Major Publications
2012,
2011, 2010, 2009,
2008, 2007, 2006,
2005, 2004, 2003,
2002, 2001, 2000,
1999, 1998, 1997,
1996, 1995, 1994,
1993, 1992, 1991,
Reviews, Reviews in
Japanese,
Complete works of Professor Shimizu
TOP PAGE in Japanese or
English
2012
- Koeberle, A., Shindou, H., Harayama, T., Shimizu, T. (2012)
Palmitoleate is a mitogen, formed upon stimulation with growth factors, and converted to palmitoleoyl-phosphatidylinositol.
J. Biol. Chem. , in press
- Sasaki, F., Okuno, T., Saeki, K, Min, L., Onohara, N., Kato, H., Shimizu, T., Yokomizo, T. (2012)
A high-affinity monoclonal antibody against the FLAG tag useful for G-protein-coupled receptor family.
Anal. Biochem. 425, 157-165
- Ishihara, K., Miyazaki, A., Nabe, T., Fushimi, H., Iriyama, N., Kanai, S., Sato, T., Uozumi, N, Shimizu, T. (2012)
Beneficial effects of Group IVA phospholipase A2 deficiency on the progression of hepatic fibrosis.
FASEB J. , in press
- Saito, Y., Watanabe, K., Fujioka, D., Nakamura, T., Obata, J., Kawabata, K., Watanabe, Y., Mishina, H., Tamaru, S., Kita, Y., Shimizu, T., Kugiyama, K. (2012)
Disruption of group IVA cytosolic phospholipase A2 attenuates myocardial ischemia-reperfusion injury partly through inhibition of TNFa-mediated pathway.
Heart Circ. Physiol. , in press
- Jonsson, F., Mancardi, DA., Zhao, W., Kita, Y., Iannascoli, B., Khun, H., van Rooijen, N., Shimizu, T., Schwartz, LB., Daeron, M., Bruhns, P. (2012)
Human FcγRIIA induces anaphylactic and allergic reactions.
Blood 119, 2533-2544
2011
- Koeberle,A., Shindou, H., Harayama, T., Yuki, K., Shimizu, T. (2011)
Polyunsaturated fatty acids are incorporated into maturating male mouse germ cells by lysophosphatidic acid acyltransferase 3.
FASEB J. 26, 169-180
- Ueno, N., Taketomi, Y., Yamamoto, K., Hirabayashi, T., Kamei, D., Kita, Y., Shimizu, T., Shinzawa, K., Tsujimoto, Y., Ikeda, K., Taguchi, R., Murakami, M. (2011)
Analysis of two major intracellular phospholipase A2s in mast cells reveals crucial contribution of cPLA2alpha, not iPLA2beta, to lipid mobilization in proximal mast cells and distal fibroblasts.
J. Biol. Chem. 286, 37249-37263
- Lopez-Vales, R., Ghasemlou, N., Redensek, A., Kerr, BJ., Barbayianni, E., Antonopoulou, G., Baskakis, C., Rathore, KI., Constantinou-Kokotou, V., Stephens, D., Shimizu, T., Dennis, EA., Kokotos, G., David, S. (2011)
Phospholipase A2 superfamily members play divergent roles after spinal cord injury.
FASEB J. 25, 4240-4252
- Soontrapa, K., Honda, T., Sakata, D., Yao, C., Hirata, T., Hori, S., Matsuoka, T., Kita, Y., Shimizu, T., Kabashima, K., Narumiya, S. (2011)
Prostaglandin E2-prostoglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppression.
Proc. Natl. Acad. Sci. U. S. A. 108, 6668-6673
- Tanaka, K., Yamamoto, Y., Ogino, K., Tsujimoto, S., Saito, M., Uozumi, N., Shimizu, T., Hisatome, I. (2011)
Cytosolic Phospholipase A2{alpha} Contributes to Blood Pressure Increases and Endothelial Dysfunction Under Chronic NO Inhibition.
Arterioscler. Thromb. Vasc. Biol. 31, 1133-1138
- Doi,K., Hamasaki, Y., Noiri, E., Nosaka, K., Suzuki, T., Toda, A., Shimizu, T., Fujita, T., Nakao, A. (2011)
Role of leukotriene B4 in accelerated hyperlipidaemic renal injury.
Nephrology 16, 304-309
- Nakamura, M., and Shimizu, T. (2011)
Leukotriene Receptors.
Chem. Rev. 111, 6231-6298
- Jonson, F., Mancardi, DA., Kita, Y., Karasuyama, H., Iannascoli, B., Rooijen, NV., Shimizu, T., Daeron, M., and Bruhns, P. (2011)
Mouse and human neutrophils induce anaphylaxis.
J. Clin. Invest. 121, 1484-1496
- Taniguchi, M., Masuda, T., Mikami, Y., Kimura, M., Yoshida, T., Mishina, M., and Shimizu, T. (2011)
Identification and characterization of a novel zebrafish semaphorin.
Neurosci. Lett. 488, 215-220
2010
- Ihara, Y., Kihara, Y., Hamano, F., Yanagida, K., Morishita, Y., Kunita, A., Yamori, T., Fukayama, M., Aburatani, H., Shimizu, T., and Ishii, S. (2010)
The G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) facilitates tumor development by serving as an extracellular pH sensor.
Proc. Natl. Acad. Sci. U. S. A. 107, 17309-17314
- Sumida, H., Noguchi, K., Kihara, Y., Abe, M., Yanagida, K., Hamano, F., Sato, S., Tamaki, K., Morishita, Y., Kano, MR., Iwata, C., Miyazono, K., Sakimura, K., Shimizu, T., and Ishii, S. (2010)
LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis.
Blood 116, 5060-5070
- Koeberle A., Shindou H., Harayama T., and Shimizu T. (2010)
Role of lysophosphatidic acid acyltransferase 3 for the supply of highly polyunsaturated fatty acids in TM4 Sertoli cells.
FASEB J. 24, 4929-4938
- Ma, J., Altomare, A., de la Monte, SM., Tong, M., Rieder, F., Fiocchi, C., Behar, J., Shindou, H., Biancani, P., Harnett, KM. (2010)
HCl-induced inflammatory mediators in esophageal mucosa increase migration and production of H2O2 by peripheral blood leukocytes.
Am. J. Physiol. Gastrointest. Liver Physiol. 299, G791-G798
- Morimoto, R., Shindou, H., Oda, Y., and Shimizu, T. (2010)
Phosphorylation of lysophosphatidylcholine acyltransferase 2 at Ser34 enhances platelet-activating factor production in endotoxin-stimulated macrophages.
J. Biol. Chem 285, 29857-29862
- Iizuka, Y., Okuno, T., Saeki, K., Uozaki, H., Okada, S., Misaka, T., Sato, T., Toh, H., Fukayama, M., Takeda, N., Kita, Y., Shimizu, T., Nakamura, M., and Yokomizo, T. (2010)
Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis.
FASEB J. 24, 4678-4690
- Hasegawa, S., Kohro, Y., Shiratori, M., Ishii, S., Shimizu, T., Tsuda, M., and Inoue, K. (2010)
Role of PAF receptor in proinflammatory cytokine expression in the dorsal root ganglion and tactile allodynia in a rodent model of neuropathic pain.
PLoS One 5, e10467
- Wu, YZ., Aholhassani, M., Ollero, M., Dif, F., Uozumi, N., Lagranderie, M., Shimizu, T., Chignard, M., and Touqui, L. (2010)
Cytosolic phospholipase A2alpha mediates Pseudomonas aeruginosa LPS-induced airway constriction of CFTR -/- mice.
Respir. Res. 11, 49
- Iwabu, M., Yamauchi, T., Okada-Iwabu, M., Sato, K., Nakagawa, T., Funata, M., Yamaguchi, M., Namiki, S., Nakayama, R., Tabata, M., Ogata, H., Kubota, N., Takamoto, I., Hayashi, YK., Yamauchi, N., Waki, H., Fukayama, M., Nishino, I., Tokuyama, K., Ueki, K., Oike, Y., Ishii, S., Hirose, K., Shimizu, T., Touhara, K., and Kadowaki, T. (2010)
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.
Nature 464, 1313-1319
- Nakamura, M., Yasuda, D., Hirota, N., and Shimizu, T. (2010)
Specific ligands as pharmacological chaperons: The transport of misfolded G-protein coupled receptors to the cell surface.
IUBMB Life 62, 453-459
- Hori, T., Sato, Y., Takahashi, N., Takio, K., Yokomizo, T., Nakamura, M., Shimizu, T., and Miyano, M. (2010)
Expression, purification and characterization of leukotriene B4 receptor, BLT1 in Pichia pastoris.
Protein Expr. Purif. 72, 66-74
- Hashidate, T., Murakami, N., Nakagawa, M., Ichikawa, M., Kurokawa, M., Shimizu, T., and Nakamura, M. (2010)
AML1 enhances the expression of leukotriene B4 type-1 receptor in leukocytes.
FASEB J. 24, 3500-3510
- Niknami, M., Vignarajan, S., Yao, M., Hua, S., Witting, P.K., Kita, Y., Shimizu, T., Sved, P., Patel, M.I., and Dong, Q. (2010)
Decrease in Expression or Activity of Cytosolic Phospholipase A2 Increases Cyclooxygenase-1 Action: A Cross-talk between Key Enzymes in Arachidonic Acid Pathway in Prostate Cancer Cells.
Biochim. Biophys. Acta. 1801, 731-737
- Kihara, Y., Yokomizo, T., Kunita, A., Morishita, Y., Fukayama, M., Ishii, S., and Shimizu, T. (2010)
The leukotriene B4 receptor, BLT1, is required for the induction of experimental autoimmune encephalomyelitis.
Biochem. Biophys. Res. Commun. 394, 673-678
- Tanimura, A., Yamazaki, M., Hashimotodani, Y., Uchigashima, M., Kawata, S., Abe, M., Kita, Y., Hashimoto, K., Shimizu, T., Watanabe, M., Sakimura, K., Kano, M. (2010)
The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase (alpha) mediates retrograde suppression of synaptic transmission.
Neuron 65, 320-327
- Le, T. D., Shirai, Y., Okamoto, T., Tatsukawa, T., Nagao, S., Shimizu, T., and Ito, M. (2010)
Lipid signaling in cytosolic phospholipase A2alpha-cyclooxygenase-2 cascade mediates cerebellar long-term depression and motor learning
Proc. Natl. Acad. Sci. U. S. A. 107, 3198-3203
- Ogiso, H., Nakamura, K., Yatomi, Y., Shimizu, T., and Taguchi, R. (2010)
Liquid chromatography/mass spectrometry analysis revealing preferential occurrence of non-arachidonate-containing phosphatidylinositol bisphosphate species in nuclei and changes in their levels during cell cycle.
Rapid. Commun. Mass Spectrom. 24, 436-442
- Tanaka, K., Yamamoto, Y., Uozumi, N., Kita, Y., Yoshida, A., Shimizu, T., Hisatome, I. (2010)
The cyclooxygenase-2-selective inhibitor, etodolac, but not aspirin reduces neovascularization in a murine ischemic hind limb model.
Eur. J. Pharmacol. 627, 223-228
- Hirota, N., Yasuda, D., Hashidate, T., Yamamoto, T., Yamaguchi, S., Nagamune, T., Nagase, T., Shimizu, T., and Nakamura, M. (2010)
Amino acid residues critical for endoplasmic reticulum export and trafficking of platelet-activating factor receptor.
J. Biol. Chem. 285, 5931-5940
- Toda, A., Terawaki, K., Yamazaki, S., Saeki, K., Shimizu, T., and Yokomizo, T. (2010)
Attenuated Th1 induction by dendritic cells from mice deficient in the leukotriene B4 receptor 1.
Biochimie 92, 682-691
2009
- Oga, T., Matsuoka, T., Yao, C., Nonomura, K., Kitaoka, S., Sakata, D., Kita, Y., Tanizawa, K., Taguchi, Y., Chin, K., Mishima ,M., Shimizu, T., and Narumiya, S. (2009)
Prostaglandin F2alpha receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-beta.
Nature Med. 12, 1426-1430
- Kihara, Y., Matsushita, T., Kita, Y., Uematsu, S., Akira, S., Kira, J.-i., Ishii, S., and Shimizu, T. (2009)
Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis.
Proc. Natl. Acad. Sci. U. S. A. 106, 21807-21812
- Hikiji, H., Ishii, S., Yokomizo, T., Takato, T., and Shimizu, T. (2009)
A distinctive role of the leukotriene B4 receptor BLT1 in osteoclastic activity during bone loss.
Proc. Natl. Acad. Sci. U. S. A. 106, 21294-21299
- Matsumoto, T., Inoue, H., Sato, Y., Kita, Y., Nakano, T., Noda, N., Eguchi-Tsuda, M., Moriwaki, A., Kan-O, K., Matsumoto, K., Shimizu, T., Nagasawa, H., Sakuda, S., and Nakanishi, Y. (2009)
Demethylallosamidin, a chitinase inhibitor, suppresses airway inflammation and hyperresponsiveness.
Biochem. Biophys. Res. Commun. 390, 103-108
- Murakami, N., Hashidate, T., Harayama, T., Yokomizo, T., Shimizu, T., and Nakamura, M. (2009)
Transcriptional regulation of human G2A in monocytes/macrophages : involvement of c/EBPs, Runx and Pu.1.
Genes Cells 14, 1441-1455
- Nakanishi, H., Iida, Y., Shimizu, T., and Taguchi, R. (2009)
Separation and quantification of sn-1 and sn-2 fatty acid positional isomers in phosphatidylcholine by RPLC-ESIMS/MS.
J. Biochem. 147, 245-256
- Ishii, S., Noguchi, K., and Yanagida, K. (2009)
Non-Edg family lysophosphatidic acid (LPA) receptors.
Prostaglandins Other Lipid Mediat. 89, 57-65
- Ikeda, K., Oike, Y., Shimizu, T., and Taguchi, R. (2009)
Global analysis of triacylglycerols including oxidized molecular species by reverse-phase high resolution LC/ESI-QTOF MS/MS.
J. Chromatogr. B Analyt. Technol. Biomed. Life. Sci. 877, 2639-2647
- Yanagida, K., Masago, K., Nakanishi, H., Kihara, Y., Hamano, F., Tajima, Y., Taguchi, R., Shimizu T., and Ishii, S. (2009)
Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6.
J. Biol. Chem. 284, 17731-17741
- Harayama, T., Shindou, H., and Shimizu, T. (2009)
Biosynthesis of phosphatidylcholine by human lysophosphatidylcholine acyltransferase 1.
J. Lipid Res. 50, 1824-1831
- Shindou, H., Hishikawa, D., Harayama, T., Yuki, K., and Shimizu, T. (2009)
Recent progress on Acyl-CoA:lysophospholipid acyltransferase research.
J. Lipid Res. 50, S46-S51
- Shindou, H., Eto, M., Morimoto, R., and Shimizu, T. (2009)
Identification of membrane O-acyltransferase family motifs.
Biochem. Biophys. Res. Commun. 383, 320-325
- Shimizu, T. (2009)
Lipid mediators in health and diseases.
Ann. Rev. Pharmacol. Toxicol. 49, 123-150
- Yuki, K., Shindou, H., Hishikawa, D., and Shimizu, T. (2009)
Characterization of mouse lysophosphatidic acid acyltransferase 3: An enzyme with dual functions in the testis.
J. Lipid Res. 50, 860-869
- Fahy, E., Subramaniam, S., Murphy, RC., Nishijima, M., Raetz, CR., Shimizu, T., Spener, F., van Meer, G., Wakelam, MJ., and Dennis, EA. (2009)
Update of the LIPID MAPS comprehensive classification system for lipids.
J. Lipid Res. 50, S9-14
- Nakanishi, H., Iida, Y., Shimizu, T., and Taguchi, R. (2009)
Analysis of oxidized phosphatidylcholines as markers for oxidative stress, using multiple reaction monitoring with theoretically expanded data sets with reversed-phase liquid chromatography/tandem mass spectrometry.
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 877, 1366-1374
- Yasuda, D., Okuno, T., Yokomizo, T., Hori, T., Hirota, N., Hashidate, T., Miyano, M., Shimizu, T., and Nakamura, M. (2009)
Helix 8 of leukotriene B4 type-2 receptor is required for the folding to pass the ER quality control.
FASEB J. 23, 1470-1481
- Mogi, C., Tobo, M., Tomura, H., Murata, N., He, X.-d., Sato, K., Kimura, T., Ishizuka, T., Sasaki, T., Sato, T., Kihara, Y., Ishii, S., Harada, A., and Okajima, F. (2009)
Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.
J. Immunol. 182, 3243-3251
- Welch, E. J., Naikawadi, R. P., Li, Z., Lin, P., Ishii, S., Shimizu, T., Tiruppathi, C., Du, X., Subbaiah, P. V., and Ye, R. D. (2009)
Opposing Effects of Platelet-activating Factor and Lyso-Platelet-activating Factor on Neutrophil and Platelet Activation.
Mol. Pharmacol. 75, 227-234
- Prevost, N., Mitsios, J., Kato, H., Burke, J. E., Dennis, E.A., Shimizu, T. and Shattil, S. J. (2008)
Group IVA cytosolic phospholipase A2 (cPLA2) and integrin a IIbb3 reinforce each other's functions during IIb3 signaling in platelets.
Blood 113, 447-457
- Shindou H. and Shimizu T. (2009)
Acyl-CoA:lysophospholipid acyltransferases.
J. Biol. Chem. 284, 1-5
2008
- Li, Y., Yamada, H., Kita, Y., Suzuki, M., Endo, Y., Horita, S., Yamazaki, O., Shimizu, T., Seki, G., and Fujita, T. (2008)
Arachidonic acid metabolites inhibit the stimulatory effect of angiotensin II in renal proximal tubules.
Hypertens. Res. 31, 2155-2164
- Lopes-Vales, R., Navarro, X., Shimizu, T.., Baskakis, C., Kokotos, G., Constanious-Kokotou, V., Stephen, D., Dennis, E. A., and David, S. (2008)
Intracellular phospholipase A2 group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury.
Brain 131, 2620-2631
- Ikeda, K., Shimizu, T., and Taguchi, R. (2008)
Targeted analysis of ganglioside and sulfatide molecular species by LC/ESI-MS/MS with theoretically expanded multiple reaction monitoring.
J. Lipid Res. 49, 2678-2689
- Moos, M. P. W., Mewburn, J. D., Kan, F. W. K., Ishii, S., Abe, M., Sakimura, K., Noguchi, K., Shimizu, T., and Funk, C. D. (2008)
Cysteinyl leukotriene 2 receptor-mediated vascular permeability via transendothelial vesicle transport.
FASEB J. 22, 4352-4362
- Marusic, S., Thakker, P., Pelker, JW., Stedman, NL., Lee, KL., McKew, JC., Han, L., Xu, X., Wolf, SF., Borey, AJ., Cui, J., Shen, MW., Donahue, F., Hassan-Zahraee, M., Leach, MW., Shimizu, T., and Clark, JD. (2009)
Blockade of cytosolic phospholipase A2 alpha prevents experimental autoimmune encephalomyelitis and diminishes development of Th1 and Th17 responses.
J Neuroimmunol. 204, 29-37
- Kihara, Y., Yanagida, K., Masago, K., Kita, Y., Hishikawa, D., Shindou, H., Ishii, S., and Shimizu, T. (2008)
Platelet-Activating Factor Production in the Spinal Cord of Experimental Allergic Encephalomyelitis Mice via the Group IVA Cytosolic PLA2-LysoPAFAT Axis.
J. Immunol. 181, 5008-5014
- Uozumi, N., Kita, Y., and Shimizu, T. (2008)
Modulation of lipid and protein mediators of inflammation by cytosolic phospholipase A2alpha during experimental sepsis.
J. Immunol. 181, 3558-3566
- Mashimo, M., Hirabayashi, T., Murayama, T., and Shimizu, T. (2008)
Cytosolic PLA2a activation in Purkinje neurons and its role in AMPA-receptor trafficking
J. Cell Sci. 121, 3015-3024
- Ito, S., Ito, Y., Katagiri, H., Suzuki, T., Hoka, S., Yokomizo, T.,
Shimizu, T., and Majima, M. (2008)
Leukotriene B4/Leukotriene B4 Receptor Pathway Is Involved in Hepatic Microcirculatory Dysfunction Elicited by Endotoxin.
Shock 30, 87-91
- Hase, M., Yokomizo, T., Shimizu, T., and Nakamura, M. (2008)
Characterization of an orphan G protein-coupled receptor, GPR20, that
constitutively activates Gi proteins.
J. Biol. Chem. 283, 12747-12755
- Jiang, W., Hall, S. R., Moos, M. P. W., Cao, R. Y., Ishii, S., Ogunyankin,
K. O., Melo, L. G., and Funk, C. D.(2008)
Endothelial cysteinyl leukotriene 2 receptor (CysLT2R) expression
mediates myocardial ischemia-reperfusion injury.
Am. J. Pathol. 172, 592-602
- Okuno, T., Iizuka, Y., Okazaki, H., Yokomizo, T., Taguchi, R., and
Shimizu, T. (2008)
12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for
leukotriene B4 receptor 2.
J. Exp. Med. 205, 759-766
- Tsujimura, Y., Obata, K., Mukai, K., Shindou, H., Yoshida, M., Nshikado,
H., Kawano, Y., Minegishi, Y., Shimizu, T., and Karasuyama, H. (2008)
Basophils play a pivotal role in IgG-, but not IgE-mediated systemic
anaphylaxis in contrast to mast cells.
Immunity 28, 581-589
- Harayama, T*., Shindou, H*. (*, equal contribution), Ogasawara, R.,
Suwabe, A, and Shimizu, T. (2008)
Identification of a novel non-inflammatory biosynthetic pathway of
platelet-activating factor.
J. Biol. Chem. 283, 11097-11106
- Hishikawa, D*., Shindou, H*. (*, equal contribution), Kobayashi, S.,
Nakanishi, H., Taguchi, R., and Shimizu, T. (2008)
Discovery of a lysophospholipid acyltransferase family essential for
membrane asymmetry and diversity.
Proc. Natl. Acad. Sci. USA 105, 2830-2835
- Hikiji, H., Takato, T., Shimizu, T., and Ishii, S. (2008)
The roles of prostanoids, leukotrienes, and platelet-activating factor
in bone metabolism and disease.
Prog. Lipid Res. 47, 107-126
2007
- Kimura, M., Taniguchi, M., Mikami, Y., Masuda, T., Yoshida, T., Mishina,
M., and Shimizu, T. (2007)
Identification and characterization of zebrafish semaphorine 6D.
Biochem. Biophys. Res. Commun. 363, 762-768
- Li, Y., Yamada, H., Kita, Y., Kunimi, M., Horita. S., Suzuki, M., Endo,
Y., Shimizu, T., Seki, G., and Fujita, T. (2007)
Roles of ERK and group IVA cytosolic PLA2 in biphasic regulation of renal
proximal transport by angiotensin II.
J. Amer. Soc. Nephrol. 19, 252-259
- Taguchi, R., Nishijima, M., and Shimizu, T. (2007)
Basic Analytical Systems for Lipidomics by Mass Spectrometry in Japan.
Methods Enzymol. 432, 185-211
- Kitaura, H., Uozumi, N., Tohmi, M., Yamazaki, M., Sakimura, K., Kudoh,
M., Shimizu, T., and Shibuki, K. (2007)
Roles of nitric oxide as a vasodilator in neurovascular coupling of
mouse somatosensory cortex.
Neurosci. Res. 59, 160-171
- Witzenrath, M., Gutbier, B., Owen, J.S, Schmeck, B., Mitchell, T.J.,
Mayer, K., Thomas, M.J., Ishii, S., Rosseau, S., Suttorp, N., and Schutte
H. (2007)
Role of platelet-activating factor in pneumolysin-induced acute lung
injury.
Crit. Care Med. 35, 1756-62
- Tsuda, M., Ishii, S., Masuda, T., Hasegawa, S., Nakamura, K., Nagata,
K., Yamashita, T., Furue, H., Tozaki-Saito, H., Yoshimura, M., Koizumi,
S., Shimizu, T., and Inoue, K. (2007)
Reduced pain behaviors and ERK activation in primary sensory neurons by
peripheral tissue injury in mice lacking platelet-activating factor
receptor.
J. Neurochem. 102, 1658-1668
- Shindou, H., Hishikawa, D., Nakanishi, H., Harayama, T., Ishii, S.,
Taguchi, R., and Shimizu, T. (2007)
A single enzyme catalyzes both PAF production and membrane biogenesis
of inflammatory cells: cloning and characterization of acetyl-CoA:lyso-PAF
acetyltransferase.
J. Biol. Chem. 282, 6532-6539
- Yanagida, K., Ishii, S., Hamano, F., Noguchi, K., and Shimizu, T. (2007)
LPA4/p2y9/GPR23 mediates Rho-dependent morphological changes in a rat
neuronal cell line.
J. Biol. Chem. 282, 5814-5824
- Kuniyeda, K., Okuno, T., Terawaki, K., Miyano, M., Yokomizo, T., and
Shimizu, T. (2007)
Identification of the intracellular region of the Leukotriene B4 receptor
type-1 that specifically involves in Gi-activation.
J. Biol. Chem. 282, 3998-4006
- Schaefer, M. B., Ott, J., Mohr, A., Bi, M. H., Grosz, A., Weissmann,
N., Ishii, S., Grimminger, F., Seeger, W., and Mayer, K. (2007)
Immunomodulation by n-3- vs. n-6-rich lipid emulsions in murine acute
lung injury _ role of platelet-activating factor receptor.
Crit. Care Med. 35, 544-554
2006
- Kita, Y., Ohto, T., Uozumi, N., and Shimizu, T. (2006)
Biochemical properties and pathophysiological roles of cytosolic
phospholipase A2s.
Biochim. Biophys. Acta 1761, 1317-1322
- Akiba, S., Mukaida, Y., Hane, K., Oka, M., Uozumi, N., Shimizu, T.,
and Sato, T. (2006)
Group IVA phospholipase A(2)-mediated production of fibronectin by
oxidized LDL in mesangial cells.
Kidney Int. 70, 1013-1018
- Shimizu, T., Ohto, T., and Kita, Y. (2006)
Cytosolic phospholipase A2: Biochemical properties and physiological
roles.
IUBMB Life 58, 328-333
- Chiba, Y., Shimada, A., Satoh, M., Saitoh, Y., Kawamura, N., Hanai,
A., Keino, H., Ide, Y., Shimizu, T., and Hosokawa, M. (2006)
Sensory system-predominant distribution of leukotriene a(4) hydrolase
and its colocalization with calretinin in the mouse nervous system.
Neurosci. 141, 917-927
- Nakanishi, H., Shindou, H., Hishikawa, D., Harayama, T., Ogasawara,
R., Suwabe, A., Taguchi, R., and Shimizu, T. (2006)
Cloning and characterization of mouse lung-type
acyl-coa:lysophosphatidylcholine acyltransferase 1 (LPCAT1): Expression
in alveolar type II cells, and possible involvement in surfactant
production.
J. Biol. Chem. 281, 20140-20147
- Yoshikawa, K., Kita, Y., Kishimoto, K., and Shimizu, T. (2006)
Profiling of eicosanoid production in the rat hippocampus during
kainate-induced seizure: Dual-phase regulation and differential
involvement of cox-1 and cox-2.
J. Biol. Chem. 281, 14663-14669
- Doi, K., Okamoto, K., Negishi, K., Suzuki, Y., Nakao, A., Fujita, T.,
Toda, A., Yokomizo, T., Kita, Y., Kihara, Y., Ishii, S., Shimizu, T., and
Noiri, E. (2006)
Attenuation of folic acid-induced renal inflammatory injury in
platelet-activating factor receptor-deficient mice.
Am. J. Pathol. 168, 1413-1
424
- van der Sluijs, K. F., van Elden, L. J. R., Nijhuis, M., Schuurman,
R., lorquin, S., Shimizu, T., Ishii, S., Jansen, H. M., Lutter, R., and
van der Poll, T. (2006)
Involvement of the platelet activating factor receptor in host defense
against Streptococcus pneumoniae during postinfluenza pneumonia.
Am. J. Physiol. 290, L194-L199
2005
- Toyo-oka, K., Sasaki, S., Yano, Y., Mori, D., Kobayashi, T., Toyoshima,
Y. Y., Tokuoka, S. M., Ishii, S., Shimizu, T., Muramatsu, M., Hiraiwa, N.,
Yoshiki, A., Wynshaw-Boris, A., and Hirotsune, S. (2005)
Recruitment of katanin p60 by phosphorylated NDEL1, a LIS1 interacting
protein, is essential for mitotic cell division and neuronal migration.
Hum. Mol. Genet. 14, 3113-3128
- Oikawa, Y., Yamato, E., Tashiro, F., Yamamoto, M., Uozumi, N., Shimada,
A., Shimizu, T., and Miyazaki, J. (2005)
Protective role for cytosolic phospholipase A2alpha in autoimmune
diabetes of mice.
FEBS Lett. 579, 3975-3978
- Marusic, S., Leach, M.W., Pelker, J.W., Azoitei, M.L., Uozumi, N., Cui,
J., DeClercq, C.M., Shen, M.W.H., Miyashiro, J.S., Carito, B.A., Thakker,
P., Simmons, D.L., Leonard, J.P., Shimizu, T., and Clark, J.D. (2005)
Cytosolic phospholipase A2alpha-deficient mice are resistant to
experimental autoimmune encephalomyelitis.
J. Exp. Med. 202, 841-851
- Kihara, Y., Ishii, S., Kita, Y., Toda, A., Shimada, A., and Shimizu,
T. (2005)
Dual phase regulation of experimental allergic encephalomyelitis by
platelet-activating factor.
J. Exp. Med. 202, 853-863
- Okuno, T., Yokomizo, T., Hori, T., Miyano, M., and Shimizu, T. (2005)
Leukotriene B4 receptor and the function of its helix 8.
J. Biol. Chem. 280, 32049-32052
- Terawaki, K., Yokomizo, T., Nagase, T., Toda, A., Taniguchi, M.,
Hashizume, K., Yagi, T., and Shimizu, T. (2005)
Absence of leukotriene B4 receptor 1 confers resistance to airway
hyperresponsiveness and Th2 type immune responses.
J. Immunol. 175, 4217-42
25
- Zhang, Q., Mousdicas, N., Yi, Q., Al-Hassani, M., Billings, S. D.,
Perkins, S. M., Howard, K. M., Ishii, S., Shimizu, T., and Travers, J. B.
(2005)
Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity
reactions via the platelet-activating factor receptor.
J. Clin. Invest. 115, 2855-2861
- Ando, K., Tsuji, E., Ando, Y., Kunitomo, J., Kobayashi, R., Yokomizo,
T., Shimizu, T., Yamashita, M., Ohta, S., Nabe, T., Kohno, S., and Ohishi,
Y. (2005)
Synthesis of 2-, 4- and
5-(2-alkylcarbamoyl-1-methylvinyl)-7-alkyloxybenzo[b]furans and their
leukotriene B(4) receptor antagonistic activity.
Org. Biomol. Chem. 3, 2129-2139
- Fahy, E., Subramaniam, S., Brown, A., Glass, C.K., Merrill, A.H., Jr.,
Murphy, R.C., Raetz, E.R.H., Russell, D.W., Seyama, Y., Shaw, W., Shimizu,
T., Spener, F., van Meer, G., VanNieuwenhze, M.S., Stephen H. White, S.H.,
Witztum, J.L., and Dennis, E.A. (2005)
A comprehensive classification system for lipids
J. Lipid Res. 46, 839-862
- Saiga, A., Uozumi, N., Ono, T., Seno, K., Ishimoto, Y., Arita, H.,
Shimizu, T., and Hanasaki, K. (2005)
Group X secretory phospholipase A2 can induce arachidonic acid release
and eicosanoid production without activation of cytosolic phospholipase
A2.
Prostaglandins Other Lipid Med. 75, 79-89
- Shindou, H., Ishii, S., Yamamoto, M., Takeda, K., Akira, S., and Shimizu,
T. (2005)
Priming effect of lipopolysaccharide on acetyl-CoA:lyso-PAF
acetyltransferase is MyD88 and TRIF-independent.
J. Immunol. 175, 1177-11
83
- Ohto, T., Uozumi, N., Hirabayashi, T., and Shimizu, T. (2005)
Identification of novel cytosolic phospholipase A2s, murine cPLA2 delta,
epsilon, and zeta, which form a gene cluster with cPLA2 beta.
J. Biol. Chem. 280, 24576-24583
- Iizuka, Y., Yokomizo, T., Terawaki, K., Komine, M., Tamaki, K., and
Shimizu, T. (2005)
Characterization of a mouse second leukotriene B4 receptor, mBLT2.
J. Biol. Chem. 280, 24816-24823
- Taniguchi, M., Masuda, T., Fukaya, M., Kataoka, H., Mishina, M.,
Yaginuma, H., Watanabe, M., and Shimizu, T. (2005)
Identification and characterization of a novel member of murine
semaphorin
family.
Genes to Cells 10, 785-792
- Kita, Y., Takahashi, T., Uozumi, N., and Shimizu, T. (2005)
A multiplex quantitation method for eicosanoids and platelet-activating
factor using column-switching reversed-phase liquid chromatography-tandem
mass spectrometry.
Anal. Biochem. 342, 134-143
- Ishida, M., Imagawa, M., Shimizu, T., and Taguchi, R. (2005)
Specific detection oflysphosphatidic acids in serum extracts by tandem
mass spectrometry.
J. Mass Spectrom. Soc. Jpn. 53, 25-3
2
- Kita, Y., Takahashi, T., Uozumi, N., Nallan, L., Gelb, M. H., and
Shimizu, T. (2005)
Pathway-oriented profiling of lipid mediators in macrophages.
Biochem. Biophys. Res. Commun. 330, 898-906
- Shimada, A., Satoh, M., Chiba, Y., Saitoh, Y., Kawamura, N., Keino,
H., Hosokawa, M., and Shimizu, T. (2005)
Highly selective localization of leukotriene C4 synthase in hypothalamic
and extrahypothalamic vasopressin systems of mouse brain.
Neurosci. 131, 683-689
- Houjou, T., Yamatani, K., Imagawa, M, Shimizu, T., and Taguchi, R.
(2005)
A shotgun tandem mass spectrometric analysis of hospholipids with
normal-phase and/or reverse-phase liquid chromtography/electrospray
ionization mass spectrometry.
Rapid Commun. Mass Spectrom. 19, 654-666
- Lang, P. A., Kempe, D. S., Tanneur, V., Eisele, K., Klarl, B.A., Myssina,
S., Jendrossek, V., Ishii, S., Shimizu, T., Waidmann, M., Hessler, G., Huber,
S. M., Lang, F., and Wieder, T. (2005)
Stimulation of erythrocyte ceramide formation by platelet activating
factor.
J. Cell Sci. 118, 1233-1243
- Ishii, S., Kihara, Y., and Shimizu, T. (2005)
Identification of T cell death-associated gene 8 (TDAG8) as a novel acid
sensing G-protein-coupled receptor.
J. Biol. Chem. 280, 9083-9087
2004
- Houjou, T, Yamatani, K., Nakanishi, H., Imagawa, M., Shimizu, T.,
and Taguchi, R. (2004)
Rapid and selective identification of molecular species in
phosphatidylcholine and sphingomyelin by conditional neutral loss scanning
and MS3.
Rapid Commun. Mass Spectrom. 18, 3123-3130
- Ando, K., Tsuji, E., Ando, Y., Kunitomo, J., Yamashita, M., Ohta,
S., Nabe, T., Kohno, S., Yokomizo, T., Shimizu, T., and Ohishi, Y. (2004)
Preparation of 2- and
4-(2-alkylcarbamoyl-1-methylvinyl)-7-alkyloxybenzo[b]furans having
potent antagonistic activity against human leukotriene B4 BLT1 and/or BLT2
receptors.
Org. Biomol. Chem. 2, 3427-3431
- Branger, J., Wieland, C. W., Florquin, S., Maris, N. A., Pater, J.
M., Speelman, P., Shimizu, T., Ishii, S., van der Poll, T. (2004)
Platelet-activating factor receptor deficient mice show an unaltered
clearance of Haemophilus influenzae from their respiratory tract.
Shock 22, 543-547
- Ishikawa, S., Uozumi, N., Shiibashi, T, Izumi, T., Fukayama, M.,
Shimizu, T., Watanbabe, J., and Nogami, S. (2004)
Lethal malaria in cytosolic phospholipase A2- and phospholipase
IIA-deficient mice. Amer. J. Tropical Med Hyg. 70, 645-650
- Hirabayashi, T., Murayama, T., and Shimizu, T. (2004)
Regulatory mechanism and physiological role of cytosolic phospholipase A2
(review) Biol. Pharm. Bull. 27, 1168-1173
- Angeli, V, Llordra, J., Rong, J. X., Satoh, K., Ishii, S., Shimizu,
T., Fisher, E, A., and Randolph, G. J. (2004) Dyslipidemia associated
with atherosclerotic disease systemically alters dendritic cell
mobilization. Immunity 21, 561-574
- Murakami, N., Yokomizo, T., Okuno, T., and Shimizu, T. (2004)
G2A is a proton-sensing G-protein coupled receptor antagonized by
lysophosphatidylcholine. J. Biol. Chem. 279, 42484-4249
1
- Hikiji, H., Ishii, S., Shindou, H., Takato, T., and Shimizu, T. (2004)
Absence of platelet-activating factor receptor protects mice from
osteoporosis following ovariectomy. J. Clin. Invest. 114,
85-93
- Ishii, S., Nagase, T., Shindou, H., Takizawa, H., Ouchi, Y., and
Shimizu, T.
(2004) Platelet-activating factor receptor develops airway
hyperresponsiveness
independently of airway inflammation in a murine asthma model.
J. Immunol. 172, 7095-7102
- Takai, D., Nagase, T., and Shimizu, T. (2004) New
therapeutic key for cystic fibrosis: a role for lipoxins. Nature Immunol.
(News and Views) 5, 357-358
- Lu, P., Chandrakanthan, V., Cahana, A., Ishii, S., and O'Neill,
C. (2004)
Trophic signals acting via phosphatidylinositol-3 kinase are required
for normal pre-implantation mouse embryo development.
J. Cell Sci. 117, 1567-1576
- Hori, T., Yokomizo, T., Ago, H., Sugahara, M., Ueno, G.,
Yamamoto, M., Kumasaka, T., Shimizu, T. and Miyano, M. (2004)
Structural basis of leukotriene B4
12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase catalytic
mechanism and a possible SH3 binding loop.
J. Biol. Chem. 279, 22615-22623
- Brink, C., Dahlen, S.E., Drazen, J., Evans, J.F., Hay, D.W.,
Rovati, G.E., Serhan, C.N., Shimizu, T. and Yokomizo, T. (2004)
International Union of Pharmacology XLIV. Nomenclature for the
Oxoeicosanoid Receptor.
Pharmacol. Rev., 56, 149-157
- Tashiro, S., Sumi, T., Uozumi, N., Shimizu, T., and Nakamura, T.
(2004)
B-Myb-dependent regulation of c-Myc expression by cytosolic
phospholipase A2
J. Biol. Chem. 279, 17715-17722
- Rijneveld, A.W., Weijer, S., Florquin, S., Speelman, P., Shimizu,
T., Ishii, S., and van der Poll, T. (2004)
Platelet activating factor receptor deficient mice have an improved
host defense against pneumococcal pneumonia.
J. Infect. Dis. 189, 711-716
2003
-
Taniguchi, T. and Shimizu, T. (2003)
Characterization of a novel member of murine semaphorin family.
Biochem. Biophys. Res. Commun. 30, 242-248
- Obinata, H., Yokomizo, T., Shimizu, T. and Izumi, T. (2003)
Glucocorticoids up-regulate leukotriene B4 receptor-1 expression during
neutrophilic differentiation of HL-60 cells.
Biochem. Biophys. Res. Commun. 309, 114-119
- Okuno, T., Ago, H., Terawaki., K, Miyano, M., Shimizu, T. and
Yokomizo T. (2003)
Helix 8 of the leukotriene B4 receptor is required for the
conformational change to the low-affinity state after G-protein
activation.
J. Biol. Chem. 278, 41500-41509
- Weijer, S., Leemans, J. C., Florquin, S., Shimizu, T., Ishii, S.,
and van der Poll, T. (2003) Host response of platelet-activating factor
receptor-deficient mice during pulmonary tuberculosis.
Immunology,
109, 552-556
- Souza, D. G., Pinho, V., Soares, A. C. Shimizu, T., Ishii, S.,
and Teixeira, M. M. (2003) Role of PAF receptors during intestinal
ischemia and reperfusion injury. A comparative study between PAF
receptor-deficient mice and PAF receptor antagonist treatment. Brit.
J. Pharmacol. 139, 733-740
- Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T.,
Kta, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., Murakami,
K., Ohteki T., Uchida, S., Takenawa, S., Waki H., Tsuno, N.H., Shibata,
Y., Terauchi, Y., Froguel, P., Tobe, K., Koyasu, S., Taira, K.,
Kitamura, T., Shimizu, T., Nagai, R., and Kadowaki, T. (2003) Cloning
of adiponectin receptors that mediate antidiabetic metabolic effects.
Nature
423, 762-768
- Talvani, A., Santana, G., Barcelos, L. S., Ishii, S., Shimizu,
T., Romanha, J., Silva, J. S., Soares, M. B. P. and Teixeira, M. M.
(2003)
Experimental Trypanosoma cruzi infection in platelet-activating factor
-deficient mice.
Microb. Infect. 5, 789-796
- Wong, D. A., Uozumi, N., Kita, Y., and Shimizu, T. (2003)
Cytosolic phospholipase A2a in mouse platelets: Clinical andtherapeutic
implications. Advances in Prostaglandin,Leukotriene and Other
Bioactive Lipid Research. (Yazici, Z. Folco,G, C., Drazen, J.
M., Niigam, S., and Shimizu, T. eds) pp 81-86, Kluwer Academic/Plenum
Publishers, New York. :ISBN: 0306477637
- Shimizu, T., Yokomizo, T., and Izumi, T. (2003)
Characterizationof two distinct types of leukotriene B4 receptors.
Oxygen
and Life: Oxygenases, Oxidase, and Lipid Mediators (Ishimura,
Y.,Nozaki, M. Yamamoto, S., Shimizu, T., Narumiya, S., and Mitani,
F.eds) pp 415-420, Elsevier, Amsterdam. :ISBN: 0444508724
- Tokuoka, S. M., Ishii, S., Kawamura, N., Satoh, M., Shimada, A.,
Sasaki, S., Hirotsune, S., Wynshaw-Boris, A., and Shimizu, T. (2003)
Involvement of Platelet-Activating Factor and LIS1 in Neuronal
Migration.
Eur. J. Neurosci. 18, 563-570
- Masuda, K., Itoh, H., Sakihama, T., Akiyama, C., Takahashi, K.,
Fukuda, R. Yokomizo, T., Shimizu, T., Kodama, T., and Hamakubo, T.
(2003)
A combinatorial G protein-coupled receptor reconstitution system on
budded baculovirus: Evidence for Gai and Gao coupling to a human leukotriene B4 receptor.
J. Biol. Chem. 278, 24552-24562
- Noguchi, K., Ishii, S., and Shimizu, T. (2003)
Identification of p2y9/GPR23 as a Novel G Protein-Coupled Receptor for
Lysophosphatidic Acid, Structurally Distant from the Edg Family
J. Biol. Chem. 278, 25600-25606
- Hegen, M., Sun L., Uozumi N., Kume K., Goad, E.M.,
Nickerson-Nutter L.C., Shimizu T., and Clark D.J. (2003)
Cytosolic Phospholipase A2a
deficient Mice Are Resistant to Collagen-induced Arthritis
J. Exp. Med. 197, 1297-1302
- Miyaura, C., Inada, M., Matsumoto, C., Ohshiba, C., Uozumi, N.,
Shimizu, T., and Ito, A. (2003)
An Essential Role of Cytosolic Phospholipase A2a in Prostaglandin E2-mediated Bone Resorption
Associated with Inflammation
J. Exp. Med. 197, 1303-1310
- Omura, M., Sekine, H., Shimizu, T., Kataoka, H, and Touhara, K.
(2003)
In situ Ca imaging of odor responses in a coronal olfactory
epithelium slice.
Neuroreport 14, 1123-1127
- Asai, K, Hirabayashi, T, Houjou, T, Uozumi, N., Taguchi, R., and
Shimizu, T. (2003)
Human Group IVC phospholipase A2 (cPLA2):
roles in the membrane remodeling and activation induced by oxidative
stress.
J. Biol. Chem. 278, 8909-8914
- Nagase T., Uozumi N., Aoki-Nagase T., Terawaki K., Ishii S.,
Tomita T., Yamamoto H., Hashizume K., Ouchi Y., Shimizu T. (2003)
A potent inhibitor of cytosolic phospholipase A2,
arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury
in mice.
Am J Physiol. Lung Cell Mol. Physiol. 284,
L720-L726
- Usui, H., Taniguchi, M., Yokomizo, T., and Shimizu, T. (2003)
Interaction of plexin A1 and plexin B1 at the cytoplamic domain.
Biochem. Biophys. Res. Commun. 24,927-31
- Brink, C., Dahle'n, S.K., Drazen, J., Evans, J.F., Hay, D.W.P.,
Nicosia, S., Serhan, C.N., Shimizu, T., and Yokomizo, T. (2003)
Classification of Leukotriene and Lipoxin Receptors: Distribution,
Function and Molecular Aspects.
Pharmacol. Rev. 55,
195-227
- Taniguchi, M., Nagao, H., Takahashi Y.K., Yamaguchi, M., Mitsui,
S., Yagi, T., Mori, K. and Shimizu, T. (2003)
Distorted odor maps in the olfactory bulb of semaphorin 3A-deficient
mice.
J. Neurosci.
23,1390-1397.
- Vogensen, S.B., Stromgaard, K., Shindou, H., Jaracz, S.,
Suehiro, M., Ishii, S., Shimizu, T., and Nakanishi, K. (2003)
Preparation of 7-substituted ginkgolide derivatives: potent
platelet-activating factor (PAF) receptor antagonists.
J. Med. Chem. 46,
601-608
2002
- Uozumi, N., Shimizu,T. (2002) Roles for cytosolic phospholipase
A2alpha as revealed by gene-targeted mice. Prostaglandins Other
Lipid Mediat.
68-69:
59-69
- Toda A, Yokomizo T, Shimizu T. (2002) Leukotriene B4 receptors.
Prostaglandins Other Lipid Mediat. 68-69:575-85
- Ishii, S., Nagase, T., and Shimizu, T. (2002) Platelet-activating
factor receptor. Prostaglandins Other Lipid Mediat. 68-69,
599-609
- Ito, N., Yokomizo, T., Sasaki, T., Kurosu, H., Penninger, J.,
Kanaho, Y., Katada, T., Hanaoka, K., and Shimizu, T. (2002) Requirement
of phosphatidylinositol 3-kinase-activation and Ca influx for
leukotriene B4-induced enzyme release. J. Biol.
Chem. 277,
44898-44904
- Noiri, E., Satoh, H., Taguchi, J., Brodsky, S.V., Nakao, A.,
Ogawa, Y.,
Nishijima, S., Yokomizo, T., Tokunaga, K. and Fujita, T. (2002)
Association
of eNOS Glu298Asp polymorphism with end-stage renal disease.
Hypertension
40,
535-540
- Soares, A.C., Pinho, V.S., Souza, D.G., Shimizu, T., Ishii, S.,
Nicoli,
J.R., and Teixeira, M.M. Role of the platelet-activating factor (PAF)
receptor during pulmonary infection with gram negative bacteria.
Brit.
J. Pharmacol. 137,
621-628
- Stromgaard, K., Saito, D.R., Shindou, H., Ishii, S., Shimizu, T.,
and Nakanishi, K. (2002) Ginkgolide derivatives for photolabeling
studies: preparation and pharmacological evaluation. J. Med.
Chem. 45,4038-46
- Wong, D.A., Uozumi, N., Kita, Y., and Shimizu, T. (2002) Discrete
role for cytosolic phospholipase A2-alpha in platelets:
Studies using single and double mutant mice of cytosolic and group
IIA-secretory phospholipase A2. J. Exp. Med.
196,349-57
- Izumi, T., Yokomizo, T., Obinata, H., Ogasawara, H., Shimizu, T.
(2002) Leukotriene receptors: classification, gene expression, and
signal transduction. J. Biochem. 132,1-6
- Honda, Z., Ishii, S., and Shimizu, T. (2002) Platelet-activating
factor
receptor. J. Biochem. 131,773-779
- Barbuti, A., Ishii, S., Shimizu, T., Robinson, R.B., and
Feinmark, S.J. (2002) Block of the background K+ channel,
TASK-1, contributes to the arrhythmogenic effects of
platelet-activating factor. Am. J. Physiol. 282,
H2024-H2030
- Ogasawara, H., Ishii, S., Yokomizo, T., Kakinuma, T., Komine, M.,
Tamaki, K., Shimizu, T., and Izumi, T. (2002) Characterization of mouse
cysteinyl leukotriene receptors, mCysLT1 and
mCysLT2: Differential pharamacological properties and
tissue distribution. J. Biol. Chem. 277,
18763-18768
- Nagase, T., Uozumi, N., Ishii, S., Kita, Y., Yamamoto, H., Ohga,
E., Ouchi,
Y. and Shimizu, T. (2002) A pivotal role of cytosolic phospholipase
A2
in
bleomycin-induced pulmonary fibrosis. Nature Med. 8,
480-484
- Ohshima, N., Ishii, S., Izumi, T., and Shimizu, T. (2002)
Receptor-dependent metabolism of platelet-activating factor in murine
macrophages. J. Biol. Chem. 277,
9722-9727
- Shimizu, T. (2002) Leukotriene receptors. in Wiley
Encyclopedia of Molecular Medicine, Vol. 5, pp. 1920-1921,
John Wiley & Sons, Inc.
- Klein, A., Pinho, V., Alessandrini, A. L., Shimizu, T., Ishii,
S., Teixeira, M. M. (2002). Platelet-activating factor drives eotaxin
production in an allergic pleurisy in mice. Brit. J.
Pharmacol.
135,
1213-1218
- Nagase, T., Ishii, S., Shindou, H., Ouchi, Y., and Shimizu, T.
(2002) Airway hyperresponsiveness in transgenic mice overexpressing
platelet activating factor receptor is mediated by an
atropine-sensitive pathway. Am. J. Respir. Crit. Care Med.
165,
200-205
- Hanaka, H., Shimizu, T., and Izumi, T. (2002)
Nuclear-localization-signal-dependent and
nuclear-export-signal-dependent mechanisms determine the localization
of 5-lipoxygenase. Biochem. J. 361,
505-514
2001
- Shimizu, T. (2001) Biological control by lipid mediators and
pathophysiology. Jap. Med. Assoc. J. 44, 369-374.
- Yokomizo, T., Izumi, T., and Shimizu, T. (2001) Leukotriene
B4:
metabolism and signal transduction. Arch. Biochem. Biophys.
385,
231-241
- Yamamoto, T., Yokomizo, T., Nakao, A., Izumi, T., and Shimizu, T.
(2001) Immunohistochemical localization of guinea-pig leukotriene
B4
12-hydroxydehydrogenase/15-ketoprostaglandin 13-reductase. Eur.
J. Biochem. 268,
6105-6113
- Yokomizo, T., Kato, K., Hagiya, H., Izumi, T., and Shimizu, T.
(2001) Hydroxyeicosanoids bind to and activate the low affinity
leukotriene B4 receptor, BLT2.
J. Biol. Chem. 276,
12454-12459
- Wu, C., Stojanov, T., Chami, O., Ishii, S., Shimizu, T., Li, A.,
and O'Neill, C. (2001) Evidence for the autocrine induction of
capacitation of mammalian spermatozoa. J. Biol. Chem. 276,
26962-26968
- Yamashita, A., Kawagishi, N., Miyashita, T., Nagatsuka, T.,
Sugiura, T., Kume, K., Shimizu, T., and Waku, K. (2001) ATP-independent
fatty acyl-coenzyme A synthesis from phospholipid: coenzyme A-dependent
transacylation activity toward lysophosphatidic acid catalyzed by
acyl-coenzyme A:lysophosphatidic acid acyltransferase. J. Biol.
Chem. 276,
26745-26752
- Kim, Y. J., Noguchi, S., Hayashi, Y. K., Tsukahara, T., Shimizu,
T., and Arahata, K. (2001) The product of an oculopharyngeal muscular
dystrophy gene, poly(A)-binding protein 2, interacts with SKIP and
stimulates muscle-specific gene expression. Hum. Mol. Genet.
10,
1129-1139
- Fukunaga, K., Ishii, S., Asano, K., Yokomizo, T., Shiomi, T.,
Shimizu, T., and Yamaguchi, K. (2001) Single nucleotide polymorphism of
human platelet-activating factor receptor impairs G-protein activation.
J. Biol. Chem. 276,
43025-43030
- Yokomizo, T., Izumi, T., and Shimizu, T. (2001) Co-expression of
two LTB4 receptors in human mononuclear cells. Life Sci. 68,
2207-2212
- Banno, Y., Wang, S., Ito, Y., Izumi, T., Nakashima, S., Shimizu,
T., and Nozawa, Y. (2001) Involvement of ERK and p38 MAP kinase in
oxidative stress-induced phospholipase D activation in PC12 cells.
Neuroreport 12,
2271-2275
2000
- Yokomizo, T., Masuda, K., Kato, K., Toda, A., Izumi, T., and
Shimizu, T. (2000) Leukotriene B4 receptor.
Cloning and intracellular signaling. Am. J. Respir. Crit. Care
Med. 161,
S51-55
- Shindou, H., Ishii, S., Uozumi, N., and Shimizu, T. (2000) Roles
of cytosolic phospholipase A(2) and platelet-activating factor receptor
in the Ca-induced biosynthesis of PAF. Biochem. Biophys. Res.
Commun. 271,
812-817
- Kawasawa, Y., Kume, K., Nakade, S., Haga, H., Izumi, T., and
Shimizu, T. (2000) Brain-specific expression of novel G-protein-coupled
receptors, with homologies to Xenopus PSP24 and human GPR45.
Biochem. Biophys. Res. Commun. 276,
952-956
- Kawasawa, Y., Kume, K., Izumi, T., and Shimizu, T. (2000)
Mammalian PSP24s (alpha and beta isoforms) are not responsive to
lysophosphatidic acid in mammalian expression systems. Biochem.
Biophys. Res. Commun. 276,
957-964
- Hirabayashi, T., and Shimizu, T. (2000) Localization and
regulation of cytosolic phospholipase A(2). Biochim. Biophys.
Acta 1488,
124-138
- Aihara, M., Ishii, S., Kume, K., and Shimizu, T. (2000)
Interaction between neurone and microglia mediated by
platelet-activating factor. Genes Cells 5,
397-406
- Noiri, E., Yokomizo, T., Nakao, A., Izumi, T., Fujita, T.,
Kimura, S., and Shimizu, T. (2000) An in vivo approach showing the
chemotactic activity of leukotriene B(4) in acute renal
ischemic-reperfusion injury. Proc. Natl. Acad. Sci. USA 97,
823-828
- Nagase, T., Uozumi, N., Ishii, S., Kume, K., Izumi, T., Ouchi,
Y., and Shimizu, T. (2000) Acute lung injury by sepsis and acid
aspiration: a key role for cytosolic phospholipase A2.
Nat. Immunol. 1,
42-46
- Kato, K., Yokomizo, T., Izumi, T., and Shimizu, T. (2000)
Cell-specific transcriptional regulation of human leukotriene B(4)
receptor gene. J. Exp. Med. 192,
413-420
- Yokomizo, T., Kato, K., Terawaki, K., Izumi, T., and Shimizu, T.
(2000) A second leukotriene B(4) receptor, BLT2. A new
therapeutic target in inflammation and immunological disorders.
J. Exp. Med. 192,
421-432
- Takaku, K., Sonoshita, M., Sasaki, N., Uozumi, N., Doi, Y.,
Shimizu, T., and Taketo, M. M. (2000) Suppression of intestinal
polyposis in Apc(delta 716) knockout mice by an additional mutation in
the cytosolic phospholipase A(2) gene. J. Biol. Chem. 275,
34013-34016
- Nakatani, N., Uozumi, N., Kume, K., Murakami, M., Kudo, I., and
Shimizu, T. (2000) Role of cytosolic phospholipase A2 in
the production of lipid mediators and histamine release in mouse
bone-marrow-derived mast cells. Biochem. J. 352
Pt 2, 311-317
- Okamoto, H., Takuwa, N., Yokomizo, T., Sugimoto, N., Sakurada,
S., Shigematsu, H., and Takuwa, Y. (2000) Inhibitory regulation of Rac
activation, membrane ruffling, and cell migration by the G
protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or
EDG3. Mol. Cell Biol. 20,
9247-9261
- Tabuchi, S., Kume, K., Aihara, M., and Shimizu, T. (2000)
Expression of lysophosphatidic acid receptor in rat astrocytes:
mitogenic effect and expression of neurotrophic genes.
Neurochem. Res. 25,
573-582
- Ishii, S., and Shimizu, T. (2000) Platelet-activating factor
(PAF) receptor and genetically engineered PAF receptor mutant mice.
Prog. Lipid Res. 39,
41-82
1999
- Izumi, T., Yokomizo, T., Igarashi, T., and Shimizu, T. (1999)
Molecular cloning and characterization of leukotriene
B4
receptor. Adv. Exp. Med. Biol. 469,
237-244
- Sato, S., Kume, K., Ito, C., Ishii, S., and Shimizu, T. (1999)
Accelerated proliferation of epidermal keratinocytes by the transgenic
expression of the platelet-activating factor receptor. Arch.
Dermatol. Res. 291,
614-621
- Toda, A., Yokomizo, T., Masuda, K., Nakao, A., Izumi, T., and
Shimizu, T. (1999) Cloning and characterization of rat leukotriene B(4)
receptor. Biochem. Biophys. Res. Commun. 262,
806-812
- Igarashi, T., Yokomizo, T., Tsutsumi, O., Taketani, Y., Shimizu,
T., and Izumi, T. (1999) Characterization of the leukotriene
B4
receptor in porcine leukocytes. Separation and reconstitution with
heterotrimeric GTP-binding proteins. Eur. J. Biochem. 259,
419-425
- Kobayashi, K., Ishii, S., Kume, K., Takahashi, T., Shimizu, T.,
and Manabe, T. (1999) Platelet-activating factor receptor is not
required for long-term potentiation in the hippocampal CA1 region.
Eur. J. Neurosci. 11,
1313-1316
- Boie, Y., Stocco, R., Sawyer, N., Greig, G. M., Kargman, S.,
Slipetz, D. M., O'Neill, G. P., Shimizu, T., Yokomizo, T., Metters, K.
M., and Abramovitz, M. (1999) Characterization of the cloned guinea pig
leukotriene B4 receptor: comparison to its
human orthologue. Eur. J. Pharmacol. 380,
203-213
- Ishizaka, N., Nakao, A., Ohishi, N., Suzuki, M., Aizawa, T.,
Taguchi, J., Nagai, R., Shimizu, T., and Ohno, M. (1999) Increased
leukotriene A(4) hydrolase expression in the heart of angiotensin
II-induced hypertensive rat. FEBS Lett. 463,
155-159
- Fukasawa, K. M., Fukasawa, K., Harada, M., Hirose, J., Izumi, T.,
and Shimizu, T. (1999) Aminopeptidase B is structurally related to
leukotriene-A4 hydrolase but is not a bifunctional enzyme with epoxide
hydrolase activity. Biochem. J. 339
(Pt 3), 497-502
- Masuda, K., Yokomizo, T., Izumi, T., and Shimizu, T. (1999) cDNA
cloning and characterization of guinea-pig leukotriene
B4
receptor. Biochem. J. 342
(Pt 1), 79-85
- Nagase, T., Ishii, S., Kume, K., Uozumi, N., Izumi, T., Ouchi,
Y., and Shimizu, T. (1999) Platelet-activating factor mediates
acid-induced lung injury in genetically engineered mice. J.
Clin. Invest. 104,
1071-1076
- Hirabayashi, T., Kume, K., Hirose, K., Yokomizo, T., Iino, M.,
Itoh, H., and Shimizu, T. (1999) Critical duration of intracellular
Ca2+ response required for continuous translocation and activation of
cytosolic phospholipase A2. J. Biol. Chem.
274,
5163-5169
- Nakao, A., Watanabe, T., Ohishi, N., Toda, A., Asano, K.,
Taniguchi, S., Nosaka, K., Noiri, E., Suzuki, T., Sakai, T., Kurokawa,
K., Shimizu, T., and Kimura, S. (1999) Ubiquitous localization of
leukotriene A4 hydrolase in the rat nephron. Kidney Int. 55,
100-108
1998
- Hirabayashi, T., Kume, K., and Shimizu, T. (1998) Conditional
expression of the dual-specificity phosphatase PYST1/MKP-3 inhibits
phosphorylation of cytosolic phospholipase A2 in Chinese
hamster ovary cells. Biochem. Biophys. Res. Commun. 253,
485-488
- Nishiyama, M., Okamoto, H., Watanabe, T., Hori, T., Sasaki, T.,
Kirino, T., and Shimizu, T. (1998) Endothelium is required for
12-hydroperoxyeicosatetraenoic acid-induced vasoconstriction.
Eur. J. Pharmacol. 341,
57-63
- Ito, K., Suzuki, H., Hirohashi, T., Kume, K., Shimizu, T., and
Sugiyama, Y. (1998) Functional analysis of a canalicular multispecific
organic anion transporter cloned from rat liver. J. Biol. Chem.
273,
1684-1688
- Ishii, I., Saito, E., Izumi, T., Ui, M., and Shimizu, T. (1998)
Agonist-induced sequestration, recycling, and resensitization of
platelet-activating factor receptor. Role of cytoplasmic tail
phosphorylation in each process. J. Biol. Chem. 273,
9878-9885
- Hoshino, M., Izumi, T., and Shimizu, T. (1998) Leukotriene
D4
activates mitogen-activated protein kinase through a protein kinase
Calpha-Raf-1-dependent pathway in human monocytic leukemia THP-1 cells.
J. Biol. Chem. 273,
4878-4882
- Ishii, S., Kuwaki, T., Nagase, T., Maki, K., Tashiro, F., Sunaga,
S., Cao, W. H., Kume, K., Fukuchi, Y., Ikuta, K., Miyazaki, J., Kumada,
M., and Shimizu, T. (1998) Impaired anaphylactic responses with intact
sensitivity to endotoxin in mice lacking a platelet-activating factor
receptor. J. Exp. Med. 187,
1779-1788
- Shimada, A., Ota, Y., Sugiyama, Y., Sato, S., Kume, K., Shimizu,
T., and Inoue, S. (1998) In situ expression of
platelet-activating factor (PAF)-receptor gene in rat skin and effects
of PAF on proliferation and differentiation of cultured human
keratinocytes. J. Invest. Dermatol. 110,
889-893
- Hirohashi, T., Suzuki, H., Ito, K., Ogawa, K., Kume, K., Shimizu,
T., and Sugiyama, Y. (1998) Hepatic expression of multidrug
resistance-associated protein-like proteins maintained in eisai
hyperbilirubinemic rats. Mol. Pharmacol. 53,
1068-1075
1997
- Yokomizo, T., Ogawa, Y., Uozumi, N., Kume, K., Izumi, T., and
Shimizu, T. (1997) cDNA cloning and mutagenesis study of leukotriene
B4
12-hydroxydehydrogenase. Adv. Exp. Med. Biol. 407,
151-156
- Shimizu, T., and Mutoh, H. (1997) Structure and regulation of
platelet activating factor receptor gene. Adv. Exp. Med. Biol.
407,
197-204
- Mori, M., Aihara, M., Kume, K., Hamanoue, M., Kohsaka, S., and
Shimizu, T. (1997) Localization of platelet-activating factor receptor
in the rat brain. Adv. Exp. Med. Biol. 407,
357-363
- Ishii, S., Nakamura, M., Waga, I., Kume, K., Izumi, T., and
Shimizu, T. (1997) Cloning and characterization of a murine
platelet-activating factor receptor gene. Adv. Exp. Med. Biol.
407,
347-355
- Ishii, I., Izumi, T., Ui, M., and Shimizu, T. (1997) High and low
affinity mutants of platelet-activating factor receptor. Adv.
Exp. Med. Biol. 433,
249-253
- Bito, H., and Shimizu, T. (1997) Molecular characterization and
physiological functions of PAF receptors. Adv. Exp. Med. Biol.
400A,
215-221
- Ogita, T., Tanaka, Y., Nakaoka, T., Matsuoka, R., Kira, Y.,
Nakamura, M., Shimizu, T., and Fujita, T. (1997)
Lysophosphatidylcholine transduces Ca2+ signaling via the
platelet-activating factor receptor in macrophages. Am. J.
Physiol. 272,
H17-24
- Ito, K., Suzuki, H., Hirohashi, T., Kume, K., Shimizu, T., and
Sugiyama, Y. (1997) Molecular cloning of canalicular multispecific
organic anion transporter defective in EHBR. Am. J. Physiol.
272,
G16-22
- Nagase, T., Ishii, S., Katayama, H., Fukuchi, Y., Ouchi, Y., and
Shimizu, T. (1997) Airway responsiveness in transgenic mice
overexpressing platelet-activating factor receptor. Roles of
thromboxanes and leukotrienes. Am. J. Respir. Crit. Care Med.
156,
1621-1627
- Kume, K., Waga, I., and Shimizu, T. (1997) Microplate
chromatography assay for acetyl-CoA: lysoplatelet-activating factor
acetyltransferase. Anal Biochem. 246,
118-122
- Kume, K., and Shimizu, T. (1997) cDNA cloning and expression of
murine 1-acyl-sn-glycerol-3-phosphate acyltransferase. Biochem.
Biophys. Res. Commun. 237,
663-666
- Liu, B., Nakashima, S., Adachi, T., Ito, Y., Takano, T., Shimizu,
T., and Nozawa, Y. (1997) Prolonged activation of phospholipase D in
Chinese hamster ovary cells expressing platelet-activating-factor
receptor lacking cytoplasmic C-terminal tail. Biochem. J.
327
(Pt 1), 239-244
- Ishii, S., Nagase, T., Tashiro, F., Ikuta, K., Sato, S., Waga,
I., Kume, K., Miyazaki, J., and Shimizu, T. (1997) Bronchial
hyperreactivity, increased endotoxin lethality and melanocytic
tumorigenesis in transgenic mice overexpressing platelet-activating
factor receptor. Embo J. 16,
133-142
- Kume, K., and Shimizu, T. (1997) Platelet-activating factor (PAF)
induces growth stimulation, inhibition, and suppression of oncogenic
transformation in NRK cells overexpressing the PAF receptor. J.
Biol. Chem. 272,
22898-22904
- Ishii, I., Izumi, T., Tsukamoto, H., Umeyama, H., Ui, M., and
Shimizu, T. (1997) Alanine exchanges of polar amino acids in the
transmembrane domains of a platelet-activating factor receptor generate
both constitutively active and inactive mutants. J. Biol. Chem.
272,
7846-7854
- Honda, Z., Suzuki, T., Hirose, N., Aihara, M., Shimizu, T., Nada,
S., Okada, M., Ra, C., Morita, Y., and Ito, K. (1997) Roles of
C-terminal Src kinase in the initiation and the termination of the high
affinity IgE receptor-mediated signaling. J. Biol. Chem. 272,
25753-25760
- Yokomizo, T., Izumi, T., Chang, K., Takuwa, Y., and Shimizu, T.
(1997) A G-protein-coupled receptor for leukotriene
B4
that mediates chemotaxis. Nature 387,
620-624
- Uozumi, N., Kume, K., Nagase, T., Nakatani, N., Ishii, S.,
Tashiro, F., Komagata, Y., Maki, K., Ikuta, K., Ouchi, Y., Miyazaki,
J., and Shimizu, T. (1997) Role of cytosolic phospholipase
A2
in allergic response and parturition. Nature 390,
618-622
- Tabuchi, S., Kume, K., Aihara, M., Ishii, S., Mishina, M., and
Shimizu, T. (1997) Lipid mediators modulate NMDA receptor currents in a
Xenopus oocyte expression system. Neurosci. Lett. 237,
13-16
- Mori, M., Aihara, M., and Shimizu, T. (1997) Differential
expression of somatostatin receptors in the rat eye: SSTR4 is intensely
expressed in the iris/ciliary body. Neurosci. Lett. 223,
185-188
1996
- Shimizu, T., Mutoh, H., and Kato, S. (1996) Platelet-activating
factor receptor. Gene structure and tissue-specific regulation.
Adv. Exp. Med. Biol. 416,
79-84
- Sato, S., Kume, K., Takan, T., Mutoh, H., Taketani, Y., and
Shimizu, T. (1996) Up-regulation of the intracellular Ca2+ signaling
and mRNA expression of platelet-activating factor receptor by estradiol
in human uterine endometrial cells. Adv. Exp. Med. Biol. 416,
95-100
- Ferby, I., Waga, I., Kume, K., Sakanaka, C., and Shimizu, T.
(1996) PAF-induced MAPK activation is inhibited by wortmannin in
neutrophils and macrophages. Adv. Exp. Med. Biol. 416,
321-326
- Iwase, H., Takatori, T., Nagao, M., Iwadate, K., Takahashi, M.,
Nakajima, M., Takahashi, T., Shimizu, T., and Takahashi, K. (1996)
Superoxide anion reduces the ability of myeloperoxidase to damage
lipids. Biochem. Biophys. Res. Commun. 219,
625-632
- Ishii, S., Matsuda, Y., Nakamura, M., Waga, I., Kume, K., Izumi,
T., and Shimizu, T. (1996) A murine platelet-activating factor receptor
gene: cloning, chromosomal localization and up-regulation of expression
by lipopolysaccharide in peritoneal resident macrophages.
Biochem. J. 314
(Pt 2), 671-678
- Hirano, D., Aoki, Y., Ogasawara, H., Kodama, H., Waga, I.,
Sakanaka, C., Shimizu, T., and Nakamura, M. (1996) Functional coupling
of adenosine A2a receptor to inhibition of the mitogen-activated
protein kinase cascade in Chinese hamster ovary cells. Biochem.
J. 316
(Pt 1), 81-86
- Kishimoto, S., Shimazu, W., Izumi, T., Shimizu, T., Fukuda, T.,
Makino, S., Sugiura, T., and Waku, K. (1996) Enhanced expression of
platelet-activating factor receptor on human eosinophils by
interleukin-3, interleukin-5 and granulocyte-macrophage
colony-stimulating factor. Int. Arch. Allergy Immunol. 111
Suppl 1, 63-65
- Yokomizo, T., Ogawa, Y., Uozumi, N., Kume, K., Izumi, T., and
Shimizu, T. (1996) cDNA cloning, expression, and mutagenesis study of
leukotriene B4 12-hydroxydehydrogenase.
J. Biol. Chem. 271,
2844-2850
- Kishi, K., Hayashi, H., Wang, L., Kamohara, S., Tamaoka, K.,
Shimizu, T., Ushikubi, F., Narumiya, S., and Ebina, Y. (1996)
Gq-coupled receptors transmit the signal for GLUT4 translocation via an
insulin-independent pathway. J. Biol. Chem. 271,
26561-26568
- Ferby, I. M., Waga, I., Hoshino, M., Kume, K., and Shimizu, T.
(1996) Wortmannin inhibits mitogen-activated protein kinase activation
by platelet-activating factor through a mechanism independent of
p85/p110-type phosphatidylinositol 3-kinase. J. Biol. Chem.
271,
11684-11688
- Kishimoto, S., Shimadzu, W., Izumi, T., Shimizu, T., Fukuda, T.,
Makino, S., Sugiura, T., and Waku, K. (1996) Regulation by IL-5 of
expression of functional platelet-activating factor receptors on human
eosinophils. J. Immunol. 157,
4126-4132
- Waga, I., Kume, K., Ferby, I., Honda, Z., and Shimizu, T. (1996)
Micro-trap phosphorylation assay of mitogen-activated protein (MAP)
kinases to detect their activation by lipopolysaccharides. J.
Immunol. Methods 190,
71-77
- Shimizu, T., Mori, M., Bito, H., Sakanaka, C., Tabuchi, S.,
Aihara, M., and Kume, K. (1996) Platelet-activating factor and
somatostatin activate mitogen-activated protein kinase (MAP kinase) and
arachidonate release. J. Lipid Mediat. Cell Signal 14,
103-108
- Mori, M., Aihara, M., Kume, K., Hamanoue, M., Kohsaka, S., and
Shimizu, T. (1996) Predominant expression of platelet-activating factor
receptor in the rat brain microglia. J. Neurosci. 16,
3590-3600
- Mutoh, H., Fukuda, T., Kitamaoto, T., Masushige, S., Sasaki, H.,
Shimizu, T., and Kato, S. (1996) Tissue-specific response of the human
platelet-activating factor receptor gene to retinoic acid and thyroid
hormone by alternative promoter usage. Proc. Natl. Acad. Sci.
USA 93,
774-779
1995
- Izumi, T., Honda, Z., Mutoh, H., Kume, K., and Shimizu, T. (1995)
Regulation and signal transduction of PAF receptor. Adv.
Prostaglandin Thromboxane Leukot. Res. 23,
461-466
- Liu, B., Nakashima, S., Takano, T., Shimizu, T., and Nozawa, Y.
(1995) Implication of protein kinase C alpha in PAF-stimulated
phospholipase D activation in Chinese hamster ovary (CHO) cells
expressing PAF receptor. Biochem. Biophys. Res. Commun. 214,
418-423
- Iwase, H., Takahashi, T., Takatori, T., Shimizu, T., Aono, K.,
Yamada, Y., Iwadate, K., Nagao, M., and Takahashi, K. (1995) pH
dependent alterations of monoepoxides and monochlorohydrins of linoleic
acid, and their existence in vivo. Biochem. Biophys. Res.
Commun. 215,
945-951
- Izumi, T., Kishimoto, S., Takano, T., Nakamura, M., Miyabe, Y.,
Nakata, M., Sakanaka, C., and Shimizu, T. (1995) Expression of human
platelet-activating factor receptor gene in EoL-1 cells following
butyrate-induced differentiation. Biochem. J. 305
(Pt 3), 829-835
- Izumi, T., and Shimizu, T. (1995) Platelet-activating factor
receptor: gene expression and signal transduction. Biochim.
Biophys. Acta 1259,
317-333
- Minami, M., Mutoh, H., Ohishi, N., Honda, Z., Bito, H., and
Shimizu, T. (1995) Amino-acid sequence and tissue distribution of
guinea-pig leukotriene A4 hydrolase. Gene 161,
249-251
- Watanabe, T., Waga, I., Honda, Z., Kurokawa, K., and Shimizu, T.
(1995) Prostaglandin F2 alpha stimulates formation of p21ras-GTP
complex and mitogen-activated protein kinase in NIH-3T3 cells via
Gq-protein-coupled pathway. J. Biol. Chem. 270,
8984-8990
- Nakamura, M., Sakanaka, C., Aoki, Y., Ogasawara, H., Tsuji, T.,
Kodama, H., Matsumoto, T., Shimizu, T., and Noma, M. (1995)
Identification of two isoforms of mouse neuropeptide Y-Y1 receptor
generated by alternative splicing. Isolation, genomic structure, and
functional expression of the receptors. J. Biol. Chem. 270,
30102-30110
- Honda, Z., Takano, T., Hirose, N., Suzuki, T., Muto, A., Kume,
S., Mikoshiba, K., Itoh, K., and Shimizu, T. (1995) Gq pathway
desensitizes chemotactic receptor-induced calcium signaling via
inositol trisphosphate receptor down-regulation. J. Biol. Chem.
270, 4840-4844
- Aoki, Y., Nakamura, M., Kodama, H., Matsumoto, T., Shimizu, T.,
and Noma, M. (1995) A radioreceptor binding assay for
platelet-activating factor (PAF) using membranes from CHO cells
expressing human PAF receptor. J. Immunol. Methods 186,
225-231
- Yokomizo, T., Uozumi, N., Takahashi, T., Kume, K., Izumi, T., and
Shimizu, T. (1995) Leukotriene A4 hydrolase and leukotriene
B4
metabolism. J. Lipid Mediat. Cell Signal 12,
321-332
1994
- Shirasaki, H., Nishikawa, M., Adcock, I. M., Mak, J. C.,
Sakamoto, T., Shimizu, T., and Barnes, P. J. (1994) Expression of
platelet-activating factor receptor mRNA in human and guinea pig lung.
Am. J. Respir. Cell Mol. Biol. 10,
533-537
- Bigby, T. D., Lee, D. M., Minami, M., Ohishi, N., Shimizu, T.,
and Baker, J. R. (1994) Characterization of human airway epithelial
cell leukotriene A4 hydrolase. Am. J. Respir. Cell Mol. Biol.
11,
615-624
- Mori, M., Bito, H., Sakanaka, C., Honda, Z., Kume, K., Izumi, T.,
and Shimizu, T. (1994) Activation of mitogen-activated protein kinase
and arachidonate release via two G protein-coupled receptors expressed
in the rat hippocampus. Ann. N. Y. Acad. Sci. 744,
107-125
- Sakanaka, C., Ferby, I., Waga, I., Bito, H., and Shimizu, T.
(1994) On the mechanism of cytosolic phospholipase A2
activation in CHO cells carrying somatostatin receptor:
wortmannin-sensitive pathway to activate mitogen-activated protein
kinase. Biochem. Biophys. Res. Commun. 205,
18-23
- Mutoh, H., Kume, K., Sato, S., Kato, S., and Shimizu, T. (1994)
Positive and negative regulations of human platelet-activating factor
receptor transcript 2 (tissue-type) by estrogen and TGF-beta 1.
Biochem. Biophys. Res. Commun. 205,
1130-1136
- Mutoh, H., Ishii, S., Izumi, T., Kato, S., and Shimizu, T. (1994)
Platelet-activating factor (PAF) positively auto-regulates the
expression of human PAF receptor transcript 1 (leukocyte-type) through
NF-kappa B. Biochem. Biophys. Res. Commun. 205,
1137-1142
- Kobayashi, Y., Shimazaki, T., Kawajiri, K., Shimizu, T., Seyama,
Y., and Sato, F. (1994) Important contribution of the methylene part of
LTB4 toward binding affinity to the LTB4 receptors and rise in
intracellular-free calcium concentration. Biochim. Biophys.
Acta 1215,
280-284
- Bito, H., Honda, Z., Nakamura, M., and Shimizu, T. (1994)
Cloning, expression and tissue distribution of rat
platelet-activating-factor-receptor cDNA. Eur. J. Biochem.
221,
211-218
- Liu, B., Nakashima, S., Kanoh, H., Takano, T., Shimizu, T., and
Nozawa, Y. (1994) Activation of phospholipase D in Chinese hamster
ovary cells expressing platelet-activating factor receptor. J.
Biochem. (Tokyo) 116,
882-891
- Takano, T., Honda, Z., Sakanaka, C., Izumi, T., Kameyama, K.,
Haga, K., Haga, T., Kurokawa, K., and Shimizu, T. (1994) Role of
cytoplasmic tail phosphorylation sites of platelet-activating factor
receptor in agonist-induced desensitization. J. Biol. Chem.
269,
22453-22458
- Honda, Z., Takano, T., Gotoh, Y., Nishida, E., Ito, K., and
Shimizu, T. (1994) Transfected platelet-activating factor receptor
activates mitogen-activated protein (MAP) kinase and MAP kinase kinase
in Chinese hamster ovary cells. J. Biol. Chem. 269,
2307-2315
- Ferby, I. M., Waga, I., Sakanaka, C., Kume, K., and Shimizu, T.
(1994) Wortmannin inhibits mitogen-activated protein kinase activation
induced by platelet-activating factor in guinea pig neutrophils.
J. Biol. Chem. 269,
30485-30488
- Bito, H., Mori, M., Sakanaka, C., Takano, T., Honda, Z., Gotoh,
Y., Nishida, E., and Shimizu, T. (1994) Functional coupling of SSTR4, a
major hippocampal somatostatin receptor, to adenylate cyclase
inhibition, arachidonate release and activation of the
mitogen-activated protein kinase cascade. J. Biol. Chem. 269,
12722-12730
- Kajihara, A., Komooka, H., Kamiya, K., Yoneda, T., Yoneda, S.,
Nakamura, M., Shimizu, T., and Umeyama, H. (1994) Three-dimensional
model of the human PAF receptor. J. Lipid Mediat. Cell Signal
9,
185-196
- Tsuge, H., Ago, H., Aoki, M., Furuno, M., Noma, M., Miyano, M.,
Minami, M., Izumi, T., and Shimizu, T. (1994) Crystallization and
preliminary X-ray crystallographic studies of recombinant human
leukotriene A4 hydrolase complexed with bestatin. J. Mol. Biol.
238,
854-856
1993
- Bito, H., Sakanaka, C., Takano, T., Kudo, Y., and Shimizu, T.
(1993) Molecular cloning of a novel type of somatostatin receptor and
platelet-activating factor receptor cDNAs from rat. Ann. N. Y.
Acad. Sci. 707,
480-481
- Waga, I., Nakamura, M., Honda, Z., Ferby, I., Toyoshima, S.,
Ishiguro, S., and Shimizu, T. (1993) Two distinct signal transduction
pathways for the activation of guinea-pig macrophages and neutrophils
by endotoxin. Biochem. Biophys. Res. Commun. 197,
465-472
- Mori, M., Izumi, T., and Shimizu, T. (1993) Energy-dependent
export of leukotriene B4 in Xenopus oocytes.
Biochim. Biophys. Acta 1168,
23-29
- Mutoh, H., Bito, H., Minami, M., Nakamura, M., Honda, Z., Izumi,
T., Nakata, R., Kurachi, Y., Terano, A., and Shimizu, T. (1993) Two
different promoters direct expression of two distinct forms of mRNAs of
human platelet-activating factor receptor. FEBS Lett. 322,
129-134
- Yokomizo, T., Izumi, T., Takahashi, T., Kasama, T., Kobayashi,
Y., Sato, F., Taketani, Y., and Shimizu, T. (1993) Enzymatic
inactivation of leukotriene B4 by a novel
enzyme found in the porcine kidney. Purification and properties of
leukotriene B4 12-hydroxydehydrogenase.
J. Biol. Chem. 268,
18128-18135
- Nakamura, M., Honda, Z., Matsumoto, T., Noma, M., and Shimizu, T.
(1993) Isolation and properties of platelet-activating factor receptor
cDNAs. J. Lipid Mediat. 6,
163-168
- Izumi, T., Minami, M., Ohishi, N., Bito, H., and Shimizu, T.
(1993) Site-directed mutagenesis of leukotriene A4 hydrolase:
distinction of leukotriene A4 hydrolase and aminopeptidase activities.
J. Lipid Mediat. 6,
53-58
- Bito, H., Kudo, Y., and Shimizu, T. (1993) Characterization of
platelet-activating factor (PAF) receptor in the rat brain. J.
Lipid Mediat. 6,
169-174
1992
- Sugimoto, T., Tsuchimochi, H., McGregor, C. G., Mutoh, H.,
Shimizu, T., and Kurachi, Y. (1992) Molecular cloning and
characterization of the platelet-activating factor receptor gene
expressed in the human heart. Biochem. Biophys. Res. Commun.
189,
617-624
- Jamil, K. M., Takano, T., Nakao, A., Honda, Z., Shimizu, T.,
Watanabe, T., and Kurokawa, K. (1992) Expression of platelet activating
factor receptor in renal tubular cell line (LLC-PK1). Biochem.
Biophys. Res. Commun. 187,
767-772
- Shimizu, T., Honda, Z., Nakamura, M., Bito, H., and Izumi, T.
(1992) Platelet-activating factor receptor and signal transduction.
Biochem. Pharmacol. 44,
1001-1008
- Sakanaka, C., Izumi, T., Nakamura, M., Honda, Z., Watanabe, T.,
Minami, M., Mutoh, H., Bito, H., Seyama, Y., Ui, M., and Shimizu, T.
(1992) Three types of Gi alpha protein of the guinea-pig lung: cDNA
cloning and analysis of their tissue distribution. Biochim.
Biophys. Acta 1175,
61-66
- Nagata, K., Takakura, K., Asano, T., Seyama, Y., Hirota, H.,
Shigematsu, N., Shima, I., Kasama, T., and Shimizu, T. (1992)
Identification of 7 alpha-hydroxy-3-oxo-4-cholestenoic acid in chronic
subdural hematoma. Biochim. Biophys. Acta 1126,
229-236
- Nakamura, M., Honda, Z., Waga, I., Matsumoto, T., Noma, M., and
Shimizu, T. (1992) Endotoxin transduces Ca2+ signaling via
platelet-activating factor receptor. FEBS Lett. 314,
125-129
- Minami, M., Bito, H., Ohishi, N., Tsuge, H., Miyano, M., Mori,
M., Wada, H., Mutoh, H., Shimada, S., Izumi, T., Abe, K., and Shimizu,
T. (1992) Leukotriene A4 hydrolase, a bifunctional enzyme. Distinction
of leukotriene A4 hydrolase and aminopeptidase activities by
site-directed mutagenesis at Glu-297. FEBS Lett. 309,
353-357
- Bito, H., Nakamura, M., Honda, Z., Izumi, T., Iwatsubo, T.,
Seyama, Y., Ogura, A., Kudo, Y., and Shimizu, T. (1992)
Platelet-activating factor (PAF) receptor in rat brain: PAF mobilizes
intracellular Ca2+ in hippocampal neurons. Neuron 9,
285-294
1991
- Takano, T., Honda, Z., Watanabe, T., Uchida, S., Shimizu, T., and
Kurokawa, K. (1991) Demonstration of platelet activating factor
receptor in guinea pig kidney. Biochem. Biophys. Res. Commun.
177,
54-60
- Watanabe, T., Shimizu, T., Nakao, A., Taniguchi, S., Arata, Y.,
Teramoto, T., Seyama, Y., Ui, M., and Kurokawa, K. (1991)
Characterization of partially purified prostaglandin E2 receptor from
the canine renal medulla: evidence for physical association of the
receptor protein with the inhibitory guanine nucleotide-binding
protein. Biochim. Biophys. Acta 1074,
398-405
- Watanabe, T., Yatomi, Y., Sunaga, S., Miki, I., Ishii, A., Nakao,
A., Higashihara, M., Seyama, Y., Ogura, M., Saito, H., Kurokawa, K.,
and Shimizu, T. (1991) Characterization of prostaglandin and
thromboxane receptors expressed on a megakaryoblastic leukemia cell
line, MEG-01s. Blood 78,
2328-2336
- Yamashita, T., Shimizu, T., and Ogata, E. (1991) Activin
A/erythroid differentiation factor induces thromboxane A2 synthetic
activity in murine erythroleukemia cells. J. Biol. Chem. 266,
3888-3892
- Nakamura, M., Honda, Z., Izumi, T., Sakanaka, C., Mutoh, H.,
Minami, M., Bito, H., Seyama, Y., Matsumoto, T., Noma, M., and Shimizu,
T. (1991) Molecular cloning and expression of platelet-activating
factor receptor from human leukocytes. J. Biol. Chem. 266,
20400-20405
- Honda, Z., Nakamura, M., Miki, I., Minami, M., Watanabe, T.,
Seyama, Y., Okado, H., Toh, H., Ito, K., Miyamoto, T., and Shimizu, T.
(1991) Cloning by functional expression of platelet-activating factor
receptor from guinea-pig lung. Nature 349,
342-346
- Mike, I., Ichikawa, Y., Shimizu, T., Honda, Z. I., Seyama, Y.,
and Ishii, A. (1991) The differences in 12-hydroxyeicosatetraenoic acid
and thromboxane B2 release from guinea pig platelets.
Prostaglandins 42,
431-440
If You Are Interested in Review Articles...
PAF receptor
- Ishii, S., and Shimizu, T. (2000) Platelet-activating factor
(PAF) receptor and genetically engineered PAF receptor mutant mice.
Prog.
Lipid Res. 39,
41-82
- Izumi, T., and Shimizu, T. (1995) Platelet-activating factor
receptor: gene expression and signal transduction. Biochim.
Biophys. Acta 1259,
317-333
- Shimizu, T., Mutoh, H., Waga, I., Nakamura, M., Honda, Z., and
Izumi, T. (1994) Structure and function of platelet-activating factor
receptor. in "Molecular Basis of Inflammation";
(Navarro, J. ed) pp 163-167, Ares Serono Symposia Publication, Rome
- Honda, Z., and Shimizu, T. (1993) Lipid mediators in defence
mechanisms in The Natural Immune System. Humoral Factors.
(Sim, E. ed.) pp. 337-367. IRL Press at Oxford University Press, Oxford
- Shimizu, T, Honda, Z., Nakamura, M., Bito, H., and Izumi, T.
(1992) Platelet-activating factor receptor and signal transduction.
Biochem.
Pharmacol 44,
1001-1008