Autologous Blood Donation and Open Heart Surgery in a Patient with Ischemic Heart Disease and Type I CD36 Deficiency

(Department of Cardiovascular Surgery, Shiga National Hospital, Yokaichi, Japan)

Satoru Okumura Jun Okawara Yoshinobu Maeda
In patients with type I CD36 deficiency, immunization with CD36 antigen (Naka) through pregnancy or transfusion, could produce anti-CD36 antibody (anti-Naka), and potentially lead to platelet transfusion refractoriness or posttransfusion purpura. We report a 72-year-old woman who had no history of pregnancy or previous blood transfusions. She had been treated medically for hypertension and heart failure since the age of 65 years. Type I CD36 deficiency was also diagnosed based on the findings of 123I--methyl-iodophenyl pentadecanoic acid cardiac scintigraphy. At 72 years of age, she suffered acute thromboembolism in the left external iliac artery. The thrombus was removed and a left external iliac artery to left superficial femoral artery bypass was performed without any blood transfusion. Echocardiography, left ventriculography and coronary angiography showed left ventricular aneurysm and coronary artery disease. Resection of the left ventricular aneurysm and coronary artery bypass grafting were performed without donor blood transfusion. Autotransfusion by autologous blood donation and intraoperative autologous blood transfusion was used to avoid sensitization by the CD36 antigen through donor blood transfusion. Autotransfusion should be performed to avoid complications associated with donor blood transfusion particularly in patients with type I CD36 deficiency.
@Jpn. J. Cardiovasc. Surg. 32: 297 -299 (2003)