Major Publications
2008,
2007,
2006,
2005,
2004,
2003,
2002,
2001,
2000,
1999,
1998,
1997,
1996,
1995,
1994,
1993,
1992,
1991,
Reviews,
Reviews in Japanese,
Complete works of Professor Shimizu
TOP PAGE in Japanese or
English
Complete works of Professor Takao Shimizu
Original Articles
- Kitamura, S., Ishihara, Y., Sasaki, K., Shimizu, T., and Kosaka, K.: Effect of mixture of prostaglandin E1 and F2a on the guinea pig trachea. Advances Prostaglandin, Thromboxane Res. 2: 962 (1976)
- Kitamura, S., Ishihara, Y., Shimizu, T., and Kosaka, K.: Prostaglandin inactivation in normal and sensitized guinea pig lung and its inhibition by indomethacin. Jap. J. Med. 15: 12-17 (1976)
- Hayaishi, O., Hirata, F., Ohnishi, T., Yoshida, R., and Shimizu, T.: A new assay procedure for indoleamine 2,3-dioxygenase. Advances Exp. Med. Biol. 74: 335-342 (1976)
- Hirata, F., Shimizu, T., Yoshida, R., Ohnishi, T., Fujiwara, M., and Hayaishi, O.: Copper content of indoleamine 2,3-dioxygenase. Advances Exp. Med. Biol. 74: 354-357 (1976)
- Kitamura, S., Ishihara, Y., Sasaki, K., Shimizu, T., and Harasawa, M.: Effect of dihydroergotoxine on activities of b-receptor stimulators. Drug Res. 27: 1959-1961 (1977)
- Shimizu, T., Nomiyama, S., Hirata, F., and Hayaishi, O.: Indoleamine 2,3-dioxygenase. Purification and some properties. J. Biol. Chem. 253: 4700-4706 (1978)
- Kitamura, S., Shimizu, T., Ishihara, Y.: Effects of 5-hydroxykynurenamine, a metabolite of 5-hydroxytryptamine, on guinea pig isolated trachea. J. Pharm. Pharmacol. 31: 45-46 (1979)
- Shimizu, T., Yamamoto, S., and Hayaishi, O.: Purification and properties of prostaglandin D synthetase from rat brain. J. Biol. Chem. 254: 5222-5228 (1979)
- Shimizu, T., Mizuno, N., Amano, T., and Hayaishi, O.: Prostaglandin D2, a neuromodulator. Proc. Natl. Acad. Sci. U. S. A. 76: 6231-6234 (1979)
- Yamamoto, S., Ohki, S., Ogino, N., Shimizu, T., Yoshimoto, T., Watanabe, K., and Hayaishi, O.: Enzymes involved in the formation and further transformations of prostaglandin endoperoxides. Advances in Prostaglandin, Thromboxane and Leukotriene Res. 6: 27-34 11.
- Watanabe, K., Shimizu, T., Iguchi, S., Wakatsuka, H., Hayashi, M., and Hayaishi, O.: An NADP-linked prostaglandin D2 dehydrogenase in swine brain. J. Biol. Chem. 255: 1779-1782 (1980)
- Shimizu, T., Kondo, K., and Hayaishi, O.: Role of prostaglandin endoperoxides in the serum thiobarbituric acid reaction. Arch. Biochem. Biophys. 206: 271-276 (1981)
- Shimizu, T., Watanabe, K., and Hayaishi, O.: Metabolism and functions of prostaglandin D2 in the brain. Neurochem. Res. 6: 113-117 (1981)
- Kondo, K., Shimizu, T., and Hayaishi, O.: Effects of prostaglandin D2 on membrane potential in neuroblastoma X glioma hybrid cells as determined with a cyanine dye. Biochem. Biophys. Res. Commun. 98: 648-655 (1981)
- Watanabe, K., Shimizu, T., and Hayaishi, O.: Enzymatic conversion of prostaglandin D2 to F2a in the rat lung. Biochem. Int. 2: 603-610 (1981)
- Watanabe, T., Shimizu, T., Narumiya, S., and Hayaishi, O.: NADP-linked prostaglandin D2 dehydrogenase in human blood platelets. Arch. Biochem. Biophys. 216: 372-379 (1982)
- Ueno, R., Shimizu, T., Kondo, K., and Hayaishi, O.: Activation mechanism of prostaglandin endoperoxide synthetase by hemoproteins. J. Biol. Chem. 257: 5584-5588 (1982)
- Kinoshita, F., Nakai, Y., Katakami, H., Imura, H., Shimizu, T., and Hayaishi, O.: Suppressive effect of prostaglandin D2 on pulsatile luteinizing hormone release in conscious rats. Endocrinology 110: 2207-2209 (1982)
- Shimizu, T., Yamashita, A., and Hayaishi, O.: Specific binding of prostaglandin D2 to rat brain synaptic membrane. Occurrence, properties and distribution. J. Biol. Chem. 257: 13570-13575 (1982)
- Tokumoto, H., Watanabe, K., Fukushima, D., Shimizu, T., and Hayaishi, O.: An NADP-linked prostaglandin 15-hydroxyprostaglandin dehydrogenase specific for prostaglandin D2 from swine brain. J. Biol. Chem. 257: 13576-13580 (1982)
- Watanabe, T., Narumiya, S., Shimizu, T., and Hayaishi, O.: Characterization of the biosynthetic pathway of prostaglandin D2 in human platelet- rich plasma. J. Biol. Chem. 257: 14847-14853 (1982)
- Radmark, O., Shimizu, T., Fitzpatrick, F., and Samuelsson, B.: Hemoprotein catalysis of leukotriene formation. Biochim. Biophys. Acta 792: 324-329 (1984)
- Shimizu, T., Radmark, O., and Samuelsson, B.: Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid. Proc. Natl. Acad. Sci. U. S. A. 81: 689-693 (1984)
- Radmark, O., Shimizu, T., Jornvall, H., and Samuelsson, B.: Leukotriene A4 hydrolase in Human Leukocytes: Purification and properties. J. Biol. Chem. 259: 12339-12345 (1984)
- Watanabe, K., Yoshida, R., Shimizu, T., and Hayaishi, O.: Enzymatic formation of prostaglandin F2a from Prostaglandin H2 and D2: Purification and properties of prostaglandin F synthetase. J. Biol. Chem. 260: 7035-7041 (1985)
- Radmark, O., Shimizu, T., Jornvall, H., and Samuelsson, B.: Leukotriene A4: Mechanism of formation and enzymatic hydrolysis. Advances Pharmacol. Therap. 25-28 (1985)
- Shimizu, T., Radmark, O., and Samuelsson, B.: The biosynthesis of leukotriene A4 from 5-hydroperoxyeicosatetraenoic acid: Possible involvement of 8-lipoxygenase reaction. Advances Prostaglandin Thromboxane Leukotriene Res. 15: 177-180 (1985)
- Watanabe, K., Yoshida, R., Shimizu, T., and Hayaishi, O.: Biosynthesis of PGF2a from PGH2 and PGD2 by an apparently homogeneous enzyme. Advances Prostaglandin Thromboxane Leukotriene Res. 15: 151-153 (1985)
- Rouzer, C., Shimizu, T., and Samuelsson, B.: On the nature of the 5-lipoxygenase reaction in human leukocytes: Characterization of a membrane-associated stimulatory factor. Proc. Natl. Acad. Sci. U. S. A. 82: 7505-7509 (1985)
- Izumi, T., Shimizu, T., Kasama, T., Seyama Y., Sumimoto, H., Takeshige, K., Minakami, S., Wetterholm, A., and Radmark, O.: A simultaneous quantitation of leukotriene B4 and its w-oxidized products by gas chromatography-mass spectrometry. Biochem. Biophys. Res. Commun. 134: 512-518 (1986)
- Izumi, T., Shimizu, T., Seyama, Y., Ohishi, N., and Takaku, F.: Tissue distribution of leukotriene A4 hydrolase activity in guinea pig. Biochem. Biophys. Res. Commun. 135: 139-145 (1986)
- Shimizu, T., Izumi, T., Seyama, Y., Tadokoro, K., Radmark, O., and Samuelsson, B.: Characterization of leukotriene A4 synthase from murine mast cells. Evidence of its identity to arachidonate 5-lipoxygenase. Proc. Natl. Acad. Sci. U. S. A. 83: 4175-4179 (1986)
- Rouzer, C., Matsumoto, T., Shimizu, T., and Samuelsson, B: Purification and properties of 5-lipoxygenase in human leukocytes. Advances. Prostaglandin, Thromboxane and Leukotriene Res. 16: 3-16 (1986)
- Shimizu, T., Takusagawa, Y., Izumi, T., Ohishi, N., and Seyama, Y: Enzymatic synthesis of leukotriene B4 in the guinea pig brain. J. Neurochem. 48: 1541-1546 (1987)
- Kume, K., Shimizu, T., and Seyama, Y: Characterization of sn-Glycerol 3-phosphate acyltransferase from guinea pig Harderian gland. J. Biochem. 101: 653-660 (1987)
- Kitamura, S., Shimizu, T., Izumi, T., and Seyama, Y: Synthesis of 11,12-leukotriene A4 (11S, 12S-oxido-5-cis-8,10trans-14- ciseicosatetraenoic acid, a novel leukotriene of 12-lipoxygenase pathway. FEBS Lett. 213: 169-173 (1987)
- Shimizu, T., Izumi, T., Ohishi, N., Seyama, Y, and Kitamura, S: Biosynthesis and further transformations of leukotriene A4. Advances Prostaglandin Thromboxane Leukotriene Res. 17: 64-68 (1987)
- Ohishi, N., Izumi, T., Kitamura, S., Minami, M., Seyama, Y., Ohkawa, S., Terao, S., Yotsumoto, H., Takaku, F., and Shimizu, T: Leukotriene A4 hydrolase in human lung: inactivation of the enzyme with leukotriene A4 isomers. J. Biol. Chem. 262, 10200-10205 (1987)
- Minami, M., Ohno, S., Kawasaki, H., Radmark, O., Samuelsson, B., Shimizu, T., Seyama, Y., and Suzuki, K: Molecular cloning of a cDNA coding for human leukotriene A4 hydrolase; complete primary structure of an enzyme involved in eicosanoid synthesis. J. Biol. Chem. 262, 13873-13878 (1987)
- Funk, C., Radmark, O., Fu, J-Y., Matsumoto, T., Jornvall, H., Shimizu, T., and Samuelsson, B: Leukotriene A4 hydrolase, molecular cloning and amino acid sequence. Proc. Natl. Acad. Sci. U. S. A. 84, 6677-6681 (1987)
- Tsuchida, S., Izumi, T., Shimizu, T., Ishikawa, T., Hatayama, I., Satoh, K., and Sato, K: Purification of a new acidic glutathione S-transferase, GST-Yn1Yn1, with a high leukotriene C4 synthase activity from rat brain. Eur. J. Biochem. 170, 159-164 (1987)
- Minami, M., Minami, Y., Emori, Y., Kawasaki, H., Ohno, S., Suzuki, K., Ohishi, N., Shimizu, T., and Seyama, Y: Expression of human leukotriene A4 hydrolase cDNA in Escherichia coli. FEBS Lett. 229, 279-282 (1988)
- Byun, D-S., Kasama, T., Shimizu, T., Yorifuji, H., and Seyama, Y: Effect of cholestanol feeding on sterol concentrations in the serum, liver and cerebellum of mice. J. Biochem. 103, 375-379 (1988)
- Watanabe, T., Asano, T., Shimizu, T., Seyama, Y., and Takakura, K: Participation of lipoxygenase products from arachidonic acid in the pathogeneses of cerebral vasospasm. J. Neurochem. 50, 1145-1150 (1988)
- Izumi, T., Honda, Z., Ohishi, N., Kitamura, S., Tsuchida, S., Sato, K., Shimizu, T., and Seyama, Y: Solubilization and partial purification of leukotriene C4 synthase from guinea pig lung: a microsomal enzyme with high specificity towards 5,6-epoxide leukotriene A4. Biochim. Biophys. Acta 959: 305-315 (1988)
- Shimizu, T., Watanabe, T., Asano, T., Seyama, Y., and Takakura, K: Activation of the arachidonate 5-lipoxygenase pathway in the canine basilar artery after the subarachnoidal hemorrhage. J. Neurochem. 51, 1126-1131 (1988)
- Kitamura, S., Shimizu, T., Miki, I., Izumi, T., and Seyama, Y: Synthesis and structural identification of four dihydroxy acids and 11,12- leukotriene C4 derived from 11,12-leukotriene A4. Eur. J. Biochem. 176 725-731 (1988)
- Izumi, T., Honda, Z., Ohishi, N., Kitamura, S., Seyama, Y., and Shimizu, T: Partial purification and characterization of leukotriene C4 synthase from guinea pig lung. Advances Prostaglandin, Thromboxane and Leukotriene Res. 19, 90-93 (1989)
- Minami, M., Minami, Y., Ohno, S., Suzuki, K., Ohishi, N., Shimizu, T., and Seyama, Y: Molecular cloning and expression of human leukotriene A4 hydrolase cDNA. Advances Prostaglandin, Thromboxane and Leukotriene Res. 19, 478-483 (1989)
- Miki, I., Kitamura, S., Shimizu, T., and Seyama, Y: 11,12-Leukotriene A4: Synthesis and metabolism. Advances Prostaglandin, Thromboxane and Leukotriene Res. 19, 98-101 (1989)
- Bito, H., Ohishi, N., Miki, I., Minami, M., Tanabe, T., Shimizu, T., and Seyama, Y: Purification and properties of leukotriene A4 hydrolase from the guinea pig lung. J. Biochem. 105 , 261-264 (1989)
- Kurachi, Y., Ito, H., Sugimoto, T., Shimizu, T., Miki, I., and Ui, M.: Arachidonic acid metabolites as intracellular modulators of G protein-gated cardiac K channel. Nature 337, 555-557 (1989)
- Miki, I., Shimizu, T., Seyama, Y., Kitamura, S., Yamaguchi, K., Sano, H., Ueno, H., Hiratsuka, A., and Watabe, T.: Enzymic conversion of 11,12-leukotriene A4 to 11,12-dihydroxy-5,14-cis-7,9- trans-eicosatetraenoic acid: Purification of an epoxide hydrolase from the guinea pig liver cytosol. J. Biol. Chem. 264, 5799-5805 (1989)
- Takeuchi, K., Shimizu, T., Ohishi, N., Seyama, Y., Takaku, F., and Yotsumoto, S: Purification of human lung angiotensin converting enzyme by high performance liquid chromatography: Properties and N-terminal amino acid sequence. J. Biochem. 106, 442-445 (1989)
- Kurachi, Y., Ito, H., Sugimoto, T., Shimizu, T., Miki, I., and Ui, M.: a-Adrenergic activation of the muscarinic K+ channel is mediated by arachidonic acid metabolites. Pflugers Arch. 414, 102-104 (1989)
- Sugiyama, Y., Izumi, T., Ohishi, N., Yotsumoto, H., Shimizu, T., Kitamura, S., and Takaku, F: Effects of smoking on the synthesis of leukotriene B4 by rat alveolar macrophages. Respiration 56: 198-203 (1989)
- Kuo, T-M., Taketani, Y., Shimizu, T., and Mizuno, M: A possible mechanism of infertility in endometriosis. a role of Interleukin-1 in peritoneal fluid. Assisted Reproductive Technology Andrology 1, 24-31 (1990)
- Miki, I., Seyama, Y., Ui, M., Sato, F., and Shimizu, T: Characterization of leukotriene B4 receptor in porcine spleen and leukocytes. Biochem. Biophys. Res. Commun. 166 342-348 (1990)
- Ohishi, N., Minami, M., Kobayashi, J., Seyama, Y., Hata, J., Yotsumoto, H., Takaku, F., and Shimizu, T: Immunological quantitation and immunohistochemical localization of leukotriene A4 hydrolase. J. Biol. Chem. 265 7520-7525 (1990)
- Nagase, T., Fukuchi, Y., Shimizu, T., Matsuse, T., and Orimo, H: Reduction of 15-hydroxyeicosatetraenoic acid (15-HETE) in tracheal fluid with high frequency oscillatory ventilation. Prostaglandin, Leukotrienes and Essential Fatty Acids. 40 177-180 (1990)
- Watanabe, T., Shimizu, T., Miki, I., Sakanaka, C., Honda, Z., Seyama, Y., Teramoto, T., Matsushima, T., Ui, M., and Kurokawa, K: Characterization of the guinea pig lung membrane leukotriene D4 receptor solubilized in an active form: Association and dissociation with an islet-activating protein -sensitive GTP binding protein. J. Biol. Chem. 265 21237-21241 (1990)
- Nagase, T., Fukuchi, Y., Shimizu, T., and Orimo, H: Endothelin-1 stimulates arachidonate 15-lipoxygenase activity and oxygen radical formation in the rat distal lung. Biochem. Biophys. Res. Commun. 168 485-489 (1990)
- Toh, H., Minami, M., and Shimizu, T: Molecular evolution and zinc ion binding motif of leukotriene A4 hydrolase. Biochem. Biophys. Res. Commun. 171 216-219 (1990)
- Ishihara, O., Kinoshita, K., Satoh, K., Mizuno, M., and Shimizu, T: An inhibitor of prostaglandin biosynthesis from human decidua: partial purification and properties. Prostaglandins Leukotrienes and Essential Fatty Acids 40 223-226 (1990)
- Minami, M., Ohishi, N., Mutoh, H., Izumi, T., Bito, H., Wada, H., Seyama, Y., Toh, H., and Shimizu, T.: Leukotriene A4 hydrolase is a zinc-containing aminopeptidase. Biochem. Biophys. Res. Commun. 173 620-626 (1990)
- Shimizu, T., Miki, I., Ohishi, N., and Seyama, Y: Biosynthesis and receptor of leukotriene B4. Advances Prostaglandin, Thromboxane and Leukotriene Res. 21: 387-394 (1990)
- Takano, T., Honda, Z., Watanabe, T., Uchida, S., Shimizu, T., and Kurokawa, K. (1991) Demonstration of platelet activating factor receptor in guinea pig kidney. Biochem. Biophys. Res. Commun. 177, 54-60
- Watanabe, T., Shimizu, T., Nakao, A., Taniguchi, S., Arata, Y., Teramoto, T., Seyama, Y., Ui, M., and Kurokawa, K. (1991) Characterization of partially purified prostaglandin E2 receptor from the canine renal medulla: evidence for physical association of the receptor protein with the inhibitory guanine nucleotide-binding protein. Biochim. Biophys. Acta 1074, 398-405
- Watanabe, T., Yatomi, Y., Sunaga, S., Miki, I., Ishii, A., Nakao, A., Higashihara, M., Seyama, Y., Ogura, M., Saito, H., Kurokawa, K., and Shimizu, T. (1991) Characterization of prostaglandin and thromboxane receptors expressed on a megakaryoblastic leukemia cell line, MEG-01s. Blood 78, 2328-2336
- Yamashita, T., Shimizu, T., and Ogata, E. (1991) Activin A/erythroid differentiation factor induces thromboxane A2 synthetic activity in murine erythroleukemia cells. J. Biol. Chem. 266, 3888-3892
- Nakamura, M., Honda, Z., Izumi, T., Sakanaka, C., Mutoh, H., Minami, M., Bito, H., Seyama, Y., Matsumoto, T., Noma, M., and Shimizu, T. (1991) Molecular cloning and expression of platelet-activating factor receptor from human leukocytes. J. Biol. Chem. 266, 20400-20405
- Honda, Z., Nakamura, M., Miki, I., Minami, M., Watanabe, T., Seyama, Y., Okado, H., Toh, H., Ito, K., Miyamoto, T., and Shimizu, T. (1991) Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung. Nature 349, 342-346
- Mike, I., Ichikawa, Y., Shimizu, T., Honda, Z. I., Seyama, Y., and Ishii, A. (1991) The differences in 12-hydroxyeicosatetraenoic acid and thromboxane B2 release from guinea pig platelets. Prostaglandins 42, 431-440
- Sugimoto, T., Tsuchimochi, H., McGregor, C. G., Mutoh, H., Shimizu, T., and Kurachi, Y. (1992) Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart. Biochem. Biophys. Res. Commun. 189, 617-624
- Jamil, K. M., Takano, T., Nakao, A., Honda, Z., Shimizu, T., Watanabe, T., and Kurokawa, K. (1992) Expression of platelet activating factor receptor in renal tubular cell line (LLC-PK1). Biochem. Biophys. Res. Commun. 187, 767-772
- Shimizu, T., Honda, Z., Nakamura, M., Bito, H., and Izumi, T. (1992) Platelet-activating factor receptor and signal transduction. Biochem. Pharmacol. 44, 1001-1008
- Sakanaka, C., Izumi, T., Nakamura, M., Honda, Z., Watanabe, T., Minami, M., Mutoh, H., Bito, H., Seyama, Y., Ui, M., and Shimizu, T. (1992) Three types of Gi alpha protein of the guinea-pig lung: cDNA cloning and analysis of their tissue distribution. Biochim. Biophys. Acta 1175, 61-66
- Nagata, K., Takakura, K., Asano, T., Seyama, Y., Hirota, H., Shigematsu, N., Shima, I., Kasama, T., and Shimizu, T. (1992) Identification of 7 alpha-hydroxy-3-oxo-4-cholestenoic acid in chronic subdural hematoma. Biochim. Biophys. Acta 1126, 229-236
- Nakamura, M., Honda, Z., Waga, I., Matsumoto, T., Noma, M., and Shimizu, T. (1992) Endotoxin transduces Ca2+ signaling via platelet-activating factor receptor. FEBS Lett. 314, 125-129
- Minami, M., Bito, H., Ohishi, N., Tsuge, H., Miyano, M., Mori, M., Wada, H., Mutoh, H., Shimada, S., Izumi, T., Abe, K., Shimizu, T. (1992) Leukotriene A4 hydrolase, a bifunctional enzyme. Distinction of leukotriene A4 hydrolase and aminopeptidase activities by site-directed mutagenesis at Glu-297. FEBS Lett. 309, 353-357
- Bito, H., Nakamura, M., Honda, Z., Izumi, T., Iwatsubo, T., Seyama, Y., Ogura, A., Kudo, Y., and Shimizu, T. (1992) Platelet-activating factor (PAF) receptor in rat brain: PAF mobilizes intracellular Ca2+ in hippocampal neurons. Neuron 9, 285-294
- Bito, H., Sakanaka, C., Takano, T., Kudo, Y., and Shimizu, T. (1993) Molecular cloning of a novel type of somatostatin receptor and platelet-activating factor receptor cDNAs from rat. Ann. N. Y. Acad. Sci. 707, 480-481
- Waga, I., Nakamura, M., Honda, Z., Ferby, I., Toyoshima, S., Ishiguro, S., and Shimizu, T. (1993) Two distinct signal transduction pathways for the activation of guinea-pig macrophages and neutrophils by endotoxin. Biochem. Biophys. Res. Commun. 197, 465-472
- Mori, M., Izumi, T., and Shimizu, T. (1993) Energy-dependent export of leukotriene B4 in Xenopus oocytes. Biochim. Biophys. Acta 1168, 23-29
- Mutoh, H., Bito, H., Minami, M., Nakamura, M., Honda, Z., Izumi, T., Nakata, R., Kurachi, Y., Terano, A., and Shimizu, T. (1993) Two different promoters direct expression of two distinct forms of mRNAs of human platelet-activating factor receptor. FEBS Lett. 322, 129-134
- Yokomizo, T., Izumi, T., Takahashi, T., Kasama, T., Kobayashi, Y., Sato, F., Taketani, Y., and Shimizu, T. (1993) Enzymatic inactivation of leukotriene B4 by a novel enzyme found in the porcine kidney. Purification and properties of leukotriene B4 12-hydroxydehydrogenase. J. Biol. Chem. 268, 18128-18135
- Bito, H., Kudo, Y., and Shimizu, T. (1993) Characterization of platelet-activating factor (PAF) receptor in the rat brain. J. Lipid Mediat. 6, 169-174
- Shirasaki, H., Nishikawa, M., Adcock, I. M., Mak, J. C., Sakamoto, T., Shimizu, T., and Barnes, P. J. (1994) Expression of platelet-activating factor receptor mRNA in human and guinea pig lung. Am. J. Respir. Cell Mol. Biol. 10, 533-537
- Bigby, T. D., Lee, D. M., Minami, M., Ohishi, N., Shimizu, T., and Baker, J. R. (1994) Characterization of human airway epithelial cell leukotriene A4 hydrolase. Am. J. Respir. Cell Mol. Biol. 11, 615-624
- Mori, M., Bito, H., Sakanaka, C., Honda, Z., Kume, K., Izumi, T., and Shimizu, T. (1994) Activation of mitogen-activated protein kinase and arachidonate release via two G protein-coupled receptors expressed in the rat hippocampus. Ann. N. Y. Acad. Sci. 744, 107-125
- Sakanaka, C., Ferby, I., Waga, I., Bito, H., and Shimizu, T. (1994) On the mechanism of cytosolic phospholipase A2 activation in CHO cells carrying somatostatin receptor: wortmannin-sensitive pathway to activate mitogen-activated protein kinase. Biochem. Biophys. Res. Commun. 205, 18-23
- Mutoh, H., Kume, K., Sato, S., Kato, S., and Shimizu, T. (1994) Positive and negative regulations of human platelet-activating factor receptor transcript 2 (tissue-type) by estrogen and TGF-beta 1. Biochem. Biophys. Res. Commun. 205, 1130-1136
- Mutoh, H., Ishii, S., Izumi, T., Kato, S., and Shimizu, T. (1994) Platelet-activating factor (PAF) positively auto-regulates the expression of human PAF receptor transcript 1 (leukocyte-type) through NF-kappa B. Biochem. Biophys. Res. Commun. 205, 1137-1142
- Kobayashi, Y., Shimazaki, T., Kawajiri, K., Shimizu, T., Seyama, Y., and Sato, F. (1994) Important contribution of the methylene part of LTB4 toward binding affinity to the LTB4 receptors and rise in intracellular-free calcium concentration. Biochim. Biophys. Acta 1215, 280-284
- Bito, H., Honda, Z., Nakamura, M., and Shimizu, T. (1994) Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA. Eur. J. Biochem. 221, 211-218
- Liu, B., Nakashima, S., Kanoh, H., Takano, T., Shimizu, T., and Nozawa, Y. (1994) Activation of phospholipase D in Chinese hamster ovary cells expressing platelet-activating factor receptor. J. Biochem. (Tokyo) 116, 882-891
- Takano, T., Honda, Z., Sakanaka, C., Izumi, T., Kameyama, K., Haga, K., Haga, T., Kurokawa, K., and Shimizu, T. (1994) Role of cytoplasmic tail phosphorylation sites of platelet-activating factor receptor in agonist-induced desensitization. J. Biol. Chem. 269, 22453-22458
- Honda, Z., Takano, T., Gotoh, Y., Nishida, E., Ito, K., and Shimizu, T. (1994) Transfected platelet-activating factor receptor activates mitogen-activated protein (MAP) kinase and MAP kinase kinase in Chinese hamster ovary cells. J. Biol. Chem. 269, 2307-2315
- Ferby, I. M., Waga, I., Sakanaka, C., Kume, K., and Shimizu, T. (1994) Wortmannin inhibits mitogen-activated protein kinase activation induced by platelet-activating factor in guinea pig neutrophils. J. Biol. Chem. 269, 30485-30488
- Bito, H., Mori, M., Sakanaka, C., Takano, T., Honda, Z., Gotoh, Y., Nishida, E., and Shimizu, T. (1994) Functional coupling of SSTR4, a major hippocampal somatostatin receptor, to adenylate cyclase inhibition, arachidonate release and activation of the mitogen-activated protein kinase cascade. J. Biol. Chem. 269, 12722-12730
- Kajihara, A., Komooka, H., Kamiya, K., Yoneda, T., Yoneda, S., Nakamura, M., Shimizu, T., and Umeyama, H. (1994) Three-dimensional model of the human PAF receptor. J. Lipid Mediat. Cell Signal 9, 185-196
- Tsuge, H., Ago, H., Aoki, M., Furuno, M., Noma, M., Miyano, M., Minami, M., Izumi, T., and Shimizu, T. (1994) Crystallization and preliminary X-ray crystallographic studies of recombinant human leukotriene A4 hydrolase complexed with bestatin. J. Mol. Biol. 238, 854-856
- Liu, B., Nakashima, S., Takano, T., Shimizu, T., and Nozawa, Y. (1995) Implication of protein kinase C alpha in PAF-stimulated phospholipase D activation in Chinese hamster ovary (CHO) cells expressing PAF receptor. Biochem. Biophys. Res. Commun. 214, 418-423
- Iwase, H., Takahashi, T., Takatori, T., Shimizu, T., Aono, K., Yamada, Y., Iwadate, K., Nagao, M., and Takahashi, K. (1995) pH dependent alterations of monoepoxides and monochlorohydrins of linoleic acid, and their existence in vivo. Biochem. Biophys. Res. Commun. 215, 945-951
- Izumi, T., Kishimoto, S., Takano, T., Nakamura, M., Miyabe, Y., Nakata, M., Sakanaka, C., and Shimizu, T. (1995) Expression of human platelet-activating factor receptor gene in EoL-1 cells following butyrate-induced differentiation. Biochem. J. 305 (Pt 3), 829-835
- Izumi, T., and Shimizu, T. (1995) Platelet-activating factor receptor: gene expression and signal transduction. Biochim. Biophys. Acta 1259, 317-333
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- Nishiyama, M., Okamoto, H., Watanabe, T., Hori, T., Sasaki, T., Kirino, T., and Shimizu, T. (1998) Endothelium is required for 12-hydroperoxyeicosatetraenoic acid-induced vasoconstriction. Eur. J. Pharmacol. 341, 57-63
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- Ishii, I., Saito, E., Izumi, T., Ui, M., and Shimizu, T. (1998) Agonist-induced sequestration, recycling, and resensitization of platelet-activating factor receptor. Role of cytoplasmic tail phosphorylation in each process. J. Biol. Chem. 273, 9878-9885
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- Ishii, S., Kuwaki, T., Nagase, T., Maki, K., Tashiro, F., Sunaga, S., Cao, W. H., Kume, K., Fukuchi, Y., Ikuta, K., Miyazaki, J., Kumada, M., and Shimizu, T. (1998) Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor. J. Exp. Med. 187, 1779-1788
- Shimada, A., Ota, Y., Sugiyama, Y., Sato, S., Kume, K., Shimizu, T., and Inoue, S. (1998) In situ expression of platelet-activating factor (PAF)-receptor gene in rat skin and effects of PAF on proliferation and differentiation of cultured human keratinocytes. J. Invest. Dermatol. 110, 889-893
- Hirohashi, T., Suzuki, H., Ito, K., Ogawa, K., Kume, K., Shimizu, T., and Sugiyama, Y. (1998) Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats. Mol. Pharmacol. 53, 1068-1075
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- Igarashi, T., Yokomizo, T., Tsutsumi, O., Taketani, Y., Shimizu, T., and Izumi, T. (1999) Characterization of the leukotriene B4 receptor in porcine leukocytes. Separation and reconstitution with heterotrimeric GTP-binding proteins. Eur. J. Biochem. 259, 419-425
- Kobayashi, K., Ishii, S., Kume, K., Takahashi, T., Shimizu, T., and Manabe, T. (1999) Platelet-activating factor receptor is not required for long-term potentiation in the hippocampal CA1 region. Eur. J. Neurosci. 11, 1313-1316
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- Ishizaka, N., Nakao, A., Ohishi, N., Suzuki, M., Aizawa, T., Taguchi, J., Nagai, R., Shimizu, T., and Ohno, M. (1999) Increased leukotriene A(4) hydrolase expression in the heart of angiotensin II-induced hypertensive rat. FEBS Lett. 463, 155-159
- Fukasawa, K. M., Fukasawa, K., Harada, M., Hirose, J., Izumi, T., and Shimizu, T. (1999) Aminopeptidase B is structurally related to leukotriene-A4 hydrolase but is not a bifunctional enzyme with epoxide hydrolase activity. Biochem. J. 339 (Pt 3), 497-502
- Masuda, K., Yokomizo, T., Izumi, T., and Shimizu, T. (1999) cDNA cloning and characterization of guinea-pig leukotriene B4 receptor. Biochem. J. 342 (Pt 1), 79-85
- Nagase, T., Ishii, S., Kume, K., Uozumi, N., Izumi, T., Ouchi, Y., and Shimizu, T. (1999) Platelet-activating factor mediates acid-induced lung injury in genetically engineered mice. J. Clin. Invest. 104, 1071-1076
- Hirabayashi, T., Kume, K., Hirose, K., Yokomizo, T., Iino, M., Itoh, H., and Shimizu, T. (1999) Critical duration of intracellular Ca2+ response required for continuous translocation and activation of cytosolic phospholipase A2. J. Biol. Chem. 274, 5163-5169
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- Yokomizo, T., Masuda, K., Kato, K., Toda, A., Izumi, T., and Shimizu, T. (2000) Leukotriene B4 receptor. Cloning and intracellular signaling. Am. J. Respir. Crit. Care Med. 161, S51-55
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- Kawasawa, Y., Kume, K., Nakade, S., Haga, H., Izumi, T., and Shimizu, T. (2000) Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. Biochem. Biophys. Res. Commun. 276, 952-956
- Kawasawa, Y., Kume, K., Izumi, T., and Shimizu, T. (2000) Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems. Biochem. Biophys. Res. Commun. 276, 957-964
- Hirabayashi, T., and Shimizu, T. (2000) Localization and regulation of cytosolic phospholipase A(2). Biochim. Biophys. Acta 1488, 124-138
- Aihara, M., Ishii, S., Kume, K., and Shimizu, T. (2000) Interaction between neurone and microglia mediated by platelet-activating factor. Genes Cells 5, 397-406
- Noiri, E., Yokomizo, T., Nakao, A., Izumi, T., Fujita, T., Kimura, S., and Shimizu, T. (2000) An in vivo approach showing the chemotactic activity of leukotriene B(4) in acute renal ischemic-reperfusion injury. Proc. Natl. Acad. Sci. USA 97, 823-828
- Nagase, T., Uozumi, N., Ishii, S., Kume, K., Izumi, T., Ouchi, Y., and Shimizu, T. (2000) Acute lung injury by sepsis and acid aspiration: a key role for cytosolic phospholipase A2. Nat. Immunol. 1, 42-46
- Kato, K., Yokomizo, T., Izumi, T., and Shimizu, T. (2000) Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene. J. Exp. Med. 192, 413-420
- Yokomizo, T., Kato, K., Terawaki, K., Izumi, T., and Shimizu, T. (2000) A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. J. Exp. Med. 192, 421-432
- Takaku, K., Sonoshita, M., Sasaki, N., Uozumi, N., Doi, Y., Shimizu, T., and Taketo, M. M. (2000) Suppression of intestinal polyposis in Apc(delta 716) knockout mice by an additional mutation in the cytosolic phospholipase A(2) gene. J. Biol. Chem. 275, 34013-34016
- Nakatani, N., Uozumi, N., Kume, K., Murakami, M., Kudo, I., and Shimizu, T. (2000) Role of cytosolic phospholipase A2 in the production of lipid mediators and histamine release in mouse bone-marrow-derived mast cells. Biochem. J. 352 Pt 2, 311-317
- Tabuchi, S., Kume, K., Aihara, M., and Shimizu, T. (2000) Expression of lysophosphatidic acid receptor in rat astrocytes: mitogenic effect and expression of neurotrophic genes. Neurochem. Res. 25, 573-582
- Ishii, S., and Shimizu, T. (2000) Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice. Prog. Lipid Res. 39, 41-82
- Yokomizo, T., Izumi, T., and Shimizu, T. (2001) Leukotriene B4: metabolism and signal transduction. Arch. Biochem. Biophys. 385, 231-241
- Yamamoto, T., Yokomizo, T., Nakao, A., Izumi, T., and Shimizu, T. (2001) Immunohistochemical localization of guinea-pig leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin 13-reductase. Eur. J. Biochem. 268, 6105-6113
- Yokomizo, T., Kato, K., Hagiya, H., Izumi, T., and Shimizu, T. (2001) Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. J. Biol. Chem. 276, 12454-12459
- Wu, C., Stojanov, T., Chami, O., Ishii, S., Shimizu, T., Li, A., O'Neill, C., and Shimuzu, T. (2001) Evidence for the autocrine induction of capacitation of mammalian spermatozoa. J. Biol. Chem. 276, 26962-26968
- Yamashita, A., Kawagishi, N., Miyashita, T., Nagatsuka, T., Sugiura, T., Kume, K., Shimizu, T., and Waku, K. (2001) ATP-independent fatty acyl-coenzyme A synthesis from phospholipid: coenzyme A-dependent transacylation activity toward lysophosphatidic acid catalyzed by acyl-coenzyme A:lysophosphatidic acid acyltransferase. J. Biol. Chem. 276, 26745-26752
- Kim, Y. J., Noguchi, S., Hayashi, Y. K., Tsukahara, T., Shimizu, T., and Arahata, K. (2001) The product of an oculopharyngeal muscular dystrophy gene, poly(A)-binding protein 2, interacts with SKIP and stimulates muscle-specific gene expression. Hum. Mol. Genet. 10, 1129-1139
- Fukunaga, K., Ishii, S., Asano, K., Yokomizo, T., Shiomi, T., Shimizu, T., and Yamaguchi, K. (2001) Single nucleotide polymorphism of human platelet-activating factor receptor impairs G-protein activation. J. Biol. Chem. 276, 43025-43030
- Yokomizo, T., Izumi, T., and Shimizu, T. (2001) Co-expression of two LTB4 receptors in human mononuclear cells. Life Sci. 68, 2207-2212
- Banno, Y., Wang, S., Ito, Y., Izumi, T., Nakashima, S., Shimizu, T., and Nozawa, Y. (2001) Involvement of ERK and p38 MAP kinase in oxidative stress-induced phospholipase D activation in PC12 cells. Neuroreport 12, 2271-2275
- Shimizu, T. (2001) Biological control by lipid mediators and pathophysiology. Jap. Med. Assoc. J. 44, 369-374.
- Nagase, T., Ishii, S., Shindou, H., Ouchi, Y., and Shimizu, T. (2002) Airway hyperresponsiveness in transgenic mice overexpressing platelet activating factor receptor is mediated by an atropine-sensitive pathway. Am. J. Respir. Crit. Care Med. 165, 200-205
- Hanaka, H., Shimizu, T., and Izumi, T. (2002) Nuclear-localization-signal-dependent and nuclear-export-signal-dependent mechanisms determine the localization of 5-lipoxygenase. Biochem. J. 361, 505-514
- Klein, A., Pinho, V., Alessandrini, A. L., Shimizu, T., Ishii, S., Teixeira, M. M. (2002). Platelet-activating factor drives eotaxin production in an allergic pleurisy in mice. Brit. J. Pharmacol. 135, 1213-1218
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- Nagase, T., Uozumi, N., Ishii, S., Kita, Y., Yamamoto, H., Ohga, E., Ouchi,
Y. and Shimizu, T. (2002) A pivotal role of cytosolic phospholipase A2 in
bleomycin-induced pulmonary fibrosis. Nature Med. 8, 480-484
- Ogasawara, H., Ishii, S., Yokomizo, T., Kakinuma, T., Komine, M., Tamaki, K., Shimizu, T., and Izumi, T. (2002) Characterization of mouse cysteinyl leukotriene receptors, mCysLT1 and mCysLT2: Differential pharamacological properties and tissue distribution. J. Biol. Chem.277, 18763-18768
- Barbuti, A., Ishii, S., Shimizu, T., Robinson, R.B., and Feinmark, S.J. (2002) Block of the background K+ channel, TASK-1, contributes to the arrhythmogenic effects of platelet-activating factor. Am. J. Physiol. 282, H2024-H2030
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receptor. J. Biochem. 131, 773-779
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- Stromgaard, K., Saito, D.R., Shindou, H., Ishii, S., Shimizu, T., and Nakanishi, K. (2002) Ginkgolide derivatives for photolabeling studies: preparation and pharmacological evaluation. J. Med. Chem. 45,4038-46
- Soares, A.C., Pinho, V.S., Souza, D.G., Shimizu, T., Ishii, S., Nicoli,
J.R., and Teixeira, M.M. Role of the platelet-activating factor (PAF)
receptor during pulmonary infection with gram negative bacteria. Brit. J. Pharmacol. 137, 621-628
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Nishijima, S., Yokomizo, T., Tokunaga, K. and Fujita, T. (2002) Association
of eNOS Glu298Asp polymorphism with end-stage renal disease. Hypertension 40, 535-540
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68-69: 59-69
- Vogensen, S.B., Stromgaard, K., Shindou, H., Jaracz, S., Suehiro, M., Ishii, S., Shimizu, T., and Nakanishi, K. (2003)
Preparation of 7-substituted ginkgolide derivatives: potent platelet-activating factor (PAF) receptor antagonists.
J. Med. Chem. 46, 601-608
- Taniguchi, M., Nagao, H., Takahashi K.Y., Yamaguchi, M., Mitsui, S., Yagi, T., Mori, K. and Shimizu, T. (2003)
Distorted Odor Maps in the Olfactory Bulb of Semaphorin 3A-Deficient Mice.
J. Neurosci. 23: 1390-1397.
- Usui, H., Taniguchi, M., Yokomizo, T., and Shimizu, T. (2003)
Interaction of plexin A1 and plexin B1 at the cytoplamic domain.
Biochem. Biophys. Res. Commun. 24,927-31
- Nagase T., Uozumi N., Aoki-Nagase T., Terawaki K., Ishii S., Tomita T., Yamamoto H., Hashizume K., Ouchi Y., Shimizu T. (2003)
A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice.
Am J Physiol. Lung Cell Mol. Physiol. 284, L720-L726
- Asai, K, Hirabayashi, T, Houjou, T, Uozumi, N., Taguchi, R., and Shimizu, T. (2003)
Human Group IVC phospholipase A2 (cPLA2): roles in the membrane remodeling and activation induced by oxidative stress.
J. Biol. Chem. 278,8909-8914
- Miyaura, C., Inada, M., Matsumoto, C., Ohshiba, C., Uozumi, N., Shimizu, T., and Ito, A. (2003)
An Essential Role of Cytosolic Phospholipase A2a in Prostaglandin E2-mediated Bone Resorption Associated with Inflammation
J. Exp. Med. 197, 1303-1310
- Hegen, M., Sun L., Uozumi N., Kume K., Goad, E.M., Nickerson-Nutter L.C., Shimizu T., and Clark D.J. (2003)
Cytosolic Phospholipase A2a deficient Mice Are Resistant to Collagen-induced Arthritis
J. Exp. Med. 197, 1297-1302
- Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., Murakami, K., Ohteki T., Uchida, S., Takenawa, S., Waki H., Tsuno, N.H., Shibata, Y., Terauchi, Y., Froguel, P., Tobe, K., Koyasu, S., Taira, K., Kitamura, T., Shimizu, T., Nagai, R., and Kadowaki, T. (2003)
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects.
Nature 423, 762-768
- Noguchi, K., Ishii, S., and Shimizu, T. (2003)
Identification of p2y9/GPR23 as a Novel G Protein-Coupled Receptor for Lysophosphatidic Acid, Structurally Distant from the Edg Family
J. Biol. Chem. 278, 25600-25606
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Sasaki, S., Hirotsune, S., Wynshaw-Boris, A., and Shimizu, T. (2003)
Involvement of Platelet-Activating Factor and LIS1 in Neuronal
Migration.
Eur. J. Neurosci. 18, 563-570
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Fukuda, R. Yokomizo, T., Shimizu, T., Kodama, T., and Hamakubo, T.
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A combinatorial G protein-coupled receptor reconstitution system on
budded baculovirus: Evidence for Gai and Gao coupling to a human leukotriene B4 receptor.
J. Biol. Chem. 278, 24552-24562
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In situ Ca imaging of odor responses in a coronal olfactory epithelium slice.
Neuroreport 14, 1123-1127
- Talvani, A., Santana, G., Barcelos, L. S., Ishii, S., Shimizu, T., Romanha, J., Silva, J. S., Soares, M. B. P. and Teixeira, M. M. (2003)
Experimental Trypanosoma cruzi infection in platelet-activating factor -deficient mice.
Microb. Infect. 5, 789-796
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Role of PAF receptors during intestinal ischemia and reperfusion injury. A comparative study between PAF receptor-deficient mice and PAF receptor antagonist treatment.
Brit. J. Pharmacol. 139, 733-740
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Host response of platelet-activating factor receptor-deficient mice during pulmonary tuberculosis.
Immunology, 109, 552-556
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Helix 8 of the leukotriene B4 receptor is required for the conformational change to the low-affinity state after G-protein activation.
J. Biol. Chem. 278, 41500-41509
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Glucocorticoids up-regulate leukotriene B4 receptor-1 expression during
neutrophilic differentiation of HL-60 cells.
Biochem. Biophys. Res. Commun.
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Taniguchi, T. and Shimizu, T. (2003)
Characterization of a novel member of murine semaphorin family.
Biochem. Biophys. Res. Commun. 30, 242-248
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T., Ishii, S., and van der Poll, T. (2004)
Platelet activating factor receptor deficient mice have an improved
host defense against pneumococcal pneumonia.
J. Infect. Dis. 189, 711-716
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(2004)
B-Myb-dependent regulation of c-Myc expression by cytosolic
phospholipase A2
J. Biol. Chem. 279, 17715-17722
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therapeutic key for cystic fibrosis: a role for lipoxins.
Nature Immunol. (News and Views) 5, 357-358
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Yamamoto, M., Kumasaka, T., Shimizu, T. and Miyano, M. (2004)
Structural basis of leukotriene B4
12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase catalytic
mechanism and a possible SH3 binding loop.
J. Biol. Chem. 279, 22615-22623
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(2004) Platelet-activating factor receptor develops airway hyperresponsiveness
independently of airway inflammation in a murine asthma model.
J. Immunol. 172, 7095-7102
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Absence of platelet-activating factor receptor protects mice from
osteoporosis following ovariectomy. J. Clin. Invest. 114, 85-93
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G2A is a proton-sensing G-protein coupled receptor antagonized by
lysophosphatidylcholine. J. Biol. Chem. 279, 42484-42491
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T., Fisher, E, A., and Randolph, G. J. (2004) Dyslipidemia associated
with atherosclerotic disease systemically alters dendritic cell
mobilization. Immunity 21, 561-574
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Shimizu, T., Watanbabe, J., and Nogami, S. (2004)
Lethal malaria in cytosolic phospholipase A2- and phospholipase
IIA-deficient mice. Amer. J. Tropical Med Hyg. 70, 645-650
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Rapid and selective identification of molecular species in phosphatidylcholine and sphingomyelin by conditional neutral loss scanning and MS3.
Rapid Commun. Mass Spectrom. 18, 3123-3130
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Preparation of 2- and 4-(2-alkylcarbamoyl-1-methylvinyl)-7-alkyloxybenzo[b]furans having potent antagonistic activity against human leukotriene B4 BLT1 and/or BLT2 receptors.
Org. Biomol. Chem. 2, 3427-3431
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Platelet-activating factor receptor deficient mice show an unaltered
clearance of Haemophilus influenzae from their respiratory tract. Shock 22, 543-547
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A shotgun tandem mass spectrometric analysis of hospholipids with normal-phase and/or reverse-phase liquid chromtography/electrospray ionization mass spectrometry.
Rapid Commun. Mass Spectrom. 19, 654-666
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Stimulation of erythrocyte ceramide formation by platelet activating factor.
J. Cell Sci. 118, 1233-1243
- Ishii, S., Kihara, Y., and Shimizu, T. (2005)
Identification of T cell death-associated gene 8 (TDAG8) as a novel acid sensing G-protein-coupled receptor.
J. Biol. Chem. 280, 9083-9087
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Highly selective localization of leukotriene C4 synthase in hypothalamic and extrahypothalamic vasopressin systems of mouse brain.
Neurosci. 131, 683-689
- Kita, Y., Takahashi, T., Uozumi, N., Nallan, L., Gelb, M. H., and Shimizu, T. (2005)
Pathway-oriented profiling of lipid mediators in macrophages.
Biochem. Biophys. Res. Commun. 330, 898-906
- Ishida, M., Imagawa, M., Shimizu, T., and Taguchi, R. (2005)
Specific detection oflysphosphatidic acids in serum extracts by tandem mass spectrometry.
J. Mass Spectrom. Soc. Jpn. 53, 25-32
- Saiga, A., Uozumi, N., Ono, T., Seno, K., Ishimoto, Y., Arita, H.,
Shimizu, T., and Hanasaki, K. (2005)
Group X secretory phospholipase A2 can induce arachidonic acid release and eicosanoid production without activation of cytosolic phospholipase A2.
Prostaglandins Other Lipid Med. 75, 79-89
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A comprehensive classification system for lipids
J. Lipid Res. 46, 839-862
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Synthesis of 2-, 4- and 5-(2-alkylcarbamoyl-1-methylvinyl)-7-alkyloxybenzo[b]furans and their leukotriene B(4) receptor antagonistic activity.
Org. Biomol. Chem. 3, 2129-2139
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A multiplex quantitation method for eicosanoids and platelet-activating factor using column-switching reversed-phase liquid chromatography-tandem mass spectrometry.
Anal. Biochem. 342, 134-143
- Ohto, T., Uozumi, N., Hirabayashi, T., and Shimizu, T. (2005)
Identification of novel cytosolic phospholipase A2s, murine cPLA2 delta, epsilon, and zeta, which form a gene cluster with cPLA2 beta.
J. Biol. Chem. 280, 24576-24583
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Characterization of a mouse second leukotriene B4 receptor, mBLT2.
J. Biol. Chem. 280, 24816-24823
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Priming effect of lipopolysaccharide on acetyl-CoA:lyso-PAF acetyltransferase is MyD88 and TRIF-independent.
J. Immunol. 175, 1177-1183
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Identification and characterization of a novel member of murine semaphorin
family.
Genes to Cells 10, 785-792
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Cytosolic phospholipase A2alpha-deficient mice are resistant to experimental autoimmune encephalomyelitis.
J. Exp. Med. 202, 841-851
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Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor.
J. Exp. Med. 202, 853-863
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Protective role for cytosolic phospholipase A2alpha in autoimmune diabetes of mice.
FEBS Lett. 579, 3975-3978
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Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity reactions via the platelet-activating factor receptor.
J. Clin. Invest. 115, 2855-2861
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Absence of leukotriene B4 receptor 1 confers resistance to airway hyperresponsiveness and Th2 type immune responses.
J. Immunol. 175, 4217-4225
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Recruitment of katanin p60 by phosphorylated NDEL1, a LIS1 interacting protein, is essential for mitotic cell division and neuronal migration.
Hum. Mol. Genet. 14, 3113-3128
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Involvement of the platelet activating factor receptor in host defense against Streptococcus pneumoniae during postinfluenza pneumonia.
Am. J. Physiol. 290, L194-L199
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Attenuation of folic acid-induced renal inflammatory injury in platelet-activating factor receptor-deficient mice.
Am. J. Pathol. 168, 1413-1424
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Profiling of eicosanoid production in the rat hippocampus during kainate-induced seizure: Dual-phase regulation and differential involvement of cox-1 and cox-2.
J. Biol. Chem. 281, 14663-14669
- Nakanishi, H., Shindou, H., Hishikawa, D., Harayama, T., Ogasawara, R., Suwabe, A., Taguchi, R., and Shimizu, T. (2006)
Cloning and characterization of mouse lung-type acyl-coa:lysophosphatidylcholine acyltransferase 1 (LPCAT1): Expression in alveolar type II cells, and possible involvement in surfactant production.
J. Biol. Chem. 281, 20140-20147
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Sensory system-predominant distribution of leukotriene a(4) hydrolase and its colocalization with calretinin in the mouse nervous system.
Neurosci. 141, 917-927
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Biochemical properties and pathophysiological roles of cytosolic phospholipase A2s.
Biochim. Biophys. Acta 1761, 1317-1322
- Akiba, S., Mukaida, Y., Hane, K., Oka, M., Uozumi, N., Shimizu, T., and Sato, T. (2006)
Group IVA phospholipase A(2)-mediated production of fibronectin by oxidized LDL in mesangial cells.
Kidney Int. 70, 1013-1018
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Immunomodulation by n-3- vs. n-6-rich lipid emulsions in murine acute lung injury - role of platelet-activating factor receptor.
Crit. Care Med. 35, 544-554
- Yanagida, K., Ishii, S., Hamano, F., Noguchi, K., and Shimizu, T. (2007)
LPA4/p2y9/GPR23 mediates Rho-dependent morphological changes in a rat neuronal cell line.
J. Biol. Chem. 282, 5814-5824
- Shindou, H., Hishikawa, D., Nakanishi, H., Harayama, T., Ishii, S., Taguchi, R., and Shimizu, T. (2007)
A single enzyme catalyzes both PAF production and membrane biogenesis of inflammatory cells: cloning and characterization of acetyl-CoA:lyso-PAF acetyltransferase.
J. Biol. Chem. 282, 6532-6539
- Kuniyeda, K., Okuno, T., Terawaki, K., Miyano, M., Yokomizo, T., and Shimizu, T. (2007)
Identification of the intracellular region of the Leukotriene B4 receptor type-1 that specifically involves in Gi-activation.
J. Biol. Chem. 282, 3998-4006
- Tsuda, M., Ishii, S., Masuda, T., Hasegawa, S., Nakamura, K., Nagata, K., Yamashita, T., Furue, H., Tozaki-Saito, H., Yoshimura, M., Koizumi, S., Shimizu, T., and Inoue, K. (2007)
Reduced pain behaviors and ERK activation in primary sensory neurons by peripheral tissue injury in mice lacking platelet-activating factor receptor.
J. Neurochem. 102, 1658-1668
- Kitaura, H., Uozumi, N., Tohmi, M., Yamazaki, M., Sakimura, K., Kudoh,
M., Shimizu, T., and Shibuki, K. (2007)
Roles of nitric oxide as a vasodilator in neurovascular coupling of
mouse somatosensory cortex.
Neurosci. Res. 59, 160-171
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Y., Shimizu, T., Seki, G., and Fujita, T. (2007)
Roles of ERK and group IVA cytosolic PLA2 in biphasic regulation of renal
proximal transport by angiotensin II.
J. Amer. Soc. Nephrol. 19, 252-259
- Kimura, M., Taniguchi, M., Mikami, Y., Masuda, T., Yoshida, T., Mishina,
M., and Shimizu, T. (2007)
Identification and characterization of zebrafish semaphorine 6D.
Biochem. Biophys. Res. Commun. 363, 762-768
- Hishikawa, D*., Shindou, H*. (*, equal contribution), Kobayashi, S.,
Nakanishi, H., Taguchi, R., and Shimizu, T. (2008)
Discovery of a lysophospholipid acyltransferase family essential for
membrane asymmetry and diversity.
Proc. Natl. Acad. Sci. USA 105, 2830-2835
- Harayama, T*., Shindou, H*. (*, equal contribution), Ogasawara, R.,
Suwabe, A, and Shimizu, T. (2008)
Identification of a novel non-inflammatory biosynthetic pathway of
platelet-activating factor.
J. Biol. Chem. 283, 11097-11106
- Tsujimura, Y., Obata, K., Mukai, K., Shindou, H., Yoshida, M., Nshikado,
H., Kawano, Y., Minegishi, Y., Shimizu, T., and Karasuyama, H. (2008)
Basophils play a pivotal role in IgG-, but not IgE-mediated systemic
anaphylaxis in contrast to mast cells.
Immunity 28, 581-589
- Okuno, T., Iizuka, Y., Okazaki, H., Yokomizo, T., Taguchi, R., and
Shimizu, T. (2008)
12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for
leukotriene B4 receptor 2.
J. Exp. Med. 205, 759-766
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K. O., Melo, L. G., and Funk, C. D.(2008)
Endothelial cysteinyl leukotriene 2 receptor (CysLT2R) expression
mediates myocardial ischemia-reperfusion injury.
Am. J. Pathol. 172, 592-602
- Hase, M., Yokomizo, T., Shimizu, T., and Nakamura, M. (2008)
Characterization of an orphan G protein-coupled receptor, GPR20, that
constitutively activates Gi proteins.
J. Biol. Chem. 283, 12747-12755
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Shimizu, T., and Majima, M. (2008)
Leukotriene B4/Leukotriene B4 Receptor Pathway Is Involved in Hepatic Microcirculatory Dysfunction Elicited by Endotoxin.
Shock 30, 87-91
- Mashimo, M., Hirabayashi, T., Murayama, T., and Shimizu, T. (2008)
Cytosolic PLA2a activation in Purkinje neurons and its role in AMPA-receptor trafficking
J. Cell Sci. 121, 3015-3024
- Uozumi, N., Kita, Y., and Shimizu, T. (2008)
Modulation of lipid and protein mediators of inflammation by cytosolic phospholipase A2alpha during experimental sepsis.
J. Immunol. 181, 3558-3566
- Kihara, Y., Yanagida, K., Masago, K., Kita, Y., Hishikawa, D., Shindou, H., Ishii, S., and Shimizu, T. (2008)
Platelet-Activating Factor Production in the Spinal Cord of Experimental Allergic Encephalomyelitis Mice via the Group IVA Cytosolic PLA2-LysoPAFAT Axis.
J. Immunol. 181, 5008-5014
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Cysteinyl leukotriene 2 receptor-mediated vascular permeability via transendothelial vesicle transport.
FASEB J. 22, 4352-4362
- Ikeda, K., Shimizu, T., and Taguchi, R. (2008)
Targeted analysis of ganglioside and sulfatide molecular species by LC/ESI-MS/MS with theoretically expanded multiple reaction monitoring.
J. Lipid Res. 49, 2678-2689
- Lopes-Vales, R., Navarro, X., Shimizu, T.., Baskakis, C., Kokotos, G., Constanious-Kokotou, V., Stephen, D., Dennis, E. A., and David, S. (2008)
Intracellular phospholipase A2 group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury.
Brain 131, 2620-2631
- Li, Y., Yamada, H., Kita, Y., Suzuki, M., Endo, Y., Horita, S., Yamazaki, O., Shimizu, T., Seki, G., and Fujita, T. (2008)
Arachidonic acid metabolites inhibit the stimulatory effect of angiotensin II in renal proximal tubules.
Hypertens. Res. 31, 2155-2164
- Prevost, N., Mitsios, J., Kato, H., Burke, J. E., Dennis, E.A., Shimizu, T. and Shattil, S. J. (2008)
Group IVA cytosolic phospholipase A2 (cPLA2) and integrin a IIbb3 reinforce each other's functions during IIb3 signaling in platelets.
Blood 113, 447-457
- Yasuda, D., Okuno, T., Yokomizo, T., Hori, T., Hirota, N., Hashidate, T., Miyano, M., Shimizu, T., and Nakamura, M. (2009)
Helix 8 of leukotriene B4 type-2 receptor is required for the folding to pass the ER quality control.
FASEB J. 23, 1470-1481
- Yuki, K., Shindou, H., Hishikawa, D., and Shimizu, T. (2009)
Characterization of mouse lysophosphatidic acid acyltransferase 3: An enzyme with dual functions in the testis.
J. Lipid Res. 50, 860-869
- Shindou, H., Eto, M., Morimoto, R., and Shimizu, T. (2009)
Identification of membrane O-acyltransferase family motifs.
Biochem. Biophys. Res. Commun. 383, 320-325
- Harayama, T., Shindou, H., and Shimizu, T. (2009)
Biosynthesis of phosphatidylcholine by human lysophosphatidylcholine acyltransferase 1.
J. Lipid Res. 50, 1824-1831
- Yanagida, K., Masago, K., Nakanishi, H., Kihara, Y., Hamano, F., Tajima, Y., Taguchi, R., Shimizu T., and Ishii, S. (2009)
Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6.
J. Biol. Chem. 284, 17731-17741
- Murakami, N., Hashidate, T., Harayama, T., Yokomizo, T., Shimizu, T., and Nakamura, M. (2009)
Transcriptional regulation of human G2A in monocytes/macrophages : involvement of c/EBPs, Runx and Pu.1.
Genes Cells 14, 1441-1455
- Matsumoto, T., Inoue, H., Sato, Y., Kita, Y., Nakano, T., Noda, N., Eguchi-Tsuda, M., Moriwaki, A., Kan-O, K., Matsumoto, K., Shimizu, T., Nagasawa, H., Sakuda, S., and Nakanishi, Y. (2009)
Demethylallosamidin, a chitinase inhibitor, suppresses airway inflammation and hyperresponsiveness.
Biochem. Biophys. Res. Commun. 390, 103-108
- Hikiji, H., Ishii, S., Yokomizo, T., Takato, T., and Shimizu, T. (2009)
A distinctive role of the leukotriene B4 receptor BLT1 in osteoclastic activity during bone loss.
Proc. Natl. Acad. Sci. U. S. A. 106, 21294-21299
- Kihara, Y., Matsushita, T., Kita, Y., Uematsu, S., Akira, S., Kira, J.-i., Ishii, S., and Shimizu, T. (2009)
Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis.
Proc. Natl. Acad. Sci. U. S. A. 106, 21807-21812
- Oga, T., Matsuoka, T., Yao, C., Nonomura, K., Kitaoka, S., Sakata, D., Kita, Y., Tanizawa, K., Taguchi, Y., Chin, K., Mishima ,M., Shimizu, T., and Narumiya, S. (2009)
Prostaglandin F2alpha receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-beta.
Nature Med. 12, 1426-1430