<Title>Induction of extremely low protein expression level by fusion of C-terminal region of Nef
<Authors>Takamune N, Irisaka Y, Yamamoto M, Harada K, Shoji S, and Misumi S
<Journal> Biotechnol Appl Biochem., (2012), in press
<Title>Fluorescence imaging of potassium ions in living cells using a fluorescent probe based on a thrombin binding aptamer-peptide conjugate.
<Authors>Ohtsuka K, Sato S, Sato Y, Sota K, Ohzawa S, Matsuda T, Takemoto K, Takamune N, Juskowiak B, Nagai T, Takenaka S.
<Journal>Chem. Commun., (2012), in press
<Title>Characterization of the hepatic cellular uptake of α(1) -acid glycoprotein (AGP), part 1: a peptide moiety of human AGP is recognized by the hemoglobin β-chain on mouse liver parenchymal cells.
<Authors>Nishi K, Komori H, Kikuchi M, Uehara N, Fukunaga N, Matsumoto K, Watanabe H, Nakajou K, Misumi S, Suenaga A, Maruyama T, Otagiri M
<Journal>J Pharm Sci., 101 (4), 1599-606. (2012)
<Title>Effect of recipient-derived cells on the progression of familial amyloidotic polyneuropathy after liver transplantation: a retrospective study
<Authors>Ohya Y, Jono H, Nakamura M, Hayashida S, Ueda M, Obayashi K, Misumi S, Asonuma K, Ando Y, Inomata Y.
<Journal> Ann Clin Biochem.,47, 529-534 (2010)
<Title>Suppression of human immunodeficiency virus type-1 production by coexpression of catalytic-region-deleted N-myristoyltransferase mutants
<Authors>Takamune N, Kuroe T, Tanada N, Shoji S, and Misumi S
<Journal> Biological & Pharmaceutical Bulletin, 33 (12) 2018-2023 (2010)
<Title>Treatment of breast cancer cells with proteasome inhibitor lactacystin increases the level of sensitivity to cell death induced by Human immunodeficiency virus type 1
<Authors> Endo M, Gejima S, Endo A, Takamune N, Shoji S, and Misumi S
<Journal> Biological & Pharmaceutical Bulletin, 33 (11) 1903-1906 (2010)
<Title>Uncoating of human immunodeficiency virus type 1 requires prolyl isomerase PIN1.
<Authors>Misumi S, Inoue M, Dochi T, Kishimoto N, Hasegawa N, Takamune N, Shoji S
<Journal>J Biol Chem. 285 (33) 25185-95. (2010)
<Title>Highly sensitive analysis of the interaction between HIV-1 Gag and phosphoinositide derivatives based on surface plasmon resonance.
<Authors>Anraku K, Fukuda R, Takamune N, Misumi S, Okamoto Y, Otsuka M, Fujita M.
<Journal>Biochemistry 49 (25): 5109-15 (2010)
<Title>Targeted delivery of immunogen to primate m cells with tetragalloyl lysine dendrimer.
<Authors>Misumi S, Masuyama M, Takamune N, Nakayama D, Mitsumata R, Matsumoto H, Urata N, Takahashi Y, Muneoka A, Sukamoto T, Fukuzaki K, Shoji S.
<Journal>J Immunol. ;182(10):6061-70. (2009)
<Title>Polypseudorotaxane Formation of Randomly-Pegylated Insulin with Cyclodextrins: Slow Release and Resistance to Enzymatic Degradation
<Authors>Taishi HIGASHI, Fumitoshi HIRAYAMA,* Shogo MISUMI, Keiichi MOTOYAMA, Hidetoshi ARIMA, and Kaneto UEKAMA
<Journal>Chem. Pharm. Bull. 57(5) 541—544 (2009)
<Title>Slow-release system of pegylated lysozyme utilizing formation of polypseudorotaxanes with cyclodextrins
<Authors>Taishi Higashi, Fumitoshi Hirayama, Shogo Yamashita, Shogo Misumi, Hidetoshi Arima, Kaneto Uekama
<Journal>International Journal of Pharmaceutics 374, 26–32 (2009)
<Title>Development of cell-expressed and virion-incorporated CCR5-targeted
vaccine.
<Authors> Misumi S, Eto A, Mitsumata R, Yamada M, Takamune N, Shoji
S.
<Journal>Biochem Biophys Res Commun. 377(2):617-621 (2008)
<Title>Nonhuman primate intestinal villous M-like cells: an effective
poliovirus entry site.
<Authors> Takahashi Y, Misumi S, Muneoka A, Masuyama M, Tokado
H, Fukuzaki K, Takamune N, Shoji S
<Journal>Biochem Biophys Res Commun. 368(3):501-507 (2008)
<Title>HIV-1 production is specifically associated with human NMT1
long form in human NMT isozymes
<Authors> Takamune N, Gota K, Misumi S, Tanaka K, Okinaka S, and
Shoji S.
<Journal>Microbes and Infection, 10(2) 143-150 (2008)
<Title> Design and evaluation of polypseudorotaxanes of pegylated
insulin with cyclodextrins as sustained release system
<Authors> Higashi T, Hirayama F, Misumi S, Arima H, Uekama K.
<Journal> Biomaterials. 28, 3866-3871 (2008)
<Title>Human immunodeficiency virus-induced apoptosis of human breast
cancer cells via CXCR4 is mediated by the viral envelope protein but does not
require CD4.
<Authors> Endo E, Inatsu A., Hashimoto K., Takamune N, Shoji S.
and Misumi S.
<Journal>Curr. HIV Res., 6(1), 34-42 (2008)
<Title>A transgenic rat with the human ATTR V30M: a novel tool for
analyses of ATTR metabolisms
<Authors> Ueda M, Ando Y, Hakamata Y, Nakamura M, Yamashita T,
Obayashi K, Himeno S, Inoue S, Sato Y, Kaneko T, Takamune N, Misumi S, Shoji
S, Uchino M, Kobayashi E.
<Journal>Biochem Biophys Res Commun. 2007 Jan 12;352(2):299-304.
<Title>Immunoreactive cycloimmunogen design based on conformational
epitopes derived from human immunodeficiency virus type 1 coreceptors: cyclic
dodecapeptides mimic undecapeptidyl arches of extracellular loop-2 in chemokine
receptor and inhibit human immunodeficiency virus type 1 infection
<Authors> Shogo Misumi, Nobutoki Takamune, and Shozo Shoji
<Journal>Endocrine, Metabolic & Immune Disorders - Drug Targets 2007
Jun (2); 141-52. Review.
<Title>Analysis of amyloid fibrils in the cheetah (Acinonyx jubatus).
<Authors> Bergstrom J, Ueda M, Une Y, Sun X, Misumi S, Shoji S,
Ando Y.
<Journal>Amyloid. 2006 Jun;13(2):93-8.
<Title>Lipid droplets are present in amyloid deposits in familial
amyloidotic polyneuropathy and dialysis related amyloidosis.
<Authors> Sun X, Ueda M, Yamashita T, Nakamura M, Bergstrom J,
Zeledon Ramirez ME, Okajima M, Misumi S, Shoji S, Motomiya Y, Ando Y.
<Journal>Amyloid. 2006 Mar;13(1):20-3.
<Title>Effects of Immunization with CCR5-Based Cycloimmunogen
on Simian/HIVSF162P3 Challenge.
<Authors> Misumi S, Nakayama D, Kusaba M, Iiboshi T, Mukai R, Tachibana
K, Nakasone T, Umeda M, Shibata H, Endo M, Takamune N, Shoji S.
<Journal>J Immunol. 176, 463-471 (2006)
<Title>Suppression of multiclade R5 and X4 human immunodeficiency
virus type-1 infections by a coreceptor-based anti-HIV strategy.
<Authors> Nakayama D, Misumi S, Mukai R, Tachibana K, Umeda M,
Shibata H, Takamune N, Shoji S.
<Journal>J Biochem. 138, 571-582 (2005)
<Title>Zn2+ binding to cysteine-rich domain of extracellular human
Immunodeficiency virus type-1 Tat protein is associated with Tat protein-induced
apoptosis.
<Authors> Misumi,S., Takamune,N., Ohtsubo,Y., Waniguchi,K., and
Shoji,S.
<Journal>AIDS Res. Hum. Retroviruses. 20, 297-304 (2004)
<Title>Blocking of Human Immunodeficiency Virus Type-1 Virion
Autolysis by Autologous p2gag Peptide
<Authors> Shogo Misumi, Yukimi Morikawa, Mitsunori Tomonaga, Kouichi
Ohkuma, Nobutoki Takamune, and Shozo Shoji
<Journal>Journal of Biochemistry. 135, 447-453 (2004)
<Title>Proteomics of HIV-1 virion
<Authors>Misumi,S., Takamune,N., and Shoji, S.
<Journal>BIOMEDICAL AND PHARMACEUTICAL APPLICATIONS OF PROTEOMICS
(Editor H. Hondermarck) Kluwer Academic Publisher, The Netherland. Chapter 14,
339-366 (2004)
<Title>HIV-1粒子のプロテオーム研究
<Authors> 三隅将吾、高宗暢暁、庄司省三
<Journal>遺伝子医学 in press (2004)
<Title>A novel cyclic peptide immunization strategy for preventing
HIV-1/AIDS infection and progression.
<Authors> Misumi S, Endo M, Mukai R, Tachibana K, Umeda M, Honda
T, Takamune N, Shoji S.
<Journal>J. Biol. Chem. 278,32335-32343 (2003)
<Title>HIV-1感染および病態進行を阻止する新規環状ぺプチドワクチンの開発に向かって -HIV-1コレセプターに対する自己抗体誘導によるHIV-1感染阻害-
<Authors>三隅将吾、高宗暢暁、庄司省三
<Journal>医学のあゆみ 207, 67-72. (2003)
<Title>Three isoforms of cyclophilin A associated with human immunodeficiency
virus type 1 were found by proteomics using two-dimensional gel electrophoresis
and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry
<Authors> Shogo Misumi, Takashi Fuchigami, Nobutoki Takamune, Ichiro
Takahashi, Michiho Takama, and Shozo Shoji
<Journal>J. Virol. 76,10000-10008. (2002)
<Title>Development of enzyme-linked immunosorbent assay for measurement
of activity of myristoyl Coenzyme A: protein N-myristoyltransferase
<Authors> Nobutoki Takamune, Hirotoshi Hamada, Hideki Sugawara,
Shogo Misumi, and Shozo Shoji
<Journal>Anal. Biochem. 309,137-142 (2002)
<Title>Novel strategy for anti-HIV-1 action: selective cytotoxic
effect of N-myristoyltransferase inhibitor on HIV-1-infected cells.
<Authors> Nobutoki Takamune, Hirotoshi Hamada, Shogo Misumi, and
Shozo Shoji
<Journal>FEBS Lett.527,138-142(2002)
<Title>A novel localized amyloidosis associated with lactoferrin
in the cornea.
<Authors> Ando Y, Nakamura M, Kai H, Katsuragi S, Terazaki H, Nozawa
T, Okuda T, Misumi S, Matsunaga N, Hata K, Tajiri T, Shoji S, Yamashita T, Haraoka
K, Obayashi K, Matsumoto K, Ando M, Uchino M.
<Journal>Lab Invest. 82, 757-766 (2002)
<Title>Acid-labile formylation of amino terminal proline of human
immunodeficiency virus type 1 p24gag was found by proteomics using two-dimensional
gel electrophoresis and matrix-assisted laser desorption/ionization-time-of
flight mass spectrometry
<Authors> Takashi Fuchigami, Shogo Misumi, Nobutoki Takamune, Ichiro
Takahashi, Michiho Takama, and Shozo Shoji
<Journal>Biochem. Biophys. Res. Commun. 293, 1107-1113 (2002)
<Title>HIV-1粒子のプロテオーム解析
<Authors>庄司省三、三隅将吾
<Journal>日本臨床60巻4号、636-640 (2002)
<Title>Presence of autoantibody against ATTR Val30Met after sequential
liver transplantation.
<Authors> Ando Y, Terazaki H, Haraoka K, Tajiri T, Nakamura M,
Obayashi K,
Misumi S, Shoji S, Hata K, Nakagawa K, Ishizaki T, Uemoto S, Inomata Y,
Tanaka K, Okabe H.
<Journal>Transplantation, 73, 751-755 (2002).
<Title>Presence of variant transthyretin in aqueous humor of a
patient with familial amyloidotic polyneuropathy after liver transplantation.
<Authors> 6) Haraoka, K., Ando, Y., Ando, E., Sun, X., Nakamura,
M., Terazaki, H., Misumi, S., Tanoue, Y., Tajiri, T., Shoji, S., Ishizaki, T.,
Okabe, H., and Tanihara, H.
<Journal>Amyloid, 9, 247-251 (2002).
<Title>Down-regulation of N-myristoyl transferase expression in
human T-cell line CEM by human immunodeficiency virus type-1 infection.
<Authors>Nobutoki Takamune, Tadahiro Tanaka, Hiroki Takeuchi, Shogo
Misumi, and Shozo Shoji
<Journal>FEBS Letters 506, 81-84, (2001).
<Title>A cyclic dodecapeptide-multiple-antigen-peptide-conjugate
from
undecapeptidyl arch (from Arg168 to Cys178) of extracellular loop2 in
CCR5 as a novel HIV-1 vaccine.
<Authors>Shogo Misumi, Reina Nakajima, Nobuoki Takamune, and Shozo
Shoji,
<Journal>J. Virol. 75, 11614-11620 (2001).
<Title>Variant transthyretin in blood circulation can transverse
the blood-cerebrospinal barrier: qualitative analyses of transthyretin metabolism
in sequential liver transplantaion.
<Authors> Hisayasu Terazaki, Yukio Ando, Masaaki Nakamura, Konen
Obayashi, Shogo Misumi, Shozo Shoji, Sonoka Yamashita, Kazuko Nakagawa, Takashi
Ishizaki, Ole Suhr, Shinji Uemoto, Yukihiro Inomata, and Koichi Tanaka.
<Journal>Transplantation, 72, 296-299 (2001).
<Title>Evidence as a HIV-1 self-defense vaccine of cyclic chimeric
dodecapeptide warped from undecapeptidyl arch of exracellular loop 2 in
both CCR5 and CXCR4.
<Authors>Shogo Misumi, Nobuoki Takamune, Yasuhide Ido, Shinichiro
Hayashi,
Masafumi Endo, Ryouzaburou Mukai, Kuniomi Tachibana, Mamoru Umeda, and
Shozo Shoji
<Journal>Biochem. Biophys. Res. Commun. 285(5), 1309-1316 (2001)
<Title> Myristoylation of Human Immunodeficiency Virus Type 1 gag
Protein Is Required for Efficient env Protein Transportation to the Surface
of Cells.
<Authors> Shiraishi T, Misumi S, Takama M, Takahashi I, and Shoji
S.
<Journal> Biochem. Biophys. Res. Commun. 282, 1201-1205 (2001)
<Title> Cyclic Zinc-Dithiocarbamate-S,S'-Dioxide Blocks CXCR4-mediated
HIV-1 Infection.
<Authors> Nobutoki Takamune, Shogo Misumi, and Shozo Shoji
<Journal> Biochem. Biophys. Res. Commun. 272, 351-356 (2000)
<Title> A novel compound heterozygote (FAP ATTR Arg104His/ATTR
Val30Met) with high serum transthyretin (TTR) and retinol binding protein (RBP)
levels.
<Authors> Terazaki H, Ando Y, Misumi S, Nakamura M, Ando E, Matsunaga
N, Shoji S, Okuyama M, Ideta H, Nakagawa K, Ishizaki T, Ando M, and Saraiva
MJ
<Journal> Biochem Biophys Res Commun, 264(2), 365-70 (1999).
<Title> Blockage of HIV-1 production through inhibition of proviral
DNA synthesis by N,O-didecanoyl serinal dimethylacetal.
<Authors> Nobutoki Takamune, Shogo Misumi, Kazuchika Furuishi,
and Shozo Shoji
<Journal> IUBMB Life, 48, 311-315 (1999)
<Title> 難薬剤耐性抗HIV剤の開発，Developement of anti-HIV-1 drug for drug-resistant
HIV-1.
<Authors> 庄司 省三
<Journal> 最新医学 第53巻2047-2060(1998).
<Title> タンパク質のN-ミリストイル化の生物学的意義 −とくにHIV-1 gagタンパク質のN-ミリストイル化の役割−，Role
of protein N-myristoylation in HIV-1 gag protein.
<Authors> 庄司 省三
<Journal> 生化学，70, 222-226 (1998).
<Title> An allosteric drug, o,o'-bismyristoyl thiamine disulfide
suppresses HIV-1 replication through prevention of nuclear translocation of
both HIV-1 Tat and NF-kB.
<Authors> Shozo Shoji, Kazuchika Furuishi, Akihito Ogata, Kazunobu
Yamataka, Kuniomi Tachibana, Ryozaburo Mukai, Akihiko Uda, Kazunobu Harano,
Shuzo Matsushita, and Shogo Misumi
<Journal> Biochem. Biophys. Res. Commun., 249(3), 745-53 (1998).
<Title> The p2gag peptide, AEAMSQVTNTATIM, produced from HIV-1
Pr55 gag was found to be a suicide inhibitor of HIV-1 protease.
<Authors> Shogo Misumi, Akiko Kudo, Ryuji Azuma, Mitsunori Tomonaga,
Kazuchika Furuishi, and Shozo Shoji
<Journal> Biochem. Biophys. Res. Commun., 241, 275-280 (1997).
<Title> Blockage of N-myristoylation of HIV-1 gag induces the production
of impotent progeny virus.
<Authors> Kazuchika Furuishi, Hidekazu Matsuoka, Michiho Takama,
Ichiro Takahashi, Shogo Misumi, and Shozo Shoji
<Journal> Biochem. Biophys. Res. Commun., 237, 504-511 (1997).
出願番号
発明の名称
特許論文
特願2002-325506
ペプチド及びその利用
J. Biol. Chem. 278,32335-32343 (2003)
特願2002−230699
抗HIV剤、エイズ予防治療剤
特願2002-212406
N-ミリストイルトランスフェラーゼの性能の評価方法及び評価するためのキット
Anal. Biochem. 309,137-142 (2002)
環状ペプチド
WO99JP5973
J. Virol. 75, 11614-11620 (2001)
環状ペプチド
WO99JP6174
Biochem. Biophys. Res. Commun. 285, 1309-1316 (2001)
WO98JP2059
HIV-1プロテアーゼ阻害剤
Biochem. Biophys. Res. Commun. (1997) 241, 275-280
WO96JP3341
チアミンジスルフィド類及びこれを有効成分とする医薬
Biochem. Biophys. Res. Commun. (1998) 249, 745-753.
WO95JP85
抗HIV剤
Biochem. Biophys. Res. Commun.(1994)20, 967-975
WO93JP981
抗HIV剤
Biochem. Biophys. Res. Commun.(1993)194, 610-621
平9-139372
HIV-1プロテアーゼ阻害剤
Biochem. Biophys. Res. Commun. (1997) 241, 275-280
平9-256071
抗NMTモノクローナル抗体、ハイブリドーマ及びNMTを検出する方法
平7-147259
チアミンジスルフィド類
Biochem. Biophys. Res. Commun. (1998) 249, 745-753
平6-173042
抗HIV剤
Biochem. Biophys. Res. Commun.(1994)20, 967-975.
平6-7160
抗HIV剤
Biochem. Biophys. Res. Commun.(1993)194, 610-621
平4-34439
抗HIV剤
IUBMB Life, 48: 1-5 (1999)
平4-201209
抗HIV剤
IUBMB Life, 48: 1-5 (1999)
韓国227095
抗HIV剤
Biochem. Biophys. Res. Commun. (1998) 249, 745-753
米国5886000
ANTI-HIV AGENT
Biochem. Biophys. Res. Commun. (1998) 249, 745-753
特許2725772
ミリストイル化合物である、ウイルス構成蛋白のミリストイル化抑制剤
J. Biochem. (1988) 103, 747-749.
特許2627896
ミリストイル化合物、その調製法及び用途
特許2524505
ミリストイルグリシン部位を識別する抗体
Biochem. Biophys. Res. Commun. (1996)222, 344-351