Early Induction of Continuous Hemodiafiltration for the Prevention of Organ Failure after Cardiac Surgery

iDepartment of Cardiovascular Surgery, Teikyo University School of Medicine, and Present address:Clinical Pathology, Showa University Hospital, Tokyo, Japanj

Satoshi Kugawa
Systemic inflammation after cardiac surgery using cardiopulmonary bypassiCPB), is closely associated with postoperative organ dysfunction. We evaluated the efficacy of continuous hemodiafiltrationiCHDFjin controlling postoperative organ dysfunction, focusing on serum inflammatory substances and organ protection. We enrolled 14 patients with postoperative circulatory collapse. The mean age of patients was 71 years. Heart valve surgery was performed in 9 patients, coronary artery bypass grafting in 5 and graft replacement of the thoracic aorta in 2. The mean CPB time was 297}28 min. CHDF was initiated on the first or second postoperative day in 12 patients. A polysulfone membrane dialyzer and nafamostat mesilate were used for CHDF. 1jOn blood examinations, serum IL-6 and IL-8 concentrations decreased 12 h after the initiation of CHDFi216}5092}27pg/dl, 71}2330}7 pg/dl, respectively). Serum aldosterone decreased at 12 hi144}20104}21pg/ml). Four hours after the initiation of CHDF, systemic blood pressure significantly increased from 94}6 to 123}6 mmHg. The systemic vascular resistance index significantly increased from 1,431}137 dynseccm|5m2 to 1,893}167. Urine volume significantly increased from 42}38 to 100}29ml/h. Serum creatinine decreased from 2.1}0.3mg/dl to 1.7}0.2mg/dl on the second day. Respiratory function had significantly improved at 24 h. Early induction of CHDF reduced serum inflammatory substances, resulting in quick circulatory recovery without organ failure.
  Jpn. J. Cardiovasc. Surg. 39:294-299i2010j

KeywordsFextracorporeal circulation, continuous hemodiafiltration, circulatory collapse, organ failure