Collagen Gel Droplet-Embedded Culture Drug Sensitivity Test(CD-DST) for a Leiomyosarcoma Originating in the Inferior Vena Cava

(Department of Surgery II, Kochi Medical School, Nangoku, Japan)

Nobuo Kondo Masaki Yamamoto Hideaki Nishimori
Takashi Fukutomi Seiichiro Wariishi Kazuki Kihara
Miwa Tashiro Kazumasa Orihashi
The collagen gel droplet-embedded culture drug sensitivity test(CD-DST)identifies effective anticancer drug using resected tumor specimen, enabling tailor-made chemotherapy for a rare tumor. We report a case of the patient with leiomyosarcoma originating in the inferior vena cava, to which CD-DST was applied. This application has not been previously reported to the best of our knowledge. A 61-year-old woman consulted a nearby hospital because of abdominal pain. Computed tomography revealed an inferior vena cava tumor. The tumor was resected with the inferior vena cava, which was reconstructed with a 16mm ePTFE graft. The tumor was diagnosed as leiomyosarcoma histopathologically. CDDP, VP-16, ADR, and VDS were CD-DST showed the tumor to be sensitive. Her postoperative course has been good without recurrence of tumor for 6 months, and the results of CD-DST may be helpful for chemotherapy strategy in case of recurrence.
  Jpn. J. Cardiovasc. Surg. 42:124-127(2013)

Keywords:leiomyosarcoma in the inferior Vena cava, CD-DST, reconstruction of inferior Vena cava, anticancer drug sensitive test