」（第2回日本臨床疫学会）

三谷明久．特別報告「受動喫煙に関する最新知見」（第58回日本呼吸器学会学術講演会）


2017年以前

三谷明久．ポスター「健康診断時における呼吸音聴取の現状と課題」（第55回全国大学保健管理研究集会）

三谷明久．ポスター「定期健診発見の自然気胸症例のまとめ」（第57回日本呼吸器学会学術講演会）

三谷明久．口演「慢性呼吸器疾患におけるTAZ/YAPの働きの解明」（第14回東京呼吸器リサーチフォーラム）優秀賞

田宮浩之．口演「キノロン系抗菌薬点眼によりアナフィラキシーを発症した 1 例」（第65回日本アレルギー学会学術大会）

田宮浩之．ポスター「アナフィラキシーの原因診断にホルマリン特異的IgE検査が有用であった1例」（第64回日本アレルギー学会学術大会）

田宮浩之．ポスター「粟粒型肺転移をきたした非小細胞肺癌症例の臨床的検討」（第7回呼吸機能イメージング研究会学術集会）

三谷明久．口演「ステロイド感受性におけるmTORの役割」（第16回IREF）IREF Young Investigator’s Award

田中　剛．シンポジウム「肺MAC症に関わる遺伝因子の解析」（第89回日本結核病学会総会）

三谷明久．シンポジウム「転写コアクチベーターTAZと肺の発生・発達」（第50回日本呼吸器学会学術講演会）

三谷明久．口演「ブレオマイシン肺におけるTAZ遺伝子の関与」（第14回東京呼吸病態研究会）研究症例賞（Kyorin Respiratory Research Award）

田宮浩之．ポスター「関節リウマチ(RA)患者における血清中アスペルギルス抗原の測定」（第49回日本呼吸器学会学術講演会）

三谷明久．ポスター「Abnormal Lung Development and Emphysema-like Phenotype in TAZ-deficient Mice」（第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会）

三谷明久．ポスター「Inhibition of Distal Lung Morphogenesis in Mice Lacking TAZ」（第40回日本発生生物学会・第59回日本細胞性物学会 合同大会）

三谷明久．口演「Abnormal lung development and COPD-like phenotype in TAZ-deficient mice」（第4回東京呼吸器リサーチフォーラム）審査員特別賞