Japanese Journal of Cardiovascular Surgery Vol44,No6

Three Cases of Coronary Artery Disease Associated with Hereditary Protein S Deficiency

Masamichi Ito Yasuhiro Kamikubo Makoto Takahira

(Cardiovascular Surgery, Kushiro City General Hospital, Kushiro, Japan)

We encountered 3 cases of protein S deficiency accompanied by coronary artery disease(CAD). None of the patients had been given diagnoses of congenital protein S deficiency prior to referral to our department. Our examination revealed three-vessel CAD with distal lesions. CAD was of early onset in two patients in their 40s. In 2 of the 3 patients, off-pump coronary artery bypass was performed, and continuous heparin infusion was postoperatively changed to oral warfarin. These patients had a favorable postoperative course and graft patency was maintained. In the third patient, who underwent repeated percutaneous coronary revascularization, in whom coronary artery bypass was contrain-dicated, oral warfarin alleviated the symptoms of CAD. No disease progression was observed in coronary angiography performed at the one-year follow-up examination.


Jpn. J. Cardiovasc. Surg. 44:354-357(2015)

Keywords:hereditary protein S deficiency:coronary artery disease:coronary artery bypass grafting

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