東京大学医学部 漢方生体防御機能学
本文へジャンプ

岡部哲郎 業績
1977--2008

1.Asano,S.,Urabe,A.,Okabe,T., Sato,N., Kondo,Y., Ueyama,Y., Chiba,S.,Ohsawa,N. and Kosaka,K. Demonstration of granulopoietic factor(s) in the plasma of nude mice transplanted with a human lung cancer and in the tumor tissue. Blood 49: 845-852, l977
2.Okabe,T., Sato,N., Kondo,Y., Asano,S., Ohsawa,N., Kosaka,K., and Uyeyama,Y. Establishment and characterization of a human cancer cell line that produces human colony -stimulating factor. Cancer Res. 38:3910-3917, 1978.
3.Okabe,T., Suzuki,A., Ohsawa,N., Kosaka,K. and Terasima,T. Immune elimination of host fibroblasts for the cultivation of human tumors transplanted into nude mice. Cancer Res. 39: 4189-4194, 1979.
4. Sato,N., Asano,S., Ueyama,Y., Mori,M., Okabe,T., Kondo,Y., Ohsawa,N. and Kosaka,K. Granulocytosis and colony-stimulating activity (CSA) produced by a human squamous cell carcinoma. Cancer 43: 605-610, 1979.
5.Hamada,N., Okabe,T., Kubota,K., Chiu,S.C., Uchimura,H., Minura,T., Ito,K. and Nagataki,S. Bioassay of thyrotropin by release of
triiodothyronine from cultured human thyroid slices. Proc. 8th. International Thyroid Congress. Sydney, Australia, 3-8 Feb. 1980, 759-762.
6.Okabe,T., Suzuki,A., Ishikawa,H., Yotsumoto,H. and Ohsawa, N. Cells originating from sarcoid granulomas in vitro. Am. Rev. Respir. Dis. 124:608-612, 1981.
7.Okabe, T., and Ohsawa, N. Human colony-stimulating factor producing cell line. Cell. Mol. Biol. 27: 578-587, 1981.
8.Sasaki, N., Okabe,T., Imai,Y., Matsuzaki,F., Kosaka,K., Wakui,K. and Tsushima,T. Basic peptide with insulin-like activity in human serum. Endocrinol. Jpn. 28: 157-167, 1981.
9.Okabe,T., Suzuki,A., Ohsawa,N. and Terasima,T. Isolation of human tumor cell lines from xenotransplanted human tumorsin nude mice by immuneelimination of host fibroblasts. Proc. 3rd. International Workshop on Nude Mice. Gustav Fisher, New York, 1981, 527-541.
10.Okabe,T., Suzuki,A., Yotsumoto,H., Ohsawa,N., Ishikawa,H., Matsui,Y. and Furuiye, T. Cultivation and characterization of sarcoid epithelioid cells in vitro. 9th. International Conference on Sarcoidosis and Granulomatous Disorders. Pergamon Press,Paris, 1981, 84-92.
11.Okabe,T., Nomura,H., Sato,N. and Ohsawa,N. Large-scale preparation and characterization of human colony-stimulating factor. J. Cell. Physiol.110: 43-49, 1982.
12.Okabe,T.,Yamaguchi,N. and Ohsawa, N. Establishment and characterization of a human colony-stimulating factor (CSF)-producing cell line from a squamous cell carcinoma of the thyroid gland. J. Natl. Cancer Inst. 69: 1235-1243, 1982.
13.Okabe,T., Yamaguchi,N. and Ohsawa,N. Establishment and characterzation of a carcinoembryonic antigen (CEA)-producing cell line
from a human carcinoma of the exocrine pancreas. Cancer 51: 662-668,1983.
14.Sasaki,N., Matsuzaki,M., Okabe,T., Imai,Y., Kaneko,Y. and Matsuzaki,F. Stimulation of human chorionic gonadotropin and progesterone secretion by tumor promoters, phorbol esters and teleocidin B, in cultured choriocarcinoma cells. Experientia 39: 330-331, 1983.
15.Okabe,T., Hidaka,H., Ohsawa,N. and Tsushima,T. Long-term survival and aldosterone secretion pattern of aldosteronoma in culture. Acta
Endocrinol. 104: 495-501, 1983.
16.Hamada,N., Okabe,T., Kubota,K., Chiu,S.C., Uchimura, H., Mimura,T. Ito,K., and Nagataki, S. Chronic effect of TSH on human thyroid tissue in organ culture. Proc. Soc. Exp. Biol. Med. 172: 153-157, 1983.
17.Kondo,Y.,Sato,N.,Ohsawa,H., Ueyama,Y., Okabe,T., Sato,N., Asano,S.,Mori,M., Ohsawa,N. and Kosaka,K. Association of hypercalcemia with tumors producing colony-stimulating factor(s). Cancer Res. 43: 2368-2374, 1983.
18.Okabe,T., Sasaki.N., Matsuzaki,F., Imai,Y., Kaneko,Y., Matsuzaki, F., Takaku,F. and Tsushima, T. Establishment and characterzation of a new human functional cell line from a choriocarcinoma. Cancer Res. 43:4920-4926, 1983.
19.Okabe,T., Suzuki,A., Hirono,M., Tamaoki,N., Oshimura,M. and Takaku,F.  Establishment of a different clonal strains from a human sarcoma of the stomach: Tumorigenic heterogeneity in athymic nude mice. Cancer Res. 43: 5456-5461, 1983.
20.Okabe,T., Fujisawa,M. and Takaku,F. Long-term cultivation and differentiation of human erythroleukemia cells in a protein-free chemically defined medium. Proc. Natl. Acad. Sci. U.S.A. 81: 453-455, l984.
21.Okabe, T., Fujisawa, M., Kudoh, H., Honma, H., Ohsawa, N. and Takaku,F. Establishment of a human colony-stimulating factor (CSF)-producing cell line from a large cell carcinoma of the lung. Cancer 54: 1024-1029, 1984.
22. Okabe, T., Yorifuji, H., Yamada, E., and Takaku, F. Isolation and characterization of vitamin A-storing lung cells. Exp. Cell Res. 154:
125-135, 1984.
23.Okabe, T. and Takaku, F. Long-term cultivation of a human colony-stimulating factor (CSF)-producing cell line in a protein-free
chemically defined medium. Cancer Res. 44: 4503-4506, 1984.
24.Okabe, T., Ishizuka, S., Fujisawa, M., Watanabe, J. and Takaku, F. Sarcoid granulomas metabolize 25-hydroxyvitamin D3 in vitro. Biochem.Biophys. Res. Commun. 123: 822-830, 1984.
25.Bessho, M.,Hirashima, K., Nomura, H., Ono, M., Okabe, T., Ohsawa, N.,Nara, N. and Mori, H. Effects on human bone marrow cells of
colony-stimulating factors produced in large quantities from conditioned medium of thyroid cancer cells. Acta Hematologica Jap. 47: 1265-1272,1984.
26.Okabe, T., Yorifuji, H., Murase, T. and Takaku, F. Pulmonary macrophage: A major source of lipoprotein lipase in the lung. Biochem.
Biophys. Res. Commun. 125: 273-278, 1984.
27.Okabe, T., Hirashima, K., Terasima, T., Shimizu, B., Ohsawa, N. and Takaku, F. Retroviruses released from a human tumor xenografts in nude mice induced colony-stimulating factor (CSF) activity in human fibroblastic cells. Experientia 40: 982-984, 1984.
28.Okabe, T., Kaizu, T., Fujisawa, M., Watanabe, J., Kojima, K., Yamashita, T. and Takaku, F. Monoclonal antibodies to surface antigens of small cell carcinoma of the lung. Cancer Res. 44: 5273-5278, 1984.
29.Kodama, T., Takada, K., Kameya, T., Shimosato, Y., Tsuchiya, R. and Okabe, T. Large cell carcinoma of the lung associated with marked
eosinophilia. Cancer 54: 2313-2317, 1984.
30.Okabe, T., Fujisawa, M., Yotsumoto, H., Takaku, F., Lanzillo, J.J. and Fanburg, B.L. Familial elevation of serum angiotensin converting
enzyme. Quart. J. Med. 55: 55-61, 1985.
31.Miyazono, K., Okabe, T., Urabe, A., Yamanaka, M. and Takaku, F. A platelet factor that stimulating the proliferation of vascular endothelial cells. Biochem. Biophys. Res. Commun. 126: 83-88, 1985.
32.Ohta, M., Ozawa, K., Okabe, T., Urabe, A. and Takaku, F. Induction of proliferation of human circulating monocytes in vitro by lectin-induced factor(s) from lymphocytes. Biochem. Biophys. Res. Commun. 126: 705-711, 1985.
33.Hirai, H., Okabe, T., Anraku, Y., Fujisawa, M., Urabe, A. and Takaku, F. Activation of c-K-ras oncogne in a human pancreas carcinoma. Biochem. Biophys. Res. Commun. 127: 168-174, 1985.
34.Okabe, T., Ishizuka, S., Fujisawa, M., Watanabe, J. and Takaku, F. Human myeloid leukemia cells metabolize 25-hydroxyvitamin D3 in vitro. Biochem. Biophys. Res. Commun. 127: 635-641, 1985.
35.Okabe, T., Yamagata, K., Fujisawa, M., Watanabe, J., Takaku, F.,Lanzillo, J. J. and Fanburg, B.L. Increased angiotensin-converting enzyme in peripheral blood monocytes from patients with sarcoidosis. J. Clin. Invest. 75: 911-914, 1985.
36. Okabe, T., Urabe, A., Kato, T., Chiba, S., and Takaku, F. Production of erythropoietin-like activity by human renal and hepatic carcinomas in cell culture. Cancer 55, 1918-1923, 1985.
37.Hara, T., Umeda, T., Niijima, T. and Okabe, T. Cytostasis of tumor cell lines by promyelocytic leukemia cell line HL-60 differentiated to
granulocyte lineage. J. Cancer Res. Clin. Oncol. 109: 103-1106, 1985.
38.Nishida, J., Yoshikura, H., Okabe, T., Urabe, A. and Takaku, F.
Interferons inhibit syncytia-forming ability and in vitro transmission of human T-cell leukemia virus. Jpn. J. Cancer Res. 76: 249-2252, 1985.
39.Okabe, T., Kaizu, T., Ozawa, K., Urabe, A., and Takaku, F.
Elimination of small cell lung cancer cells in vitro from human bone marrowby a monoclonal antibody. Cancer Res. 45: 1930-1933, 1985.
40.Ohta, M., Okabe, T., Ozawa, K., Urabe, A. and Takaku, F. 1a,25-dihydroxyvitamin D3 (calcitriol) stimulates proliferation of human
circulating monocytes in vitro. Febs Letters 185: 9-13, 1985.
41.Okabe, T., Kaizu, T., Fujisawa, M., Watanabe, J. and Takaku, F. Clinical application of monoclonal antibodies to small cell lung cancer.
Jpn. J. Med. 24: 250-256, 1985.
42.Kobayashi, Y., Hirai, H., Okabe, T., Urabe, T. and Takaku, F. T-cell receptor gene rearrangement in a patient with common acute lymphatic leukemia. Jpn. J. Cancer Res. 76: 791-798, 1985.
43.Miyazono, K., Okabe, T., Ishibashi, S., Urabe, A. and Takaku, F. A platelet factor stimulating the proliferation of vascular endothelial
cells. partial purification and characterization. Exp. Cell Res. 159:487-494, 1985.
44.Hosoi, T., Ozawa, K., Ohta, M., Okabe, T., Urabe, A. and Takaku, F. Recombinant immune interferon inhibits leukemic cell growth by a
macrophage-mediated mechanism. Exp. Hematol. 13: 597-602, 1985.
45.Hirai, H., Tanaka, S., Azuma, M., Anraku, Y., Kobayashi, Y., Fujisawa, M., Okabe, T., Urabe, T. and Takaku, F. Transforming genes in human leukemia cells. Blood 66: 1371-1378, 1985.
46.Fujisawa, M., Okabe, T., Murakami, T. and Takaku, F. Corticosteroidreceptor in type II pneumocytes of the rat. Life Sci. 38: 413-416, 1985.
47.Awata, T., Shibasaki, Y., Hirai, H., Okabe, T., Kanazawa, Y. and Takaku, F. Restriction fragment length polymorphism of the insulin gene
region in Japanese diabetic and non-diabetic subjects. Diabetologia 28:
911-913, 1985.
48.Yamaguchi, N., Okabe, T., and Kawai, K. Establishment of a human carcinoembryonic antigen (CEA)-producing cell line in a protein-free
chemically defined medium. J. Cancer Res. Clin. Oncol. 110: 42-47, 1985.
49.Okabe, T., Fujisawa, M., Mihara, A., Sato, S., Fujiyoshi, N. and Takaku, F. Growth factor(s) produced by a human leukemic cell line growing in a proetin-free chemically defined medium. Cancer Res. 46: 1043-1046,1986.
50.Okabe, T. and Takaku, F. A macrophage factor that stimulates the proliferation of vascular endothelial cells. Biochem. Biophys. Res.
Commum. 134: 344-350, 1986.
51.Okabe, T., Suzuki, A., Ishikawa, H., Watanabe, I. and Takaku, F. Chromosomal aneuploidy in sarcoid granuloma cells. Am. Rev. Respir. Dis.134: 300-304, 1986.
52.Sato, K., Mimura, H., Han, D. C., Kakiuchi, T., Ueyama, Y., Ohkawa, H., Okabe, T., Kondo, Y., Ohsawa, N., Tsushima, T. and Shizume, K. Produciton of bone-resorbing activity and colony-stimulating activity in vivo and in vitro by human squamous cell carcinoma associated with hypercalcemia and leukocytosis. J. Clin. Invest. 78: 145-154, 1986.
53.Okabe, T. and Takaku, F. Diagnostic and therapeutic applications of monoclonal antibodies to small cell carcinoma of the lung. Jpn. J. Clin.Oncol. 16: 243-252, 1986.
54.Fujisawa, M., Kobayashi, Y., Okabe, T., Takaku, F., Komatsu, Y. and Itoh, S. Recombinant human granulocyte colony-stimulating factor induces granulocytosis in vivo. Jpn. J. Cancer Res. 77: 866-869, 1986.
55.Nishida, J., Hirai, H., Kubota, M., Lin, F. K., Okabe, T. and Takaku,
F. Detection of erythropoitin message in hypoxic mouse kidney. Jpn. J.Exp. Med. 56: 321-323, 1986.
56.Tomida, M., Yamamoto-Yamaguchi,Y., Hozumi, M., Okabe, T. and Takaku,F. Induction by recombinant human granulocyte colony-stimulating factor of differentiation of mouse myeloid leukemic M1 cells. Febs Letters 207:271-277, 1986.
57.Ohata, M., Okabe, T., Ozawa, K., Urabe, A., and Takaku, F. In vitro
formation of macrophage-epithelioid cells and multinucleated giant cells by 1α, 25-dihydroxyvitamin D3 from human circulating monocytes. Ann. N.Y.Acad. Sci. 465: 211-220, 1987.
58.Watanabe, J., Okabe, T., Fujisawa, M., Takaku, F., Hirohashi, S. and Shimosato, Y. Monoclonal antibody that distinguishes small-cell lung cancer from non-small cell lung cancer. Cancer Res. 47: 826-829, 1987.
59.Watanabe, J., Okabe, T., Fujisawa, M., Takaku, F. and Fukayama, M.
Isolation of small cell lung cancer associated antigen from human brain. Cancer Res. 47: 960-962, 1987.
60.Shimamura, M., Kobayashi, Y., Yuo, A., Urabe, A., Okabe, T., Komatsu,
Y., Itoh, S. and Takaku, F. Effect of human recombinant granulocyte
colony-stimulating factor on hematopoietic injury in mice induced by
5-fluorouracil. Blood 69: 353-355, 1987.
61.Miyazono, K., Okabe, T., Urabe, A., Takaku, F. and Heldin, C.H.
Purification and properties of an endothelial cell growth factor from human platelets. J. Biol. Chem. 262: 4093-4103, 1987.
62.Okabe, T., Fujisawa, M., Watanabe, J., Yotsumoto, H. and Takaku, F. Familial hyper-angiotensin converting enzyme (ACE)-emia. Increased produciton of ACE by monocyte-macrophage. Jpn. J. Med. 26: 140-146, 1987.
63.Yuo, A., Kitagaawa, S., Okabe, T., Urabe, A., Komatsu, Y., Itoh, S. and Takaku, F. Recombinant human granulocyte colony-stimulating factor repairs the abnormalities of neutrophils in patients with myelodysplastic syndromes and chronic myelogenous leukemia. Blood 70: 404-411, 1987.
64.Mihara, A., Fujiwara, K., Sato, S., Okabe, T. and Fujiyoshi, N.  N-terminal amino acid sequence of leukemia derived growth factor (LGF) from human erythroleukemia cell culture. In vitro Cell & Develop. Biol. 23: 317-322, 1987.
65.Okabe, T., Fujisawa, M., Watanabe, J. and Takaku, F. Production of
colony-stimulating factor by sarcoid granulomas in vitro. Jpn. J. Med.26: 36-40, 1987.
66.Kobayashi, Y., Okabe, T., Urabe, A., Suzuki, N. and Takaku, F. Human granulocyte colony-stimulating factor produced by escherichia coli
shortens the period of granulocytopenia induced by irradiation in mice. Jpn. J. Cancer Res. 78: 763-766, 1987.
67.Okabe, T., Yamagata, K., Fujisawa, M., Takaku, F., Hidaka, H. and Umezawa, Y. Induction by fibroblast growth factor of angiotensin
converting enzyme in vascular endothelial cells in vitro. Biochem.Biophys. Res. Commun. 145: 1211-1216, 1987.
68.Ohara, A., Suda, T., Saito, M., Miura, Y., Okabe, T. and Takaku, F. Effect of recombinant human granulocyte colony-stimulating factor on
hematopoietic cell in serum-free culture. Exp. Hematol. 15: 695-699, 1987.
69.Tsao C. J., Hosoi, T., Hirai, H., Saito, T., Okabe, T., Urabe, A. and Takaku, F. Protoplast-mediated gene transfer into human leukemia (K562)cells. Int. J. Cell Clon. 5: 220-230, 1987.
70.Mano, H., Nishida, J., Usuki, K., Maru, Y., Kobayashi, Y., Hirai, H.,
Okabe, T., Urabe, A. and Takaku, F. Constitutive expression of the granulocyte-macrophage colony-stimulating factor gene in human solid
tumors. Jpn. J. Cancer Res. 78: 1041-1043, 1987.
71.Ohdama, S., Yoshizawa, Y., Tanoue, M., Tanaka, M., Ikeda, A., Masuda,S. and Okabe, T. Chemotactic factors present in the supernatants of cultured sarcoid granulomas. Respiration 52: 205-213, 1987.
72.Komatsu, Y., Matsumoto, M., Itoh, T., Kuga, T., Nishi, T., Sekine, S.,Saito, A., Okabe, M., Morimoto, M., Itoh, S., Okabe, T. and Takaku, F. Cloning of granulocyte colony-stimulating factor cDNA from humanmacrophages and its expression in escherichia coli. Jpn. J. Cancer Res.78: 1179-1181, 1987.
73.Okabe, T. Immunodetection of small cell lung cancer. Jpn. J. Med.27: 103-105, 1988.
74.Yoneda, S., Fujisawa, M., Watanabe, J., Okabe, T., Takaku, F., Homma,
T. and Yoshida, K. Radioimmunotherapy of transplanted small cell lung cancer with 131I-laballed monoclonal antibody. Br. J. Cancer 58: 292-295, 1988.
75.Shimamura, M., Takigawa, T., Urabe, A., Okabe, T., Sauza, L.M. and
Takaku, F. Synergistic effect of dolichyl phosphate and human recombinant granulocyte colony-stimulating factor on recovery from neutropenia in mice treated with anti-cancer drugs. Exp. Hematol. 16: 681-685, 1988.
76.Sugiyama, Y., Yotsumoto, H., Okabe, T. and Takaku, F. Measurement of angiotensin-converting enzyme and effects of smoking. Respiration 53:153-157, 1988.
77.Uzumaki, H., Okabe, T., Sasaki, N., Hagiwara, K. Takaku, F., and
Itoh, S. Characterization of receptor for granulocyte colony-stimulating factor on human circulating neutrophils. Biochem. Biophys. Res. Commun.156: 1026-1032, 1988.
78.Watanabe, J., Fukayama, M., Fujisawa, M., Takaku, F. and Okabe, T.
Brain-associated small cell lung cancer antigen (BASCA) has at least three
epitopes. Lung Cancer 4: 105-106, 1988.
79.Kobayashi, Y., Okabe, T., Ozawa, K., Chiba, S., Hino, M., Miyazono,
K., Urabe, A. and takaku, F. Treatment of myelodysplastic syndromes with
recombinant human granulocyte colony-stimulating factor: A preliminary
report. Am. J. Med. 86: 178-182, 1989.
80.Yuo, A., Kitagawa, S., Suzuki, I., Urabe, A., Okabe, T., Saito, M.
and Takaku, F. Tumor necrosis factor as an activator of human
granulocytes. J. Immunol. 142: 1678-1684, 1989.
81.Yamamoto-Yamaguchi,Y., Tmonida, M., Hozumi, M., Maurer, H.R., Okabe,T., and Takaku, F. Combined effects of differentiation-inducing factor and other cytokines on induction of differentiation of mouse myeloid leukemic cells. Jpn. J. Cancer Res. 80: 115-121, 1989.
82.Ando, M., Okabe, T., Nagai, S., Takeuchi, M., Sugimoto, M., Tsuda, T.,Kobayashi, K. and Kawai, T. Role of macrophages in the pathogenesis of sarcoidodis. Sarcoidosis 6: 76-78, 1989.
83.Uzumaki, K., Okabe, T., Sasaki, N., Hagiwara, K., Takaku, F., Tobita,
M., Yasukawa, K., Itoh, S. and Umezawa, Y. Identification and
characterization of receptors for granulocyte colony-stimulating factor on human placenta and trophoblastic cells. Proc. Natl. Acad. Sci. U.S.A. 86: 9323-9326, 1989.
84.Yuo, A., Kitagawa, S., Ohsaka, A., Ohta, M., Miyazono, K., Okabe, T.,
Urabe, A., Saito, M. and Takaku, F. Recombinant human granulocyte
colony-stimulating factor as an activator of human granulocytes:
Potentiation of responses triggered by receptor-mediated agonists and
stimulation of C3bi receptor expression and adherence. Blood 74:
2144-2149, 1989.
85.Sato, K., Fujii, Y., Kakiuchi, T., Kasano, K., Imamura, H., Kondo, Y.,
Mano, H., Okabe, T., Asano, S., Takaku, F., Tsushima, T. and Shizume, K. Paraneoplastic syndrome of hypercalcemia and leukocytosis caused by
squamous cell carcinoma cells (T3M-1) producing parathyroid hormone-related protein, interleukin 1a and granulocyte colony-
stimulating factor. Cancer Res. 49: 4740-4746, 1989.
86.Motoyoshi, K., Yoshida, K., Hatake, K., Saito, M., Miura, Y., Yanai,
N., Yamada, M., Kawashima, T., Wong, G.G., Temple, P.A., Leary, A.C.,
Witek-Giannoti, J.S., Fujisawa, M., Yuo, A., Okabe, T. and Takaku, F.
Recombinant and native human urinary colony-stimulating factor directly
augments granulocytic and granulocyte-macrophage colony-stimulating factor production of human peripheral blood monocytes. Exp. Hematol. 17: 68-71,1989.
87.Piao, Y.F. and Okabe, T. Receptor binding of human granulocyte
colony-stimulating factor to the blast cells of myeloid leukemia. Cancer
Res. 50: 1671-1674, 1990.
88.Nakamura, Y.,Tomita, N.,Nisida, T., Emi, M., Horii, A., Ogawa, M., Mori, T., Kosaki, G., Okabe, T., Fujisawa, M., Ohsawa, N.,Kameya, T. and Matsubara, K. Production of salivary type α-amylase in human lung cancer. Gene 77:107-112, 1989
89.Okabe, T. and Yasukawa, K. A human monocyte growth factor produced by lung cancer cells. Cancer Res. 50: 3863-3865, 1990.
90.Fukayama, M., Funata, N., Hayashi, Y., Maeda, Y., Koike, M., Watanabe,J. and Okabe, T. Brain-associated small-cell lung caner antigen (BASCA)is expressed in developing lung: An immunohistochemical and immunoelectron microscopic study. J. Histochem. Cytochem. 38: 51-57, 1990.
91.Goto, M., Fujisawa, M., Yamada, A., Okabe, T., Takaku, F., Sasano, M. and Nishioka, K. Spontaneous release of angiotensin converting enzyme and interleukin 1 from peripheral blood monocytes from patients with rheumatoid arthritis under a serum free condition. Ann. Rheum. Dis. 49: 172-176,1990.
92.Okabe, T. and Kasuga, T. Clonal heterogeneity of a human functioning tumor which produces granulocyte colony-stimulating factor. Jpn. J. Clin. Oncol. 20: 349-355, 1990.
93.Koshi, T., Suzuki, C., Arai, K., Mizoguchi, T., Torii, T., Hirata, M.and Okabe, T. Synthesis and biological activities of endothelin-1 analogs. Chem. Pharm. Bull. 39: 1295-1297, 1991.
94.Koshi, T., Torii, T., Arai, K., Edano, T., Hirata, M., Ohkuchi, M.
and Okabe, T. Inhibition of endothelin (ET)-1- and ET-2-induced
vasoconstriction by anti-ET-1 monoclonal antibody. Chem. Pharm. Bull. 39:326-329, 1991.
95.Okabe, T., Ishizuka, S. and Fujisawa, M. Human trophoblastic cells
metabolize 25-hydroxyvitamin D3 in vitro. Jpn. J. Med. 30: 326-329, 1991.
96.Umezawa, Y., Kuge, S., Kikyo, N., Shirai, T., Watanabe, J., Fujisawa,
M. and Okabe, T. Identity of brain-associated small cell lung cancer
antigen and the CD56 (NKH-1/Leu-19) leukocyte differentiation antigen and the neural cell adhesion molecule. Jpn. J. Clin. Oncol. 21: 251-255, 1991.
97.Arai, K., Koshi, T., Edano, T., Ohkuchi, M., Hirata, M. and Okabe, T. Characterization of immunoreactive endothelin in human urine. Biochem. Biophys. Res. Commun. 182: 1506-1513, 1992.
98.Koshi, T., Etoh, Y., Torii, T., Wada, Y., Hirata, M., Ohkuchi, M. and Okabe, T. Induction of dyspnea by aerosol of endothelin-1/histamin or/methacholin in the conscious guinea pig. Chem. Pharm. Bull. 40:1064-1065, 1992.
99.Goto, M., Sasano, M., Fujisawa, M., Okabe, T. and Nishizawa, K.
Constitutive production of angiotensin converting enzyme from rheumatoid
nodule cells under serum free conditions. Ann. Rheum. Dis. 51: 741-742,
1992.
100.Koshi, T., Edano, T., Arai, K., Suzuki, C., Ehara, Y., Hirata, M.,
Ohkuchi, M. and Okabe, T. Pyrogenic action of endothelin in conscious
rabbit. Biochem. Biophys. Res. Commun. 186: 1322-1326, 1992.
101.Kikyo, N., Hagiwara, K., Suda, M., Kikyo, N., Fujisawa, M., Yazaki,
Y. and Okabe, T. Purification and characterization of a cell growth
factor from a human leukemia cell line: Immunological identity with
ferritin. Cancer Res. 54: 1-4, 1994.
102. Edano, T., Arai, K., Koshi, T., Torii, T., Ohshima, T., Hirata, M.,
Ohkuchi, M. and Okabe, T. Digestion of endothelin-1 on cultured vascular
smooth muscle cells. Biol. Pharm. Bull. 17: 376-378,1994.
103.Edano, T., Arai, K., Ohshima, T., Koshi, T., Hirata, M., Ohkuchi, M.and Okabe, T. Purification and characterization of endothelin-1 digestion activity from porcine kidney. Biol. Pharm. Bull. 17: 379-382, 1994.
104. Kikyo, N., Hagiwara, K.., Fujisawa, M., Kikyo, N., Yazaki, Y. and
Okabe, T. Purification of a cell growth factor from a human lung cancer
cell line; its relationship with ferritin. J. Cell. Physiol. 161:106-110,1994.
105.Hasegawa, K.,Hirata, M.,Koshi, T.,Ohshima, T.,Miyashita, Y.,Sasaki, S. and Okabe, T. Quantitative structure-activity relationships of endothelin-1 analogs. Bioorg.&Med. Chem. Lett. 4:1157-1160,1994.
106.Okabe, T., and Fujisawa, M. Steroid hormone in pulmonary fibrosis,
in Basic and clinical aspects of pulmonary fibrosis, Takishima, T. ed.,CRC Press, Boca Raton, 1994, 267-281.
107.Kikyo, N., Hagiwara, K., Yazaki, Y. and Okabe, T. Growth stimulation
of human leukemia cells by ferritin in serum-depleted culture. J. Cancer.
Res. Clin. Oncol. 121: 76-78,1995
108.Hagiwara, H., Kobayashi, T.,Tobita, M., Kikyo, N., Yazaki, Y. and
Okabe, T. Isolation of a cDNA for a growth factor of vascular endothelial
cells from human lung cancer cells; its identity with insulin-like growth factor II. Jpn. J. Cancer Res. 86: 202ー207, 1995.
109.Fujioka, H., Okabe, T., and Yamaguchi, H. Purification and characterization of angiotensin II degradation factor from porcine endothelial cells. Tohoku J. Exp. Med. 177: 183-192,1995.
110.Okabe,T., Fujisawa, M., Yamane, A., and Yamamoto, K. Long-term remission of bronchial asthma by holistic therapy with traditional Chinese medicine. Eur. Respir. J.16(Suppl.31): 32s, 2000
111.Nakanishi,H.,Suda,T.,Katoh,M.,Watanabe,A.,Igishi,T.,Kodani,M.,
Matsumoto,S.,Nakamoto,M.,Shigeoka,Y.,Okabe,T.,Oshimura,M.,and Shimizu,E. Loss of imprinting of PEG/MEST in lung cancer cell lines. Oncol. Rep. 12: 1273-1278,2004
112.Kaneko,A.,Cho,S.,Hirai,K.,Okabe,T.,Iwasaki,K.,Ouchi,Y.,Cyong,J.C. Hange-koboku-to, a Kampo medicine, modulates cerebral levels oh 5HT (5-hydroxytriptamine) and DA(dopamine) in mice. Phytother. Res. 19:491-495, 2005.
113.Yu, J., Eto. M., Akishita, M.,Kaneko, A., Ouchi, Y.and Okabe, T. Signaling pathway of nitric oxide production by ginsenoside Rb1 in human aortic endothelial cells: A possible involvement of androgen receptor. Biochem. Biophys. Res. Commun. 353:764-769, 2007.
114.Okabe, T., Fujisawa, M., Sekiya, T., Ichikawa, Y., and Goto, J. Successful treatment of spinocerebellar ataxia 6 with medicinal herbs. Geriatr. Gerontol. Int.7:199-201,2007.
115. Okabe, T. Differential diagnosis of arterial hypertension by systems review and treatment with medicinal herbs: A preliminary report. International Medical Journal (IMJ) 14;113-116, 2007.
116. Okabe, T. Differential diagnosis of bronchial asthma by systems review and induction of symptom-free remission with medicinal herbs: An alternative therapeutic approach. International Medical Journal (IMJ) 14: 117-121,2007.
117. Okabe T. Remission induction by systems therapy with medicinal herbs of inhaled steroid resistant asthma. International Medical Journal (IMJ) 14: 211-214,2007.
118. Tsuji K., Koizumi H., and Okabe T. Successful treatment of spondylolisthesis with medicinal herbs. Geriatr. Gerontol. Int. in press, 2008.
119. Yu, J., Eto. M., Kozaki K., Akishita M., Okabe, T.,and Ouchi Y. Raloxifene analogue LY 117018 suppresses oxidative stress - induced endothelial cell apoptosis through activating ERK1/2 signaling pathway. Eur. J. Pharmacol. in press, 2008.


喩 静 業績

1) 喩静、江頭正人、秋下雅弘、金子明代、大内尉義、岡部哲郎:Ginsenoside-Rb1の血管内皮細胞におけるNO産生に対する促進作用及びその機序の解析.第39回日本動脈硬化学会総会・抄録集.Page221.2007
2) Jing Yu, Masato Eto, Masahiro Akishita, Akiyo Kaneko, Yasuyoshi Ouchi2, Tetsuro Okabe1. Ginsenoside-Rb1 Activates Endothelial Nitric Oxide Synthase via Akt and ERK Activation. 8th Asia/oceania Regional Congress of Gerontology and Geriatrics. Page , 2007
3) J Yu, Eto M, Akishita M, Iijima K, Ouchi Y. Raloxifene Analog LY117018 Inhibits Endothelial Apoptosis by Activating MEK/ERK Signaling. XIV International Symposium on Atherosclerosis. Page217, 2006
4) 喩静、江頭正人、神崎恒一、秋下雅弘、大内尉義:Raloxifen Analog LY117018 Inhibits Oxidative Stress or TNF alpha Induced Apoptosis by Activating ERK Signaling in Vascular Endothelial Cells. 第70回記念日本循環器学会総会・抄録集.Page676.2006
5) 喩静、江頭正人、神崎恒一、小島太郎、秋下雅弘、大内尉義:LY117018の血管内皮細胞のアポトーシスに対する抑制作用およびその作用機序の解析.第37回日本動脈硬化学会総会・抄録集.Page239.2005


論文

1. J Yu., Eto. M., Kozaki K., Akishita M., Okabe, T.,and Ouchi Y. Raloxifene analogue LY 117018 suppresses oxidative stress -induced endothelial cell apoptosis through activation of ERK 1/2 signaling pathway. Eur. J. Pharmacol. in press, 2008.
2. J Yu., Eto. M., Akishita, M.,Kaneko, A., Ouchi, Y.and Okabe, T. Signaling pathway of nitric oxide production by ginsenoside Rb1 in human aortic endothelial cells: A possible involvement of androgen receptor. Biochem. Biophys. Res. Commun. 353:764-769, 2007.
3. 喩静、岡部哲郎 脳神経疾患の漢方治療—脳卒中を中心にー 漢方と最新治療 14(3)217−221,2005
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