A Case of Disseminated Intravascular Coagulation Complicating Thoracic Aortic Aneurysm for Which Recombinant Human Soluble Thrombomodulin Was Effective

(Cardiovascular Surgery, Tokyo Jikeikai University, Kashiwa Hospital, Kashiwa, Japan, Cardiovascular Surgery, Jichi Medical University Hospital* Shimotsuke, Japan, and Cardiovascular Surgery, Tokyo Jikeikai University Hospital**, Tokyo, Japan)

Ken Nakamura Koji Kawahito* Hirokuni Naganuma
Kei Tanaka Yoko Matsumura Noriyasu Kawada
Norimasa Haijma Kazuhiro Hashimoto**
Chronic disseminated intravascular coagulation(DIC)complicates 5.7% of thoracic aortic aneurysm. DIC with thoracic aortic aneurysm is characterized by hyperfibrinolysis, but usually shows a stable condition in a state of compensated non-overt DIC with limited hemorrhagic symptoms. However, in some cases, hemorrhage caused by external factors may induce uncompensated overt DIC and lead to serious hemorrhagic tendencies. In the present study, we report a patient with a thoracic aortic aneurysm complicated by DIC who exhibited marked hemorrhagic tendencies. DIC remarkably improved following administration of recombinant human soluble thrombomodulin.
  Jpn. J. Cardiovasc. Surg. 41:148-151(2012)

Keywords:recombinant human soluble thrombomodulin, disseminated intravascular coagulation, thoracic aortic aneurysm