The Effect of FR-167653 on Postoperative Intimal Hyperplasia of the Interposition Vein Graft in Rat

Mitsuhiro Yamamura Takashi Miyamoto Hideki Yao

(Department of Cardiovascular Surgery, Hyogo College of Medicine, Nishinomiya, Japan)

Recently we reported that tumor necrosis factor-ƒż (TNF-ƒż) mRNA expression and the development of postoperative intimal hyperplasia (IH) is different in rat epigastric vein interposition graft, compared to femoral artery re-anastomosis. We evaluated whether a TNF-ƒż suppressive agent, FR-167653 (Fujisawa Pharm. Co., Ltd., Osaka) could suppress IH or not. Eleven Lewis male rats (480}8g) were studied. The epigastric vein graft was interposed into the common femoral artery. They were divided into two groups: group FR (n=5) with 2.0ƒĘg/g of FR-167653, and group C (n=6) with same dose of saline instead of FR-167653. The intimal areas of vein grafts were measured at 4 weeks postoperatively. The mean intimal area in group FR was significantly decreased, compared with group C (0.160}0.057mm2 vs. 0.434}0.045mm2, P<0.01). These results suggest that the TNF-ƒż suppressive agent FR-167653 may suppress the postoperative intimal hyperplasia that occurs on the interposition vein graft in rats.
@Jpn. J. Cardiovasc. Surg. 31: 173-176 (2002)