/* ===========================
   	　　基本設定
   =========================== */
:root{
  --brand:#0a4a9e;
  --brand-ink:#072e60;
  --accent:#f59f00;
  --text:#2b2b2b;
  --muted:#6b7280;
  --bg:#f6f8fb;
  --card:#ffffff;
  --line:#e5e7eb;
}
*{box-sizing:border-box}
html,body{margin:0;padding:0}
body{font-family: -apple-system,BlinkMacSystemFont,"Segoe UI","Hiragino Kaku Gothic ProN","Meiryo",sans-serif;color:var(--text);background:var(--bg); line-height:1.75;}
a{color:var(--brand); text-decoration:none}
a:hover{text-decoration:underline}
@media (prefers-color-scheme: dark){
 :root{--bg:#0f1320; --card:#131a2b; --text:#e8ecf5; --line:#283148}
 .hero::after{background:linear-gradient(180deg,rgba(0,0,0,.45),rgba(0,0,0,.7))}
 a{color:#8bb7ff}
 .badge{background:#203155;color:#cfe0ff;border-color:#30436a}
 }
/* ===========================
   	　　ヘッダー
   =========================== */
.header{color:#fff; padding:18px 20px; border-bottom:4px solid #072e60;background-image: url("images/geometric pattern.png");background-size: cover;background-position: left center;background-repeat: no-repeat;}
.header .inner{max-width:1200px;margin:0;display:flex;flex-direction: row;flex-wrap: nowrap;gap:14px;align-items:center;padding:8px 14px;background: rgba(255,255,255,0.88);backdrop-filter: blur(6px);-webkit-backdrop-filter: blur(6px);border-radius:12px;width: fit-content;}
.header img.logo{height:36px;width:auto;}
.header h1{margin:0;font-size:22px;font-weight:700;letter-spacing:.2px;background: linear-gradient(90deg,#0b3d86 0%, #c9a227 100%);-webkit-background-clip: text;-webkit-text-fill-color: transparent;text-shadow: 0 2px 4px rgba(0,0,0,0.25);}
.header .sub{font-size:13px;margin-top:2px;color:#0b3d86;border-top:2px solid #0b3d86;width:fit-content;}
.header-home{display:flex;align-items:center;gap:14px;text-decoration:none;color:inherit;}
.header-home h1{ margin:0; }
.header-home .sub{ margin-top:2px; }
@media (max-width: 600px) {
  .header .inner{gap:10px;padding:6px 10px;}
  .header img.logo{height:36px;}
  .header h1{font-size: 16.5px; -webkit-text-fill-color:#0b3d86;background:none;line-height: 1.2;}
  .header .sub{font-size: 9px;border-top: 1px solid rgba(11,61,134,0.45);}
}
/* ===========================
   	　　フッター
   =========================== */
.footer{margin-top:24px; padding:18px 20px; background:#fdfdfd; color:#666; border-top:1px solid var(--line); font-size:14px;}
.footer .inner{max-width:1200px;margin:0 auto;padding:0 12px}
/* ===========================
   	　　ヒーロー
   =========================== */
.hero {position: relative; height: 360px; overflow: hidden;}
.hero-img {width: 100%; height: 100%; object-fit: cover; display: block;}
.hero .copy{position:absolute;top:40%;left:3%;transform:translateY(-50%);text-align:left;text-shadow:0 2px 4px rgba(0,0,0,0.25);}
.hero-title{display:flex;align-items:center;gap:16px;}
.hero-logo{height:100px;width:auto;}
.hero h2{margin:0;font-size:40px;font-weight:700;line-height:1.3;background: linear-gradient(90deg, #1e3a8a, #facc15);-webkit-background-clip: text;-webkit-text-fill-color: transparent;}
.hero-sub{margin-top:.6rem;color:#1e3a8a;font-size:16px;}
.hero-text{background: rgba(255,255,255,0.75);padding: 10px 16px;border-radius: 10px;backdrop-filter: blur(4px);}
@media (max-width:600px){
 .hero-title{flex-direction:column;align-items:flex-start;gap:8px;}
 .hero-logo{height:80px;}
 .hero h2{font-size:20px;line-height:1.4;}
 .hero-sub{font-size:11px;}
 .hero .copy{top:50%;left:5%;}
 .hero {height: 220px;}
 }
/* ===========================
   	　　ボタン
   =========================== */
.btn{display:inline-block; margin-top:14px; padding:10px 16px; border-radius:8px;background:#ffffff; color:#0a4a9e; font-weight:700; border:2px solid transparent;}
.btn:hover{background:#eef4ff; text-decoration:none}
/* ===========================
   	　レイアウト
   =========================== */
.container{max-width:1200px;margin:20px auto;padding:0 16px; display:grid; grid-template-columns:280px 1fr; gap:22px}
.sidebar{background:var(--card); border:1px solid var(--line); border-radius:12px; padding:14px; height:max-content; position:sticky; top:14px;}
.nav{list-style:none;margin:0;padding:0}
.nav a{display:block; padding:10px 12px; border-radius:8px; color:var(--text); border:1px solid transparent;}
.nav a:hover{background:#f0f6ff; border-color:#d7e6ff}
.nav .current{background:#e9f2ff; border-color:#c8d9ff; font-weight:700; color:var(--brand-ink)}
.main{min-width:0}
.card{background:var(--card); border:1px solid var(--line); border-radius:12px; padding:20px; margin-bottom:18px;}
h2{margin:0 0 10px; color:var(--brand-ink); border-bottom:3px solid var(--brand); padding-bottom:6px}
@media (max-width: 900px) {
 .container {display: grid;grid-template-columns: 1fr;grid-template-areas:"main""sidebar";padding: 0 12px;}
 .nav a {padding: 12px 14px;font-size: 15px;}
 .card {padding: 16px;}
 .main {grid-area: main;}
 .sidebar {grid-area: sidebar;position: static;margin-top: 16px;width: 100%;}
  h2 {font-size: 18px;}
 }
@media (max-width: 600px) {
 .sidebar {padding: 10px;border-radius: 10px;}
 .nav a {padding: 8px 10px;font-size: 14px;}
 .container {padding: 0 8px;}
 }
/* ===========================
   　　グリッド（トップ）
   =========================== */
.grid-3{display:grid; grid-template-columns:repeat(3,1fr); gap:14px}
.grid-3 .card h3{margin-top:0}
.badge{display:inline-block; font-size:12px; color:#07366e; background:#dfeafe; border:1px solid #c7dcff;padding:2px 8px; border-radius:999px; margin-left:6px;}
/* ===========================
   　　　  グリッド
   =========================== */
.grid-3 { display:grid; grid-template-columns:repeat(3,1fr); gap:14px; }
.mini-card{display:block;background:#fff;border:1px solid var(--line, #e5e7eb);border-radius:12px;overflow:hidden;padding:0;text-decoration:none;color:inherit;text-align:center;}
.mini-card .mini-thumb{display:block;width:100% !important;height:140px !important;object-fit:cover;margin:0 0 8px 0;border-radius:0;}
.mini-card h3{margin:10px 0 12px;padding:0 12px;font-size:16px;color:var(--brand-ink);}
.figures {display: flex;gap: 16px;flex-wrap: wrap;}
.figures img {width: 48%;}
.figures figcaption {font-size: 13px;color: #555;text-align: center;margin-top: 4px;}
.theme-grid {display: grid;grid-template-columns: repeat(3, 1fr);gap: 16px;}
.theme-card {display: block;background: #fff;border: 1px solid var(--line, #e5e7eb);border-radius: 12px;overflow: hidden;color: inherit;text-decoration: none;transition: transform .08s ease, box-shadow .12s ease;}
.theme-card:hover { transform: translateY(-2px); box-shadow: 0 4px 10px rgba(0,0,0,.06); }
.theme-thumb {width: 100%;height: 160px;object-fit: cover;display: block;}
.theme-body { padding: 12px 14px;}
.theme-body h3 { margin: 0 0 6px; font-size: 16px; color: var(--brand-ink,#0a3b78);}
.theme-body p { margin: 0; color: #475569; font-size: 14px;}
.year-nav {margin-bottom: 1em;font-size: 14px;}
@media (max-width: 900px){.topics-grid,.theme-grid,.grid-3{grid-template-columns: repeat(2, 1fr);}}
@media (max-width: 768px){.topics-grid,.theme-grid,.grid-3{grid-template-columns: 1fr;}.topics-card{width:100%;}.topics-thumb{width:100%;
height:auto;}}
/* ===========================
   	　トピックス
   =========================== */
.topics-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:14px}
.topics-card{display:block;background:var(--card);border:1px solid var(--line);border-radius:12px;overflow:hidden;text-decoration:none;color:inherit}
.topics-thumb{aspect-ratio:16/9;width:100%;object-fit:cover;display:block}
.topics-body{padding:12px 14px}
.topics-meta{font-size:12px;color:var(--muted);margin-bottom:6px}
.topics-title{font-weight:700;margin:0 0 6px;font-size:16px;color:var(--brand-ink)}
.topics-ex{margin:0;color:#444}
.badge-new{display:inline-block;font-size:11px;background:#ffefcc;color:#7a4a00;border:1px solid #f2cf7a;border-radius:999px;padding:2px 8px;margin-left:6px}
@media (max-width: 900px){ .news-grid{grid-template-columns:1fr} }
@media (min-width: 901px) and (max-width: 1200px){ .news-grid{grid-template-columns:repeat(2,1fr)} }
details {margin-bottom: 8px;padding: 6px 10px;border: 1px solid #ccc;border-radius: 6px;background: #fafafa;}
details[open] {background: #f0f8ff;}

.section{background:#fff;border-radius:12px;padding:22px;margin:16px 0;box-shadow:0 2px 6px rgba(0,0,0,.05)}
.section h2{font-size:20px;margin:0 0 10px;color:#0a3b78;border-left:4px solid #0a3b78;padding-left:8px}
.pub{list-style:none;margin:0;padding:0}
.pub li{margin:14px 0;line-height:1.6;padding-bottom:12px;border-bottom:1px dashed #ddd}
.pub li strong{display:block;font-weight:700;font-size:1.05em;margin-bottom:4px}
.nav-year{display:flex;gap:10px;margin-bottom:10px;font-size:14px}
.nav-year a{color:#0a3b78;text-decoration:none}
.nav-year a:hover{text-decoration:underline}
.nav-year .current{font-weight:700;color:#555;cursor:default}
.award-name{font-weight:700;color:#004080}
.awardee{font-style:italic;color:#444}
.title{display:block;margin-top:4px;color:#555}
.chart-img {max-width: 240px;width: 70%;height: auto;display:block;margin: 0 auto;}
@media (hover: none) and (pointer: coarse) {.topics-grid { grid-template-columns: 1fr; }}
/* ===========================
	      概要
   =========================== */
.professor-message{background:#ffffff;border-radius:14px;box-shadow:0 6px 18px rgba(0,0,0,0.06);}
.professor-message .message{max-width: 900px;}
.msg-h3{font-size: 18px;font-weight: 700;margin: 28px 0 10px;padding-left: 12px;border-left: 4px solid #0b3d86;color: #0b3d86;}
.msg-h3:first-of-type{margin-top: 10px;}
.professor-message p{margin: 10px 0 14px;text-align: justify;}
.msg-list{margin: 12px 0 18px 0;padding-left: 0;list-style: none;}
.msg-list li{position: relative;padding-left: 26px;margin-bottom: 10px;}
.msg-list li::before{content: "◆";position: absolute;left: 0;top: 0;color: #e0b400;font-size: 12px;transform: translateY(3px);}
/* ===========================
   	　　研究内容
   =========================== */
body.invivo .main .card + .card { margin-top: 16px; }
body.invivo .lead {font-size: 1.05rem;line-height: 1.9;color: #222;margin: 6px 0 2px;}
body.invivo ul {margin: 8px 0 6px 1.2em;padding: 0;}
body.invivo ul li {margin: 6px 0;line-height: 1.7;}
body.invivo .chart-img,
body.invivo .method-figure img,
body.invivo .figure img {max-width: 720px;width: 100%;height: auto;display: block;margin: 8px auto 4px;border-radius: 8px;}
body.invivo .figure,
body.invivo .method-figure {text-align: center;}
body.invivo .figcap {font-size: 0.92rem;color: var(--muted, #666);margin-top: 4px;}
body.invivo .card h2 {font-size: 20px;color: #0a3b78;border-left: 4px solid #0a3b78;padding-left: 8px;margin: 0 0 10px;}
body.invivo .pub-mini {list-style: none;margin: 0;padding: 0;}
body.invivo .pub-mini li {margin: 10px 0;padding-bottom: 8px;border-bottom: 1px dashed #e3e5e8;}
body.invivo .pub-mini a {color: var(--brand-ink, #0a3b78);text-decoration: none;}
body.invivo .pub-mini a:hover { text-decoration: underline;}
.pub-list {margin: 0;padding-left: 1.4em;font-size: 0.9rem;color: #333;}
.pub-list li {margin: 6px 0;line-height: 1.4;}
.pub-list a {color: var(--brand-ink, #0a3b78);font-size: 0.85rem;text-decoration: none;}
.pub-list a:hover {text-decoration: underline;}
.research-section h2 {border-bottom: 2px solid #1a4f8b;padding-bottom: 6px;margin-bottom: 20px;font-size: 1.5em;color: #1a4f8b;}
.research-section h3 {margin-top: 20px;font-size: 1.2em;color: #333;}
.research-section p {margin: 8px 0 16px 0;line-height: 1.7;font-size: 0.95em;}
/* ===========================
   	　　メンバー
   =========================== */
.member-photo{width: 130px;height: 170px;overflow: hidden;border-radius: 12px;margin: 0 0 10px 0;  margin-bottom:0px;}
.member-photo img{width: 100%;height: 100%;display: block;object-fit: cover;object-position: center 22%;}
.member-card{width: 200px;text-align: left;}
.member-card p{margin:0px 0;line-height:0;}
.member-card a{font-size:15px;margin-right:6px;}
.card img{max-width: 100%;height: auto;}
.member-grid{display:grid;grid-template-columns:repeat(3, 1fr);gap:24px 28px;}
summary {font-weight: bold;cursor: pointer;list-style: none;}
summary::-webkit-details-marker {display: none;}
summary::before {content: "▶ ";font-size: 12px;}
details[open] summary::before {content: "▼ ";}
@media (max-width: 900px){.member-grid{grid-template-columns: repeat(2, 1fr);gap:18px 16px;}
 .member-card, .member-photo{width:120px;}
 .member-photo{height:160px;margin:0 auto 6px;}
 }
@media (max-width: 600px){
 .member-grid{grid-template-columns:1fr;justify-items:start;}
 .member-card{width:100%;}}
 .member-photo{width:120px;height:160px;margin:0 0 6px 0;}
 .chart-wrap{display:flex;flex-wrap:wrap;gap:12px;justify-content:center;}
 }