Successful Implantations of Autologous Peripheral Blood-Derived Mononuclear Cells Pretreated by Erythropoietin and Blood Donation in a Patient with Buerger Disease and Intractable Finger Ulcers

(Department of Cardiovascular Surgery, Department of Cardiovascular Medicine*, and Department of Medicine and Bioregulatory Sciences**, The University of Tokushima Graduate School, Tokushima, Japan)

Hajime Kinoshita Tamotsu Kanbara Hirotsugu Kurobe
Tatsuo Motoki Mikio Sugano Homare Yoshida
Takashi Kitaichi Masataka Sata* Toshio Matsumoto**
Tetsuya Kitagawa
A 48-year-old man with Buerger disease and intractable finger ulcers underwent successful transplantation of autologous peripheral blood-derived mononuclear cells pretreated with erythropoietin and blood donation to activate bone marrow function. Clinical symptoms on his finger ulcers improved significantly within 1 month after mononuclear cell transplantation, however, one of the intractable ulcers reappeared 2 months later. In total three transplantations were performed. Every cell transplantation revealed similar effectiveness 1 month later, and the interval of the subsequent disappearance of finger ulcers ranged from 3-6 months. There were no adverse effects based on this new therapy. These findings suggest that autologous peripheral mononuclear cell transplantation pretreated with erythropoietin and blood donation might be a non-invasive and safe alternatives for patients with Buerger disease and intractable finger ulcers.
  Jpn. J. Cardiovasc. Surg. 39:29-33(2010)

Keywords:Buerger disease, peripheral blood-derived, mononuclear cell transplantation, intractable ulcer, CD34-positive cell