私の胆汁酸研究の歩み
滝川 一
帝京大学医学部長
内科学主任教授
昭和55年に東京大学第2内科に戻ると共に、研究目的で山川民夫教授の主催する医学部第1生化教室にお世話になりました。当時、助手として胆汁酸のGC-MSの研究をしていた故 別府倫兄先生(前順天堂大学肝胆膵外科客員教授)の研究を引き継いで、GC-MSを用いた胆汁酸グルクロナイドの測定法を確立し、それを臨床応用中心に研究しました。当時の脊山洋右助教授が医学部栄養学教室の教授に就任されたのに伴い、私も栄養学教室に研究の場所を移しました。(注 橙色は主要論文)
- Takikawa H, Otsuka H, Beppu T, Seyama Y, Yamakawa T. Quantitative determination of bile acid glucuronides in serum by mass fragmentography. J. Biochem. 92: 985-998, 1982.
- Takikawa H, Beppu T, Seyama Y, Wada T. Quantitative determination of non-sulfated bile acids in the serum of patients with hepatobiliary diseases by mass fragmentography. Gastroenterol. Jpn. 18: 246-251, 1983.
- Takikawa H, Otsuka H, Beppu T, Seyama Y, Yamakawa T. Serum concentrations of bile acid glucuronides in hepatobiliary diseases. Digestion. 27: 189-195, 1983.
- Murata N, Beppu T, Takikawa H, Otsuka H, Kasama T, Seyama Y. Determination of sulfated and nonsulfated bile acids in serum by mass fragmentography. Steroids. 42: 575-592, 1983.
- Takikawa H, Beppu T, Seyama Y. Urinary concentrations of bile acid glucuronides and sulfates in hepatobiliary diseases. Gastroenterol. Jpn. 19: 104-109, 1984.
- Takikawa H, Beppu T, Seyama Y. Profiles of bile acids and their glucuronide and sulphate conjugates in the serum, urine and bile from patients undergoing bile drainage. Gut. 26: 38-42, 1985.
- Takikawa H, Beppu T, Seyama Y, Obinata K, Nittono H. Serum concentrations of glucuronidated and sulfated bile acids in children with cholestasis. Biochem. Med. 33: 381-386, 1985.
- Takikawa H, Otsuka H, Beppu T, Seyama Y. Determination of 3β-hydroxy-5-cholenoic acid in serum of hepatobiliary diseases - its glucuronidated and sulfated conjugates. Biochem. Med. 33: 393-400, 1985.
その後、昭和59年8月からUCLAに留学が決まり、薬学部製剤学教室(花野 学教授)の杉山雄一助手(その後、薬学系研究科長)のところで、蛋白の生成や蛋白結合の測定法を勉強しました。
- Takikawa H, Seyama Y, Sugiyama Y, Nagase S. Bile acid profiles in analubuminemic rats. J. Biochem. 97: 199-203, 1985.
- Takikawa H, Sugiyama Y, Hanano M, Kurita M, Yoshida H, Sugimoto T. A novel binding site for bile acids on human serum albumin. Biochim. Biophys. Acta. 926: 145-153, 1987.
UCLAのNeil Kaplowitzの研究室では主に、肝サイトゾールの胆汁酸結合蛋白の研究を行いました。昭和61年に帰国後も、しばらく共同研究を続けました。
- Takikawa H, Stolz A, Sugimoto M, Sugiyama Y, Kaplowitz N. Comparison of the affinities of newly identified human bile acid binder and cationic glutathione S-transferase for bile acids. J. Lipid Res. 27: 652-657, 1986.
- Takikawa H, Sugiyama Y, Kaplowitz N. Binding of bile acids by glutathione S-transferases from rat liver. J. Lipid Res. 27: 955-966, 1986.
- Takikawa H, Stolz A, Kaplowitz N. Purification of a 32.5 kDa monomeric sulfotransferase from rat liver with activity for bile acids and phenolic steroids. FEBS Lett. 207: 193-197, 1986.
- Takikawa H, Kaplowitz N. Binding of bile acids, oleic acid, and organic anions by rat and human hepatic Z protein. Arch. Biochem. Biophys. 251: 385-392, 1986.
- Stolz A, Takikawa H, Sugiyama Y, Kuhlenkamp J, Kaplowitz N. 3α-Hydroxysteroid dehydrogenase activity of the Y' bile acid binders in rat liver cytosol. Identification, kinetics, and physiologic significance. J. Clin. Invest. 79: 427-434, 1987.
- Takikawa H, Stolz A, Kaplowitz N. Cyclical oxidation-reduction of the C3 position on bile acids catalyzed by rat hepatic 3α-hydroxysteroid dehydrogenase: I. Studies with purified enzyme, isolated rat hepatocytes, and inhibition by indomethacin. J. Clin. Invest. 80: 852-860, 1987.
- Takikawa H, Ookhtens M, Stolz A, Kaplowitz N. Cyclical oxidation-reduction of the C3 position on bile acids catalyzed by 3α-hydroxysteroid dehydrogenase: II. Studies in the prograde and retrograde single-pass, perfused rat liver and inhibition by indomethacin. J. Clin. Invest. 80: 861-866, 1987.
- Takikawa H, Kaplowitz N. Comparison of the binding sites of GSH S-transferases of the Ya- and Yb-subunit classes: effect of glutathione on the binding of bile acids. J. Lipid Res. 29: 279-286, 1988.
- Takikawa H, Sugiyama Y, Kaplowitz N. Comparison of the effects of bile acids and GSH on the fluorescence of bound 1-anilino-8-naphthalene sulfonate and the enzymatic activity of cationic and neutral human hepatic GSH S-transferases. Biochim. Biophys. Acta. 954: 37-43, 1988.
- Stolz A, Takikawa H, Ookhtens M, Kaplowitz N. The role of cytoplasmic proteins in hepatic bile acid transport. Annu. Rev. Physiol. 51: 161-176, 1989.
- Takikawa H, Stolz A, Sugiyama Y, Yoshida H, Yamanaka M, Kaplowitz N. Relationship between the newly identified bile acid binder and bile acid oxidoreductases in human liver. J. Biol. Chem. 265: 2132-2136, 1990.
- Takikawa H, Stolz A, Kuroki S, Kaplowitz N. Oxidation-reduction of bile acid precursors by rat hepatic 3α-hydroxysteroid dehydrogenase and inhibition by bile acids and indomethacin. Biochim. Biophys. Acta. 1043: 153-156, 1990.
- Takikawa H, Fernandez-Checa JC, Kuhlenkamp J, Stolz A, Ookhtens M, Kaplowitz N. Effect of indomethacin on the uptake, metabolism and excretion of 3-oxo-cholic acid: studies in isolated hepatocytes and perfused rat liver. Biochim. Biophys. Acta. 1084: 247-250, 1991.
- Stolz A, Hammond J, Lou H, Takikawa H, Ronk M, Shively JE. cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family. J. Biol. Chem. 268: 10448-10457, 1993.
- Yamamuro W, Stolz A, Takikawa H, Sugimoto M, Kaplowitz N. Distribution of 3α-hydroxysteroid dehydrogenase (bile acid binder) in rat small intestine: Comparison with glutathione S-transferases subunits. J. Gastroenterol. 29: 115-119, 1994.
- Takikawa H, Sugiyama Y, Fernandez-Checa JC, Kuhlenkamp J, Ookhtens M, Kaplowitz N. Evidence that interference with binding to hepatic cytosol binders can inhibit bile acid excretion in rats. Hepatology. 23: 1642-1649, 1996.
帰国後、昭和62年7月から、山中正己教授の主催される帝京大学医学部第1内科に講師として赴任し、胆汁分泌、胆汁酸の輸送や胆汁うっ滞の仕事を中心に行い、現在に至っています。
- Takikawa H, Sano N, Ohki H, Yamanaka M. Comparison of biliary excretion and metabolism of lithocholic acid and its sulfate and glucuronide conjugates in rats. Biochim. Biophys. Acta. 1004: 147-150, 1989.
- Takikawa H, Sano N, Narita T, Yamanaka M. The ursodeoxycholate dose-dependent formation of ursodeoxycholate-glucuronide in the rat and the choleretic potencies. Hepatology. 11: 743-749, 1990.
- Takikawa H, Ohki H, Sano N, Kasama T, Yamanaka M. Cholestasis induced by lithocholate and its glucuronide: their biliary excretion and metabolism. Biochim. Biophys. Acta. 1081: 39-44, 1991.
- Takikawa H, Tomita J, Takemura T, Yamanaka M. Cytotoxic effect and uptake mechanism by isolated rat hepatocytes of lithocholate and its glucuronide and sulfate. Biochim. Biophys. Acta. 1091: 173-178, 1991.
- Takikawa H, Narita T, Sano N, Yamanaka M. Glucuronidation of bile acids by their high-dose infusion into rats. Hepatology. 13: 1222-1228, 1991.
- Takikawa H, Sano N, Narita T, Uchida Y, Yamanaka M, Horie T, Mikami T, Tagaya O. Biliary excretion of bile acid conjugates in a hyperbilirubinemic mutant Sprague-Dawley rat. Hepatology. 14: 352-360, 1991.
- Takikawa H, Arai S, Yamanaka M. Binding of bile acids, organic anions, and fatty acids by bovine intestinal Z protein. Arch. Biochem. Biophys. 291: 151-155, 1992.
- Takikawa H, Sano N, Minagawa M, Yamanaka M. Effects of ursodeoxycholate, its glucuronide and disulfate and β-muricholate on biliary bicarbonate concentration and biliary lipid excretion. J. Hepatol. 15: 77-84, 1992.
- Takikawa H, Fujiyoshi H, Nishikawa K, Yamanaka M. Purification of 3α-hydroxysteroid and 3β-hydroxysteroid dehydrogenases from human liver cytosol. Hepatology. 16: 365-371, 1992.
- Takikawa H, Arai S, Yamanaka M. Lithocholate binding by Y and Y' proteins in bovine small intestine. Arch. Biochem. Biophys. 298: 486-491, 1992.
- Sano N, Takikawa H, Yamanaka M. Estradiol-17β-glucuronide-induced cholestasis. Effects of ursodeoxycholate-3-O-glucuronide and 3,7-disulfate. J. Hepatol. 17: 241-246, 1993.
- Takikawa H, Sano N, Wako Y, Yamanaka M. Effects of organic anions and bile acids on biliary lipid excretion in hyperbilirubinemic mutant Sprague-Dawley rats. J. Hepatol. 17: 247-252, 1993.
- Takikawa H, Minagawa K, Sano N, Yamanaka M. Lithocholate-3-O-glucuronide-induced cholestasis. A study with congenital hyperbilirubinemic rats and the effects of ursodeoxycholate conjugates. Dig. Dis. Sci. 38: 1543-1548, 1993.
- Takikawa H, Yamanaka M, Miyake K, Kako M, Ohki H, Narita T, Sugata F, Yoshiba M, Sekiyama K, Aoyagi T, Nakajima H, Kamii K, Matsumoto K. Ursodeoxycholic acid therapy for chronic type C hepatitis: a multicenter, dose-finding trial. Curr. Ther. Res. 55: 16-21, 1994.
- Takikawa H, Takemura T, Yamanaka M. The mechanism of tauroursodeoxycholate uptake by isolated rat hepatocytes. Int. Hepatol. Commun. 3: 20-25, 1995.
- Takikawa H, Sano N, Yamazaki R, Takamori Y, Yamanaka M. Inhibition of biliary glutathione excretion by lithocholate-3-O-glucuronide. A possible role in initiating lithocholate-3-O-glucuronide-induced cholestasis. Int. Hepatol. Commun. 3: 48-52, 1995.
- Takikawa H, Sano N, Yamazaki R, Yamanaka M. Colchicine inhibits lithocholate-3-O-glucuronide-induced cholestasis in rats. J. Hepatol. 22: 88-93, 1995.
- Takikawa H, Takemura T, Yamanaka M. Effects of organic anions and bile acids on hepatocellular uptake of lithocholate-3-sulfate. Int. Hepatol. Commun. 3: 267-272, 1995.
- Takikawa H, Uchida Y, Sano N, Yamanaka M. Biliary cefpiramide excretion - its relation to biliary excretion of bile acids and sulfobromophthalein. Pharmacology. 51: 24-32, 1995.
- Takikawa H, Sekiya Y, Yamanaka M, Sugiyama Y. Binding of lithocholate and its glucuronide and sulfate by human serum albumin. Biochim. Biophys. Acta. 1244: 277-282, 1995.
- Takikawa H, Yokote M, Sano N, Nakaki M, Yamanaka M. Intestinal absorption of lithocholate and its sulfate and glucuronide in rats. J. Gastroenterol. Hepatol. 10: 383-386, 1995.
- Takikawa H, Nishikawa K, Sano N, Yamanaka M, Horie T. The mechanisms of biliary excretion of lithocholate-3-sulfate in Eisai hyperbilirubinemic rats (EHBR). Dig. Dis. Sci. 40: 1792-1797, 1995.
- Takikawa H, Takemura T, Fukumura S, Kitaura K, Yamanaka M. Efflux of lithocholate and its sulfate and glucuronide from isolated hepatocytes is normal in EHBR and is not affected by cellular ATP depletion. Int. Hepatol. Commun. 4: 133-138, 1995.
- Takikawa H, Wako Y, Sano N, Yamanaka M. Changes in biliary excretory mechanisms in the bile duct-ligated rat. Dig. Dis. Sci. 41: 256-262, 1996.
- Takikawa H, Sano N, Kitaura K, Fukumura S, Aiso M, Yamanaka M. Effect of lithocholate-3-sulfate and its amides on biliary excretion of glutathione and phospholipid. Int. Hepatol. Commun. 4: 255-262, 1996.
- Takikawa H, Yamazaki R, Sano N, Yamanaka M. Biliary excretion of estradiol 17β-glucuronide in the rat. Hepatology. 23: 607-613, 1996.
- Takikawa H, Sano N, Yamanaka M. Effects of ursodeoxycholate and its conjugates on biliary glutathione excretion in rats. Dig. Dis. Sci. 41: 1953-1958, 1996.
- Takikawa H, Sano N, Aiso M, Takamori Y, Yamanaka M. Effect of tauro-α-muricholate and tauro-β-muricholate on estradiol-17β-glucuronide-induced cholestasis in rats. J. Gastroenterol. Hepatol. 12: 84-86, 1997.
- Takikawa H, Sano N, Sato A, Yamanaka M. Effect of sulfobromophthalein on biliary excretion of taurocholate and pravastatin in bile duct-ligated rat. Int. Hepatol. Commun. 6: 339-344, 1997.
- Takikawa H, Sano N, Uegaki S, Yamanaka M. Effects of bile acid conjugates on biliary excretion of estradiol-17β-glucuronide in the rat. Hepatol. Res. 7: 28-34, 1997.
- Takikawa H, Sano N, Sato A, Yamanaka M. Effect of taurolithocholate-3-sulfate on biliary excretion of sulfobromophthalein and dibromosulfophthalein in Eisai hyperbilirubinemic rat (EHBR). J. Gastroenterol. Hepatol. 12: 528-531, 1997.
- Kitaura K, Takikawa H, Yamanaka M. Effects of organic anions and bile acid conjugates on biliary excretion of LTC4 in the rat. Prostaglandins. 54: 745-755, 1997.
- Takikawa H, Yokote M, Sano N, Kuyama Y, Yamanaka M. Absorption of unconjugated bile acids and tauroursodeoxycholate in the rat intestine. J. Gastroenterol. Hepatol. 12: 815-821, 1997.
- Fukumura S, Takikawa H, Yamanaka M. Effects of organic anions and bile acid conjugates on biliary excretion of pravastatin in the rat. Pharmaceut. Res. 15: 72-76, 1998.
- Takikawa H, Sano N, Ogasawara T, Yamanaka M. Enhanced biliary excretion of lithocholate-3-sulfate by ursodeoxycholate-3,7-disulfate in Eisai hyperbilirubinemic rat (EHBR). Dig. Dis. Sci. 43: 188-192, 1998.
- Takikawa H, Takamori Y, Sano N, Kuyama Y, Yamanaka M. Changes in biliary excretory mechanisms in rats with ethinylestradiol-induced cholestasis. J. Gastroenterol. Hepatol. 13: 186-191, 1998.
- Takikawa H, Sano N, Suzuki C, Takada Y, Yamanaka M. Effect of organic anions and taurolithocholate-3-sulfate on biliary excretion of temocapril in the rat. Hepatol. Res. 15: 157-162, 1999.
- Uegaki S, Takikawa H, Yamanaka M. Effect of organic anions and bile acid conjugates on biliary excretion of taurine-conjugated bile acid sulfates in the rat. Steroids. 64: 790-795, 1999.
- Aiso M, Takikawa H, Yamanaka M. Biliary excretion of bile acids and organic anions in zone 1- and zone 3-injured rats. Liver. 20: 38-44, 2000.
- Hirohashi T, Suzuki S, Takikawa H, Sugiyama Y. ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (mrp3). J. Biol. Chem. 275: 2905-2910, 2000.
- Akita H, Suzuki H, Ito K, Kinoshita S, Sato N, Takikawa H, Sugiyama Y. Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump. Biochim. Biophys. Acta. 1511: 7-16, 2001.
- Takikawa H, Sano N, Takada Y, Toda A, Tanaka H, Takamori Y. Effect of bile acids on biliary excretion of cyclosporin A in the rat. Hepatol. Res. 20: 128-132, 2001.
- Akimoto K, Sano N, Takikawa H. Biliary excretion of tauroursodeoxycholate-3-sulfate in the rat. Steroids. 66: 701-705, 2001.
- Takikawa H, Ogasawara T, Sato A, Ohashi M, Hasegawa Y, Hojo M. Effect of colestimide on intestinal absorption of ursodeoxycholic acid in men. Int. J. Clin. Pharmacol. Ther. 39: 558-560, 2001.
- Akita H, Suzuki H, Hirohashi T, Takikawa H, Sugiyama Y. Transport activity of human MRP3 expressed in Sf9 cells: comparative studies with rat MRP3. Pharmaceut. Res. 19: 34-41, 2002.
- Onishi T, Sano N, Takikawa H. Effect of colestimide on absorption of unconjugated bile acids in the rat jejunum. J. Gastroenterol. Hepatol. 17: 697-701, 2002.
- Ohashi M, Sano N, Takikawa H. Effects of phalloidin on biliary excretion of cholephilic compounds in rats. Pharmacology. 66: 31-35, 2002.
- Hasegawa Y, Takikawa H. Effect of ursodeoxycholate-3,7-disulfate on biliary excretion of lithocholate-3-O-glucuronide in Eisai hyperbilirubinemic rat (EHBR). Hepatol. Res. 22: 296-300, 2002.
- Takikawa H, Sano N, Onishi T, Toda A, Tanaka H, Hojo M, Marumo T, Hanawa N, Tachizawa H, Nishikawa K. Biliary excretion of taurolithocholate-sulfate and temocaprilat in cholestatic rats induced by bile duct-ligation and ethinylestradiol. Hepatol. Res. 24: 136-140, 2002.
- Takikawa H. Hepatobiliary transport of bile acids and organic anions. J. Hep-Bil-Panc. Surg. 9: 443-447, 2002.
- Suzuki C, Sano N, Takikawa H. Effect of dexamethasone on biliary excretion of bile acids and organic anions in rats. Hepatol. Res. 25: 48-54, 2003.
- Takeuchi A, Sano N, Takikawa H. Inhibition of ileal bile acid absorption by colestimide. J. Gastroenterol. Hepatol. 18: 548-553, 2003.
- Hojo M, Sano N, Takikawa H. Effects of lipopolysaccharide on the biliary excretion of bile acids and organic anions in rats. J. Gastroenterol. Hepatol. 18: 815-821, 2003.
- Takada Y, Sano N, Takikawa H. Urinary excretion of bile acids in bile duct-ligated rats. J. Gastroenterol. 38: 561-566, 2003.
- Takada Y, Tachizawa Y, Kurihara H, Takayanagi M, Sasamoto T, Akashi M, Aiso M, Takamori Y, Sano N, Takikawa H. Comparison of urinary excretion of pravastatin and temocapril in bile duct ligated rats and Eisai hyperbilirubinemic rats (EHBR). J. Hep-Bil-Panc. Surg. 11: 125-128, 2004.
- Tachizawa H, Sano N, Takikawa H. Effects of colchicine on the maximum biliary excretion of cholephilic compounds in rats. J. Gastroenterol. Hepatol. 19: 1016-1022, 2004.
- Marumo T, Fukusato T, Takikawa H. Biliary excretion of bile acids and organic anions in rats with dichloroethylene-induced bile canalicular injury. J. Gastroenterol. 39: 981-987, 2004.
- Kurihara H, Sano N, Takikawa H. Biliary excretion of taurocholate, organic anions and vinblastine in rats with α-naphthylisothiocyanate-induced cholestasis. J. Gastroenterol. Hepatol. 20: 1069-1074, 2005.
- Sasamoto T, Sano N, Takikawa H. Biliary excretion of sulfated bile acids and organic anions in zone 1- and zone 3-injured rats. J. Gastroenterol. Hepatol. 21: 26-31, 2006.
- Akashi M, Tanaka A, Takikawa H. Effect of cyclosporin A on the biliary excretion of cholephilic compounds in rats. Hepatol. Res. 34: 193-198, 2006.
- Nagasaka H, Chiba H, Hui SP, Takikawa H, Miida T, Takayanagi M, Yorifuji T, Hasegawa M, Ota A, Hirano K, Kikuchi H, Tsukahara H, Kobayashi K. Depletion of high-density lipoprotein and appearance of triglyceride-rich low-density lipoprotein in a Japanese patient with FIC1 deficiency manifesting benign recurrent intrahepatic cholestasis. J. Pediatr. Gastroenterol. Nutr. 45: 96-105, 2007.
- Mikami M, Takikawa H. Effect of genipin on the biliary excretion of cholephilic compounds in rats. Hepatol. Res. 38: 614-621, 2008.
- Morisawa Y, Takikawa H. Effect of bile acids on the biliary excretion of pravastatin in rats. Hepatol. Res. 39: 595-600, 2009.
- Negoro S, Tanaka A, Takikawa H. Urinary bile acid sulfate levels in patients with hepatitis C virus-related chronic liver diseases. Hepatol. Res. 39: 760-765, 2009.
- Nagasaka H, Yorifuji T, Kobayashi K, Takikawa H, Komatsu H, Inui A, Fujisawa T, Miida T, Tsukahara H, Takatani T, Hayashi H. Favorable effect of 4-phenylacetate on liver functions attributable to enhanced bile salt export pump expression in ornithine transcarbamylase-deficient children. Mol. Gen. Metab. 100: 123-128, 2010.
- Goto H, Takikawa H. Effect of genipin on cholestasis induced by estradiol-17β-glucuronide and lithocholate-3-O-glcuornide in rats. Hepatol. Res. 40: 524-529, 2010.
- Miura R, Tanaka A, Takikawa H. Urinary bile acid sulfate levels in patients with primary biliary cirrhosis. Hepatol. Res. 41: 358-363, 2011.
- Fukami M, Tanaka A, Takikawa H. Effect of penicillin G on the biliary excretion of cholephilic compounds in rats. J. Hepatobiliary Pancreat. Sci. 18: 684-688, 2011.
- Hayashi H, Mizuno T, Horikawa R, Nagasaka H, Yabuki T, Takikawa H, Sugiyama Y. 4-Phenylbutyrate modulates ubiquitination of hepatocanalicular MRP2 and reduces serum total bilirubin concentration. J. Hepatol. 56: 1136-1144, 2012.
- Mizuochi T, Kimura A, Tanaka A, Muto A, Nittono H, Seki Y, Takahashi T, Kurosawa T, Kage M, Takikawa H, Matsuishi T. Characterization of urinary bile acids in a pediatric BRIC-1 patient: Effect of rifampicin treatment. Clin. Chim. Acta. 413: 1301-1304, 2012.
- Honda A, Ikegami T, Nakamuta M, Miyazaki T, Iwamoto J, Hirayama T, Saito Y, Takikawa H, Imawari M, Matsuzaki Y. Anticholestatic effects of bezafibrate in patients with primary biliary cirrhosis treated with ursodeoxycholic acid. Hepatology. 57: 1931-1941, 2013.
- Hayashi H, Nao S, Inoue T, Tanikawa K, Igarashi K, Nagasaka H, Kage M, Takikawa H, Sugiyama Y, Inui A, Kusuhara H. Improved liver function and relieved pruritus after 4-phenylbutyrate therapy in a patient with progressive familial intrahepatic cholestasis type 2. J. Pediatr. 164: 1219-1227, 2014.
- Kagawa T, Hirose S, Arase Y, Anzai K, Tsuruya K, Shiraishi K, Orii R, Ieda S, Nakazawa T, Tomita K, Hokari R, Miura S, Ebinuma H, Saito H, Kitamura T, Horie Y, Okuse C, Wasada M, Inoko H, Tokin M, Saito Y, Maekawa K, Takikawa H, Mine T. No contribution of the ABCB11 p.444A polymorphism in Japanese patients with drug-induced cholestasis. Drug. Metab. Dispos. 43: 691-697, 2015.