Change of Oxidative Stress in Cases of Cardiac and Aortic Surgeries

(Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Kawasaki Medical School Hospital, Kurashiki, Japan)

Eiichiro Inagaki Sohei Hamanaka Hitoshi Minami
Hisao Masaki Atsushi Tabuchi Yasuhiko Yunoki
Hiroshi Kubo Takuro Yukawa Kazuo Tanemoto
We measured oxidative stress and antioxidative stress in clinical cases of cardiac and aortic surgery, especially in extracorporeal circulation cases. From June to October 2007, 18 cases who underwent cardiac and aortic surgery with extracorporeal circulation(ECC group)and 8 cases with an infra-renal abdominal aortic aneurysm(AAA group)were studied. We measured reactive oxygen metabolites(d-ROM)in oxidative stress for the operative time, after the operation endpoint, and at one day postoperatively, one, two, and three weeks postoperatively, and one, two, three, and four months postoperatively. Regarding d-ROM, the level in the ECC group was significantly higher than that in the AAA group(p<0.0001). Peak values were observed 3 weeks postoperatively in the ECC group and 2 weeks postoperatively in the AAA group. Although the oxidative stress increased in both groups, the peak value in the ECC group was more marked than that in the AAA group. We concluded that oxidative stress under surgical stress in cardiovascular surgery with extracorporeal circulation was higher than that under surgical stress in cardiovascular surgery for infra-renal abdominal aortic aneurysms.
  Jpn. J. Cardiovasc. Surg. 38:169-174(2009)