Publication

2025

• Komeda K, Toyoshima K, Yasuda D, Ishida H, Kojima K, Osawa M, Hirano T, Ohe T, Tago K, and Funakoshi-Tago M, "KMN003 activates Nrf2 via disruption of the Keap1-Nrf2 interaction and p38-dependent transcriptional regulation"Cellular Signalling 137, 112194 (2025), doi:10.1016/j.cellsig.2025.112194.

• Yasuda D, Toyoshima K, Kojima K, Ishida H, Kaitoh K, Imamura R, Kanamitsu K, Kojima H, Funakoshi-Tago M, Osawa M, Ohe T, and Hirano T, "Development of Keap1-Nrf2 Protein-Protein Interaction Inhibitor Activating Intracellular Nrf2 Based on the Naphthalene-2-acetamide Scaffold, and its Anti-Inflammatory Effects"ChemMedChem 20, e202500474 (2025), doi:10.1002/cmdc.202500474.

2024

• Enomoto S, Nakatsuka S, Kuwayama T, Kawatsu K, Yokogawa M, and Osawa M. “NMR 1H, 13C, 15N backbone resonance assignments of 14-3-3ζ binding region of human FOXO3a (residues 1-284)”Biomolecular NMR Assignments 18, 275-283 (2024), doi:10.1007/s12104-024-10200-7.

• Stillinovic M, Sarangdhar M. A., Andina N, Tardivel A, Greub F, Bombaci G, Ansermet C, Zatti M, Saha D, Xiong J, Sagae T, Yokogawa M, Osawa M, Heller M, Keogh A, Keller I, Angelillo-Scherrer A, and Allam R. “Ribonuclease inhibitor and angiogenin system regulates cell type-specific global translation”Science Advances 10, eadl0320 (2024), doi:10.1126/sciadv.adl0320.

2023

• Shimizu Y, Ohta M, Ishida S, Terayama K, Osawa M, Honma T, and Ikeda K. “AI-driven molecular generation of not-patented pharmaceutical compounds using world open patent data”Journal of Cheminformatics 15, 120 (2023), doi: 10.1186/s13321-023-00791-z.

• Tsuchiya Y, Yonezawa T, Yamamori Y, Inoura H, Osawa M, Ikeda K, and Tomii K. “PoSSuM v.3: A Major Expansion of the PoSSuM Database for Finding Similar Binding Sites of Proteins”Journal of Chemical Information and Modeling 63, 7578-7587 (2023), doi: 10.1021/acs.jcim.3c01405.

• Miura M, Sakaue F, Matsuno H, Morita K, Yoshida A, Hara RI, Nishimura R, Nishida Y, Yokogawa M, Osawa M, and Yokota T. “TDP-43 N-terminal domain dimerisation or spatial separation by RNA binding decreases its propensity to aggregate”FEBS Letters 597, 1667-1676 (2023), doi: 10.1002/1873-3468.14635.

• Shimizu Y, Yonezawa T, Bao Y, Sakamoto J, Yokogawa M, Furuya T, Osawa M, and Ikeda K. “Applying deep learning to iterative screening of medium-sized molecules for protein-protein interaction-targeted drug discovery”Chemical Communications 59, 6722-6725 (2023), doi: 10.1039/d3cc01283b.

• 米澤朋起、池田和由、「化合物ライブラリーの情報検索におけるポイント」、『ケモインフォマティクスにおけるデータ収集の最適化と解析手法　-　組成予測や化学構造の生成、合成経路探索や反応条件最適化、毒性評価』 技術情報協会(2023)第８章 医薬品開発への活用事例　７節

2022

• Ikeda K, Maezawa Y, Yonezawa T, Shimizu Y, Tashiro T, Kanai S, Sugaya N, Masuda Y, Inoue N, Niimi T, Masuya K, Mizuguchi K, Furuya T and Osawa M. “DLiP-PPI library: An integrated chemical database of small-to-medium-sized molecules targeting protein-protein interactions”Frontiers in Chemistry 10, 1090643 (2022), doi: 10.3389/fchem.2022.1090643.

• 清水祐吾、米澤朋起、池田和由、「AI創薬における適切な学習データとは？」、『革新的AI創薬 : 医療ビッグデータ、人工知能がもたらす創薬研究の未来像』 エヌ・ティー・エス(2022)小長谷明彦 監修、第2章　第5節

• Sagae T, Yokogawa M, Sawazaki R, Ishii Y, Hosoda N, Hoshino S, Imai S, Shimada I, and Osawa M. “Paip2A inhibits translation by competitively binding to the RNA recognition motifs of PABPC1 and promoting its dissociation from the poly(A) tail” Journal of Biological Chemistry 298, 101844 (2022), doi: 10.1016/j.jbc.2022.101844.

2021

• Ikeda K, Kezuka Y, Nonaka T, Yonezawa T, Osawa M, and Katoh E. “Comprehensive Approach of 19F Nuclear Magnetic Resonance, Enzymatic, and In Silico Methods for Site-Specific Hit Selection and Validation of Fragment Molecules that Inhibit Methionine γ-Lyase Activity” Journal of Medicinal Chemistry 64, 14299-14310 (2021), doi: 10.1021/acs.jmedchem.1c00766.

• Matsumura K, Yokogawa M, and Osawa M. “Peptide Toxins Targeting KV Channels” Handbook of Experimental Pharmacology. Springer, Berlin, Heidelberg 267, 481-505 (2021), doi: 10.1007/164_2021_500.

• Shimizu Y, Yonezawa T, Sakamoto J, Furuya T, Osawa M, and Ikeda K. "Identification of novel inhibitors of Keap1/Nrf2 by a promising method combining protein-protein interaction-oriented library and machine learning" Scientific Reports 11, 7420 (2021), doi: 10.1038/s41598-021-86616-1.

• Matsumura K, Shimomura T, Kubo Y, Oka T, Kobayashi N, Imai S, Yanase N, Akimoto M, Fukuda M, Yokogawa M, Ikeda K, Kurita J, Nishimura Y, Shimada I, and Osawa M. "Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization" BMC Molecular and Cell Biology 22:3 (2021), doi: 10.1186/s12860-020-00337-3.

2020

• Iwahashi Y, Toyama Y, Imai S, Itoh H, Osawa M, Inoue M, and Shimada I. "Conformational equilibrium shift underlies altered K+ channel gating as revealed by NMR" Nature Communications 11, 5168 (2020), doi: 10.1038/s41467-020-19005-3.

• Kato Y, Kunimasa K, Takahashi M, Harada A, Nagasawa I, Osawa M, Sugimoto Y, and Tomida A. "GZD824 Inhibits GCN2 and Sensitizes Cancer Cells to Amino Acid Starvation Stress" Molecular Pharmacology 98, 669-676 (2020), doi: 10.1124/molpharm.120.000070.

2019

• Kano H, Toyama Y, Imai S, Iwahashi Y, Mase Y, Yokogawa M, Osawa M, and Shimada I. "Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel" Nature Communications 10, 2018 (2019), doi: 10.1038/s41467-019-10038-x.
• Yokogawa M, Fukuda M, and Osawa M. "Nanodiscs for Structural Biology in a Membranous Environment" Chemical and Pharmaceutical Bulletin 67, 321-326 (2019), doi: 10.1248/cpb.c18-00941

2018

• Maruyama T, Imai S, Kusakizako T, Hattori M, Ishitani R, Nureki O, Ito K, Maturana AD, Shimada I, and Osawa M. "Functional roles of Mg²⁺ binding sites in ion-dependent gating of a Mg²⁺ channel, MgtE, revealed by solution NMR" eLife e31596 (2018), doi: 10.7554/eLife.31596 .
• Toyama Y, Kano H, Mase Y, Yokogawa M, Osawa M, and Shimada I. "Structural basis for the ethanol action on G-protein-activated inwardly rectifying potassium channel 1 revealed by NMR spectroscopy." Proc Natl Acad Sci USA 115, 3858-3863 (2018), doi: 10.1073/pnas.1722257115.
• Sawazaki R, Imai S, Yokogawa M, Hosoda N, Hoshino S, Mio M, Mio K, Shimada I, and Osawa M. "Characterization of the multimeric structure of poly(A)-binding protein on a poly(A) tail." Scientific Reports 8, 1455 (2018), doi: 10.1038/s41598-018-19659-6.
• Toyama Y, Mase Y, Kano H, Yokogawa M, Osawa M, and Shimada I. "Nuclear magnetic resonance approaches for characterizing protein-protein interactions", Methods in Molecular Biology 1684, 115-128 (2018), doi: 10.1007/978-1-4939-7362-0_10.
• 岡村康司, 大澤匡範　"脂質ーイオンチャネル相互連関"　実験医学増刊 Vol.36 No.10 脂質クオリティ~生命機能と健康を支える脂質の多様性 (2018)

2017

• Tomita A, Zhang M, Jin F, Zhuang W, Takeda H, Maruyama T, Osawa M, Hashimoto KI, Kawasaki H, Ito K, Dohmae N, Ishitani R, Shimada I, Yan Z, Hattori M, and Nureki O. "ATP-dependent modulation of MgtE in Mg²⁺ homeostasis." Nature Communications 8, 148 (2017), doi: 10.1038/s41467-017-00082-w.
• Toyama Y, Kano H, Mase Y, Yokogawa M, Osawa M, and Shimada I. "Dynamic regulation of GDP binding to G proteins revealed by magnetic field-dependent NMR relaxation analyses."Nature Communications 8, 14523 (2017), doi: 10.1038/ncomms14523.

2016

• Nozaki T, Ozawa SI, Harada H, Kimura T, Osawa M, and Shimada I. "Disulfide mapping the voltage-sensing mechanism of a voltage-dependent potassium channel."Scientific Reports 6, 37303 (2016), doi: 10.1038/srep37303.
• Toyama Y, Osawa M, Yokogawa M, and Shimada I. "NMR Method for Characterizing Microsecond-to-Millisecond Chemical Exchanges Utilizing Differential Multiple-Quantum Relaxation in High Molecular Weight Proteins" Journal of the American Chemical Society 138, 2302-2311 (2016), doi: 10.1021/jacs.5b12954.

2015

• Ozawa S, Kimura T, Nozaki T, Harada H, Shimada I, and Osawa M. "Structural basis for the inhibition of voltage-dependent K⁺ channel by gating modifier toxin" Scientific Reports 18, 14226 (2015), doi: 10.1038/srep14226.
• Marshall C B, Nishikawa T, Osawa M, Stathopulos P B, and Ikura M. "Calmodulin and STIM proteins: Two major calcium sensors in the cytoplasm and endoplasmic reticulum" Biochemical and Biophysical Research Communications 460, 5-21 (2015), doi: 10.1016/j.bbrc.2015.01.106.

Copyright (C) 2017　Keio University　Faculty of Pharmacy　Division of Physics for Life Functions　All Rights Reserved.