Hiroko Otsubo, Ph, Keiko Kishimoto, PhD, Iyori Hirano, RPT, Hitoshi Nakano, MD, Kazuhiro Itaya, MD, PhD, Ryota Kumaki, Ph, MS, Hiroyuki Osumi, Ph, MS
Jpn J Compr Rehabil Sci 13: 4-11, 2022
Purpose: The purpose of this study was to examine the
relationship between cognitive dysfunction affecting
motor Functional Independence Measure (FIM) and
hypnotics.
Methods: This was a retrospective study involving
509 patients aged >- 65 years who were discharged
from a convalescent rehabilitation ward.
Results: Multiple regression analysis was performed
with motor FIM efficiency and motor FIM effectiveness
(motor FIM-e) as independent variables and the presence
or absence of cognitive dysfunction as the dependent
variable. The use of hypnotics in patients with cognitive
dysfunction showed a positive relationship with motor
FIM efficiency (B=0.147, P=0.019) and motor FIM-e
(B=0.141, P=0.026). Multiple regression analyses were
performed after further classifying hypnotics by
therapeutic class into hypnotics with new mechanisms,
non-benzodiazepine (BZ) hypnotics, and BZ hypnotics.
Non-BZ hypnotics (B=0.141, P=0.021) showed a
positive relationship with motor FIM efficiency. Non-BZ
hypnotics (B=0.158, P=0.009) and BZ hypnotics (B=0.178, P=0.003) showed a positive relationship with
motor FIM-e, whereas hypnotics with new mechanisms
of action did not. In contrast, none of the three
combinations of hypnotics showed any significant
relationship with either motor FIM efficiency or motor
FIM-e in patients without cognitive dysfunction.
Conclusion: The results suggested that the use of
hypnotics in patients with cognitive dysfunction
increases motor FIM efficiency and motor FIM-e.
Key words: convalescent rehabilitation ward, motor FIM, cognitive function, hypnotics