Sunday, 12 May

Registration

Keynote Address

Presidential Address

Monday, 13 May

Symposia

1, 2

Workshop

1, 2, 3, 4, 5, 6

Tuesday, 14 May

Symposia

3, 4

Workshop

7, 8, 9, 10, 11, 12

Wednesday, 15 May

Symposia

5, 6

Thursday, 16 May

Workshop

13, 14, 15, 16, 17, 18

10:00-

Lobby

Registration desk open

16:30-17:20

Room: Asama

Keynote Address

<Chair> Yoshio Yazaki,

International Medical Center of Japan, Japan

THE CLAUDIN FAMILY: A KEY PLAYER IN THE BARRIER FUNCTION OF EPITHELIUM / ENDOTHELIUM IN MULTICELLULAR ORGANISMS

Shoichiro Tsukita, Kyoto University, Japan

17:20-17:40

Room: Asama

Presidential Address

<Chair> Fujio, Numano,

Tokyo Medical and Dental University, School of Medicine, Japan

LORD OF THE VESSEL: ADVENTURE OF VASOACTIVE PEPTIDES

Yoshio Yazaki, International Medical Center of Japan, Japan

 

==== Symposia ====

8:30-10:00

Room: Nagano

<S01>

Stem Cell Biology
<Chair>

Yasufumi Sato, International Medical Center of Japan, Japan

Francoise Dieterlen-Lievre, C.N.R.S. et du College de France, France

CELL BIOLOGY OF VASCULAR REMODELING

Shin-Ichi Nishikawa, Kyoto University, Japan

HEMANGIOBLASTS AND HEMATOPOIETIC STEM CELLS DURING ONTOGENY

Francoise Dieterlen-Lievre, C.N.R.S. et du College de France, France

HEMANGIOBLAST DIFFERENTIAION IN ZEBRAFISH

Didier Yves Stainier, University of California, San Francisco, USA

10:20-11:50

Room: Nagano

<S02>

Genetics
<Chair>

Toshio Ogihara, Osaka University, Japan

Theodore W. Kurtz, University of California, San Francisco, USA

STRATEGIES FOR IDENTIFICATION OF THE GENES RESPONSIBLE FOR ESSENTIAL HYPERTENSION

Tomohiro Katsuya, Osaka University, Japan

THE CHALLENGES FACING CARDIOVASCULAR GENETICS

Stephen Brian Harrap, The University of Melbourne, Australia

GENETICS AND PHARMACOGENETICS OF THE HYPERTENSION METABOLIC SYNDROME

Theodore W. Kurtz, University of California, San Francisco, USA
 
==== Workshops ====

13:30-14:50

Room: Asama1-3

<W01>

Angiogenesis
<Chair>

Masabumi Shibuya, The University of Tokyo, Japan

Kari Kustaa Alitalo, University of Helsinki, Finland

HEMATOPOIETIC CELLS AND ANGIOGENESIS

Nobuyuki Takakura, Kanazawa University, Japan

GROWTH FACTOR REGULATION OF LYMPHANGIOGENESIS AND METASTASIS

Kari Kustaa Alitalo, University of Helsinki, Finland

THE CONTRIBUTION OF NOTCH SIGNALING TO VASCULAR CELL SPECIFICATION

Luisa Iruela-Arispe, University of California, San Francisco, USA

A UNIQUE SIGNAL TRANSDUCTION OF VEGF AND ITS RECEPTOR FAMILY INVOLVED IN ANGIOGENESIS AND VASCULAR PERMEABILITY

Masabumi Shibuya, The University of Tokyo, Japan

13:30-14:50

Room: Asama4-6

<W02>

Nuclear Receptors
<Chair>

Christopher K. Glass,University of California, San Diego, USA

Yasuyoshi Ouchi, The University of Tokyo, Japan

(TBA)

Christopher K. Glass,University of California, San Diego, USA

ER Éø COACTIVATOR COMPLEXES AND AR KO MICE

Shigeaki Kato, The University of Tokyo, Japan

DIFFERENTIAL GROWTH CONTROL OF CELLS VIA MULTIPLE ESTROGEN-RESPONSIVE PATHWAYS

Satoshi Inoue, The University of Tokyo, Japan

(TBA)

Jorge Plutzky, Harvard Medical School, USA

13:30-14:50

Room: Chikuma

<W03>

SMC Lineage
<Chair>

Gary K. Owens,University of Virginia, USA

Kenji Sobue, Osaka University, Japan

MOLECULAR CONTROL OF SMOOTH MUSCLE CELL LINEAGE

Gary K. Owens,University of Virginia, USA

SIGNAL TRANSDUCTION AND GENE REGULATION IN A DIFFERENTIATED PHENOTYPE OF VASCULAR SMOOTH MUSCLE CELLS

Kenji Sobue, Osaka University, Japan

ORIGIN OF THE CORONARY SMOOTH MUSCLE CELL LINEAGE

Takashi Mikawa, Cornell University Medical College, USA

STUDYING VASCULAR DEVELOPMENT USING THE ZEBRAFISH

Brant Michael Weinstein, National Institutes of Health, USA

15:20-16:40

Room: Asama1-3

<W04>

Tissue Engineering & Artificial Blood Vessel
<Chair>

Gordon R. Campbell,The University of Queensland, Australia

Kazuwa Nakao, Kyoto University, Japan

DEVELOPMENT OF AN ARTIFICIAL BLOOD VESSEL

Gordon R. Campbell,The University of Queensland, Australia

POTENTIALS OF EMBRYONIC STEM (ES) CELL-DERIVED VASCULAR PROGENITOR CELLS (VPC) IN REGENERATION MEDICINE

Hiroshi Itoh, Kyoto University, Japan

CHARACTERIZATION AND USE OF BONE MARROW-DERIVED ANGIOBLASTS FOR NEOVASCULARIZATION OF ISCHEMIC MYOCARDIUM

Silviu Itescu, Columbia University, USA

ANGIOGENESIS FOR TISSUE ENGINEERING BASED ON GROWTH FACTOR RELEASE

Yasuhiko Tabata, Kyoto University, Japan

15:20-16:40

Room: Asama4-6

<W05>

Proteomics and Genetics Informatics
<Chair>

Stephen M.Schwartz,University of Washington, USA

Tatsuhiko Kodama, The University of Tokyo, Japan

DYNAMIC SYSTEM BIOLOGY OF ATHEROSCLEROSIS

Tatsuhiko Kodama, The University of Tokyo, Japan

UNDERSTANDING ATHEROSCLEROSIS THROUGH STUDIES OF NATURALLY OCCURRING VARIATIONS IN MICE

Aldons Jake Lusis, University of California, Los Angels, USA

USING GENETICS, GENOMICS AND COMPUTATIONAL ANALYSIS TO IDENTIFY MECHANISMS PREDISPOSING TO ANEURYSM

Eileen R. Mulvihill,University of Washington, USA

LEVEL CROSSING TO STRENGTHEN CASE-CONTROL STUDIES OF VASCULAR DISEASE: AN APPLICATION TO PARAOXONASE

Gail Jarvik, University of Washington, USA

15:20-16:40

Room: Chikuma

<W06>

Vascular Development
<Chair>

Mark W. Majesky, Baylor College of Medicine, USA

Hiroki Kurihara, The University of Tokyo, Japan

CARDIAC NEURAL CREST DEVELOPMENT AND ENDOTHELIN SIGNALING

Hiroki Kurihara, The University of Tokyo, Japan

MOLECULAR PATHWAYS CONTROLLING CORONARY SMOOTH MUSCLE DIFFERENTIATION

Mark W. Majesky, Baylor College of Medicine, USA

Vezf1: AN EARLY ENDOTHELIAL ZINC FINGER GENE REQUIRED DURING DEVELOPMENT OF THE VASCULAR SYSTEM

Heidi Stuhlmann, The Scripps Research Institute, USA

DEVELOPMENTALLY REGULATED EXPRESSION OF CARTILAGE-DERIVED ANGIOGENESIS INHIBITOR, CHONDROMODULIN-I; ITS INVOLVEMENT IN THE ANTI-ANGIOGENEC PROPERTY OF CARTILAGE AND OTHER MESENCHYMAL TISSUES

Yuji Hiraki, Kyoto University, Japan

==== Symposia ====

8:30-10:00

Room: Nagano

<S03>

Signaling & Gene Transcription
<Chair>

Bradford C. Berk, University of Rochester, USA

Yoshio Yazaki, International Medical Center of Japan, Japan

ROLES OF KLF5/BTEB2 IN PHENOTYPIC MODULATION OF SMOOTH MUSCLE CELL AND CARDIOVASCULAR REMODELING

Ryozo Nagai, The University of Tokyo, Japan

FLOW-MEDIATED ATHEROPROTECTIVE MECHANISMS

Bradford C. Berk, University of Rochester, USA

ANTI-INFLAMMATORY BALANCE IN ATHEROSCLEROSIS

Alain Tedgui, Institute National de la Santa et de la Recherrch Medicale, France

10:20-11:50

Room: Nagano

<S04>

Immunology and Inflammation in Atherosclerosis
<Chair>

Seiitsu Murota, Tokyo Medical and Dental University, Japan

Goeran K. Hansson, Karolinska Hospital, Sweden

IMMUNE MECHANISMS IN ATHEROSCLEROSIS

Goeran K. Hansson, Karolinska Hospital, Sweden

IMPORTANCE OF RHO-KINASE IN THE PATHOGENESIS OF VASCULAR INFLAMMATION AND ARTERIOSCLEROSIS

Hiroaki Shimokawa, Kyushu University, Japan

NOVEL IMMUNE AND INFLAMMATORY PATHWAYS IN ATHEROGENESIS

Peter Libby, Harvard Medical School, USA
 
==== Workshops ====

13:30-14:50

Room: Asama1-3

<W07>

Signaling
<Chair>

Kenneth Walsh, Boston University, USA

Yoshimi Takai, Osaka University, Japan

ROLE OF AKT/PKB SIGNALING IN ANGIOGENESIS

Kenneth Walsh, Boston University, USA

NECTIN: A KEY ORGANIZER OF INTERCELLULAR JUNCTIONS

Yoshimi Takai, Osaka University, Japan

GROWTH FACTORS DIRECT SPECIFIC VASCULAR DEVELOPMENT IN EMBRYOID BODIES

Lena Claesson-Walsh, Uppsala University, Sweden

PROTEIN ARGININE METHYLTRANSFERASE 2(PRMT2) FORMS A COMPLEX WITH RB AND REGULATES E2F1 TRANSCRIPTIONAL ACTIVITY AND CELL CYCLE PROGRESSION

Takanobu Yoshimoto, National Institute of Health, Japan

13:30-14:50

Room: Asama4-6

<W08>

Foam Cell Biology
<Chair>

Rodolfo Paoletti,University of Milan, Italy

Toru Kita, Kyoto University, Japan

MACROPHAGES AS DRUG TARGETS

Rodolfo Paoletti,University of Milan, Italy

OXIDIZED LDL RECEPTORS AND ATHEROGENESIS

Noriaki Kume, Kyoto University, Japan

REGULATION OF ACYL-COENZYME A: CHOLESTEROL ACYLTRANSFERASE (ACAT) AND FOAM CELL FORMATION IN MACROPHAGES

Seikoh Horiuchi, Kumamoto University, Japan

(TBA)

13:30-14:50

Room: Chikuma

<W09>

Leukocyte-endothelial Interaction
<Chair>

Wendy Jessup,University of New South Wales, USA

Ikuo Morita, Tokyo Medical and Dental University, Japan

DIETARY AND GENETIC INFLUENCES ON MONOCYTE-ENDOTHELIAL ADHESION

Wendy Jessup,University of New South Wales, USA

LEUKOCYTE-ENDOTHELIAL INTERACTIONS IN VASCULAR DISORDERS

Masayuki Yoshida, Tokyo Medical and Dental University, Japan

(TBA)

Peter I. Lelkes, Drexel University, USA

ROLE OF GAP JUNCTION-RELATED COMMUNICATION AND ITS ABNORMALITY INDUCED BY ACTIVATED LEUKOCYTES

Ikuo Morita, Tokyo Medical and Dental University, Japan

15:20-16:40

Room: Asama1-3

<W10>

Transcriptional Control
<Chair>

Levon Michal Khachigian,The University of New South Wales, Australia

Masahiko Kurabayashi, Gunma University, Japan

CONTROL OF IMMEDIATE-EARLY TRANSCRIPTION FACTOR EXPRESSION IN INJURED ARTERIES

Levon Michal Khachigian,The University of New South Wales, Australia

AN SRF-DEPENDENT TRANSCRIPTIONAL REGULATORY PROGRAM CONTROLS EXPRESSION SM22Éø IN SMCS

Michael S. Parmacek, University of Pennsylvania, USA

PERIPHERAL CLOCK REGULATERS CIRCADIAN GENE EXPRESSION IN VASCULAR ENDOTHELIAL CELLS

Koji Maemura, The University of Tokyo, Japan

(TBA)

15:20-16:40

Room: Asama4-6

<W11>

Genetics of Atherogenesis
<Chair>

Peter Carmeliet, Flanders Interuniversity, Belgium

Mitsuhiro Yokoyama, Kobe University, Japan

OVEREXPRESSION OF ENDOTHELIAL NITRIC OXIDE SYNTHASE ACCELERATES ATHEROSCLEROTIC LESION FORMATION IN APOE-DEFICIENT MICE

Mitsuhiro Yokoyama, Kobe University, Japan

ATHEROSCLEROTIC PROGRESSION: THE GENE CHIP VIEW

Stephen M. Schwartz, University of Washington, USA

ANGIOGENESIS IN ATHEROSCLEROSIS AND OTHER DISEASE

Peter Carmeliet, Flanders Interuniversity, Belgium

GNAS1 GENE VARIANT IS ASSOCIATED WITH HYPERTENSION IN NON-SMOKERS

Michiko Abe, Ehime University, Japan

15:20-16:40

Room: Chikuma

<W12>

Platelet Thrombus Formation under Flow Condition
<Chair>

Yasuo Ikeda, Keio Univerisity, Japan

Shaun P. Jacson, Monash University, Australia

OVERVIEW

Yasuo Ikeda, Keio Univerisity, Japan

INTEGRIN aIIbb3-DERIVED CALCIUM SIGNALS REGULATING PLATELET ADHESION AND THROMBUS GROWTH

Shaun P. Jacson, Monash University, Australia

(TBA)

Shinya Goto, University Tokai, Japan

IMPLICATION OF P-SELECTION IN PLATELET - PLATELET INTERACTIONS UNDER FLOW

Makoto Handa, Keio Univerisity, Japan

==== Symposia ====

8:30-10:00

Room: Nagano

<S05>

Cell Biology of Unstable Plaque
<Chair>

Peter Libby, Harvard Medical School, USA

Katsuo Sueishi, Kyushu University, Japan

ANGIOGENESIS IN ATHEROSCLEROSIS: ITS PATHOPHYSIOLOGICAL IMPLICATION FOR PLAQUE INSTABILITY

Katsuo Sueishi, Kyushu University, Japan

MATRIX METALLOPROTEINASE DISRUPTION OF THE EXTRACELLULAR MATRIX AND ATHEROSCLEROSIS

Jeanine Marie D'Armiento, Columbia University, USA

THE BALANCE OF POWER IN UNSTABLE PLAQUES: COLLAGENASES VS. COLLAGEN

Masanori Aikawa, Harvard Medical School, USA

10:20-11:50

Room: Nagano

<S06>

Vascular Regeneration
<Chair>

Julie Hazel Campbell, The University of Queensland, Australia

Shin-ichi Nishikawa, Kyoto Univerisity, Japan

NEOINTIMAL FORMATION BY CIRCULATING BONE MARROW CELLS

Julie Hazel Campbell, The University of Queensland, Australia

ENDOTHELIAL PROGENITOR CELLS FOR VASCULAR REGENERATION

Takayuki Asahara, Tufts University, USA

(TBA)

Napoleone Ferrara, Genentech Inc., USA

==== Workshops ====

08:30-09:50

Room: Asama1-3

<W13>

Imaging of Atherosclerosis
<Chair>

Masunori Matsukaze, Yamaguchi University, Japan

Thomas Hatsukami, University of Washington, USA

MAGNETIC RESONANCE IMAGING OF ATHEROSCLEROTIC PLAQUES

Masanori Aikawa, Harvard Medical School, USA

HIGH-RESOLUTION MRI OF CAROTID ATHEROSCLEROSIS

Thomas Hatsukami, University of Washington, USA

DETECTION OF VULNERABLE ATHEROSCLEROTIC PLAQUE BY INTRAVASCULAR ULTRASOUND

Takafumi Hiro, Yamaguchi University, Japan

MAGNETIC RESONANCE IMAGING REVEALS DISSECTION AND REMODELING OF ATHEROSCLEROTIC LESIONS IN NONHUMAN PRIMATES AFTER ANGIOPLASTY

Eiji Kaneko, Tokyo Medical and Dental University, Japan

08:30-09:50

Room: Asama4-6

<W14>

Extracellular Matrix
<Chair>

Giulio Gabbiani,University of Geneva, Switzerland

Kentaro Shimokado, Tokyo Medical and Dental University, Japan

SMOOTH MUSCLE CELL AND HETEROGENEITY: ROLE IN ATHEROMA AND RESTENOSIS FORMATION

Giulio Gabbiani,University of Geneva, Switzerland

PROTEGLYCANS IN ATHEROSCLEROSIS AND RESTENOSIS

Thomas N. Wight, The Hope Heart Institute, USA

TYPE 1 COLLAGEN AND ITS INTEGRIN RECEPTOR: ROLES IN SMOOTH MUSCLE CELL FUNCTION AND ATHEROSCLEROSIS

Hidenori Koyama, Osaka City University, Japan

REGULATION OF MATRIX METALLOPROTEINASE-9ACTIVATION THROUGH CD147/EXTRACELLULAR MATRIX METALLOPROTEINASE INDUCER (EMMPRIN) ON PLAQUE STABILITY IN ATHEROGENESIS

Se-Hwa Kim, Sungkyunkwan University, Korea

08:30-09:50

Room: Chikuma

<W15>

Regulation of Vascular Tone
<Chair>

Akira Takeshita, Kyushu University, Japan

Donald D. Heistad, University of Iowa, USA

Ca2+ SENSITIZATION OF VASCULAR SMOOTH MUSCLE -MOLECULAR MECHANISMS AND THEIR INVOLVEMENT IN HYPERTENSION-

Masaaki Ito, Mie University, Japan

EFFECTS OF GENE TRANSFER OF EXTRACELLULAR SUPEROXIDE DISMUTASE IN HYPERTENSIVE RATS: ROLE OF THE HEPARIN-BINDING DOMAIN

Donald D. Heistad, University of Iowa, USA

THE ACTIONS OF NATRIURETIC PEPTIDES ON VASCULAR TONE

Chiming Wei, University of Maryland School of Medicine, USA

REGULATION OF INTRACELLULAR Ca2+ IN VASCULAR SMOOTH MUSCLE CELLS

Masamitsu Iino, The University of Tokyo, Japan

10:10-11:30

Room: Asama1-3

<W16>

Clinical Implications of Vascular Biology
<Chair>

Alexander W. Clowes, University of Washington, USA

Yuji Matsuzawa, Osaka University, Japan

INTIMAL HYPERPLASIA AND THE HUMAN RESPONSE TO ARTERIAL INJURY

Alexander W. Clowes, University of Washington, USA

ROLES OF THE PROSTANOIDS IN THE CARDIOVASCULAR SYSTEM

Fumitaka Ushikubi, Asahikawa Medical College, Japan

INHIBITION OF TUMOR ANGIOGENESIS, INVASION, AND METASTASIS BY NK4, A NEWLY IDENTIFIED HGF-ANTAGONIST AND ANGIOGENESIS INHIBITOR

Toshikazu Nakamura, Osaka University, Japan

10:10-11:30

Room: Asama4-6

<W17>

Mechanotransduction
<Chair>

Michael A. Gimbrone, Brigham and Women's Hospital, Harvard Medical School, USA

Akira Kamiya, Nihon University, Japan

CONTROL OF ARTERIAL IDENTITY BY HEMODYNAMIC ENVIRONMENTS

Guillermo Garcia-Cardena, Harvard Medical University, USA

THE ROLE OF INTEGRINS AND RHO SMALL GTPase IN MEDIATING SREBP IN VASCULAR ENDOTHELIAL CELLS IN RESPONSE TO SHEAR STRESS

John Y-J. Shyy, University of California, USA

SHEAR-INDUCED REORGANIZATION OF THE CYTOSKELETON, ROLES OF SIGNALING P13-KINASE, EXTRACELLULAR SIGNAL RELATED KINASE (ERK1/2) AND INTEGRIN-LINKED KINASE (ILK)

Lowell B. Langille, University of Toronto, Canada

SHEAR STRESS-RELATED CALCIUM SIGNALING IN VASCULAR ENDOTHELIAL CELLS

Joji Ando, The University of Tokyo, Japan

10:10-11:30

Room: Chikuma

<W18>

Gene Therapy
<Chair>

Michael Simons, Dartmouth Medical School, USA

Ryuichi Morishita, Osaka University, Graduate School of Medicine, Faculty of Medicine, Japan

RESULTS FROM TREAT-HGF (JAPAN TRIAL TREAT PERIPHERAL ARTERIAL DESEASE BY THERAPEUTIC ANGIOGENESIS USING HEPATOCYTE GROWTH FACTOR GENE TRANSFER)

Ryuichi Morishita, Osaka University, Japan

EFFECTS OF ACUTE AND CHRONIC AKT ACTIVATION IN ISCHEMIA-REPERFUSION INJYRY

Anthoy Rosenzweig, Harvard Medical School, USA

(TBA)

Michael Simons, Dartmouth Medical School, USA

RECOMBINANT SENDAI VIRUS-MEDIATED INTRAMUSCULAR GENE TRANSFER OF FGF-2 RESTORES COLLATERAL BLOOD PERFUSION OF CHRONICALLY ISCHEMIC RABBIT HIND LIMB, AND INHIBITS NEOINTIMAL HYPERPLASIA OF AUTOLOGOUS FEMORAL VEIN GRAFTS

Yoshikazu Yonemitsu, Kyushu Univerisity, Japan