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Scientific Program
| 7:50 - 8:00 | Opening Remarks: Toshihiko Kuroiwa Tokyo, Japan
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| 8:00 - 8:20 | L1 | Lecture: Umeo Ito Tokyo, Japan
| Clinical strategy for brain edema
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| Moderators: Alexander Baethmann (Munich, Germany);
Geoffrey T. Manley (California, USA)
| | 8:20 - 10:00 | Oral Presentation: "Blood-Brain Barrier Disorder"
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Moderators(1-4): Alexander Baethmann (Munich, Germany);
Geoffrey T. Manley (California, USA)
| | 8:20 | 1 | Geoffrey T. | Manley | California, USA
| Decreased osmotic permeabilty in primary cultured
astrocytes from mice deficient in Aquaporin-4
| | 8:33 | 2 | Luca | Regli | Lausanne, Switzerland
| Aquaporin expression and distribution in human tissue
| | 8:46 | 3 | Bela | Kis | North Carolina, USA
| Adrenomedullin is a potential link between astrocytes
and the induction of blood-brain barrier properties
in cerebral endothelial cells
| | 8:59 | 4 | Feng | Xiao | Louisiana, USA
| Matrix metalloproteinases are not involved
in early brain edema formation after cardiac arrest in rats
| | Moderators(5-8): Joseph D. Fenstermacher (Michigan, USA);
Yukio Ikeda (Tokyo, Japan)
| | 9:17 | 5 | Nobuyuki | Kawai | Kagawa, Japan
| Treatment of cold injury-induced brain edema
with a nonspecific matrix metalloproteinase inhibitor MMI270 in rats
| | 9:30 | 7 | Maria | Spatz | Maryland, USA
| Signal transduction pathways in endothelial responses
to novel vasoactive substances (endocannabinoids)
| | 9:43 | 8 | Hari S. | Sharma | Uppsala, Sweden
| Neurotrophic factors attenuate microvascular
permeability disturbances and axonal injury following
trauma to the rat spinal cord
| | 10:00 - 10:30 | Coffee Break and Poster Viewing
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| 10:30 - 11:30 | Oral Presentation: "Trauma"
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Moderators(9-13): Hiroshi Nawashiro (Saitama, Japan);
Robert Vink (South Australia, Australia)
| | 10:30 | 9 | Robert | Vink | South Australia, Australia
| Neuropeptide release influences brain edema formation
after diffuse traumatic brain injury
| | 10:42 | 10 | | |
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| | 10:54 | 11 | Naoya | Hattori | California, USA
| PET investigations of post-traumatic cerbral
blood volume and blood flow
| | 11:06 | 12 | Arturo | Chieregato | Cesena, Italy
| Induced acute arterial hypertension and regional
cerebral flow in intracontusional low density area
| | 11:18 | 13 | Naoki | Otani | Saitama, Japan
| A role of glial fibrillary acidic protein in the
hippocampal degeneration after traumatic
or kainate-induced exitotoxicity
| | 11:30 - 12:00 | L2 | Special Lecture: Igor Klatzo Maryland, USA
| C. and O. Vogt - the significance of their contributions
in modern neuroscience
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| Moderator: Toshihiko Kuroiwa (Tokyo, Japan)
| | 12:00 - 13:00 | Lunch
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| 13:00 - 13:20 | L3 | Lecture: Riki Okeda Tokyo, Japan
| Hypoxic-ischemic encephalopathy
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Moderators: W. D. Heiss (Cologne, Germany);
Umeo Ito (Tokyo, Japan)
| | 13:25 - 15:30 | Oral Presentation: "Ischemia 1"
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Moderators(15-18): W. D. Heiss (Cologne, Germany);
Umeo Ito (Tokyo, Japan)
| | 13:25 | 15 | Guohua | Xi | Michigan, USA.
| Thrombin exacerbates brain edema in focal cerebral ischemia
| | 13:38 | 16 | Masaharu | Sakoh | Ehime, Japan
| Prediction of tissue survival after stroke
based on changes in the apparent diffusion of water
(cytotoxic edema)
| | 13:51 | 17 | Robert J. | Dempsey | Wisconsin, USA
| Regionally specific neurogenesis in response
to focal cerebral ischemia
| | 14:04 | 18 | | |
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Moderators(19-22): Minoru Fujiki (Oita, Japan);
Konstantin A. Hossmann (Cologne, Germany)
| | 14:22 | 19 | Nobutaka | Kawahara | Tokyo, Japan
| DNA microarray-based gene expression analysis
for induced ischemic tolerance and delayed neuronal death
following transient global ischemia in rats
| | 14:35 | 20 | Hiroshi | Nawashiro | Saitama, Japan
| Post-ischemic transcriptional and translational
responses of EC-SOD in mouse brain and serum
| | 14:48 | 21 | Hiroyuki | Uchino | Tokyo, Japan
| Neuroprotection by differential immunosuppressants
following ischemia corresponds with differing abilities
to inhibit calcineurin and the mitochondrial permeability transition
| | 15:01 | 22 | Hirokzau | Ueda | Osaka, Japan
| Regional N-acetyl-aspartate level and immunohistochemical damage
after transient forebrain ischemia in gerbils
| | Poster Discussion A
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| 15:30 - 17:00 | Coffee Break and Poster Discussion A
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Moderators(PA1-PA8): Zbigniew Czerncki (Warsaw, Poland);
Nobuhiko Omori (Okayama, Japan)
| | 15:30 | PA-1 | Shingo | Toyota | Koeln, Germany
| Prediction of malignant infarction: Perifocal neurochemical
monitoring following prolonged MCA occlusion in cats
| | 15:36 | PA-2 | Hiroshi | Kamada | Okayama, Japan
| Temporal and spatial changes of free cholesterol
and neutral lipids in rat brain after transient
middle cerebral artery occlusion
| | 15:42 | PA-3 | Hirokazu | Ohtaki | Tokyo,Japan
| Decreased oxidative neuronal cell death after
transient middle cerebral artery occlusion in
mice lacking interleukin-1
| | 15:48 | PA-4 | Sadaharu | Tabuchi | Yonago, Japan
| Mice defficient in cytosolic phospholipase A2 are
less susceptible to cerebral ischemia/reperfusion injury
| | 15:54 | PA-5 | | |
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| | 16:00 | PA-6 | Kentaro | Ohta | Okayama, Japan
| Dissociative increase of oligodendrocyte progenitor cells
between young and aged rats after transient cerebral ischemia
| | 16:06 | PA-7 | Takashi | Mitsuhashi | Chiba, Japan
| Regional distribution for potassium and phosphorus in
ischemic brain tissue of rats with X-ray fluorescence analysis
| | 16:12 | PA-8 | Li | Yin | Tokyo, Japan
| Expression of tumor necrosis factor alpha (TNF alpha) and
type I TNF receptor following transient cerebral ischemia
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Moderators(PA9-PA15): Julian T. Hoff (Michigan, USA);
Tatsuro Kawamata (Tokyo, Japan)
| | 16:18 | PA-9 | Naoki | Otani | Saitama, Japan
| Temporal and spatial profile of phosphorylated
mitogen-activated protein kinase (MAPK) pathways following
lateral fluid percussion brain injury in rats
| | 16:24 | PA-10 | Wang | Jun | Tochigi, Japan
| Changes of perivascular cells in the process of
brain edema induced by cold injury
| | 16:30 | PA-11 | Arturo | Chieregato | Cesena, Italy
| Mixed dishomogeneous hemorrhagic brain contusions.
Mapping of cerebral blood flow and frequency of ischenia
| | 16:36 | PA-12 | Hidehiko | Kushi | Tokyo, Japan
| Neuronal damage in pericontusional edema zone
| | 16:42 | PA-13 | Ullrich | Meier | Berlin, Germany
| The use of decompressive craniectomy for
the management of severe head injuries
| | 16:48 | PA-14 | Mostafa A. | Khashab | Al Khobar, Saudi Arabia
| The neuropsychological assessment of head injured patients
with frontal lobe injury harboring structural frontal lobe damage
| | 16:54 | PA-15 | Kosaku | Kinoshita | Tokyo, Japan
| Characteristics of parietal-parasagittal hemorrhage
after mild or moderate traumatic brain injury
| | Poster Discussion B
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| 15:30 - 17:00 | Coffee Break and Poster Discussion B
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Moderators(PB1-PB8): Alexander Baethmann (Munich, Germany);
Ken-ichiro Katsura (Tokyo, Japan)
| | 15:30 | PB-1 | Tatsuro | Mori | Tokyo, Japan.
| Inhibition of ERK phosphorylation attenuates MMP-9
upregulation and brain edema following cortical contusion
| | 15:44 | PB-3 | T. | Winkler | Uppsala, Sweden
| Topical application of TNF-α antiserum attenuates
spinal cord trauma induced edema formation,
microvascular permeability disturbances and cell injury in the rat
| | 15:51 | PB-4 | Hari S. | Sharma | Uppsala, Sweden
| A new antioxidant compound H-290/51 attenuates
spinal cord injury induced expression of constitutive
and inducible isoforms of nitricoxide synthase and
edema formation in the rat
| | 15:58 | PB-5 | Mitsuru | Ikeda | Kobe, Japan
| Quantitative analysis of hyperosmotic and hypothermic
blood-brain barrier opening
| | 16:05 | PB-6 | Shigeru | Hoshino | Tokyo, Japan
| Prion prevents brain damage and blood-brain-barrier
disruption after experimental brain injury
| | 16:12 | PB-7 | Hidehiko | Kushi | Tokyo, Japan
| IL-8 is a key mediator of neuroinflammation in
severe head injuries
| | 16:19 | PB-8 | Takahiro | Atsumi | Tokyo, Japan
| The glutamate AMPA receptor antagonist, YM872,
attenuates cortical tissue loss, regional cerebral edema,
and breakdown of the blood-brain barrier following
experimental brain injury in rats
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Moderators(PB9 -PB13): Tatsushi Kamiya (Tokyo, Japan);
Hari S. Sharma (Uppsala, Sweden)
| | 16:26 | PB-9 | Ken-ichiro | Katsura | Tokyo, Japan
| Effects of FK506 on protein phosphorylation
system in the gerbil hippocampal CA1 neurons
| | 16:33 | PB-10 | Keiko | Sato | Okayama, Japan
| Highly polysialylated neural cell adhesion molecule
(PSA-NCAM) positive cells increased and changed localization
in rat hippocampus with exposure to repeated kindled seizures
| | 16:40 | PB-11 | Naoki | Otani | Saitama, Japan
| Temporal and spatial phosphorylation of extracellular
signal-regulated kinase pathways after kainate-induced
seizures in the rat brain
| | 16:47 | PB-12 | Masaru | Yamada | Kanagawa Japan
| Iodoamphetamine (IMP) uptake in the brain is increased
after experimental cerebral venous hypertension in the rat
| | 16:54 | PB-13 | Ryota | Kimura | Nara,Japan
| Cytotoxic and vasogenic edema in the pathological process
of cerebral venous infarction
| | 17:00 - 18:30 | Sponsored Session 1:
"Clinical Approaches to Brain Edema: ICP, CPP, and BP Control"
- Sponsored by: Eisai Co., Ltd., and Mitsubishi Pharma Corporation
- Chairperson: Yoichi Katayama and David Mendelow
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Moderators(S1-1 - S1-4): Yoichi Katayama (Tokyo, Japan);
A. David Mendelow (Newcastle upon Tyne, UK)
| | | S1-1 | Katsuji | Shima | Saitama, Japan
| Hydrostatic brain edema: Basic mechanisms and clinicalaspects
| | | S1-2 | Yoichi | Katayama | Tokyo, Japan
| Cerebral contusion edema: the combination of traumatic
and ischemic edema mechanisms
| | | S1-3 | Carl-Henrik | Nordstrom | Lund, Sweden
| Volume-targeted therapy of increased ICP
| | | S1-4 | Anthony | Marmarou | Virginia, USA
| The pathophysiologic basis of traumatic brain edema: Current concepts
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| 7:50 - 8:20 | L4 | Special Lecture: Seong-Gi Kim Pennsylvania, USA
| Brain mapping using functional MRI
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Moderators: Yoichi Katayama (Tokyo, Japan);
Anthony Marmarou (Virginia, USA)
| | 8:20 - 10:00 | Oral Presentation: "Imaging and Diagnosis / Tumor"
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Moderators(24-27): Yoichi Katayama (Tokyo, Japan);
Anthony Marmarou (Virginia, USA)
| | 8:20 | 24 | W. D. | Heiss | Cologne, Germany
| Identification of malignant brain edema after
hemispheric stroke by PET-imaging and microdialysis
| | 8:33 | 25 | Tadashi | Nariai | Tokyo, Japan
| PET neuroreceptor imaging as predictor of
severe cerebral ischemic insult
| | 8:45 | 26 | Joseph D. | Fenstermacher | Michigan, USA
| Estimating blood-brain barrier opening in
a rat model of hemorrhagic transformation with
Patlak plots of Gd-DTPA contrast enhanced MRI
| | 8:58 | 27 | Peter | Smielewski | Cambridge, UK
| Continuous assessment of autoregulation
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Moderators(28-31): Lawrence Litt (California, USA);
Toshiyuki Shiogai (Kyoto, Japan)
| | 9:10 | 28 | Marios C. | Papadopoulos | London, UK
| Role of water channel proteins (Aquaporins) in brain tumor edema
| | 9:23 | 29 | Ya | Hua | Michigan, USA
| A thrombin inhibitor reduces brain edema,
glioma mass and neurological deficits in a rat glioma model
| | 9:35 | 30 | Tatsuya | Nagashima | Kobe, Japan
| Pathophysiology and treatment of brain edema associated
with pediatric brain tumors
| | 9:48 | 31 | Goro | Nagashima | Kanagawa, Japan
| Tissue reconstruction process in the area of peri-tumoral
edema, caused by glioblastoma immunohistochemical and
graphical analysis using autopsy brain
| | 10:00 - 10:30 | Coffee Break and Poster Viewing
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| 10:30 - 10:50 | L5 | Lecture: Konstantin A. Hossmann Cologne, Germany
| Non-invasive imaging techniqes for the characterization
of brain pathophysiology
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Moderator: Hans J. Reulen (Munich, Germany)
| | 10:55 - 11:55 | Sponsored Session 2: "New Dimensions of Neuroimaging"
- Sponsored by: Hitachi Medical Corporation,
Nihon Medi-Physics Co., Ltd.,
Siemens Asahi Medical Technologies Ltd.,
and TOSHIBA Corporation, Medical Systems Company
- Chairperson: Kikuo Ohno
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Moderator(S2-1 - S2-4): Kikuo Ohno (Tokyo, Japan)
| | S2-1 | Kyojiro | Nambu | Tochigi, Japan
| Quantitative evaluation of cerebral
vascular permeability using multi-slice dynamic CT
| | S2-2 | Makoto | Kato-Azuma | Tokyo, Japan
| Development of interface software and implementation of
3D stereotactic surface projections (3D-SSP)
for routine brain SPECT image analysis
| | S2-3 | Osamu | Takizawa | Tokyo, Japan
| Recent developments of MR Imaging technique
for the investigation of the brain function
| | S2-4 | Tsuneaki | Kawaguchi | Tokyo, Japan
| Functional brain imaging of optical topography
| | 12:00 - 16:00 | Lunch and Excursion
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| 16:30 - 17:30 | Oral Presentation: "Ischemia 2"
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Moderators(32-36): Carl-Henrik Nordstrom (Lund, Sweden)
Katsuji Shima (Saitama, Japan)
| | 16:30 | 32 | Lawrence | Litt | California, USA
| ATP and PCr responses to hypoxia of hypothermic and normothermic
respiring, superfused, neonatal rat cerebrocortical silces:
An NMR spectroscopy study at 14.1 tesla
| | 16:42 | 33 | Minoru | Tomita | Tokyo, Japan
| Astroglial swelling in the neuronal depolarization ensemble
| | 16:54 | 34 | Seiji | Yamamoto | Hamamatsu, Japan
| A Na+/H+ exchanger inhibitor suppresses cellular swelling
and neuronal death induced by glutamate in cultured cortical neurons
| | 17:06 | 35 | Eiji | Kumura | Osaka, Japan
| Significant shrinkage of extracellular space during
global cerebral ischemia: Differences in gray and white matter ischemia
| | 17:18 | 36 | Ryszard | Pluta | Warsaw, Poland
| Blood-brain barrier dysfunction and amyloid precursor
protein accumulation in microvascular compartment following
ischemia-reperfusion brain injury with 1-year survival
| | Poster Discussion C
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| 17:30 - 19:00 | Coffee Break and Poster Discussion C
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Moderators(PC1-PC7): Tatsuo Mima (Kochi, Japan);
Feng Xiao (Louisiana, USA)
| | 17:30 | PC-1 | Feng | Xiao | Louisiana, USA
| The role of Aquaporin 4 in brain edema formation after
normothermic and hypothermic cardiac arrest in rats
| | 17:37 | PC-2 | Kenji | Dohi | Tokyo, Japan
| Peroxynitrite (ONOO-) expression in the mouse cardiac arrest model
| | 17:44 | PC-3 | Yohichi | Imaizumi | Tokyo, Japan
| Expression of Heme Oxigenase-1 after global cerebral ischemia in the mice
| | 17:51 | PC-4 | Hirokazu | Ohtaki | Tokyo,Japan
| The suppression of ischemic neuronal cell death and caspases
activation after cerebral ischemia in tumor necrosis
factor-alpha (TNF-alpha) gene deficient mice
| | 17:58 | PC-5 | Nobuhiko | Omori | Okayama, Japan
| Enhanced phosphorylation of PTEN in rat brain after
transient middle cerebral artery occlusion
| | 18:05 | PC-6 | Satoru | Ishibashi | Tokyo, Japan
| Sensorimotor and cognitive deficits after focal cerebral
ischemia in Mongolian gerbils
| | 18:12 | PC-7 | Kiyoshi | Hirai | California, USA
| AKTphosphorylation and cell survival after hypoxia-induced
cytochrome C release in superfused respiring neonatal
rat cerebrocortical slices
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Moderators(PC9-PC13): A. David Mendelow (Newcastle upon Tyne, UK)
Keiko Sato (Okayama, Japan)
| | 18:26 | PC-9 | Joho | Tokumine | Okinawa, Japan
| Spinal GDNF level is increased after transient spinal cord ischemia in the rat
| | 18:33 | PC-10 | Yoji | Tanaka | Tokyo, Japan
| Recovery of apparent diffusion coefficient in a rat model of
embolic stroke does not mean completely salvage from ischemic neuronal injury
| | 18:40 | PC-11 | Daisaku | Kurita | Kanagawa, Japan
| Energy metabolism and cerebral blood flow during cytotoxic
brain edema induced by 6-aminonicotinamide
| | 18:47 | PC-12 | Qing | Lu | Singapore
| Stroke prevention by candesartan cilexetil in normotensive experimetal
stroke rats
| | 18:54 | PC-13 | Kenji | Dohi | Tokyo, Japan
| Neuroprotective effect and direct free radical scavenging
activity of Choto-san (kampo medicine)
| | Poster Discussion D
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| 17:30 - 19:00 | Coffee Break and Poster Discussion D
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Moderators(PD1-PD8): Takehiko Iijima (Tokyo, Japan);
Ryszard Pluta (Warsaw, Poland)
| | 17:30 | PD-1 | Angela M. | Amorini | Virginia, USA
| The mechanism of traumatic cellular edema development via astrocytic foot processes
| | 17:36 | PD-2 | Kosaku | Kinoshita | Tokyo, Japan
| Changes in cerebrovascular response during brain hypothermia after
traumatic brain injury
| | 17:42 | PD-3 | Ryuta | Suzuki | Yokohama, Japan
| Ultra early expression of vascular endothelial growth factor in
brain edema tissue associated with brain contusion
| | 17:48 | PD-4 | Shinji | Fukui | Virginia, USA
| The effect of cyclosporin A on brain edema formation
following experimental traumatic brain injury
| | 17:54 | PD-5 | Homare | Nakamura | Kanagawa, Japan
| Free radical reaction and effect of edaravone on experimental brain injury
| | 18:00 | PD-6 | Yuichi | Oka | Aichi, Japan
| Expression of mouse brain serine protease (mBSP) mRNA in
cold injury model of rat brain
| | 18:06 | PD-7 | Takeshi | Saito | Tokyo, Japan
| The risk factors for the occurrence of acute brain swelling in
acute subdural hematoma
| | 18:12 | PD-8 | Mostafa A. | Khashab | Al Khobar, Saudi Arabia
| The management of severe head injury with malignant brain edema after
evacuation of acute subdural hematoma. A study of the results and
response of the edema after surgical evacuation
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Moderators(PD10-PD15): Nobutaka Kawahara (Tokyo, Japan)
Anthony Marmarou (Virginia, USA)
| | 18:24 | PD-10 | Anna | Skottner | Uppsala, Sweden
| Low molecular weight compounds with affinity to melanocortin receptors
exert neuroprotection spinal cord injury. An experimental study in the rat
| | 18:30 | PD-11 | Minoru | Fujiki | Oita, Japan
| Electrically induced GFAP upregulation attenuates progressive
necrosis and caviatation following spinal cord injury
| | 18:36 | PD-12 | Chihiro | Akiyama | Osaka, Japan
| Src family kinase inhibitor PP1 improves motor function by
reducing edema after spinal cord contusion in rats
| | 18:42 | PD-13 | Jan | Westman | Uppsala, Sweden
| Depletion of endogenous serotonin synthesis with p-CPA,
attenuates upregulation of constitutive isoform of Heme Oxygenase-2
expression following a focal trauma to the rat spinal cord
| | 18:48 | PD-14 | T. | Winkler | Uppsala, Sweden
| An L-type calcium channel blocker, Nimodipine influences trauma
induced cord conduction and axonal injury in the rat
| | 18:54 | PD-15 | John H. | Zhang | Louisiana, USA
| Optimal HBO therapeutic windows for acute spinal cord injury in rats
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| 7:50 - 8:10 | L6 | Lecture: Julian T. Hoff Michigan, USA
| Brain edema from intracerebral hemorrhage
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Moderators: A. David Mendelow (Newcastle upon Tyne, UK);
Seigo Nagao (Kagawa, Japan)
| | 8:10 - 10:15 | Oral Presentation:
"Intracerebral Hemorrhage, Subarchnoid Hemorrhage, Hydrocephalus"
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Moderators(37-41): A. David Mendelow (Newcastle upon Tyne, UK)
Seigo Nagao (Kagawa, Japan)
| | 8:10 | 37 | A David | Mendelow | Newcastle upon Tyne, UK | The International surgical trial in intracerebral haemorrhage (ISTICH)
| | 8:22 | 38 | Juan R. | Carhuapoma | Michigan, USA. | Human brain hemorrhage: Quantification of perihematoma edema using diffusion magnetic resonance imaging
| | 8:35 | 39 | Xiangjun | Chen | Michigan, USA. | Thrombin preconditioning upregulates transferrin and transferrin receptor and reduces brain edema induced by lysed red blood cells
| | 8:47 | 40 | Motoki | Inaji | Tokyo, Japan | Chronological change of perihematomal edema in human intracerebral hemorrhage
| | 9:00 | 41 | Masahiko | Kawanishi | Kagawa, Japan | Effect of hypothermia on brain edema formation following intracerebral hemorrhage in rats
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Moderators(42-46): Julian T. Hoff (Michigan, USA);
Tatsuya Nagashima (Kobe, Japan)
| | 9:12 | 42 | Zbigniew | Czernicki | Warsaw, Poland | Acute decrease of cerebrocortical microflow and lack of carbon dioxide reactivity following subarachnoid haemorrhage in the rat
| | 9:25 | 43 | John H. | Zhang | Louisiana, USA | Heat shock protein expression in the brain stem after subarachnoid hemorrhage in rats
| | 9:37 | 44 | Stephanie C. P. | Ng | New Territories, Hong Kong | The role of ultrasound guided aspiration in the management of patients with thalamic brain haemorrhage: a pilot study with continuous compliance monitoring
| | 9:50 | 45 | Ullrich | Meier | Berlin, Germany | Does the ventricle size change after shunt operation of normal pressure hydrocephalus?
| | 10:02 | 46 | Tatsuro | Kawamata | Tokyo, Japan | Metabolic derangements in interstitial brain edema with preserved blood flow: Selective vulnerability of the hippocampal CA3 region in rat hydrocephalus
| | 10:15 - 10:45 | Coffee Break and Poster Viewing
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| 10:45 - 11:05 | L7 | Lecture: Alexander Baethmann Munich, Germany
| Current significance and future perspectives of brain edema research
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Moderator: Kintomo Takakura (Tokyo, Japan)
| | 11:10 - 12:30 | Sponsored Session 3:
"Radiation Effects on Nervous Tissue: Neuromodulation, Injury and Edema"
- Sponsored by: Elekta K.K.,
GE Yokogawa Medical Systems, Ltd.
and Meditec Corporation
- Chairperson: Toshiki Yoshimine and Toshihiko Inoue
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Moderators(S3-1 - S3-3): Toshihiko Inoue (Osaka, Japan);
Toshiki Yoshimine (Osaka, Japan)
| | S3-1 | Kengo | Sato | Okayama, Japan | Radiation necrosis and brain edema associated with CyberKnife treatment
| | S3-2 | Ferenc A. | Jolesz | Massachusetts, USA | Non-invasive opening of BBB by focused ultrasound
| | S3-3 | Jean | Regis | Marseille, France | What evidence for neuromodulation effects in gamma knife surgery?
| | 12:30 - 13:30 | Lunch
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| 13:30 - 14:30 | Oral Presentation: "Treatment / Others"
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Moderators(47-51): Zbigniew Czerncki (Warsaw, Poland);
Ryuta Suzuki (Yokohama, Japan)
| | 13:30 | 47 | Tsuneo | Kano | Tokyo, Japan | Tissue plasminogen activator infiltrates through cerebral vessels: Evaluation using rat embolic stroke model
| | 13:42 | 48 | Tatsushi | Kamiya | Tokyo, Japan | Mild hypothermia enhances the neuroprotective effect of a selective thrombin inhibitor following transient focal ischemia in rats
| | 13:54 | 49 | Nils I | Stahl | Lund, Sweden | Intracerebral microdialysis in severe head injuries, a comparison between different treatment protocols
| | 14:06 | 50 | Tatsuo | Mima | Kochi, Japan | Doxorubicin and aclarubicin, RNA synthesis inhibitors, prevented cerebral vasospasm in severe SAH patients
| | 14:18 | 51 | Hiroki | Kurita | Tokyo, Japan | Radiation-induced apoptosis of oligodendrocytes in the adult rat brain
| | Poster Discussion E
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| 14:30 - 16:00 | Coffee Break and Poster Discussion E
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Moderators(PE1-PE8): Seiji Yamamoto (Hamamatsu, Japan);
John H. Zhang (Louisiana, USA)
| | 14:30 | PE-1 | Takuji | Kitaoka | Michigan, USA | Effect of delayed Argatroban treatment on intracerebral hemorrhage-induced edema in the rat
| | 14:36 | PE-2 | Tetsuya | Masada | Kagawa, Japan | Attenuation of intracerebral hemorrhage and thrombin-induced brain edema by overexpression of interleukin-1 receptor antagonist
| | 14:42 | PE-3 | Kenji | Dohi | Tokyo, Japan | Transient elevation of serum bilirubin level (a hemeoxygenase-1 metabolite) in hemorrhagic stroke patients
| | 14:54 | PE-5 | John H. | Zhang | Louisiana, USA | Role of apoptosis in microvascular permeability increase after SAH
| | 15:00 | PE-6 | Tatsuo | Mima | Kochi, Japan | Importance of microcirculatory disturbances in pathophysiological conditions of SAH: Clinical and experimental evidences
| | 15:06 | PE-7 | Hiroshi | Nawashiro | Saitama, Japan | Focal brain edema and natriuretic peptides in patients with subarachnoid hemorrhage
| | 15:12 | PE-8 | Ullrich | Meier | Berlin, Germany | The ICP-dependency of resistance to cerebrospinal fluid outflow: a new mathematical method for CSF-parameter calculation in a model with H-Tx rats
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Moderators(PE9-PE15): Nariyuki Hayashi (Tokyo, Japan);
Marios C. Papadopoulos (London, UK)
| | 15:18 | PE-9 | Kotaro | Oshio | California, USA | Aquaporin-1 deletion reduces osmotic water permeability and cerebrospinal fluid production
| | 15:24 | PE-10 | Kenichi | Isomura | Aichi, Japan | Expression of aquapolins in kaolin induced hydrocephalus in rat brain
| | 15:30 | PE-11 | Peter | Smielewski | Cambridge, UK | Hysteresis of the cerebrospinal pressure-volume curve in patients with hydrocephalus
| | 15:36 | PE-12 | Chikako | Nito | Tokyo, Japan | The effect of radical scavenger, edaravone and extra-mild hypothermia following transient focal ischemia in rats
| | 15:42 | PE-13 | Jan | Westman | Uppsala, Sweden | Antioxidant compounds EGB-761 and BN 520 21 attenuate brain edema formation and hemeoxygenase (HO) expression following hyperthermic brain injury in the rat
| | 15:48 | PE-14 | Kosaku | Kinoshita | Tokyo, Japan | Importance of hemodynamics management during brain hypothermia in patients with severe head injury
| | 15:54 | PE-15 | Atsushi | Sakurai | Tokyo, Japan | Relationship between brain oxygen metabolism and temperature gradient between brain and bladder
| | Poster Discussion F
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| 14:30 - 16:00 | Coffee Break and Poster Discussion F
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Moderators(PF1-PF8): Tadashi Nariai (Tokyo, Japan);
Wai S. Poon (Hong Kong, China)
| | 14:30 | PF-1 | Joseph D. | Fenstermacher | Michigan, USA | Tracking neuronal injury by perfusion-and diffuson-weighted MR imaging in a rat model of permanent focal cerebral ischemia
| | 14:36 | PF-2 | Ichiro | Yamada | Tokyo, Japan | Temporal evolution of apparent diffusion coefficient and T2 value following trasient focal cerebral ischmia in gerbils
| | 14:42 | PF-3 | Alonso | Pena | Cambridge, UK | Two-dimensional pq histograms as portraits of global tissue changes in magnetic resonance diffusion tensor imaging
| | 14:48 | PF-4 | Ken-ichi | Morita | Niigata, Japan | Diffusion tensor lambda chart analysis of peritumoral brain edema
| | 14:54 | PF-5 | Naoyuki | Miyasaka | Tokyo, Japan | Diffusion tensor changes in vasogenic and cellular brain edema in cats
| | 15:00 | PF-6 | Takeshi | Maeda | Tokyo, Japan | Ultra-early study of edema formation in cerebral contusion using diffusion MRI and ADC mapping
| | 15:06 | PF-7 | Feng | Xiao | Louisiana, USA | Real time monitoring of cerebral hemodynamic and neurometabolic changes by near-infrared spectroscopy following normothermic or hypothermic cardiac arrest in rats
| | 15:12 | PF-8 | Toshiyuki | Shiogai | Kyoto, Japan | Acetazolamide vasoreactivity evaluated by transcranial harmonic perfusion imaging: Relationship with transcranial doppler sonography and dynamic CT
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Moderators(PF9-PF15): Geoffrey T. Manley (California, USA);
Nobuyuki Kawai (Kagawa, Japan)
| | 15:18 | PF-9 | Hironaka | Igarashi | Tokyo, Japan | Cerebral blood flow index: Dynamic perfusion MRI delivers a simple and good predictor for the outcome of acute stage ischemic lesion
| | 15:24 | PF-10 | Makoto | Nakane | Kanagawa, Japan | Characteristic changes of the secondary degeneration in thedorsomedial nucleus of the thalamus on magnetic resonance imaging
| | 15:30 | PF-11 | Shoichiro | Ishihara | Saitama, Japan | Spontaneous intracranial hypotension; The early appearance of urinary bladder activity in RI cisternography was not necessary characteristic sign?
| | 15:36 | PF-12 | Geoffrey | Manley | California, USA | Expression of membrane water channels, Aquaporin 1 and Aquaporin 4, in human brain tumors suggests a potential novel therapeutic target for tumor-associated edema
| | 15:42 | PF-13 | Tatsuo | Mima | Kochi, Japan | Potential risk of aggravation of brain edema at the time of chemotherapy against brain tumor
| | 15:48 | PF-14 | Kojiro | Wada | Kanagawa, Japan | MRI analysis of hydrocephalus associated with acoustic neuroma
| | 15:54 | PF-15 | Hiroshi | Nawashiro | Saitama, Japan | Vascular endothelial growth factor expression in pituitary adenoma
| | 16:00 - 17:00 | Roundtable Discussion
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Moderators: Julian T. Hoff (Michigan, USA);
Konstantin A. Hossmann (Cologne, Germany);
Anthony Marmarou (Virginia, USA)
| | 17:00 - 17:20 | Hakone Best Presentation Award / Closing Remarks
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The six most outstanding papers (three from oral presentations, three from
poster presentations) will be selected by the International Advisory Board and
the Organizing Committee. Prizes will be awarded to the authors at the end of
the symposium. Members of the selection committee will be announced on our web
site.
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Program