Curriculum Vitae
June
1, 2006
Name: Tadafumi
Kato (42 years
old, male)
Degrees: M.D.
and Ph.D.
Position: Director,
Aging and Psychiatric Research Group
Head,
Laboratory for Molecular Dynamics of Mental Disorders
RIKEN
Brain Science Institute
Address: Laboratory
for Molecular Dynamics of Mental Disorders
Brain Science
Institute
RIKEN
(The Institute of Physical and Chemical Research)
Hirosawa 2-1,
Wako, Saitama, 351-0198, Japan
Web Site: http://www.brain.riken.go.jp/labs/mdmd/
Place of Birth: Tokyo, Japan.
Education:
March 1995, get Ph.D. degree at the Shiga University of Medical Science
March 1988,
graduated from Faculty of Medicine, University of Tokyo, with the degree of
Medical Doctor.
Research Area: Neurobiology
of bipolar disorder (Molecular Biology, Neuroimaing, Psychopharmacology)
Research Experiences:
August 2004 – Present Director,
Aging and Psychiatric Research Group
RIKEN
Brain Science Institute
September 2000 – Present Head,
Laboratory for Molecular Dynamics of Mental Disorders
RIKEN
Brain Science Institute
July 1999 – December 2000 Lecturer (Assistant Professor)
Department
of Neuropsychiatry
Faculty of Medicine, University of Tokyo
July 1997 - July 1999 Assistant
(Research Associate)
Department
of Neuropsychiatry
Faculty of Medicine, University of Tokyo
June 1989 - July 1997 Assistant
(Research Associate)
Department of Psychiatry,
Shiga Univ. of
Medical Science
April 1995 - February 1996 International
Visiting Fellow
Department of Psychiatry
University
of Iowa College of Medicine
(The laboratory of Dr. Raymond R. Crowe)
June 1988 - May 1989 Resident
Department of Neuropsychiatry
University
of Tokyo Hospital
Part-time
Lecturer
April 2001 –
Current Department
of Neuropsychiatry
University of Tokyo, Faculty of Medicine
Honors and Awards:
2000 NARSAD Independent Investigator’s Award
1998 CINP Rafaelson Fellowship Award
1995 Stanley
Foundation Research Award
1995 Academic
Prize of Japanese Society of Biological Psychiatry
Membership: Collegium
Internationale Neuro-Psychopharmacologium (CINP) (Councilor)
Society of Biological Psychiatry
International Society of Bipolar Disorder
(Councilor)
Japanese
Society of Biological Psychiatry (Councilor)
Japanese Society of Neurology and
Psychiatry
Japanese Society of Human Genetics
Japanese Society of Neurochemistry
Japanese
Society of Neuropsychopharmacology
Japanese
Society of Mood Disorders (Councilor)
Editorial Board Member of “Journal of
Affective Disorder”
Editorial Board
Member of “Bipolar Disorders”
Publication
List
Refereed
Original Articles
1.
Kasahara T,
Kubota M, Miyauchi T, Noda Y,
Mouri A, Nabeshima T, Kato T(2006) Mice with neuron-specific accumulation of
mitochondrial DNA mutations show mood disorder-like phenotypes. Molecular Psychiatry
11:577-593
2.
Masui T,
Hashimoto R, Kusumi I, Suzuki k, Tanaka T, Nakagawa S, Suzuki T,
Iwata N, Ozaki N, Kato T, Kunugi H, Koyama T(2006) Lithium response and
Val66Met polymorphism of the brain-derived neurotrophic factor gene in Japanese
patients with bipolar disorder. Psychiatric Genetics 16:2:49-50
3.
Okada T,
Hashimoto R, Numakawa T, Kosuga A, Tatsumi M, Kamijima K, Kato T, Kunugi H (in
press) A complex polymorphic region in the brain-derived neurotrophic factor
(BDNF) gene confers susceptibility to bipolar disorder and affects
transcriptional activity. Molecular Psychiatry.
4.
Iwamoto K,
Bundo M, Yamada K, Takao H, Iwayama Y, Yoshikawa T, Kato T, (in press) A
family-based and case-control association study of SOX10 in schizophrenia.
American Journal of Medical Genetics (Neuropsychiatric Genetics)
5.
Washizuka S,
Kametani M, Sasaki T, Tochigi M, Umekage T, Kohda K, Kato T (2006) Association of mitochondrial
complex I subunit gene NDUFV2 at 18p11 with schizophrenia in the Japanese
population. American Journal of Medical Genetics (Neuropsychiatric Genetics)
141:301-304
6.
Kakiuchi C,
Ishiwata M, Hayashi A, Kato T(2006) XBP1 induces WFS1 through an endoplasmic
reticulum stress response element-like motif in SH-SY5Y cells. Journal of
Neurochemistry 97:2:545-555
7.
Horiuchi Y,
Arai M, Niizato K, Iritani S, Noguchi E, Ohtsuki T, Koga M, Kato T, Itokawa M,
Arinami T (2006) A polymorphism in the PDLIM5 gene associated with gene
expression and schizophrenia. Biological Psychiatry 59:1-6
8.
Kazuno A, Munakata
K, Mori K, Tanaka M, Nanko S, Kunugi H, Umekage T, Tochigi M, Kohda K, Sasaki
T, Akiyama T, Washizuka S, Kato N, Kato T (2005) Mitochondrial DNA
sequence analysis of patients with “atypical psychosis”. Psychiatry and
Clinical Neurosciences 59:497-503
9.
Aoki-Suzuki
M, Yamada K, Meerabux J, Iwayama-Shigeno Y, Ohba H, Iwamoto K, Takao H, Toyota
T, Suto Y, Nakatani N, Dean B, Nishimura S, Seki K, Kato T, Itohara S,
Nishikawa T, Yoshikawa T (2005) A family-based association study and gene
expression analyses of netrin-G1 and -G2 genes in schizophrenia. Biol
Psychiatry. 57: 382-393.
10.
Kusumi I,
Masui T, Kakiuchi C, Suzuki K, Akimoto T, Hashimoto R, Kunugi H, Kato T, Koyama
T (2005) Rlationship between XBP1 genotype and personality traits assessed by
TCI and NEO-FFI. Neuroscience Letters 391:7-10
11.
Munakata K,
Bundo M, Kato T, Ono H, Sakura N, Oosaki M, Waki C, Tanaka M (2005) Co-existing
point mutations of mitochondrial DNA in a patient with a heart abnormality and
pearson syndrome-like symptoms. American Journal of Medical Genetics 139A:
162-164
12.
Kato C,
Kakiuchi C, Umekage T, Tochigi M, Kato N, Kato T, Sasaki T (2005) XBP1 gene
polymorphism (-116C/G) and personality. American Journal of Medical Genetics,
Part B 136B:103-105
13.
Zhang X,
Tochigi M, Ohashi J, Maeda K, Kato T, Okazaki Y, Kato N, Tokunaga K, Sawa A,
Sasaki T (2005) Association study of the DISC1/TRAX locus with schizophrenia in
a Japanese population. Schizophrenia Research 79:175-180
14.
Kohda K,
Jinde S, Iwamoto K, Bundo M, Kato N, Kato T (2005) Maternal separation stress
drastically decreases expression of transthyretin in the brains of adult rat
offspring. International Journal of Neuropsychopharmacology 9:1-8
15.
Kakiuchi C,
Ishiwata M, Kametani M, Nelson C, Iwamoto K, Kato T (2005) Quantitative analysis
of mitochondrial DNA deletions in the brains of patients with bipolar disorder
and schizophrenia. International Journal of Neuropsychopharmacology 8:515-522
16.
Kato T,
Iwayama Y, Kakiuchi C, Iwamoto K, Yamada K, Minabe Y, Nakamura K, Mori N, Fujii
K, Yoshikawa T, Nanko S (2005) Gene expression and association of LIM (PDLIM5)
in bipolar disorder and schizophrenia. Molecular Psychiatry 10:1045-1055
17.
Kakiuchi C,
Kato T (2005) Lithium response and -116C/G polymorphism of XBP1 in Japanese
patients with bipolar disrder. International Journal of Neuropsychopharmacology
8:631-632
18.
Iwamoto K,
Bundo M, Kato T (2005) Estimating RNA editing efficiency of five editing sites
in the serotonin 2C receptor by pyrosequencing. RNA 11:10:1596-1603
19.
Kakiuchi C,
Ishiwata M, Nanko S, Kunugi H, Minabe Y, Nakamura K, Mori N, Fujii K, Umekage
T, Tochigi M, Kohda K, Sasaki T, Yamada K, Yoshikawa T, Kato T (2005)
Functional polymorphisms of HSPA5:Possible association with bipolar disorder.
Biochemical and Biophysical Research Communications 336:1136-1143
20.
Iwamoto K,
Nakatani N, Bundo M, Yoshikawa T, Kato T (2005) Altered RNA editing of
serotonin 2C receptor in a rat model of depression. Neuroscience Research
53:69-76
21.
Iwamoto K,
Bundo M, Yamada K, Takao H, Iwayama-Shigeno Y, Yoshikawa T, Kato T (2005) DNA
Methylation Status of SOX10 Correlates with Its Downregulation and
Oligodendrocyte Dysfunction in Schizophrenia. The Journal of Neuroscience
25:22:5376-5381
22.
Matsuo K,
Onodera Y, Hamamoto T, Muraki K, Kato N, Kato T (2005) Hypofrontality and
microvascular dysregulation in remitted late-onset depression assessed by
functional near-infrared spectroscopy. NeuroImage 26:1:234-242
23.
Hashimoto R,
Okada T, Kato T, Kosuge A, Tatsumi M, Kamijima K, Kunugi H (2005) The
breakpoint cluster region gene on chromosome 22q11 is associated with bipolar
disorder. Biological Psychiatry 57:1097-1102
24.
Munakata K,
Iwamoto K, Bundo M, Kato T (2005) Mitochondrial DNA 3243A>G mutation and
increased expression of LARS2 gene in the brains of patients with bipolar
disorder and schizophrenia. Biological Psychiatry 57:525-532
25.
Iwamoto K,
Bundo M, Kato T (2005) Altered expression of mitochondria-related genes in
postmortem brains of patients with bipolar disorder or schizophrenia, as revealed
by large-scale DNA microarray analysis. Human Molecular Genetics 14:2:241-253
26.
Washizuka S,
Kakiuchi C, Mori K, Tajima O, Akiyama T, Kato T (2005) Expression of
mitochondria-related genes in lymphoblastoid cells from patients with bopolar
disorder. Bipolar Disorder 7:146-152
27.
Munakata K,
Tanaka M, Mori K, Washizuka S, Yoneda M, Tajima O, Akiyama T, Nanko S, Kunugi
H, Tadokoro K, Ozaki N, Inada T, Sakamoto K, Fukunaga T, Iijima Y, Iwata N,
Tatsumi M, Yamada K, Yoshikawa T, Kato T (2004) Mitochondrial DNA 3644T→C mutation associated with bipolar disorder. Genomics 84: 1041-1050
28.
Ohtani T,
Matsuo K, Kasai K, Kato T, Kato N. Hemodynamic response to emotional memory
recall with eye movement. Neuroscience Letters 2005 May 20-27;380(1-2):75-79
29.
Ohtani T,
Iwanami A, Kasai K, Yamasue H, Kato T, Sasaki T, Kato N (2004) Post-traumatic
stress disorder symptoms in victims of Tokyo subway attack: a 5-year follow-up
study. Psychiatry and Clinical Neurosciences 58: 624-629
30.
Hamakawa H,
Murashita J, Yamada N, Inubushi T, Kato N, Kato T (2004) Reduced intracellular
pH in the basal ganglia and whole brain measured by phosphorus-31 magnetic
resonance spectroscopy in bipolar disorder. Psychiatry & Clinical
Neurosciences 58: 82-88
31.
Kusumi I,
Masui T, Kakiuchi C, Suzuki K, Akimoto T, Hashimoto R, Kunugi H, Kato T, Koyama
T (2004) Lack of association between XBP1 genotype and calcium signaling in the
platelets of healthy subjects. Neurosci Letters. 369: 1-3
32.
Kunugi H,
Iijima Y, Tatsumi M, Yoshida M, Hashimoto R, Kato T, Sakamoto K, Fukunaga T,
Inada T, Suzuki T, Iwata N, Ozaki N, Yamada K, Yoshikawa T (2004) No
association between the Val66Met polymorphism of the brain-derived neurotrophic
factor gene and bipolar disorder in a Japanese population: a multicenter study.
Biol Psychiatry 56: 376-8
33.
Matsuo K,
Watanabe A, Onodera Y, Kato N, Kato T (2004) Prefrontal hemodynamic response to
verbal-fluency task and hyperventilation in bipolar disorder measured by
multi-channel near-infrared spectroscopy. Journal of Affective Disorders 82:85-92
34.
Washizuka S,
Iwamoto K, Kazuno A, Kakiuchi C, Mori K, Kametani M, Yamada K, Kunugi K, Tajima
O, Akiyama T, Nanko S, Yoshikawa T, Kato T (2004) Association of mitochondrial
complex I subunit gene NDUFV2 at 18p11 with bipolar disorder in Japanese and
the national institute of mental health pedigrees. Biological Psychiatry
56:483-489
35.
Watanabe A,
Kato T (2004) Cerebrovascular response to congnitive tasks in patients with
schizophrenia measured by near-infrared spectroscopy. Schizophrenia Bulletin
30:2:435-444
36.
Ide M,
Muratake T, Yamada K, Iwayama-Shigeno Y, Iwamoato K, Takao H, Toyota T, Kaneko
N, Minabe Y, Nakamura K, Kato T, Mori N, Asada T, Someya T, Yoshikawa T (2004)
Genetic and Expression Analyses of FZD3 in Schizophrenia. Biological Psychiatry
56:6:462-465
37.
Kakiuchi C,
Ishiwata M, Umekage T, Tochigi M, Kohda K, Sasaki T, Kato T (2004) Association
of the XBP1-116C/G polymorphism with schizophrenia in the Japanese population.
Psychiatry and Clinical Neurosciences 58:438-440
38.
Iwamoto K,
Bundo M, Yamamoto M, Ozawa H, Saito T, Kato T (2004) Decreased expression of
NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. Neuroscience
Research 49: 379-385
39.
Watanabe A,
Shibata I, Kato T (2004) Differences of satisfaction with medication between
patients with schizophrenia treated with typical antipsychotics and atypical
antipsychotics. Psychiatry and Clinical Neurosciences 58: 268-273
40.
Iwamoto K,
Bundo M, Washizuka S, Kakiuchi C, Kato T (2004) Expression of HSPF1 and LIM in
the lymphoblastoid cells derived from patients with bipolar disorder and
schizophrenia. Journal of Human Genetics 49:227-231
41.
Iwamoto K,
Kakiuchi C, Bundo M, Ikeda K, Kato T (2004) Molecular characterization of
bipolar disorder by comparing gene expression profiles of postmortem brains of
major mental disorders. Molecular Psychiatry 9:406-416
42.
Mori T,
Sasaki T, Iwanami A, Araki T, Mizuno K, Kato T, Kato N (2003) Smoking habits in
Japanese patients with schizophrenia. Psychiatry Research 120; 207-9.
43.
Yamasue H,
Fukui T, Fukuda R, Kasai K, Iwanami A, Kato N, Kato T (2003) Drug-induced
parkinsonism in relation to choline-containing compounds measured by
1H-MR-spectroscopy in putamen of chronically medicated schizophrenia patients.
International Journal of Neuropsychopharmacology 6; 353-360
44.
Kato T,
Ishiwata M, Mori K, Washizuka S, Tajima O, Akiyama T, Kato N (2003) Mechanisms
of altered Ca2+ signalling in transformed lymphoblastoid cells from patients
with bipolar disorder. International Journal of Neuropsychopharmacology
6:379-389
45.
Iwamoto K,
Kato T (2003) RNA editing of serotonin 2C receptor in human postmortem brains
of major mental disorders. Neuroscience Letters 346:169-172
46.
Washizuka S,
Ikeda A, Kato N, Kato T (2003) Possible relationship between mitochondrial DNA
polymorphisms and lithium response in bipolar disorder. International Journal of
Neuropsychopharmacology 6:421-424
47.
Kakiuchi C,
Iwamoto K, Ishiwata M, Bundo M, Kasahara T, Kusumi I, Tsujita T, Okazaki Y,
Nanko S, Kunugi H, Sasaki T, Kato T (2003) Impaired feedback regulation of XBP1
as a genetic risk factor for bipolar disorder. Nature Genetics 35:2:171-175
48.
Matsuo K,
Taneichi K, Matsumoto A, Ohtani T, Yamasue H, Sakano Y, Sasaki T, Sadamatsu M,
Kasai K, Iwanami A, Asukai N, Kato N, Kato T (2003) Hypoactivation of the
prefrontal cortex during verbal fluency test in PTSD: a near-infrared
spectroscopy study. Psychiatry Research Neuroimaging 124:1-10
49.
Kasahara T,
Kato T (2003) A new redox-cofactor vitamin for mammals. Nature 422:832
50.
Washizuka S,
Kakiuchi C, Mori K, Kunugi H, Tajima O, Akiyama T, Nanko S, Kato T (2003)
Association of decreased expressed and promotor polymor-phisms of mitochondrial
complex Ⅰ subunit gene NDUFV2 with bipolar
disorder. American Journal of Medical Genetics Part B (Neuropsychiatric
Genetics) 120B:72-78
51.
Kato T,
Iwamoto K, Washizuka S, Mori K, Tajima O, Akiyama T, Nanko S, Kunugi H, Kato N
(2003) No association of mutations and mRNA expression of WFS1/wolframin with
bipolar disorder. Neuroscience Letters 338:21-24
52.
Watanabe A,
Matsuo K, Kato N, Kato T (2003) The cerebral blood volume in healthy adult
during cognitive task and hyperventilation measured by Near-infrared
spectroscopy. Journal of Neuropsychiatry and Clinical Neurosciences 15:442-449
53.
Matsuo K,
Kato T, Taneichi K, Matsumoto A, Ohtani T, Hamamoto T, Yamasue H, Sakano Y,
Sasaki T, Sadamatsu M, Iwanami A, Asukai N, Kato N (2003) Activation of the
prefrontal cortex to trauma-related stimuli measured by near-infrared
spectroscopy in posttraumatic stress disorder due to terrorism.
Psychophysiology 40:492-500
54.
Tochigi M,
Umekage T, Otani T, Kato T, Iwanami A, Asukai N, Sasaki T, Kato N (2003) Serum Cholesterol, Uric Acid and
Cholinesterase in Victims of the Tokyo Subway Sarin Poisoning；a relation with post-traumatic stress disorder. Neuroscience Research
44:267-272
55.
Iwamoto K,
Kato T (2002) Effect of cocaine and reserpine administration on RNA editing of
rat 5-HT2C receptor estimated by primer extension combined with denaturing
high-performance liquid chromatography. The Pharmacogenomics Journal 2:335-340
56.
Yamasue H,
Fukui T, Fukuda R, Yamada H, Yamasaki S, Kuroki N, Abe O, kasai K, Tsujii K,
Iwanami A, Aoki S, Ohtomo K, Kato N, Kato T (2002) 1H-MR spectroscopy and gray
matter volume of the anterior cingulate cortex in schizophrenia. Neuro
report 13:2133-2137
57.
Matsuo K,
Kato N, Kato T (2002) Decreased cerebral haemodynamic response to cognitive and
physiological tasks in mood disorders as shown by near-infrared spectroscopy.
Psychological Medicine 32:1029-1037
58.
Ikeda A,
Kato N, Kato T (2002) Possible relationship between electro-encephalogram
finding and lithium response in bipolar disorder. Progress in
Neuro-Psychopharmacology and Biological Psychiatry 26:903-907
59.
Kato T,
Ishiwata M, Nagai T (2002) Mitochondrial calcium response in human transformed
lymphoblastoid cells. Life Sciences 71:581-590
60.
Watanabe A,
Kato N, Kato T (2002) Effects of creatine on mental fatigue and cerebral
hemoglobin oxygenation. Neuroscience Research 42:279-285
61.
Kunugi H,
Kato T, Fukuda R, Tatsumi M, Sakai T, Nanko S (2002) Association study of the
G-protein beta 3 subunit gene with schizophrenia and C825T polymorphism of mood
disorders. J. Neural Transmission 109:213-218
62.
Kato T,
Kunugi H, Nanko S, Kato N (2001) Mitochondrial DNA polymorphisms in bipolar
disorder. Journal of Affective Disorders 62: 151-164.
63.
Kato T,
Inubushi T, Kato N (2000) Prediction of lithium response by 31P-MRS in bipolar
disorder. Int J Neuropsychopharmacology 3:83-85
64.
Kato T,
Kunugi H, Nanko S, Kato N (2000) Association of bipolar disorder with the 5178
polymorphism in mitochondrial DNA. American Journal of Medical Genetics 96:
182-186
65.
Narita K,
Sasaki T, Akaho R, Okazaki Y, Kusumi I, Kato T, Hashimoto O, Fukuda R, Koyama
T, Matsuo K, Okabe Y, Nanko S, Hohjoh H, Tokunaga K (2000) Human leukocyte
antigen and season of birth in Japanese patients with schizophrenia. American
Journal of Psychiatry 157: 1173-1175
66.
Matsuo K,
Kato T, Fukuda M, Kato N (2000) Alteration of hemoglobin oxygenation in the
frontal region in elderly depressed patients measured by near-infrared
spectroscopy. Journal of Neuropsychiatry and Clinical Neuroscicences 12:
465-471
67.
Kato T,
Fujii K, Kamiya A, Kato N (2000) White matter hyperintensity detected by
magnetic resonance imaging and lithium response in bipolar disorder: A
preliminary observation. Psychiatry and Clinical Neurosciences 54: 117-120
68.
Murashita J,
Kato T, Shioiri T, Inubushi T, Kato N (2000) Altered brain energy metabolism in
lithium-resistant bipolar disorder detected by photic stimulated 31P-MR
spectroscopy. Psychological Medicine 30: 107-115
69.
Kato T,
Honda M, Kuwata S, Juji T, Kunugi H, Nanko S, Fukuda M, Honda Y (1999) A novel
polymorphism in the promoter region of the tumor necrosis factor alpha gene: No
association with narcolepsy. American Journal of Medical Genetics 88: 301-304
70.
Kato T,
Murashita J, Shioiri T, Inubushi T, Kato N (1999) Relationship of energy
metabolism detected by 31P-MRS in the human brain with mental fatigue. Neuropsychobiology
39: 214-218
71.
Kato T,
Honda M, Kuwata S, Juji T, Fukuda M, Honda Y, Kato N (1999) A search for a
mutation in the tumor necrosis factor alpha (TNF-α) gene in narcolepsy.
Psychiatry and Clinical Neurosciences 53: 421-423
72.
Kato T,
Yamanaka G, Kaiya H (1999) Efficacy of media in motivating patients with panic
disorder to visit specialists. Psychiatry and Clinical Neurosciences 53:
523-526
73.
Kunugi H,
Ishida S, Kato T, Sakai T, Tatsumi M, Hirose T, Nanko S (1999) No evidence for
an association of polymorphism of the tryptophan hydroxylase gene with
affective disorders or attempted suicide among Japanese patients. American
Journal of Psychiatry 156: 774-776
74.
Murashita J,
Kato T, Shioiri T, Inubushi T, Kato N (1999) Age-dependent alteration of
metabolic response to photic stimulation in the human brain measured by 31P
MR-spectroscopy. Brain Research 818:72-76
75.
Kunugi H,
Hattori M, Nanko S, Fujii K, Kato T (1999) Dinucleotide repeat polymorphism in
the neurotrophin-3 gene and hippocampal volume in psychoses. Schizophrenia
Research 37: 271-273
76.
Hamakawa H,
Kato T, Shioiri T, Inubushi T, Kato N (1999) Quantitative proton magnetic
resonance spectroscopy in the bilateral frontal lobes of patients with bipolar
disorder. Psychological Medicine 29: 639-644
77.
Kunugi H,
Ishida S, Kato T, Tatsumi M, Sakai T, Hattori M, Hirose T, Nanko S (1999) A
functional polymorphism in the promoter region of monoamine oxidase-A gene and
mood disorders. Molecular Psychiatry 4: 393-395
78.
Murashita J,
Yamada N, Kato T, Tazaki M, Kato N (1999) Effects of sleep deprivation: The
phosphorus metabolism in the human brain measured by 31P-magnetic resonance
spectroscopy. Psychiatry & Clinical Neurosciences 53: 199-201
79.
Kato T,
Winokur G, Coryell W, Rice J, Endicott J, Keller MB, Akiskal HS (1998) Failure
to demonstrate parent-of-origin effect in transmission of bipolar II disorder.
Journal of Affective Disorders 50: 135-141
80.
Kato T,
Murashita J, Shioiri T, Terada M, Inubushi T, Kato N (1998) Photic
stimulation-induced alteration of brain energy metabolism measured by 31P-MR
spectroscopy in patients with MELAS. Journal of Neurological Sciences 155:
182-185
81.
Kato T,
Murashita J, Kamiya A, Shioiri T, Kato N, Inubushi T (1998) Decreased brain
intracellular pH measured by 31P-MRS in bipolar disorder: A confirmation in
drug-free patients and correlation with white matter hyperintensity. European
Archives of Psychiatry & Clinical Neurosciences 248: 301-306
82.
Sasaki T,
Hattori M, Sakai T, Kato T, Kunugi H, Hirose T, Nanko S (1998) The monoamine
oxidase A (MAO-A) gene and major psychosis in Japanese subjects. Biological
Psychiatry 44: 922-924
83.
Hamakawa H,
Kato T, Shioiri T, Murashita J, Kato N (1998) Quantitative proton magnetic
resonance spectroscopy of the basal ganglia in patients with affective disorders.
European Archives of Psychiatry & Clinical Neurosciences 248:53-58
84.
Kunugi H,
Fukuda R, Hattori M, Kato T, Tatsumi M, Sakai T, Hirose T, Nanko S (1998) C677T
polymorphism in methylenetetrahydrofolate reductase gene and psychoses.
Molecular Psychiatry 3: 435-437
85.
Kato T,
Winokur G, McMahon FJ, DePaulo JR, Crowe RR (1997) Quantitative analysis of
leukocyte mitochondrial DNA deletion in affective disorders. Biological
Psychiatry 42: 311-316
86.
Kato T,
Stine OC, McMahon FJ, Crowe RR (1997) Increased levels of a mitochondrial DNA
deletion in the brains in patients with bipolar disorder. Biological Psychiatry
42: 871-875
87.
Kato T,
Shioiri T, Murashita J, Inubushi T (1997) Phosphorus-31 magnetic resonance
spectroscopic observations in 4 cases with anorexia nervosa. Progress in
Neuro-Psychopharmacology & Biological Psychiatry 21: 719-722
88.
Kunugi H,
Hattori M, Kato T, Tatsumi M, Sakai T, Sasaki T, Hirose T, Nanko S (1997)
Serotonin transporter gene polymorphisms: Ethnic difference and possible
association with bipolar affective disorder. Molecular Psychiatry 2: 457-462
89.
Shioiri T,
Someya T, Murashita J, Kato T, Hamakawa H, Inubushi T (1997) Multiple
regression analysis of relationship between the frontal lobe phosphorus
metabolism and clinical symptoms in patients with schizophrenia. Psychiatry
Research: Neuroimging 76: 113-122
90.
Kato T,
Murashita J, Shioiri T, Hamakawa H, Inubushi T (1996) Effect of photic
stimulation on energy metabolism in the human brain measured by 31P MR
spectroscopy. Journal of Neuropsychiatry and Clinical Neurosciences 8: 417-422
91.
Kato T,
Hamakawa H, Shioiri T, Murashita J, Takahashi Y, Takahashi S, Inubushi T (1996)
Choline-containing compounds detected by proton magnetic resonance spectroscopy
in the basal ganglia in bipolar disorder. Journal of Psychiatry &
Neuroscience 21: 248-254
92.
Kato T,
Fujii K, Shioiri T, Inubushi T, Takahashi S (1996) Lithium side effects in
relation to brain lithium concentration measured by lithium-7 magnetic
resonance spectroscopy. Progress in Neuro-Psychopharmacology & Biological
Psychiatry 20: 87-97
93.
Kato T,
Takahashi Y (1996) Deletion of leukocyte mitochondrial DNA in bipolar disorder.
Journal of Affective Disorders 37: 67-73
94.
Kato T, Wang
ZW, Zoega T, Crowe RR (1996) Missense mutation of the cholecystokinin B
receptor gene: Lack of association with panic disorder. American Journal of
Medical Genetics (Neuropsychiatric Genetics) 67: 401-405
95.
Kato T,
Winokur G, Coryell W, Keller MB, Endicott J, Rice J (1996) Parent-of-origin
effect in the transmission of bipolar disorder. American Journal of Medical
Genetics 67: 546-550
96.
Shioiri T,
Oshitani Y Kato T, Murashita J, Hamakawa H, Inubushi T, Nagata T, Takahashi S
(1996) Prevalence of cavum septum pellucidum detected by MRI in patients with
bipolar disorder, major depression, and schizophrenia. Psychological Medicine
26: 431-434
97.
Shioiri T
Kato T, Murashita J, Hamakawa H, Inubushi T, Takahashi S (1996) High-energy
phosphate metabolism in the frontal lobes of patients with panic disorder
detected by phase-encoded 31P-MRS. Biological Psychiatry 40: 785-793
98.
Shioiri T,
Hamakawa H, Kato T, Murashita J, Fujii K, Inubushi T, Takahashi S (1996) Proton
magnetic resonance spectroscopy of the basal ganglia in patients with
schizophrenia: a preliminary report. Schizophrenia Research 22: 19-26
99.
Shioiri T,
Murashita J, Kato T, Fujii K, Takahashi S (1996) Characteristic clinical
features and clinical course in 270 Japanese outpatients with panic disorder.
Journal of Anxiety Disorders 10: 163-172
100.Kato T, Shioiri T, Murashita J, Hamakawa H, Takahashi
Y, Inubushi T, Takahashi S (1995) Lateralized abnormality of high energy
phosphate metabolism in the frontal lobes of patients with bipolar disorder
detected by phase-encoded 31P-MRS. Psychological Medicine 25: 557-566
101.Kato T, Shioiri T, Murashita J, Hamakawa H, Takahashi
Y, Inubushi T, Takahashi S (1995) Lateralized abnormality of high energy
phosphate and bilateral reduction of phosphomonoester measured by 31P-MRS of
the frontal lobes in schizophrenia. Psychiatry Research: Neuroimaging 61:
151-160
102.Kato T, Shioiri T, Murashita J, Hamakawa H, Inubushi
T, Takahashi S (1994)
Phosphorus-31 magnetic resonance spectroscopy and ventricular
enlargement in bipolar disorder. Psychiatry Research: Neuroimaging 55: 41-50
103.Kato T, Takahashi S, Shioiri T, Murashita J, Hamakawa
H, Inubushi T (1994) Reduction of brain phosphocreatine in bipolar II disorder
detected by phosphorus-31 magnetic resonance spectroscopy. Journal of Affective
Disorders 31: 125-133
104.Kato T, Inubushi T, Takahashi S (1994) Relationship of brain lithium
concentration measured by 7Li-MRS to treatment response in mania. Journal of
Clinical Psychopharmacology 14: 330-335
105.Shioiri T, Kato T, Inubushi T, Murashita J, Takahashi
S (1994) Correlations of phosphomonoesters measured by phosphorus-31 magnetic
resonance spectroscopy in the
frontal lobes and negative symptoms in schizophrenia. Psychiatry
Research: Neuroimaging 55: 223-235
106.Nanko S, Fukuda R, Hattori M, Sasaki T, Dai XY, Kanba
S, Kato T, Kazamatsuri H (1994) Linkage studies between affective disorder and
dopamine D2, D3 and D4 receptor gene loci in four Japanese pedigrees.
Psychiatry Research 52: 149-159
107.Kato T, Takahashi S, Shioiri T, Inubushi T (1993)
Alterations in brain phosphorous metabolism in bipolar disorder detected by in
vivo 31P and 7Li magnetic resonance spectroscopy. Journal of Affective
Disorders 27: 53-60
108.Kato T, Shioiri T, Inubushi T, Takahashi S (1993)
Brain lithium concentrations measured with lithium-7 magnetic resonance
spectroscopy in patients with affective disorders: Relationship to erythrocyte
and serum concentrations. Biological Psychiatry 33: 147-152
109.Satoh K, Suzuki T, Narita M, Ishikura S, Shibasaki M,
Kato T, Takahashi S, Fukuyama H, Ohnishi H, Morita R (1993) Regional cerebral
blood flow in catatonic type of schizophrenia. Psychiatry Research:
Neuroimaging 50: 203-216
110.Shioiri T, Kato T, Murashita J, Yamada N, Takahashi S
(1993) Changes in the frequency distribution pattern of body weight in patients
with major depression. Acta Psychiatrica Scandinavica 88: 336-360
111.Kato T, Takahashi S, Inubushi T (1992) Brain lithium
concentrations by 7Li and 1H magnetic resonance spectroscopy in bipolar
disorder. Psychiatry Research: Neuroimaging 45: 53-63
112.Kato T, Takahashi S, Shioiri T, Inubushi T (1992)
Brain phosphorous metabolism in depressive disorders detected by phosphorous-31
magnetic resonance spectroscopy. Journal of Affective Disorders 26: 223-230
113.Kato T, Shioiri T, Takahashi S, Inubushi T (1991) Measurement
of brain phosphoinositide metabolism in bipolar patients using in vivo P-31
MRS. Journal of Affective Disorders 22: 185-190
114.Someya T, Shibasaki M, Kato T, Noguchi T, Ishida N,
Takahashi S (1991) Haloperidol reductase activity in red blood cells from
oriental patients on haloperidol. Progress in Neuro-Psychopharmacology and
Biological Psychiatry 15: 275-278
115.Shibasaki M, Someya T, Kato T, Noguchi T, Ishida N,
Takahashi S (1990) Measurement of haloperidol reductase activity in red blood
cells and reduced haloperidol/haloperidol ratios in plasma in oriental
psychiatric patients. Progress in Neuro-Psychopharmacology and Biological
Psychiatry 14: 941-947
Review Papers
116.Iwamoto K, Kato T (in press) Molecular profiling of
schizophrneia and related mental disorders. Neuroscientist
117.Kato T, Kuratomi G, Kato N (2005) Genetics of bipolar
disorder. Drugs of Today 41:5:335-344
118.Kato T (2005) Mitochondrial dysfunction in bipolar
disorder: from 31P-magnetic resonance spectroscopic findings to their molecular
mechanisms. International Review of Neurobiology 63: 21-40
119.Kato T, Iwamoto K, Kakiuchi C, Kuratomi G, Okazaki Y
(2005) Genetic or epigenetic difference causing discordance between monozygotic
twins as a clue to molecular basis of mental disorders. Molecular Psychiatry
10:622-630.
120.Ikeda A, Kato T (2003) Biological predictors of
lithium response in bipolar disorder. Psychiatry and Clinical Neuroscience 57:
243-250
121.Kato T (2001) The other, forgotten genome:
mitochondrial DNA and mental disorders. Molecular Psychiatry 6:625-633
122.Kato T (2001) Molecular genetics of bipolar disorder.
Neuroscience Research 40:105-113
123.Kato T, Kato N (2000) Mitochondrial dysfunction in
bipolar disorder. Bipolar Disorder 2: 180-190
124.Kato T, Inubushi T, Kato N (1998) Magnetic resonance
spectroscopy in affective disorders. Journal of Neuropsychiatry and Clinical
Neuroscience 10: 133-147
125.Kato T, Takahashi S, Inubushi T (1994) Brain lithium
concentration measured with lithium-7 magnetic resonance spectroscopy: A
review. Lithium 5: 75-81
126.Takahashi S, Someya T, Shibasaki M, Kato T, Noguchi
T, Ishida N (1990) Measurement of
haloperidol reductase activity in red blood cells from the Japanese psychiatric
patients. linical Neuropharmacology 13:2:536-537
Book Chapter
127.Kato T (2003) MRS Investigations and the
pathophysiology of affective disorders. (In Soares JC (ed) Brain Imaging in
Affective Disorders, pp159-180, Marcel Dekker, Inc., New York)
128.Kato T (2002) Imaging Studies of Mood Disorder by
Magnetic Resonance Spectroscopy and Near-infrared Spectroscopy.(In T. Okuma, S.
Kanba and Y. Inoue, (eds) Recent Advances in the Research of Affective Disorder
in Japan, p75-84, Elsevier Science, the Netherlands, Amsterdam)
129.Kato T (2002) Atypical Psychosis: The Other Boundary
of Bipolar Disorder. Bipolar Disorder. (Maj M, Akiskal H S, Lopez-Ibor J J,
Sartorius N, eds) WILEY, UK, p94-95
130.Kato T (1997) In vivo investigations of signal
transduction systems in affective disorders using magnetic resonance
spectroscopy. (In: Ozawa H, Saito T, Takahata (eds) Signal Transduction Systems
in Affective Disorders, Springer-Verlag Tokyo, Tokyo, pp133-146
Letters
131.Kasahara T, Kato T (2005) Is pyrroloquinoline quinone
a vitamin? (Reply) Nature 433: E11-E12.
132.Kakiuchi C, Nanko S, Kunugi H, Kato T. (2004) Reply
to "Lack of support for a genetic association of the XBP1 promoter
polymorphism with bipolar disorder in probands of European origin". Nature
Genetics. 2004 Aug;36(8):784-5.
133.Kato T (2001) Mitochondrial DNA
Polymorphisms and Bipolar Disorder. Am J Psychiatry 158: 1169-1170
134.Kato,T. and Takahashi,S. (1995) Reply to
“Lithium levels in brain and serum”. Journal of Clinical Psychopharmacology 15,
376
(197 original or review papers in Japanese)
Invited Presentations (International Meetings)
1.
Kato T,
Kasahara T, Kubota M(2006) Mitochondrial dysfuntion in bipolar disorder: from
molecules to behavior. Society of Biological Psychiatry 2006 Annual Meeting,
Toronto, Canada, May 18, 2006
2.
Kato T
(2005) Molecular pathophysiogy of bipolar disorder. 2005 POSTECH Brain Winter
School, Pohang, Korea, Dec. 27, 2005
3.
Kato T
(2005) Informed consent: Current Status in Clinical and Research Settings
in Japan. Twelfth Session of the International Bioethics Committee(IBC) ,
Tokyo, Dec. 16, 2005
4.
Kato T
(2005) Molecular pathophysiology of bipolar disorder. The 3rd Takeda Science
Foundation Symposium on PharmaSciences: On the Frontiers of
Neuro-PharmaSciences,
Tokyo, Dec.7 ,2005
5.
Kato T (2005)
Is bipolar disorder a mitochondrial disorder? European College of
Neuropsychopharmacology, Amsterdam, The Netherland, Oct. 23, 2005
6.
Kakiuchi C,
Kato T (2004) Role of ER stress response pathway in bipolar disorder revealed by
gene expression analysis of lymphoblasts of monozygotic discordant twins.
Korean Neuropsychiatric Association, Soul, Korea, Oct.22, 2004
7.
Kato T
(2004) Disorder brain bioenergetics in bipolar disorder. World Federation of
Societies of Biological Psychiatry International Congress of Biological
Psychiatry, Sydney, Australia,
Feb. 10, 2004
8.
Kasahara T,
Kato T(2004). Molecular basis of bipolar disorder. 6th China-India-Japan-Korea
Joint Workshop on Neurobiology and Neuroinformatics, Manesar, India,Oct.6,2004
9.
Kato T
(2004) Brain imaging and the pathophysiology of mood disorders. Functional
imaging studies with near infrared spectroscopy. XXIVth Collegium
Internationale Neuro-Psychopharmacologium (CINP) Congress, Paris, June 22, 2004
10.
Kato T,
Kakiuchi C (2004) Identification of XBP1 loop as a risk factor for bipolar
disorder from gene expression analysis of monozygotic discordant twins.
RIKEN-MIT retreat, Kennebunkport, U.S.A. ,June. 8, 2004
11.
Kato T
(2003) Mitochondrial dysfunction in bipolar disorder revealed by phosphorus-31
magnetic resonance spectroscopy, ACNP 42nd Annual Meeting, San Juan,
Dec. 9, 2003
12.
Kato T
(2003) Analysis of Gene expression, RNA editing, and mitochondrial DNA
deletion, in the Stanley foundation brain bank samples, The Stanley meeting, Bethesda,
Nov. 7,2003
13.
Kato T
(2003) Mitochondrial dysfunction in bipolar disorder, The Stanley meeting,
Bethesda, Nov. 7,2003
14.
Kato T
(2002) Search for bipolar disorder related genes using GeneChip, XII World
Congress of Psychiatry, Yokohama, August 26-28/2002
15.
Kato T
(2002) Near infrared spectroscopic investigations of mood disorders, XII World
Congress of Psychiatry, Yokohama August 26-28/2002
16.
Kato T
(2002) Neurobiological predictors of lithium response, XII World Congress of
Psychiatry, Yokohama August 26-28/2002
17.
Kato T（2001）Neurobiological mechanisms of bipolar and
treatment response. CINP Regional Meeting, Hiroshima, Oct.4, 2001
18.
Kato T
(2000) 31P-MRS studies of brain energy metabolism and treatment
response in bipolar disorder. XXIInd congress of Collegium Internationale
Neuro-Psychopharmacologium, Brussels July 9-13/2000
19.
Kato T
(1998) Mitochondrial dysfunction in bipolar disorder: MRS and molecular
genetics. Symposium “Advances in treatment of bipolar disorder”. XXIst congress
of Collegium Internationale Neuro-Psychopharmacologium, Glasgow, July
13-18/1998.
20.
Kato T
(1996) Direct measurement of lithium brain concentration by lithium-7 magnetic
resonance spectroscopy and correlation with effects. XXth Collegium
Internationale Neuro-Psychopharmacologium, Symposium ”The diminishing correlation between drug
plasma concentration and effects: fact or fallacy?” Melbourne, June 23-27.
21.
Kato T
(1996) Magnetic resonance spectroscopic investigations of affective disorders.
Society of Biological Psychiatry, Symposium “Neuroimaging II”, New York, May
1-5
(69
invited presentations at domestic meetings in Japan)