Four Cases of Delayed Hypersensitivity Reaction to Vancomycinafter Cardiac Surgery

(The Department of Cardiovascular Surgery, Anjo Kosei Hospital, Anjo, Japan)

Hitoshi Suzuki Shinji Kanemitsu Toshiya Tokui
Yuo Kanamori Yoshihiko Kinoshita
We report 4 cases of delayed hypersensitivity reaction to Vancomycin (VCM) after cardiac surgery. Case 1: A patient developed sepsis and mediastinitis after aortic valve replacement (AVR) for aortic valve insufficiency. Case 2: A patient developed mediastinitis after coronary artery bypass grafting (CABG) for effort angina pectoris. Case 3: A patient developed pneumonia after AVR for aortic valve infective endocarditis. Case 4: A patient developed sepsis after CABG for acute myocardial infarction. All of them received VCM intravenously and their infections improved. However, sudden high fever, skin rush and eosinophilia occurred 12 or 13 days after the initiation of therapy. These symptoms resolved after halting VCM administration. We need to take examine eosinophils when considering further administration of VCM.
@Jpn. J. Cardiovasc. Surg. 34F190-193 (2005)