Japanese Journal of Cardiovascular Surgery Vol44,No6

A Suspected Case of Heyde Syndrome with Bleeding of the Small Intestine before Aortic Valve Replacement for Severe Aortic Valve Stenosis

Takanori Kono Toru Takaseya Yuichiro Hirata
Kumiko Wada Takahiro Shojima Kazuyoshi Takagi
Koji Akasu Koichi Arinaga Hidetoshi Akashi
Hiroyuki Tanaka    

(Department of Cardiovascular Surgery, Kurume University School of Medicine, Kurume, Japan)

The patient was a 74-year-old woman who had undergone mitral valve replacement with a mechanical valve for rheumatic mitral valve stenosis at age 60. She was scheduled for aortic valve replacement for severe aortic stenosis. However, she had significantly worsening anemia before the operation. Capsule endoscopy showed angiodysplasia with bleeding in her small intestine, which was considered the cause of the anemia. Because of progressive anemia, we tried embolization under angiography. However, there was no evidence of extravasation. Neither melena nor exacerbation of anemia was observed, and she underwent aortic valve replacement. She was discharged on postoperative day 22 without gastrointestinal bleeding. Heyde syndrome is aortic valve stenosis associated with gastrointestinal bleeding induced by von Willebrand disease and angiodysplasia in small intestine. Molecular multimeric analysis of von Willebrand factor and the existence of angiodysplasia with hemorrhage of the digestive tract are important for definitive diagnosis. Capsule endoscopy, which is a general examination, is more useful for diagnosis than molecular multimeric analysis of von Willebrand factor. Aortic valve replacement is the only therapeutic option for Heyde syndrome. It is important to decide the appropriate timing of AVR with cardiopulmonary bypass.


Jpn. J. Cardiovasc. Surg. 44:346-349(2015)

Keywords:Heyde syndrome;aortic stenosis;angiodysplasia;von Willebrand factor

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