Role of Neutrophils in Pulmonary Dysfunction during Cardiopulmonary Bypass
Hidenori Gohra Tomoe Katoh Toshiro Kobayashi
Masahiko Nishida Ken Hirata Akihito Mikamo
Haruhiko Okada Kimikazu Hamano Nobuya Zempo
Kensuke Esato

(First Department of Surgery,Yamaguchi University School of Medicine, Ube, Japan)

To test the hypothesis that neutrophils play a role in lung injury during cardiopulmonary bypass, granulocyte elastase and myeloperoxidase release from pulmonary circulation were measured, as well as the respiratory index, before and after cardiopulmonary bypass. The production of granulocyte elastase and myeloperoxidase in the pulmonary circulation, and the respiratory index also elevated significantly after cadiopulmonary bypass. Furthermore, the level of granulocyte elastase and myeloperoxidase released from pulmonary circulation correlated with the changes of the repiratory index and preoperative pulmonary artery pressure.These data indicate that neutrophils play a major role in pulmonary dysfunction occurring after cardiopulmonary bypass, which is accentuated in patients with pulmonary hypertension.
@ Jpn. J. Cardiovasc. Surg. 29:363-367(2000)