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Watanabe M, Ishimaru N, Ashrin MN, Arakaki R, Yamada A, Ichikawa T, Hayashi Y. PLoS One 6:e19017, 2011.

Lei Y, Ripen AM, Ishimaru N, Ohigashi I, Nagasawa T, Jeker LT, Bösl MR, Holländer GA, Hayashi Y, Malefyt RW, Nitta T, Takahama Y. XCL1-mediated medullary accumulation of thymic dendritic cells contributes to thymic development of regulatory T cells. J Exp Med. 208:383-394, 2011.

Atelocollagen-mediated systemic administration of myostatin-targeting siRNA improves muscular atrophy in caveolin-3-deficient mice. Kawakami E, Kinouchi N, Adachi T, Ohsawa Y, Ishimaru N, Ohuchi H, Sunada Y, Hayashi Y, Tanaka E and Noji S. Dev Growth Differ 53:48-54, 2011

Yamano T, Watanabe S, Hasegawa H, Suzuki T, Abe R, Tahara H, Nitta T, Ishimaru N, Sprent J, Kishimoto H. Ex-vivo expanded DC induce donor-specific central and peripheral tolerance and prolong the acceptance of donor skin allografts. Blood 117:2640-2648, 2011.


Adachi T, Kawakami E, Ishimaru N, Ochiya T, Hayashi Y, Ohuchi H, Tanihara M, Tanaka E, Noji S. Delivery of small interfering RNA with a systemic collagen poly(Pro-Hyp-Gly) for gene silencing in vitro and in vivo. Dev Growth Differ. 52:693-699, 2010.

Sakai T, Liu L, Teng X, Ishimaru N, Mukai-Sakai R, Tran NH, Kim SM, Sano N, Hayashi Y, Kaji R, Fukui K. Inflammatory disease and cancer with a decrease in Kupffer cell numbers in Nucling-knockout mice. Int J Cancer. 126:1079-94. 2010.
Yamada A, Ishimaru N, Arakaki R, Katunuma N, Hayashi Y. Cathepsin L inhivition prevents murine autoimmune diabetes via suppression of CD8+ T cell activity. PLoS One. 5:e12894, 2010.

Nitta T, Murata S, Sasaki K, Fujii H, Ripen AM, Ishimaru N, Koyasu S, Tanaka K, Takahama Y. Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells. Immunity. 32:29-40. 2010. (20.589)


Yamakoshi K, Takahashi A, Hirota F, Nakayama R, Ishimaru N, Kubo Y, Mann DJ, Ohmura M, Hirao A, Saya H, Arase S, Hayashi Y, Nakao K, Matsumoto M, Ohtani N, Hara E. Real-time in vivo imaging of p16Ink4a reveals cross talk with p53. J Cell Biol. 186:393-407. 2009.

Ishimaru N, Nitta T, Arakaki R, Yamada A, Lipp M, Takahama Y, Hayashi Y. In situ patrolling of regulatory T cells is essential for protecting autoimmune exocrinopathy. PLoS One. 5:e8588. 2010.

Iwata T, Kuwajima M, Sukeno A, Ishimaru N, Hayashi Y, Wabitsch M, Mizusawa N, Itakura M, Yoshimoto K. YKL-40 secreted from adipose tissue inhibits degradation of type I collagen. Biochem Biophys Res Commun. 388:511-6. 2009.
Arakaki R, Nagaoka A, Ishimaru N, Yamada A, Yoshida S, Hayashi Y. Role of plasmacytoid dendritic cells for aberrant class II expression in exocrine glands from estrogen-deficient mice of healthy background. Am J Pathol. 174:1715-1724. 2009.

Ishimaru N, Takagi A, Kohashi M, Yamada A, Arakaki R, Kanno J, Hayashi Y. Neonatal exposure to low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin causes autoimmunity due to the disruption of T cell tolerance. J Immunol. 182:6576-6586. 2009.


Ishimaru N, Arakaki R, Yoshida S, Yamada A, Noji S, Hayashi Y. Expression of the retinoblastoma protein RbAp48 in exocrine glands leads to Sjogren's syndrome-like autoimmune exocrinopathy. J Exp Med. 205:2915-2927. 2008.

Hikosaka Y, Nitta T, Ohigashi I, Yano K, Ishimaru N, Hayashi Y, Matsumoto M, Matsuo K, Penninger JM, Takayanagi H, Yokota Y, Yamada H, Yoshikai Y, Inoue J, Akiyama T, Takahama Y. The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity. 29:438-450. 2008.

Kinouchi N, Ohsawa Y, Ishimaru N, Ohuchi H, Sunada Y, Hayashi Y, Tanimoto Y, Moriyama K, Noji S. Atelocollagen-mediated local and systemic applications of myostatin-targeting siRNA increase skeletal muscle mass. Gene Ther. 15:1126-30. 2008.

Ishimaru N, Yamada A, Kohashi M, Arakaki R, Takahashi T, Izumi K, Hayashi Y. Development of inflammatory bowel disease in Long-Evans Cinnamon rats based on CD4+CD25+Foxp3+ regulatory T cell dysfunction. J Immunol. 180:6997-7008.2008.

Kohashi M, Ishimaru N, Arakaki R, Hayashi Y. Effective treatment with oral administration of rebamipide in a mouse model of Sjogren's syndrome. Arthritis Rheum. 58:389-400. 2008.


Ohtani N, Imamura Y, Yamakoshi K, Hirota F, Nakayama R, Kubo Y, Ishimaru N, Takahashi A, Hirao A, Shimizu T, Mann DJ, Saya H, Hayashi Y, Arase S, Matsumoto M, Kazuki N, Hara E. Visualizing the dynamics of p21 (Waf1/Cip1) cyclin-dependent kinase inhibitor expression in living animals. Proc Natl Acad Sci U S A. 104:15034-9. 2007.

Satomura K, Tokuyama R, Yamasaki Y, Yuasa T, Tatehara S, Ishimaru N, Hayashi Y, Nagayama M. Possible involvement of stem cell factor and endothelin-1 in the emergence of pigmented squamous cell carcinoma in oral mucosa. J Oral Pathol Med. 36:621-4. 2007.

Izawa T, Ishimaru N, Moriyama K, Kohashi M, Arakaki R, Hayashi Y. Crosstalk between RANKL and Fas signaling in dendritic cells controls immune tolerance. Blood. 110:242-250. 2007.


Ishimaru N, Kishimoto H, Hayashi Y, Sprent J. Regulation of naive T cell function by the NF-kappaB2 pathway. Nat Immunol. 7:763-772. 2006.

Ishimaru N, Arakaki R, Omotehara F, Yamada K, Mishima K, Saito I, Hayashi Y. Novel role for RbAp48 in tissue-specific, estrogen deficiency-dependent apoptosis in the exocrine glands. Mol Cell Biol. 26:2924-2935. 2006.

Katunuma N, Le QT, Murata E, Matsui A, Majima E, Ishimaru N, Hayashi Y, Ohashi A. A novel apoptosis cascade mediated by lysosomal lactoferrin and its participation in hepatocyte apoptosis induced by D-galactosamine. FEBS Lett. 580:3699-705. 2006.

Suzue N, Nikawa T, Onishi Y, Yamada C, Hirasaka K, Ogawa T, Furochi H, Kosaka H, Ishidoh K, Gu H, Takeda S, Ishimaru N, Hayashi Y, Yamamoto H, Kishi K, Yasui N. Ubiquitin ligase Cbl-b downregulates bone formation through suppression of IGF-I signaling in osteoblasts during denervation. J Bone Miner Res. 21:722-34. 2006.

Katunuma N, Ohashi A, Sano E, Ishimaru N, Hayashi Y, Murata E. Catechin derivatives: specific inhibitor for caspases-3, 7 and 2, and the prevention of apoptosis at the cell and animal levels. FEBS Lett. 580:741-6. 2006.

Azuma M, Ashida Y, Tamatani T, Motegi K, Takamaru N, Ishimaru N, Hayashi Y, Sato M. Cepharanthin, a biscoclaurine alkaloid, prevents destruction of acinar tissues in murine Sjogren's syndrome. J Rheumatol. 33:912-920. 2006.


Miyazaki K, Takeda N, Ishimaru N, Omotehara F, Arakaki R, Hayashi Y. Analysis of in vivo role of alpha-fodrin autoantigen in primary Sjogren's syndrome. Am J Pathol. 167:1051-1059. 2005. (5.673)

Kuroda N, Mitani T, Takeda N, Ishimaru N, Arakaki R, Hayashi Y, Bando Y, Izumi K, Takahashi T, Nomura T, Sakaguchi S, Ueno T, Takahama Y, Uchida D, Sun S, Kajiura F, Mouri Y, Han H, Matsushima A, Yamada G, Matsumoto M. Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice. J Immunol. 174:1862-1870. 2005.


Kobayashi M, Yasui N, Ishimaru N, Arakaki R, Hayashi Y. Development of autoimmune arthritis with aging via bystander T cell activation in the mouse model of Sjogren's syndrome. Arthritis Rheum. 50:3974-3984. 2004.

Hayashi Y, Ishimaru N, Arakaki R, Tsukumo S, Fukui H, Kishihara K, Shiota H, Yasutomo K, Hayashi Y. Effective treatment of a mouse model of Sjogren's syndrome with eyedrop administration of anti-CD4 monoclonal antibody. Arthritis Rheum. 50:2903-2910. 2004.

Yoneda T, Ishimaru N, Arakaki R, Kobayashi M, Izawa T, Moriyama K, Hayashi Y. Estrogen deficiency accelerates murine autoimmune arthritis associated with receptor activator of nuclear factor-kappa B ligand-mediated osteoclastogenesis. Endocrinology. 145:2384-2391. 2004.


Arakaki R, Ishimaru N, Saito I, Kobayashi M, Yasui N, Sumida T, Hayashi Y. Development of autoimmune exocrinopathy resembling Sjogren's syndrome in adoptively transferred mice with autoreactive CD4+ T cells. Arthritis Rheum. 48:3603-3609. 2003.

Ogawa K, Nagahiro S, Arakaki R, Ishimaru N, Kobayashi M, Hayashi Y. Anti-alpha-fodrin autoantibodies in Moyamoya disease. Stroke. 34:e244-246. 2003.

Ishimaru N, Arakaki R, Watanabe M, Kobayashi M, Miyazaki K, Hayashi Y. Development of autoimmune exocrinopathy resembling Sjogren's syndrome in estrogen-deficient mice of healthy background. Am J Pathol. 163:1481-1490. 2003.


Saegusa K, Ishimaru N, Yanagi K, Arakaki R, Ogawa K, Saito I, Katunuma N, Hayashi Y. Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity. J Clin Invest. 110:361-369. 2002.

Saegusa K, Ishimaru N, Yanagi K, Mishima K, Arakaki R, Suda T, Saito I, Hayashi Y. Prevention and induction of autoimmune exocrinopathy is dependent on pathogenic autoantigen cleavage in murine Sjogren's syndrome. J Immunol. 169:1050-1057. 2002.


Ishimaru N, Yanagi K, Ogawa K, Suda T, Saito I, Hayashi Y. Possible role of organ-specific autoantigen for Fas ligand-mediated activation-induced cell death in murine Sjogren's syndrome. J Immunol. 167(10):6031-6037. 2001.


Saegusa K, Ishimaru N, Haneji N, Yanagi K, Yoneda T, Saito I, Hayashi Y. Mechanisms of neonatal tolerance induced in an animal model for primary Sjogren's syndrome by intravenous administration of autoantigen. Scand J Immunol. 52:264-270, 2000.

Saegusa K, Ishimaru N, Yanagi K, Haneji N, Nishino M, Azuma M, Saito I, Hayashi Y. Autoantigen-specific CD4+CD28low T cell subset prevents autoimmune exocrinopathy in murine Sjogren's syndrome. J Immunol. 165:2251-2257, 2000.
Ishimaru N, Yoneda T, Saegusa K, Yanagi K, Haneji N, Moriyama K, Saito I, Hayashi Y. Severe destructive autoimmune lesions with aging in murine Sjogren's syndrome through Fas-mediated apoptosis. Am J Pathol. 156:1557-1564, 2000.

Aota K, Azuma M, Yamashita T, Tamatani T, Motegi K, Ishimaru N, Hayashi Y, Sato M. 5-Fluorouracil induces apoptosis through the suppression of NF-kappaB activity in human salivary gland cancer cells. Biochem Biophys Res Commun. 273:1168-74. 2000.

Saegusa K, Ishimaru N, Yanagi K, Haneji N, Nishino M, Azuma M, Saito I, Hayashi Y. Treatment with anti-CD86 costimulatory molecule prevents the autoimmune lesions in murine Sjogren's syndrome (SS) through up-regulated Th2 response. Clin Exp Immunol. 119:354-360, 2000.


Ishimaru N, Saegusa K, Yanagi K, Haneji N, Saito I, Hayashi Y. Estrogen deficiency accelerates autoimmune exocrinopathy in murine Sjogren's syndrome through Fas-mediated apoptosis. Am J Pathol. 155:173-181, 1999.

Takahashi M, Ishimaru N, Yanagi K, Saegusa K, Haneji N, Shiota H, Hayashi Y. Requirement for splenic CD4+ T cells in the immune privilege of the anterior chamber of the eye. Clin Exp Immunol. 116:231-237, 1999.

Saito I, Haruta K, Shimuta M, Inoue H, Sakurai H, Yamada K, Ishimaru N, Higashiyama H, Sumida T, Ishida H, Suda T, Noda T, Hayashi Y, Tsubota K. Fas ligand-mediated exocrinopathy resembling Sjogren's syndrome in mice transgenic for IL-10. J Immunol. 162:2488-2494, 1999.


Yanagi K, Ishimaru N, Haneji N, Saegusa K, Saito I, Hayashi Y. Anti-120-kDa alpha-fodrin immune response with Th1-cytokine profile in the NOD mouse model of Sjogren's syndrome. Eur J Immunol. 28:3336-3345, 1998.

Tsubota K, Saito I, Ishimaru N and Hayashi Y: Use of topical cyclosporin A in a primary Sjogren's syndrome mouse model. Invest Ophthalmol Vis Sci 39:1551-1559, 1998


Yanagi K, Haneji N, Ishimaru N, Saito I, Hayashi Y. Analysis of T cell receptor Vbeta usage in the autoimmune sialadenitis of non-obese diabetic (NOD) mice. Clin Exp Immunol. 110:440-446, 1997.

Takahashi M, Ishimaru N, Yanagi K, Haneji N, Saito I, Hayashi Y. High incidence of autoimmune dacryoadenitis in male non-obese diabetic (NOD) mice depending on sex steroid. Clin Exp Immunol. 109:555-561. 1997.


Ishimaru N, Haneji N, Hamano H, Yanagi K, Hayashi Y. Accelerated onset of age-related autoimmune lesions in MRL/+ mice by ovariectomy. Mech Ageing Dev 93:145-156, 1997.

Hamano H, Haneji N, Yanagi K, Ishimaru N, Hayashi Y. Expression of HLA-DR and cytokine genes on interferon-gamma-stimulated human salivary gland cell line. Pathobiology 64:255-261, 1996.


Hayashi Y, Hamano H, Haneji N, Ishimaru N, Yanagi K. Biased T cell receptor V beta gene usage during specific stages of the development of autoimmune sialadenitis in the MRL/lpr mouse model of Sjogren's syndrome. Arthritis Rheum. 38:1077-1084. 1995.