Massie Ikeda, a Scot-Japanese Neurologist

Masayuki Ikeda M.D.

Present Address:

Department of Medical Informatics, Kagawa University Hospital
Miki-cho Ikenobe, Kagawa 761-0793, JAPAN

Education:

1976-1982 M.D., Tokyo Medical and Dental University, School of Medicine

Position:

1982-1984: Resident in Internal Medicine, Tokyo Medical and Dental University Hospital , Tokyo , Japan

1984-1986: Fellow in Neurology, Kantoh Teishin Hospital, Tokyo , Japan

1986-88: Researcher in Neuroscience, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo , Japan

1988-1990: Neurologist-in-Chief, Asahi General Hospital, Chiba, Japan

1990-1992: Research Scientist, Wellcome Surgical Institute, University of Glasgow, Glasgow, Scotland

1992-1999: Division Chief, Division of Neurology, Department of Medicine, Ranzan Institute for the Mentally Retarded, Saitama, & Senior Researcher, Department of Physiological Chemistry, Graduate School, Tokyo Medical and Dental University.

1999-June 2003 : Codirector, Department of Clinical Research, National Saigata Hospital, Niigata, Japan

July 2003-June 2007: Director Medical Reviewer, PMDA (Phamaceuticals & Medical Devices Agency)

July 2007-September 2008: House Staff, National Chicihbu Institute for the Mentally Retarded

October 2008- March 2013: Professor of Pharmaceutical Medicine, Nagasaki University

April 2013- present: Director of the Medical Office, Takamatsu Prison, Ministry of Justice

License:
License of Medical Practice, 1982 Japanese Government,

Fellowship:
Fellow of the Japanese Society of Neurology, 1987,
Fellow of the Japanese Society of Internal Medicine, 1988
Member of ACP, 2000

Publications

1. Orimo S, Araki M, Ishii H, Ikeda M, Kurosawa T, Arai M, Hiyamuta E. A case of myopathy with tubular aggregates with increased muscle fiber sensitivity to caffeine. J Neurol 1987;234:424-426.

2. Ikeda M, Mikuni M, Nishikawa T, Takahashi K. A neurochemical study of a new mutant mouse presenting myoclonus-like involuntary movement: a possible model of spontaneous serotonergic hyperactivity. Brain Res 1989;495:337-348.

3. Uchihara T, Ikeda M, Takahashi H, Yoshida S, Tsukagoshi H. CSF lymphocyte subsets in aseptic meningitis: dual labelling analysis with flow cytometry. Acta Neurol Scand 1990;81:468-470.

4. Ikeda M, Tsukagoshi H. Encephalopathy due to toluene sniffing, Report of a case with magnetic resonance imaging. Eur Neurol 1990;30:347-349.

5. Kurumaji A, Ikeda M, Dewar D, McCormac AG, McCulloch J. Effects of chronic administration of MK-801 upon local cerebral glucose utilization and ligand binding to the NMDA receptor complex. Brain Res 1991;563:57-65.

6. Uchihara T, Ikeda M, Tsukagoshi H. Recurrent Fisher's syndrmoe with immunological abnormalities and replicated laterality. Eur Neurol 1991;31:270-272.

7. Ikeda M, Dewar D, McCulloch J. Selective reduction of [125I]-apamin binding sites in Alzheimer hippocampus, A quantitative autoradiographic study. Brain Res 1991;567:51-56.

8. Ikeda M, Dewar D, McCulloch J. Preservation of [125I]-galanin binding sites despite loss of cholinergic neurones in Alzheimer's disease. Brain Res 1991;568:303-306.

9. Ikeda M, Tsukagoshi H. Monochorea caused by striatal lesion. Eur Neurol 1991;31:257-258.

10. Ikeda M, Tsukagoshi H. Vogt-Koyanagi-Harada disease presenting meningoencephalitis, Report of a case with magnetic resonance imaging. Eur Neurol 1992;32:83-85.

11. Ikeda M, Yoshida S, Tsukagoshi H. Interferon-g in cerebrospinal fluid without pleocytosis in scrub typhus. J Neurol Sci 1992;109:61-63.

12. Ikeda M, Dewar D, McCulloch J. A correlative study of calcium channel antagonist binding and local neuropathological features in the hippocampus in Alzheimer's disease. Brain Res 1992;589:313-319.

13. Sato I, Morita I, Kaji K, Ikeda M, Nagao M, Murota S. Reduction of nitric oxide producing activity associated with aging in cultured human umbilical vein endothelial cells. Biochem Biophys Res Commun 1993;195:1070-1076.

14. Ikeda M, Dewar D, McCulloch J. High affinity hippocampal [3H]-glibenclamide binding sites are preserved in Alzheimer's disease. J Neural Transm [P-D Sect] 1993;5:177-184.

15. Ikeda M, Morita I, Murota S, Sekiguchi F, Yuasa T, Miyatake T. Cerebellar nitric oxide synthase activity is reduced in nervous and Purkinje cell degeneration mutants but not in climbing fiber-lesioned mice. Neurosci Lett 1993;155:148-150.

16. Ikeda M, Dewar D, McCulloch J. Differential alterations of ion channel binding sites in temporal and occipital regions of the cerebral cortex in Alzheimer's disease. Brain Res 1993;630:50-56.

17. Ikeda M, Mackay KB, Dewar D, McCulloch J. Differential alterations in adenosine A1 and k1 opioid receptors in the striatum in Alzheimer's disease. Brain Res 1993;616:211-217.

18. Ikeda M, Matsui K, Ishihara Y, et al. Cerebellar nitric oxide synthase, cGMP and motor function in two lines of cerebellar mutant mice, Staggerer and Wriggle Mouse Sagami. Neurosci Lett 1994;168:65-68.

19. Ikeda M, Takahashi K, Matsunaga T, Tsukagoshi H. Reversible white matter lesions in a patient with fulminant hepatitis and acute renal failure. Intern Med 1994;33:360-362.

20. Ikeda M, Takahashi H, Yoshida S. HLA-DR+CD3+ and CD8+ cells are increased but CD4+CD45RA+ cells are reduced in the peripheral blood in human scrub typhus. Clin Immunol Immunopathol 1994;72:402-404.

21. Komachi H, Tsuchiya K, Ikeda M, Koike R, Matsunaga T, Ikeda K. Radiation myelophathy: a clinicopathological study with special reference tjo correlation between MRI findings and neuropathology. J Neurol Sci 1995;132:228-232.

22. Ikeda M, Dewar D, McCulloch J. Galanin receptor binding sites in the temporal and the occipital cortex are minimally affected in Alzheimer's disease. Neurosci Lett 1995;192:37-40.

23. Ikeda M, Sato I, Yuasa T, Miyatake T, Murota S. Nitrite, nitrate and cGMP in the cerebrospinal fluid in degenerative neurologic diseases. J Neural Transm [Gen Sect] 1995;100:263-267.

24. Ikeda M, Sato I, Matsunaga T, Takahashi M, Yuasa T, Murota S. Ikeda M, Sato I, Matsunaga T, Takahashi M, Yuasa T, Murota S. Cyclic guanosine monophosphate (cGMP), nitrite and nitrate in the cerebrospinal fluid in meningitis, multiple sclerosis and Guillain-Barré syndrome. Intern Med 1995;34:734-737.

25. Himi T, Ikeda M, Sato I, Yuasa T, Murota S. Purkinje cells express neuronal nitric oxide synthase after methylmercury administration. Brain Res 1996;718:189-192.

26. Ikeda M, Kanai H, Akaike M, et al. Nitric oxide synthase-containing neurons in the hippocampus are preserved in trimethyltin intoxication. Brain Res 1996;712:168-170.

27. Ikeda M, Komachi H, Sato I, Himi T, Yuasa T, Murota S. Induction of neuronal nitric oxide synthase by methylmercury in the cerebellum. J Neurosci Res 1999;55:352-356.

28. Ikeda M, Komiyama T, Sato I, Himi T, Murota S. Neuronal nitric oxide synthase is resistant to ethanol. Life Sci 1999;64:1623-1630.

29. Tsuchiya K, Ozawa E, Haga C, Watabiki, S, Ikeda M, Sano M, Ooe K, Taki K, Ikeda, K. Constant involvement of the Betz cells and pyramidal tract in multiple system atrophy: a clinicopathological study of seven autopsy cases. Acta Neuropathol 2000;99: 628-636

30. Suzuki R, Ikeda M, Kami M. Japanese physicians and public respect. Lancet 2000;356:598-600.

31. Ikeda M and Yoshida S. HIV-1 and scrub typhus. Lancet 2000;356:1851.

32. Ikeda M. Iron overload without the C282Y mutation in patients with epilepsy. J Neurol Neurosurg Psychiat 2001;70:551-3

33. Ikeda M, Arai Y. Longitudinal changes in brain CTscans and development of dementia in Down's syndrome. Eur Neurol 2002;47:205-208

34. Ikeda M, MatsunagaT, Irabu N, Yoshida S. Using vital signs to diagnose impaired consciousness: cross sectional observational study. BMJ 2002;325:800

35. Himi T, Ikeda M, Yasuhara T, Murota S. Oxidative neuronal death caused by glutamte uptake inhibition in cultured hippocampal neurons. J Neurosci Res 2003;71:679-688

36. Himi T, Ikeda M, Yasuhara T, Morita I. Role of Neuronal Glutamate Transporter in the Cysteine Uptake and Intracellular Glutathione Levels in Cultured Cortical Neurons. J Neural Transm [Gen Sect] 2003;110: 1337-48

37. Kishi Y, Miyakoshi S, Kami M, Ikeda M, Katayama Y, Murashige N, Kusumi E, Yuji K, Kobayashi K, Kato D, Hamaki T, Matsumura T, Kim S-W, Morinaga , Mori S, Kanemaru M, Hayashi T, Takaue Y, Taniguch S. Early central nervous system complication following reduced intensity stem-cell transplantation. Biol Blood Marrow Transplant 2004;10:561-568

38. Ikeda M. Uses of error. Family bias by proxy. Lancet 2005;365:187

39. Kobayashi K, Kami M, Ikeda M, Kishi Y, Murashige N, Tanosaki R, Mori S, Takaue Y. Fulminant septicemia caused by Bacillus cereus following reduced-intensity umbilical cord blood transplantation. Haematologica 2005;90:ECR06

40. Murashige N, Kami M, Ikeda M. Aspirin, COX-2, and the Risk of Colorectal Cancer. N Engl J Med 2007;357: 824.

41. Kondoh T, Kanno A, Itoh H, Nakashima M, Honda R, Kojima M, Noguchi M, Nakane H, Nozaki H, Sasaki H, Nagai T, Kosaki R, Kakee N, Okuyama T, Fukuda M, Ikeda M, Shibata Y, Moriuchi H. Donepezil Significantly Improves Abilities in Daily Lives of Female Down Syndrome Patients with Severe Cognitive Impairment: A 24-Week Randomized, Double-Blind, Placebo-Controlled Trial. Int J Psychiatry Med 2011;41:71-89.