Toyoko Asami, MD, PhD, Naoya Yamanouchi, MD, Akihiko Asami, MD, PhD,
Hisato Tanaka, MD, PhD, Norihiko Nogami, MD, PhD
Jpn J Compr Rehabil Sci 4: 22-29, 2013
Objectives: We investigated the analgesic effect,
degree of patient satisfaction, and QOL improvement
provided by patches containing loxoprofen sodium
hydrate (LX-P) using a questionnaire based on the
evaluation criteria of the Japanese Orthopaedic
Association Back Pain Evaluation Questionnaire
(JOABPEQ).
Methods: In this study of 53 patients (18 men, 35
women) with muscular back pain, LX-P 100mg was
applied once per day for four weeks. Patients provided
subjective feedback by answering a questionnaire.
Results: After one week of LX-P application, Visual
Analogue Scale (VAS) scores were significantly lower
and in the fourth week over 50% of the patients who
had switched from other NSAIDs reported improved
satisfaction over the drug previously used. The
JOABPEQ Severity of Illness Index (for all patients)
was significantly higher after one week for painrelated
disability and lower back functional disorder,
and was significantly higher after two weeks for daily
life disability. The rate of effectiveness of LX-P against
pain-related disabilities in the fourth week was 62.2%.
Conclusion: LX-P showed satisfactory analgesic
effect and QOL improvement. We believe it is effective
for clinical practice.
Key words: loxoprofen sodium, JOABPEQ, VAS, QOL, muscular back pain