国際シンポジウム「アルツハイマー病および関連疾患の分子神経生物学」

開催日：平成14年10月５日（土）−６日（日）
会場：ホテルオオサカサンパレス

International Symposium
"Molecular Neurobiology of Alzheimer Disease and Related Disorders"

October 5 (Saturday) - October 6 (Sunday), 2002 
Orbit Hall,  Osaka Sun Palace Hotel


プログラム===============================================

October 5 (Saturday)

[Session 1]  (9:10-10:20)
Co-chair
Peter St. George-Hyslop (University of Toronto)
Masatoshi Takeda (Osaka University)

Speakers
1) Greg M Cole (University of California)
Methods of regulating Alzheimer pathogenesis: diet, oxidative damage and inflammation. 

2) Taiichi Katayama (Osaka University), 
The RNA-binding protein causes aberrant splicing of Presenilin-2 pre-mRNA in sporadic Alzheimer's disease

3) Masayasu Okochi (Osaka University)）
γ-Cleavage, an unusual intramembranous endoproteolysis 


[Session 2]  (10:30-11:40)
Co-chair
Inge Grundke-Iqbal (NY Institute for Basic Research)
Hirosi Mori (Osaka City University)

Speakers
1) Khalid Iqbal (NY State Institute for Basic Research)
Neurofibrillary degeneration: significance, mechanism and therapeutic targets

2) Tetsuaki Arai (Tokyo Institute of Psychiatry)
Tau pathology of sporadic tauopathies

3) Yoshitaka Tatebayashi (RIKEN)
Deregulation of GSK-3β and JNK/SAPK in a mouse model of tauopathy


[Session 3]  (13:00-14:10)
Co-chair
Konrad Beyreuther (ZMBH, University Heidelberg)
Takeshi Tabira (Longitivity Science Center)

Speakers
1) Peter St. George-Hyslop (University of Toronto)
Biology of the Presenilin-Nicastrin Complex

2) Kojin Kamino（Osaka University）
Clinical assessment of genetic risk function in Alzheimer's disease

3) Hideo Kimura（National Institute of Neuroscience）
Brain hydrogen sulfide is severely decreased in Alzheimer's disease


[Session 4]  (14:10-15:20)
Co-chair
Roger M Nitsch (University of Zurich)
Katsuhio Yanagisawa (Longitivity Science Center）

Speakers
1) Konrad Beyreuther (ZMBH, University Heidelberg)
Regulation of β-amyloid production by cholesterol in Alzheimer's disease

2) Taisuke Tomita (Tokyo University）
Functional analysis of Presenilin complex and γ-secretase activity

3) Masaki Nishimura（Shiga University of Medical Science）
Mutational effects of Presenilin 1 on its endoproteolytic processing and stabilization


[Session 5]  (15:40-16:50)
Co-chair
Harald Hampel (Ludwig-Maximilian University)
Katsuya Urakami (Tottori University)

Speakers
1) Ramon Cacabelos (EuroEspes Biomedical Research Center)
Genomic screening, genetic variation and pharmacogenomics in Alzheimer's disease

2) Syun Shimohama (Kyoto University)
Nicotinic receptor-mediated neuroprotection

3) Takashi Kudo (Osaka University)
The unfolded protein responses are involved in the phathology of Alzheimer disease


October 6 (Sunday)

[Session 6]  (9:00-10:10)
Co-chair
Ramon Cacabelos (EuroEspes Biomedical Research Center)
Nobuo Yanagisawa (Kanto Rosai Hospital)

Speakers
1) Harald Hampel (Ludwig-Maximilian University)
Phosphorylated tau protein - a  biomarker for Alzheimer's disease?

2) Yosuke Wakutani (Tottori Universiyty)
Novel amyloid precursor protein mutation (D678N) in a Japanese familial Alzheimer's disease

3) Akihiko Nunomura (Asahikawa Medical College)
Oxidative stress in Alzheimer disease: the earliest cytological and biochemical feature


[Session 7]  (10:10-11:20)
Co-chair
Greg M Cole
Akihiko Takashima (Riken)

Speakers
1) Inge Grundke-Iqbal (NY State Institute for Basic Research)
Neurogenesis: a promising therapeutic target?

2) Taizo Taniguchi (Kobe University）
Analysys of transgenic mice expressing human tau containing a N279K

3) Takeshi Ishihara (Okayama University)
An animal model of tauopathies: focusing on "treatment"


[Session 8]  (11:30-12:40)
Co-chair
Khalid Iqbal (NY State Institute for Basic Research)
Yasuo Ihara (Tokyo University)

Speakers　
1) Roger M Nitsch (University of Zurich)
Roles of beta-amyloid peptide in Alzheimer's disease, mice and flies

2) Kazunori Imaizumi（Nara Institute of Science and Technology）、
Aberrant splicing of tau transcripts in FTDP-17

3) Tomohiro Miyasaka (Riken)
Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau

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ランチョンセミナー　IV脳血管性痴呆の治療
10月5日（土）(12:00 〜13:00)（オービットホール）
座長　小阪憲司　（横浜市立大学医学部　精神医学）
「脳血管性痴呆の治療戦略」
演者　岡本幸市（群馬大学医学部神経内科）